John Keane

John Keane, MD


Professor of Pediatrics, Harvard Medical School

    Contact: 617-355-7866
  • Fax: 617-713-3808

Medical Services


  • General Pediatrics
  • Pediatrics
  • Primary Care


  • Cardiology
  • Cardiovascular Program


  • Cardiac Catheterization Labs
To schedule an appointment: Call 617-355-7866

Experience and Education


Medical School

University College, Dublin, 1960



Wilson Memorial Hospital, 1963-1964

Johnson City, NY


Bayne-Jones Army Community Hospital, 1968-1970

Fort Polk, LA


Boston Children's Hospital, 1970-1972

Boston, MA


Publications powered by Harvard Catalyst Profiles
  1. Daly KP, Stack M, Eisenga MF, Keane JF, Zurakowski D, Blume ED, Briscoe DM. Vascular endothelial growth factor A is associated with the subsequent development of moderate or severe cardiac allograft vasculopathy in pediatric heart transplant recipients. J Heart Lung Transplant. 2016 Oct 03.
  2. Prakash A, Satiroglu E, Porras D, McElhinney DB, Keane JF, Lock JE, Geva T, King W, Powell AJ. Risk factors for profuse systemic-to-pulmonary artery collateral burden in hypoplastic left heart syndrome. Am J Cardiol. 2013 Aug 1; 112(3):400-4.
  3. Carr M, Bergersen L, Marshall AC, Keane JF, Lock JE, Emani SM, McElhinney DB. Bare metal stenting for obstructed small diameter homograft conduits in the right ventricular outflow tract. Catheter Cardiovasc Interv. 2013 Jan 1; 81(1):E44-52.
  4. Kulik TJ, Clark RL, Hasan BS, Keane JF, Springmuller D, Mullen MP. Pulmonary arterial hypertension: what the large pulmonary arteries tell us. Pediatr Cardiol. 2011 Aug; 32(6):759-65.
  5. Hasan BS, Keane JF, Tworetzky W, Lock JE, Marshall AC. Postnatal angiographic appearance of left ventricular myocardium in fetal patients with aortic stenosis having in-utero aortic valvuloplasty. Am J Cardiol. 2009 Nov 1; 104(9):1271-5.
  6. Brown DW, Chong EC, Gauvreau K, Keane JF, Lock JE, Marshall AC. Aortic wall injury as a complication of neonatal aortic valvuloplasty: incidence and risk factors. Circ Cardiovasc Interv. 2008 Aug; 1(1):53-9.
  7. Colan SD, McElhinney DB, Crawford EC, Keane JF, Lock JE. Validation and re-evaluation of a discriminant model predicting anatomic suitability for biventricular repair in neonates with aortic stenosis. J Am Coll Cardiol. 2006 May 2; 47(9):1858-65.
  8. McElhinney DB, Sherwood MC, Keane JF, del Nido PJ, Almond CS, Lock JE. Current management of severe congenital mitral stenosis: outcomes of transcatheter and surgical therapy in 108 infants and children. Circulation. 2005 Aug 2; 112(5):707-14.
  9. Bar-Cohen Y, Perry SB, Keane JF, Lock JE. Use of stents to maintain atrial defects and fontan fenestrations in congenital heart disease. J Interv Cardiol. 2005 Apr; 18(2):111-8.
  10. McElhinney DB, Lock JE, Keane JF, Moran AM, Colan SD. Left heart growth, function, and reintervention after balloon aortic valvuloplasty for neonatal aortic stenosis. Circulation. 2005 Feb 1; 111(4):451-8.
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  12. Martins JD, Sherwood MC, Mayer JE, Keane JF. Aortico-left ventricular tunnel: 35-year experience. J Am Coll Cardiol. 2004 Jul 21; 44(2):446-50.
  13. Armsby LR, Keane JF, Sherwood MC, Forbess JM, Perry SB, Lock JE. Management of coronary artery fistulae. Patient selection and results of transcatheter closure. J Am Coll Cardiol. 2002 Mar 20; 39(6):1026-32.
  14. Bacha EA, Satou GM, Moran AM, Zurakowski D, Marx GR, Keane JF, Jonas RA. Valve-sparing operation for balloon-induced aortic regurgitation in congenital aortic stenosis. J Thorac Cardiovasc Surg. 2001 Jul; 122(1):162-8.
  15. Moran AM, Daebritz S, Keane JF, Mayer JE. Surgical management of mitral regurgitation after repair of endocardial cushion defects: early and midterm results. Circulation. 2000 Nov 7; 102(19 Suppl 3):III160-5.
  16. Baker CM, McGowan FX, Keane JF, Lock JE. Pulmonary artery trauma due to balloon dilation: recognition, avoidance and management. J Am Coll Cardiol. 2000 Nov 1; 36(5):1684-90.
  17. Marshall AC, Perry SB, Keane JF, Lock JE. Early results and medium-term follow-up of stent implantation for mild residual or recurrent aortic coarctation. Am Heart J. 2000 Jun; 139(6):1054-60.
  18. Fratazzi C, Arbeit RD, Carini C, Balcewicz-Sablinska MK, Keane J, Kornfeld H, Remold HG. Macrophage apoptosis in mycobacterial infections. J Leukoc Biol. 1999 Nov; 66(5):763-4.
  19. Coran DL, Rodgers WB, Keane JF, Hall JE, Emans JB. Spinal fusion in patients with congenital heart disease. Predictors of outcome. Clin Orthop Relat Res. 1999 Jul; (364):99-107.
