Leslie Silberstein, MD

Leslie Silberstein, MD

Director of the Joint Program in Transfusion Medicine

Professor of Pathology, Harvard Medical School

  • Contact: 617-919-2588

  • Fax: 617-730-0765

Medical Services

Specialties

  • Blood Banking Transfusion Medicine

Departments

  • Laboratory Medicine Research Center

Languages

  • English
To schedule an appointment: Call 617-919-2588

Experience and Education

Education

Medical School

University of Leiden, 1969-1977

Leiden, The Netherlands

Internship

Georgetown University Medical Division, D.C. General Hospital, 1977-1978

Washington, DC

Residency

St. Francis Hospital and Medical Center, 1978-1980

Hartford, CT

Fellowship

New England Medical Center Hospital, 1980-1983

Boston, MA

Certifications

  • Internal Medicine/Hematology/Blood Banking/Transfusion Medicine

Publications

Publications powered by Harvard Catalyst Profiles
  1. Bajrami B, Zhu H, Kwak HJ, Mondal S, Hou Q, Geng G, Karatepe K, Zhang YC, Nombela-Arrieta C, Park SY, Loison F, Sakai J, Xu Y, Silberstein LE, Luo HR. G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling. J Exp Med. 2016 Sep 19; 213(10):1999-2018.
  2. Manis JP, Silberstein LE. Platelet refractoriness: it's not the B-all and end-all. Blood. 2016 Apr 7; 127(14):1740-1.
  3. Lane WJ, Westhoff CM, Uy JM, Aguad M, Smeland-Wagman R, Kaufman RM, Rehm HL, Green RC, Silberstein LE. Comprehensive red blood cell and platelet antigen prediction from whole genome sequencing: proof of principle. Transfusion. 2016 Mar; 56(3):743-54.
  4. Ciuculescu MF, Park SY, Canty K, Mathieu R, Silberstein LE, Williams DA. Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo. Blood. 2015 May 14; 125(20):3105-13.
  5. Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Sun Y, Zhu H, Chai L, Silberstein LE, Cheng T, Luo HR. Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity. 2015 Jan 20; 42(1):159-71.
  6. Nombela-Arrieta C, Silberstein LE. The science behind the hypoxic niche of hematopoietic stem and progenitors. Hematology Am Soc Hematol Educ Program. 2014 Dec 5; 2014(1):542-7.
  7. Lindblad RW, Ibenana L, Wagner JE, McKenna DH, Hei DJ, Hematti P, Couture LA, Silberstein LE, Armant M, Rooney CM, Gee AP, Welniak LA, Heath Mondoro T, Wood DA, Styers D. Cell therapy product administration and safety: data capture and analysis from the Production Assistance for Cellular Therapies (PACT) program. Transfusion. 2015 Mar; 55(3):674-9.
  8. Hacein-Bey-Abina S, Pai SY, Gaspar HB, Armant M, Berry CC, Blanche S, Bleesing J, Blondeau J, de Boer H, Buckland KF, Caccavelli L, Cros G, De Oliveira S, Fernández KS, Guo D, Harris CE, Hopkins G, Lehmann LE, Lim A, London WB, van der Loo JC, Malani N, Male F, Malik P, Marinovic MA, McNicol AM, Moshous D, Neven B, Oleastro M, Picard C, Ritz J, Rivat C, Schambach A, Shaw KL, Sherman EA, Silberstein LE, Six E, Touzot F, Tsytsykova A, Xu-Bayford J, Baum C, Bushman FD, Fischer A, Kohn DB, Filipovich AH, Notarangelo LD, Cavazzana M, Williams DA, Thrasher AJ. A modified ?-retrovirus vector for X-linked severe combined immunodeficiency. N Engl J Med. 2014 Oct 9; 371(15):1407-17.
  9. Gazit R, Mandal PK, Ebina W, Ben-Zvi A, Nombela-Arrieta C, Silberstein LE, Rossi DJ. Fgd5 identifies hematopoietic stem cells in the murine bone marrow. J Exp Med. 2014 Jun 30; 211(7):1315-31.
  10. Wood D, Wesselschmidt R, Hematti P, Gee AP, Rooney C, Silberstein L, Armant M, Couture L, Wagner JE, McKenna DH, Hei D, Mondoro TH, Welniak L, Lindblad R. An update from the United States National Heart, Lung, and Blood Institute-funded Production Assistance for Cellular Therapies (PACT) program: a decade of cell therapy. Clin Transl Sci. 2014 Apr; 7(2):93-9.
