John Kheir

John Kheir, MD

Assistant in Cardiology

Assistant Professor of Pediatrics, Harvard Medical School

    Contact: 617-355-7866
  • Fax: 617-730-7548

"My goal is to provide expertise, love and support to patients and their families in real time, and also to look for ways to make the care we provide better in the future."

Medical Services

Specialties

  • Cardiac Intensive Care
  • Critical Care
  • Cardiology

Departments

  • Cardiology
  • Cardiovascular Program

Programs

  • Cardiac Intensive Care Unit
To schedule an appointment: Call 617-355-7866 or Request an Appointment
John Kheir

Caring for critically ill patients and their families is a tremendous privilege and responsibility. 

A responsibility because there is nothing more precious to a human being than their child, and a privilege because I consider it an honor to walk along side families during such trying times.  The ICU can be an imposing place to be, with many caregivers to get to know and a sick child.  My goal is to provide expertise, love and support to patients and their families in real time, and also to look for ways to make the care we provide better in the future.

Experience and Education

Education

Undergraduate

University of Virginia, 1998

Charlottesville, VA

Medical Degree

University of Virginia, 2002

Charlottesville, VA

Internship

Cincinnati Children's Hospital Medical Center, 2003

Cincinnati, OH

Residency - Pediatric Chief Resident

Cincinnati Children's Hospital Medical Center, 2006

Cincinnati, OH

Fellowship - Clinical Fellow in Anesthesia

Boston Children's Hospital, 2010

Boston, MA

Certifications

  • Neonatal Resuscitation Program

  • Basic Life Support

  • Pediatric Advanced Life Support

  • Advanced Cardiac Life Support

Professional History

Dr. Kheir joined the staff of the Boston Children’s Hospital Heart Center in 2010.  He is a staff physician in the cardiac intensive care unit, where he cares for critically ill patients with congenital heart disease.  He is also the co-founder of the Translational Research Lab within the Heart Center, a group focused upon the development of new diagnostic and treatment tools related to oxygen deprivation, a common problem in patients with severe heart disease.  For example, he and his group are developing tools to deliver oxygen directly to the bloodstream for use in extreme emergencies.  Among his other interests are new ways to determine whether patients are receiving sufficient oxygen delivery following their operations, particularly in infants with hypoplastic left heart syndrome. 