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  12. Ueno S, Lu J, He J, Li A, Zhang X, Ritz J, Silberstein LE, Chai L. Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: mechanism, function, and implication for a potential novel therapeutic target. Exp Hematol. 2014 Apr; 42(4):307-316.e8.
  13. Silberstein LE, Lin CP. A new image of the hematopoietic stem cell vascular niche. Cell Stem Cell. 2013 Nov 7; 13(5):514-6.
  14. Cutler C, Multani P, Robbins D, Kim HT, Le T, Hoggatt J, Pelus LM, Desponts C, Chen YB, Rezner B, Armand P, Koreth J, Glotzbecker B, Ho VT, Alyea E, Isom M, Kao G, Armant M, Silberstein L, Hu P, Soiffer RJ, Scadden DT, Ritz J, Goessling W, North TE, Mendlein J, Ballen K, Zon LI, Antin JH, Shoemaker DD. Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood. 2013 Oct 24; 122(17):3074-81.
  15. Luckey CJ, Silberstein LE. A mouse model of hemolytic disease of the newborn. Blood. 2013 Aug 22; 122(8):1334-5.
  16. Nombela-Arrieta C, Pivarnik G, Winkel B, Canty KJ, Harley B, Mahoney JE, Park SY, Lu J, Protopopov A, Silberstein LE. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol. 2013 Aug 1; 15(8):1016.
  17. Sanchez R, Silberstein LE, Lindblad RW, Welniak LA, Mondoro TH, Wagner JE. Strategies for more rapid translation of cellular therapies for children: a US perspective. Pediatrics. 2013 Aug; 132(2):351-8.
  18. Liang OD, Lu J, Nombela-Arrieta C, Zhong J, Zhao L, Pivarnik G, Mondal S, Chai L, Silberstein LE, Luo HR. Deficiency of lipid phosphatase SHIP enables long-term reconstitution of hematopoietic inductive bone marrow microenvironment. Dev Cell. 2013 May 28; 25(4):333-49.
  19. Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Chèvre R, A-González N, Kunisaki Y, Zhang D, van Rooijen N, Silberstein LE, Weber C, Nagasawa T, Frenette PS, Castrillo A, Hidalgo A. Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell. 2013 May 23; 153(5):1025-35.
  20. Nombela-Arrieta C, Pivarnik G, Winkel B, Canty KJ, Harley B, Mahoney JE, Park SY, Lu J, Protopopov A, Silberstein LE. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol. 2013 May; 15(5):533-43.
  21. Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G, Tenen DG. Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Mol Cell. 2013 Mar 7; 49(5):934-46.
  22. Mollova M, Bersell K, Walsh S, Savla J, Das LT, Park SY, Silberstein LE, Dos Remedios CG, Graham D, Colan S, Kühn B. Cardiomyocyte proliferation contributes to heart growth in young humans. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1446-51.
  23. Park SY, Wolfram P, Canty K, Harley B, Nombela-Arrieta C, Pivarnik G, Manis J, Beggs HE, Silberstein LE. Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments. J Immunol. 2013 Feb 1; 190(3):1094-102.
  24. Amabile G, Welner RS, Nombela-Arrieta C, D'Alise AM, Di Ruscio A, Ebralidze AK, Kraytsberg Y, Ye M, Kocher O, Neuberg DS, Khrapko K, Silberstein LE, Tenen DG. In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells. Blood. 2013 Feb 21; 121(8):1255-64.
  25. Gao H, Wu X, Sun Y, Zhou S, Silberstein LE, Zhu Z. Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells. J Biol Chem. 2012 Aug 24; 287(35):29979-87.
  26. Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LE. Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol. 2012 Apr; 40(4):307-17.e3.
  27. Li Y, Prasad A, Jia Y, Roy SG, Loison F, Mondal S, Kocjan P, Silberstein LE, Ding S, Luo HR. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 2011 Jun 16; 117(24):6702-13.
  28. Lu J, Ma Y, Kong N, Alipio Z, Gao C, Krause DS, Silberstein LE, Chai L. Dissecting the role of SALL4, a newly identified stem cell factor, in chronic myelogenous leukemia. Leukemia. 2011 Jul; 25(7):1211-3.
  29. Jo H, Lo PK, Li Y, Loison F, Green S, Wang J, Silberstein LE, Ye K, Chen H, Luo HR. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6486-91.
  30. Nombela-Arrieta C, Ritz J, Silberstein LE. The elusive nature and function of mesenchymal stem cells. Nat Rev Mol Cell Biol. 2011 Feb; 12(2):126-31.
  31. Jo H, Loison F, Hattori H, Silberstein LE, Yu H, Luo HR. Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs. PLoS One. 2010; 5(4):e10318.
  32. Yu H, Li Y, Gao C, Fabien L, Jia Y, Lu J, Silberstein LE, Pinkus GS, Ye K, Chai L, Luo HR. Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN. Leukemia. 2010 May; 24(5):1077-80.
  33. Gao H, Le Y, Wu X, Silberstein LE, Giese RW, Zhu Z. VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor. Cancer Res. 2010 Jan 1; 70(1):202-11.
  34. Kasorn A, Alcaide P, Jia Y, Subramanian KK, Sarraj B, Li Y, Loison F, Hattori H, Silberstein LE, Luscinskas WF, Luo HR. Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals. J Immunol. 2009 Jul 15; 183(2):1032-43.
  35. Sarraj B, Massberg S, Li Y, Kasorn A, Subramanian K, Loison F, Silberstein LE, von Andrian U, Luo HR. Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation. J Immunol. 2009 Jun 1; 182(11):7190-200.
  36. Lu J, Jeong HW, Jeong H, Kong N, Yang Y, Carroll J, Luo HR, Silberstein LE, Chai L. Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex. PLoS One. 2009; 4(5):e5577.
  37. Le Y, Xu L, Lu J, Fang J, Nardi V, Chai L, Silberstein LE. FAK silencing inhibits leukemogenesis in BCR/ABL-transformed hematopoietic cells. Am J Hematol. 2009 May; 84(5):273-8.
  38. Jin H, Oyoshi MK, Le Y, Bianchi T, Koduru S, Mathias CB, Kumar L, Le Bras S, Young D, Collins M, Grusby MJ, Wenzel J, Bieber T, Boes M, Silberstein LE, Oettgen HC, Geha RS. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest. 2009 Jan; 119(1):47-60.
  39. Steigman SA, Armant M, Bayer-Zwirello L, Kao GS, Silberstein L, Ritz J, Fauza DO. Preclinical regulatory validation of a 3-stage amniotic mesenchymal stem cell manufacturing protocol. J Pediatr Surg. 2008 Jun; 43(6):1164-9.
  40. Jia Y, Loison F, Hattori H, Li Y, Erneux C, Park SY, Gao C, Chai L, Silberstein LE, Schurmans S, Luo HR. Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4739-44.
  41. Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen L, Silberstein LE. SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. Immunity. 2007 Nov; 27(5):811-23.
  42. Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE. Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells. Leukemia. 2007 Aug; 21(8):1723-32.
  43. Yang J, Chai L, Liu F, Fink LM, Lin P, Silberstein LE, Amin HM, Ward DC, Ma Y. Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10494-9.
  44. Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE, Stossel TP, Hartwig JH, Hoffmeister KM. In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration. Transfusion. 2007 Mar; 47(3):442-51.
  45. Zhu D, Hattori H, Jo H, Jia Y, Subramanian KK, Loison F, You J, Le Y, Honczarenko M, Silberstein L, Luo HR. Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death. Proc Natl Acad Sci U S A. 2006 Oct 3; 103(40):14836-41.
  46. Honczarenko M, Glodek AM, Swierkowski M, Na IK, Silberstein LE. Developmental stage-specific shift in responsiveness to chemokines during human B-cell development. Exp Hematol. 2006 Aug; 34(8):1093-100.
  47. Honczarenko M, Le Y, Swierkowski M, Ghiran I, Glodek AM, Silberstein LE. Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells. 2006 Apr; 24(4):1030-41.
  48. Honczarenko M, Ratajczak MZ, Nicholson-Weller A, Silberstein LE. Complement C3a enhances CXCL12 (SDF-1)-mediated chemotaxis of bone marrow hematopoietic cells independently of C3a receptor. J Immunol. 2005 Sep 15; 175(6):3698-706.