Publications

Publications powered by Harvard Catalyst Profiles
  1. DeWitt ES, Black KJ, Thiagarajan RR, DiNardo JA, Colan SD, McGowan FX, Kheir JN. Effects of commonly used inotropes on myocardial function and oxygen consumption under constant ventricular loading conditions. J Appl Physiol (1985). 2016 Jul 1; 121(1):7-14.
  2. Templin JS, Wylie MC, Kim JD, Kurgansky KE, Gorski G, Kheir J, Zurakowski D, Corfas G, Berde C. Neosaxitoxin in Rat Sciatic Block: Improved Therapeutic Index Using Combinations with Bupivacaine, with and without Epinephrine. Anesthesiology. 2015 Oct; 123(4):886-98.
  3. Walsh BK, Davis MD, Hunt JF, Kheir JN, Smallwood CD, Arnold JH. The effects of lung recruitment maneuvers on exhaled breath condensate pH. J Breath Res. 2015 Sep; 9(3):036009.
  4. Thomson LM, Polizzotti BD, McGowan FX, Kheir JN. Manufacture of concentrated, lipid-based oxygen microbubble emulsions by high shear homogenization and serial concentration. J Vis Exp. 2014; (87).
  5. Polizzotti BD, Thomson LM, O'Connell DW, McGowan FX, Kheir JN. Optimization and characterization of stable lipid-based, oxygen-filled microbubbles by mixture design. J Biomed Mater Res B Appl Biomater. 2014 Aug; 102(6):1148-56.
  6. Kheir JN, Walsh BK, Smallwood CD, Rettig JS, Thompson JE, Gómez-Laberge C, Wolf GK, Arnold JH. Comparison of 2 lung recruitment strategies in children with acute lung injury. Respir Care. 2013 Aug; 58(8):1280-90.
  7. Wolf GK, Gómez-Laberge C, Kheir JN, Zurakowski D, Walsh BK, Adler A, Arnold JH. Reversal of dependent lung collapse predicts response to lung recruitment in children with early acute lung injury. Pediatr Crit Care Med. 2012 Sep; 13(5):509-15.
  8. Kheir JN, Scharp LA, Borden MA, Swanson EJ, Loxley A, Reese JH, Black KJ, Velazquez LA, Thomson LM, Walsh BK, Mullen KE, Graham DA, Lawlor MW, Brugnara C, Bell DC, McGowan FX. Oxygen gas-filled microparticles provide intravenous oxygen delivery. Sci Transl Med. 2012 Jun 27; 4(140):140ra88.
  9. Wylie MC, Johnson VM, Carpino E, Mullen K, Hauser K, Nedder A, Kheir JN, Rodriguez-Navarro AJ, Zurakowski D, Berde CB. Respiratory, neuromuscular, and cardiovascular effects of neosaxitoxin in isoflurane-anesthetized sheep. Reg Anesth Pain Med. 2012 Mar-Apr; 37(2):152-8.
  10. Swanson EJ, Mohan V, Kheir J, Borden MA. Phospholipid-stabilized microbubble foam for injectable oxygen delivery. Langmuir. 2010 Oct 19; 26(20):15726-9.
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  12. Kheir JN, Lawlor MW, Ahn ES, Lehmann L, Riviello JJ, Silvera VM, McManus M, Folkerth RD. Neuropathology of a fatal case of posterior reversible encephalopathy syndrome. Pediatr Dev Pathol. 2010 Sep-Oct; 13(5):397-403.
  13. Brilli RJ, Gibson R, Luria JW, Wheeler TA, Shaw J, Linam M, Kheir J, McLain P, Lingsch T, Hall-Haering A, McBride M. Implementation of a medical emergency team in a large pediatric teaching hospital prevents respiratory and cardiopulmonary arrests outside the intensive care unit. Pediatr Crit Care Med. 2007 May; 8(3):236-46; quiz 247.
  14. Kheir JN, Polizzotti BD, Thomson LM, O'Connell DW, Black KJ, Lee RW, Wilking JN, Graham AC, Bell DC, McGowan FX. Bulk manufacture of concentrated oxygen gas-filled microparticles for intravenous oxygen delivery. Adv Healthc Mater. 2013 Aug; 2(8):1131-41.
  15. DeWitt ES, Black KJ, Kheir JN. Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption. J Vis Exp. 2016 Aug 16; (114).
  16. Mills K, French C, Baird C, Santos K, Tang X, Kheir J, Mehta N. 450: SUBOPTIMAL PROTEIN INTAKE MAY PROLONG CICU LENGTH OF STAY AND WORSEN NUTRITIONAL STATUS IN CHILDREN. Crit Care Med. 2016 Dec; 44(12 Suppl 1):189.
  17. French C, Mills K, Baird C, Santos K, Tang X, Kheir J, Mehta N. 462: BEDSIDE VCO2 AS A GUIDE TO INDIVIDUALIZED ENERGY PRESCRIPTION IN VENTILATED CHILDREN IN THE CICU. Crit Care Med. 2016 Dec; 44(12 Suppl 1):192.
  18. Sinha A, Tang X, Kheir J. 191: QUANTIFYING ICU SUPPORT IN THE CONTEXT OF DISEASE-MATCHED PATIENTS OVER TIME USING PERCENTILE CURVES. Crit Care Med. 2016 Dec; 44(12 Suppl 1):125.
  19. Mills KI, Kaza AK, Walsh BK, Bond HC, Ford M, Wypij D, Thiagarajan RR, Almodovar MC, Quinonez LG, Baird CW, Emani SE, Pigula FA, DiNardo JA, Kheir JN. Phosphodiesterase Inhibitor-Based Vasodilation Improves Oxygen Delivery and Clinical Outcomes Following Stage 1 Palliation. J Am Heart Assoc. 2016 Nov 2; 5(11).
  20. Seekell RP, Lock AT, Peng Y, Cole AR, Perry DA, Kheir JN, Polizzotti BD. Oxygen delivery using engineered microparticles. Proc Natl Acad Sci U S A. 2016 Nov 1; 113(44):12380-12385.
To schedule an appointment: Call 617-355-7866 or Request an Appointment

Locations

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- Sandra L. Fenwick, President and CEO

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