  49. Honczarenko M, Lu B, Nicholson-Weller A, Gerard NP, Silberstein LE, Gerard C. C5L2 receptor is not involved in C3a / C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12. Leukemia. 2005 Sep; 19(9):1682-3; author reply 1684-5.
  50. Le Y, Honczarenko M, Glodek AM, Ho DK, Silberstein LE. CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by regulator of G protein signaling 1 in pro-B cells. J Immunol. 2005 Mar 1; 174(5):2582-90.
  51. Mazo IB, Honczarenko M, Leung H, Cavanagh LL, Bonasio R, Weninger W, Engelke K, Xia L, McEver RP, Koni PA, Silberstein LE, von Andrian UH. Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity. 2005 Feb; 22(2):259-70.
  52. Burger M, Glodek A, Hartmann T, Schmitt-Gräff A, Silberstein LE, Fujii N, Kipps TJ, Burger JA. Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells. Oncogene. 2003 Nov 6; 22(50):8093-101.
  53. Glodek AM, Honczarenko M, Le Y, Campbell JJ, Silberstein LE. Sustained activation of cell adhesion is a differentially regulated process in B lymphopoiesis. J Exp Med. 2003 Feb 17; 197(4):461-73.
  54. Honczarenko M, Le Y, Glodek AM, Majka M, Campbell JJ, Ratajczak MZ, Silberstein LE. CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor. Blood. 2002 Oct 1; 100(7):2321-9.
  55. Zubair AC, Silberstein L, Ritz J. Adult hematopoietic stem cell plasticity. Transfusion. 2002 Aug; 42(8):1096-101.
  56. Westhoff CM, Silberstein LE, Wylie DE, Skavdahl M, Reid ME. 16Cys encoded by the RHce gene is associated with altered expression of the e antigen and is frequent in the R0 haplotype. Br J Haematol. 2001 Jun; 113(3):666-71.
  57. Silberstein LE, Toy P. Research opportunities in transfusion medicine. JAMA. 2001 Feb 7; 285(5):577-80.
  58. Majewski M, Korecka M, Kossev P, Li S, Goldman J, Moore J, Silberstein LE, Nowell PC, Schuler W, Shaw LM, Wasik MA. The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4285-90.
  59. Westhoff CM, Silberstein LE, Wylie DE. Evidence supporting the requirement for two proline residues for expression of c. Transfusion. 2000 Mar; 40(3):321-4.
  60. Cunto-Amesty G, Przybylski G, Honczarenko M, Monroe JG, Silberstein LE. Evidence that immunoglobulin specificities of AIDS-related lymphoma are not directed to HIV-related antigens. Blood. 2000 Feb 15; 95(4):1393-9.
  61. Majka M, Ratajczak J, Lee B, Honczarenko M, Douglas R, Kowalska MA, Silberstein L, Gewirtz AM, Ratajczak MZ. The role of HIV-related chemokine receptors and chemokines in human erythropoiesis in vitro. Stem Cells. 2000; 18(2):128-38.
  62. Dzik S, Aubuchon J, Jeffries L, Kleinman S, Manno C, Murphy MF, Popovsky MA, Sayers M, Silberstein LE, Slichter SJ, Vamvakas EC. Leukocyte reduction of blood components: public policy and new technology. Transfus Med Rev. 2000 Jan; 14(1):34-52.
  63. Stadtmauer EA, Tsai DE, Sickles CJ, Mick R, Luger SM, Porter DL, Mangan PA, Schuchter LM, Schuster SJ, Loh EY, Magee DA, Sachs RA, Wall ME, Moore J, Buzby GP, Zaleta E, Kamoun M, Silberstein LE. Stem cell transplantation for metastatic breast cancer: analysis of tumor contamination. Med Oncol. 1999 Dec; 16(4):279-88.
  64. Majka M, Rozmyslowicz T, Lee B, Murphy SL, Pietrzkowski Z, Gaulton GN, Silberstein L, Ratajczak MZ. Bone marrow CD34(+) cells and megakaryoblasts secrete beta-chemokines that block infection of hematopoietic cells by M-tropic R5 HIV. J Clin Invest. 1999 Dec; 104(12):1739-49.
  65. Honczarenko M, Douglas RS, Mathias C, Lee B, Ratajczak MZ, Silberstein LE. SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells. Blood. 1999 Nov 1; 94(9):2990-8.
  66. Rao SP, Riggs JM, Friedman DF, Scully MS, LeBien TW, Silberstein LE. Biased VH gene usage in early lineage human B cells: evidence for preferential Ig gene rearrangement in the absence of selection. J Immunol. 1999 Sep 1; 163(5):2732-40.
  67. Moore HC, Mick R, Solin LJ, Sickles C, Mangan PA, Luger SM, Fox KR, Schuchter LM, Loh E, Porter DL, Schuster S, Buzby GP, Glatstein E, Silberstein LE, Stadtmauer EA. Autologous stem-cell transplant after conventional dose adjuvant chemotherapy for high-risk breast cancer: impact on the delivery of local-regional radiation therapy. Ann Oncol. 1999 Aug; 10(8):929-36.
  68. Westhoff CM, Schultze A, From A, Wylie DE, Silberstein LE. Characterization of the mouse Rh blood group gene. Genomics. 1999 May 1; 57(3):451-4.
  69. Hillyer CD, Lankford KV, Roback JD, Gillespie TW, Silberstein LE. Transfusion of the HIV-seropositive patient: immunomodulation, viral reactivation, and limiting exposure to EBV (HHV-4), CMV (HHV-5), and HHV-6, 7, and 8. Transfus Med Rev. 1999 Jan; 13(1):1-17.
  70. Shan H, Goldman J, Cunto G, Manuppello J, Chaiken I, Cines DB, Silberstein LE. Heterogeneity of anti-phospholipid and anti-endothelial cell antibodies. J Autoimmun. 1998 Dec; 11(6):651-60.
  71. Silberstein LE, Rao SP. VH-mediated mechanisms in normal and neoplastic B cell development. Immunol Res. 1998; 17(1-2):253-9.
  72. Kraj P, Rao SP, Glas AM, Hardy RR, Milner EC, Silberstein LE. The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells. J Immunol. 1997 Jun 15; 158(12):5824-32.
  73. Przybylski GK, Goldman J, Ng VL, McGrath MS, Herndier BG, Schenkein DP, Monroe JG, Silberstein LE. Evidence for early B-cell activation preceding the development of Epstein-Barr virus-negative acquired immunodeficiency syndrome-related lymphoma. Blood. 1996 Dec 15; 88(12):4620-9.
  74. Dighiero G, Kipps T, Schroeder HW, Chiorazzi N, Stevenson F, Silberstein LE, Caligaris-Cappio F, Ferrarini M. What is the CLL B-lymphocyte? Leuk Lymphoma. 1996 Oct; 22 Suppl 2:13-39.
  75. Bird JM, Luger S, Mangan P, Edelstein M, Silberstein L, Powlis W, Ball J, Schultz DJ, Stadtmauer EA. 4-Hydroperoxycyclophosphamide purged autologous bone marrow transplantation in non-Hodgkin's lymphoma patients at high risk of bone marrow involvement. Bone Marrow Transplant. 1996 Aug; 18(2):309-13.
  76. Silberstein LE, Jefferies LC. Placental-blood banking--a new frontier in transfusion medicine. N Engl J Med. 1996 Jul 18; 335(3):199-201.
  77. Stoerker J, Hurwitz C, Rose NC, Silberstein LE, Highsmith WE. Heteroduplex generator in analysis of Rh blood group alleles. Clin Chem. 1996 Mar; 42(3):356-60.
  78. Silberstein LE, George A, Durdik JM, Kipps TJ. The V4-34 encoded anti-i autoantibodies recognize a large subset of human and mouse B-cells. Blood Cells Mol Dis. 1996; 22(2):126-38.
  79. Friedman DF, Kraj P, Silberstein LE. VH4.21 expression in the normal human B-cell repertoire. Ann N Y Acad Sci. 1995 Sep 29; 764:285-92.
  80. Jefferies LC, Carchidi CM, Silberstein LE. Immunoglobulin gene use by naturally occurring cold agglutinins. Ann N Y Acad Sci. 1995 Sep 29; 764:433-5.
  81. Moore JS, Friedman DF, Silberstein LE, Besa EC, Nowell PC. Clinical heterogeneity reflects biologic diversity in chronic lymphocytic leukemia. Crit Rev Oncol Hematol. 1995 Aug; 20(1-2):141-64.
  82. Kraj P, Friedman DF, Stevenson F, Silberstein LE. Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire. J Immunol. 1995 Jun 15; 154(12):6406-20.
  83. Stadtmauer EA, Schneider CJ, Silberstein LE. Peripheral blood progenitor cell generation and harvesting. Semin Oncol. 1995 Jun; 22(3):291-300.
  84. Monroe JG, Silberstein LE. HIV-mediated B-lymphocyte activation and lymphomagenesis. J Clin Immunol. 1995 Mar; 15(2):61-8.
  85. Biggs DD, Kraj P, Goldman J, Jefferies L, Carchidi C, Anderson K, Silberstein LE. Immunoglobulin gene sequence analysis to further assess B-cell origin of multiple myeloma. Clin Diagn Lab Immunol. 1995 Jan; 2(1):44-52.
  86. Parr TB, Johnson TA, Silberstein LE, Kipps TJ. Anti-B cell autoantibodies encoded by VH 4-21 genes in human fetal spleen do not require in vivo somatic selection. Eur J Immunol. 1994 Dec; 24(12):2941-9.
  87. Siegel DL, Silberstein LE. Expression and characterization of recombinant anti-Rh(D) antibodies on filamentous phage: a model system for isolating human red blood cell antibodies by repertoire cloning. Blood. 1994 Apr 15; 83(8):2334-44.
  88. Silberstein LE. B-cell origin of cold agglutinins. Adv Exp Med Biol. 1994; 347:193-205.
  89. Biggs D, Stadtmauer E, Mangan P, Edelstein M, Powlis W, Buzby G, Magee D, Sachs B, Silberstein L. 4-Hydroperoxycyclophosphamide purged autologous bone marrow transplantation of relapsed, responding non-Hodgkin's lymphoma with granulocyte colony stimulating factor support results in reliable hematopoietic recovery. Prog Clin Biol Res. 1994; 389:9-15.
  90. Stadtmauer EA, Hodi FS, Sickles C, Biggs DD, Mangan P, Buzby G, Zaleta E, Silberstein L. High-dose therapy and growth factor mobilized peripheral blood progenitor cell support for responding patients with metastatic breast cancer. Prog Clin Biol Res. 1994; 389:487-95.
  91. Schutte ME, van Es JH, Silberstein LE, Logtenberg T. VH4.21-encoded natural autoantibodies with anti-i specificity mirror those associated with cold hemagglutinin disease. J Immunol. 1993 Dec 1; 151(11):6569-76.
  92. Jefferies LC, Carchidi CM, Silberstein LE. Naturally occurring anti-i/I cold agglutinins may be encoded by different VH3 genes as well as the VH4.21 gene segment. J Clin Invest. 1993 Dec; 92(6):2821-33.
  93. Goodnough LT, Anderson KC, Kurtz S, Lane TA, Pisciotto PT, Sayers MH, Silberstein LE. Indications and guidelines for the use of hematopoietic growth factors. Transfusion. 1993 Nov-Dec; 33(11):944-59.
  94. Pisciotto PT, Anderson KC, Goodnough LT, Kurtz SR, Lane TA, Sayers MH, Silberstein LE. Current trends: evolving concepts in transfusion medicine. The need for standardization of cryoprecipitate-derived fibrin adhesive. Transfus Sci. 1993 Jul; 14(3):291-4.
  95. Stevenson FK, Spellerberg MB, Treasure J, Chapman CJ, Silberstein LE, Hamblin TJ, Jones DB. Differential usage of an Ig heavy chain variable region gene by human B-cell tumors. Blood. 1993 Jul 1; 82(1):224-30.
  96. Konrad RJ, Kricka LJ, Goodman DB, Goldman J, Silberstein LE. Brief report: myeloma-associated paraprotein directed against the HIV-1 p24 antigen in an HIV-1-seropositive patient. N Engl J Med. 1993 Jun 24; 328(25):1817-9.
  97. Silberstein LE. Natural and pathologic human autoimmune responses to carbohydrate antigens on red blood cells. Springer Semin Immunopathol. 1993; 15(2-3):139-53.
  98. Jefferies LC, Silverman GJ, Carchidi CM, Silberstein LE. Idiotypic heterogeneity of VKIII autoantibodies to red blood cell antigens. Clin Immunol Immunopathol. 1992 Nov; 65(2):119-28.
  99. Friedman DF, Moore JS, Erikson J, Manz J, Goldman J, Nowell PC, Silberstein LE. Variable region gene analysis of an isotype-switched (IgA) variant of chronic lymphocytic leukemia. Blood. 1992 Nov 1; 80(9):2287-97.
  100. Lane TA, Anderson KC, Goodnough LT, Kurtz S, Moroff G, Pisciotto PT, Sayers M, Silberstein LE. Leukocyte reduction in blood component therapy. Ann Intern Med. 1992 Jul 15; 117(2):151-62.
  101. Grillot-Courvalin C, Brouet JC, Piller F, Rassenti LZ, Labaume S, Silverman GJ, Silberstein L, Kipps TJ. An anti-B cell autoantibody from Wiskott-Aldrich syndrome which recognizes i blood group specificity on normal human B cells. Eur J Immunol. 1992 Jul; 22(7):1781-8.
  102. Sayers MH, Anderson KC, Goodnough LT, Kurtz SR, Lane TA, Pisciotto P, Silberstein LE. Reducing the risk for transfusion-transmitted cytomegalovirus infection. Ann Intern Med. 1992 Jan 1; 116(1):55-62.
  103. Stadtmauer EA, Edelstein M, Lin E, Spitalnik S, Silberstein L, Cassileth PA. Autologous bone marrow transplantation with in vitro chemotherapy purge in first remission of acute myeloid leukemia. Prog Clin Biol Res. 1992; 377:273-9.
  104. Reidl LS, Friedman DF, Goldman J, Hardy RR, Jefferies LC, Silberstein LE. Structural basis of a conserved idiotope expressed by an autoreactive human B cell lymphoma. Evidence that a VH CDR3 mutation alters idiotypy and specificity. J Immunol. 1991 Nov 15; 147(10):3623-31.
  105. Silberstein LE, Jefferies LC, Goldman J, Friedman D, Moore JS, Nowell PC, Roelcke D, Pruzanski W, Roudier J, Silverman GJ. Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens. Blood. 1991 Nov 1; 78(9):2372-86.
  106. Friedman DF, Cho EA, Goldman J, Carmack CE, Besa EC, Hardy RR, Silberstein LE. The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma. J Exp Med. 1991 Sep 1; 174(3):525-37.
  107. Anderson KC, Goodnough LT, Sayers M, Pisciotto PT, Kurtz SR, Lane TA, Anderson CS, Silberstein LE. Variation in blood component irradiation practice: implications for prevention of transfusion-associated graft-versus-host disease. Blood. 1991 May 15; 77(10):2096-102.
  108. Andrzejewski C, Young PJ, Cines DB, Silberstein LE. Heterogeneity of human red cell autoantibodies assessed by isoelectric focusing. Transfusion. 1991 Mar-Apr; 31(3):236-44.
  109. Eshleman JR, Silberstein LE. The development of selective plasmapheresis as a means for specific therapeutic intervention. Transfusion. 1991 Feb; 31(2):96-8.
  110. Goodnough LT, Johnston MF, Ramsey G, Sayers MH, Eisenstadt RS, Anderson KC, Rutman RC, Silberstein LE. Guidelines for transfusion support in patients undergoing coronary artery bypass grafting. Transfusion Practices Committee of the American Association of Blood Banks. Ann Thorac Surg. 1990 Oct; 50(4):675-83.
  111. Jefferies LC, Stevenson FK, Goldman J, Bennett IM, Spitalnik SL, Silberstein LE. Anti-idiotypic antibodies specific for a pathologic anti-Pr2 cold agglutinin. Transfusion. 1990 Jul-Aug; 30(6):495-502.
  112. Judd WJ, Luban NL, Ness PM, Silberstein LE, Stroup M, Widmann FK. Prenatal and perinatal immunohematology: recommendations for serologic management of the fetus, newborn infant, and obstetric patient. Transfusion. 1990 Feb; 30(2):175-83.
  113. Silberstein LE, Kruskall MS, Stehling LC, Johnston MF, Rutman RC, Samia CT, Ramsey G, Eisenstaedt RS. Strategies for the review of transfusion practices. JAMA. 1989 Oct 13; 262(14):1993-7.
  114. Silberstein LE, Litwin S, Carmack CE. Relationship of variable region genes expressed by a human B cell lymphoma secreting pathologic anti-Pr2 erythrocyte autoantibodies. J Exp Med. 1989 May 1; 169(5):1631-43.
  115. Andrzejewski C, Young PJ, Goldman J, Spitalnik SL, Silberstein LE. Production of human warm-reacting red cell monoclonal autoantibodies by Epstein-Barr virus transformation. Transfusion. 1989 Mar-Apr; 29(3):196-200.
  116. Silberstein LE, Jefferies LC, Goldman J, Spitalnik SL. Production of carbohydrate-specific human monoclonal antibodies in vitro. Methods Enzymol. 1989; 179:299-304.
  117. Silberstein LE, Williams LJ, Hughlett MA, Magee DA, Weisman RA. An autologous fibrinogen-based adhesive for use in otologic surgery. Transfusion. 1988 Jul-Aug; 28(4):319-21.
  118. Silberstein LE, Goldman J, Kant JA, Spitalnik SL. Comparative biochemical and genetic characterization of clonally related human B-cell lines secreting pathogenic anti-Pr2 cold agglutinins. Arch Biochem Biophys. 1988 Jul; 264(1):244-52.
  119. Kruskall MS, Mintz PD, Bergin JJ, Johnston MF, Klein HG, Miller JD, Rutman R, Silberstein L. Transfusion therapy in emergency medicine. Ann Emerg Med. 1988 Apr; 17(4):327-35.
  120. Webster C, Silberstein L, Hays AP, Blau HM. Fast muscle fibers are preferentially affected in Duchenne muscular dystrophy. Cell. 1988 Feb 26; 52(4):503-13.
  121. Lichtin AE, Schreiber AD, Hurwitz S, Willoughby TL, Silberstein LE. Efficacy of intensive plasmapheresis in thrombotic thrombocytopenic purpura. Arch Intern Med. 1987 Dec; 147(12):2122-6.
  122. Silberstein LE, Abrahm J, Shattil SJ. The efficacy of intensive plasma exchange in acquired von Willebrand's disease. Transfusion. 1987 May-Jun; 27(3):234-7.
  123. Silberstein LE, Berkman EM, Schreiber AD. Cold hemagglutinin disease associated with IgG cold-reactive antibody. Ann Intern Med. 1987 Feb; 106(2):238-42.
  124. White KK, Silberstein LE. Quality control in the blood bank. Clin Lab Med. 1986 Dec; 6(4):689-96.
  125. Silberstein L, Webster SG, Travis M, Blau HM. Developmental progression of myosin gene expression in cultured muscle cells. Cell. 1986 Sep 26; 46(7):1075-81.
  126. Cameron PM, Limjuco GA, Chin J, Silberstein L, Schmidt JA. Purification to homogeneity and amino acid sequence analysis of two anionic species of human interleukin 1. J Exp Med. 1986 Jul 1; 164(1):237-50.
  127. Silberstein LE, Robertson GA, Harris AC, Moreau L, Besa E, Nowell PC. Etiologic aspects of cold agglutinin disease: evidence for cytogenetically defined clones of lymphoid cells and the demonstration that an anti-Pr cold autoantibody is derived from a chromosomally aberrant B cell clone. Blood. 1986 Jun; 67(6):1705-9.
  128. Lichtin AE, Silberstein LE, Schreiber AD. Thrombotic thrombocytopenic purpura with colitis in an elderly woman. JAMA. 1986 Mar 21; 255(11):1435-6.
  129. Silberstein LE, Naryshkin S, Haddad JJ, Strauss JF. Calcium homeostasis during therapeutic plasma exchange. Transfusion. 1986 Mar-Apr; 26(2):151-5.
  130. Silberstein LE, Shaw LM. Effect of plasma exchange on phenytoin plasma concentration. Ther Drug Monit. 1986; 8(2):172-6.
  131. Silberstein LE, Shoenfeld Y, Schwartz RS, Berkman EM. A combination of IgG and IgM autoantibodies in chronic cold agglutinin disease: immunologic studies and response to splenectomy. Vox Sang. 1985; 48(2):105-9.
  132. Silberstein LE, Duggan D, Berkman EM. Therapeutic trial of plasma exchange in osteosclerotic myeloma associated with the POEMS syndrome. J Clin Apher. 1985; 2(3):253-7.
  133. Sherman LA, Silberstein LE, Berkman EM. Altered blood group expression in a patient with congenital rubella infection. Transfusion. 1984 May-Jun; 24(3):267-9.
  134. Inestrosa NC, Miller JB, Silberstein L, Ziskind-Conhaim L, Hall ZW. Developmental regulation of 16S acetylcholinesterase and acetylcholine receptors in a mouse muscle cell line. Exp Cell Res. 1983 Sep; 147(2):393-405.
  135. Silberstein LE, Berkman EM, Fanburg BL. Angiotensin-1-converting enzyme (ACE) activity in human serum following plasma exchange. Proc Soc Exp Biol Med. 1983 Jun; 173(2):222-6.
  136. Silberstein LE, Berkman EM. Plasma exchange in autoimmune hemolytic anemia (AIHA). J Clin Apher. 1983; 1(4):238-42.
  137. Shoenfeld Y, Hsu-Lin SC, Gabriels JE, Silberstein LE, Furie BC, Furie B, Stollar BD, Schwartz RS. Production of autoantibodies by human-human hybridomas. J Clin Invest. 1982 Jul; 70(1):205-8.
  138. Inestrosa NC, Silberstein L, Hall ZW. Association of the synaptic form of acetylcholinesterase with extracellular matrix in cultured mouse muscle cells. Cell. 1982 May; 29(1):71-9.
  139. Reuveny S, Silberstein L, Shahar A, Freeman E, Mizrahi A. DE-52 and DE-53 cellulose microcarriers. I. Growth of primary and established anchorage-dependent cells. In Vitro. 1982 Feb; 18(2):92-8.
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