  20. Satou GM, Perry SB, Lock JE, Piercey GE, Keane JF. Repeat balloon dilation of congenital valvar aortic stenosis: immediate results and midterm outcome. Catheter Cardiovasc Interv. 1999 May; 47(1):47-51.
  21. Bartram U, Van Praagh S, Keane JF, Lang P, van der Velde ME, Van Praagh R. Mitral and aortic atresia associated with hypoplastic right lung, crossover segment of right lower lobe, and anomalous scimitar-like right pulmonary venous connection with inferior vena cava: clinical, angiocardiographic, and autopsy findings in a rare case. Pediatr Dev Pathol. 1998 Sep-Oct; 1(5):413-9.
  22. Balcewicz-Sablinska MK, Keane J, Kornfeld H, Remold HG. Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-alpha. J Immunol. 1998 Sep 1; 161(5):2636-41.
  23. Jonas RA, Keane JF, Lock JE. Aortic valve-preserving procedure for enlargement of the left ventricular outflow tract and mitral anulus. J Thorac Cardiovasc Surg. 1998 May; 115(5):1219-22.
  24. Moran AM, Hornberger LK, Jonas RA, Keane JF. Development of a double-chambered right ventricle after repair of tetralogy of Fallot. J Am Coll Cardiol. 1998 Apr; 31(5):1127-33.
  25. Adatia I, Moore PM, Jonas RA, Colan SD, Lock JE, Keane JF. Clinical course and hemodynamic observations after supraannular mitral valve replacement in infants and children. J Am Coll Cardiol. 1997 Apr; 29(5):1089-94.
  26. Egito ES, Moore P, O'Sullivan J, Colan S, Perry SB, Lock JE, Keane JF. Transvascular balloon dilation for neonatal critical aortic stenosis: early and midterm results. J Am Coll Cardiol. 1997 Feb; 29(2):442-7.
  27. Kreutzer J, Lock JE, Jonas RA, Keane JF. Transcatheter fenestration dilation and/or creation in postoperative Fontan patients. Am J Cardiol. 1997 Jan 15; 79(2):228-32.
  28. Kreutzer J, Keane JF, Lock JE, Walsh EP, Jonas RA, Castañeda AR, Mayer JE. Conversion of modified Fontan procedure to lateral atrial tunnel cavopulmonary anastomosis. J Thorac Cardiovasc Surg. 1996 Jun; 111(6):1169-76.
  29. Moore P, Egito E, Mowrey H, Perry SB, Lock JE, Keane JF. Midterm results of balloon dilation of congenital aortic stenosis: predictors of success. J Am Coll Cardiol. 1996 Apr; 27(5):1257-63.
  30. Powell AJ, Lock JE, Keane JF, Perry SB. Prolongation of RV-PA conduit life span by percutaneous stent implantation. Intermediate-term results. Circulation. 1995 Dec 1; 92(11):3282-8.
  31. Landzberg MJ, Sloss LJ, Faherty CE, Morrison BJ, Bittl JA, Bridges ND, Casale PN, Keane JF, Lock JE. Orthodeoxia-platypnea due to intracardiac shunting--relief with transcatheter double umbrella closure. Cathet Cardiovasc Diagn. 1995 Nov; 36(3):247-50.
  32. Srivastava D, Preminger T, Lock JE, Mandell V, Keane JF, Mayer JE, Kozakewich H, Spevak PJ. Hepatic venous blood and the development of pulmonary arteriovenous malformations in congenital heart disease. Circulation. 1995 Sep 1; 92(5):1217-22.
  33. Rhodes LA, Wernovsky G, Keane JF, Mayer JE, Shuren A, Dindy C, Colan SD, Walsh EP. Arrhythmias and intracardiac conduction after the arterial switch operation. J Thorac Cardiovasc Surg. 1995 Feb; 109(2):303-10.
  34. Levine JC, Mayer JE, Keane JF, Spevak PJ, Sanders SP. Anastomotic pseudoaneurysm of the ventricle after homograft placement in children. Ann Thorac Surg. 1995 Jan; 59(1):60-6.
  35. Colli AM, Perry SB, Lock JE, Keane JF. Balloon dilation of critical valvar pulmonary stenosis in the first month of life. Cathet Cardiovasc Diagn. 1995 Jan; 34(1):23-8.
  36. Gentles TL, Keane JF, Jonas RA, Marx GE, Mayer JE. Surgical alternatives to the Fontan procedure incorporating a hypoplastic right ventricle. Circulation. 1994 Nov; 90(5 Pt 2):II1-6.
  37. Manning PB, Mayer JE, Sanders SP, Coleman EA, Jonas RA, Keane JF, VanPraagh S, Castañeda AR. Unique features and prognosis of primum ASD presenting in the first year of life. Circulation. 1994 Nov; 90(5 Pt 2):II30-5.
  38. Verma R, Keane JF. Use of cutoff pigtail catheters with intraluminal guidewires in interventional procedures in congenital heart disease. Cathet Cardiovasc Diagn. 1994 Sep; 33(1):85-8.
  39. van der Velde ME, Sanders SP, Keane JF, Perry SB, Lock JE. Transesophageal echocardiographic guidance of transcatheter ventricular septal defect closure. J Am Coll Cardiol. 1994 Jun; 23(7):1660-5.
  40. Rosenfeld HM, Landzberg MJ, Perry SB, Colan SD, Keane JF, Lock JE. Balloon aortic valvuloplasty in the young adult with congenital aortic stenosis. Am J Cardiol. 1994 Jun 1; 73(15):1112-7.
  41. Moore P, Adatia I, Spevak PJ, Keane JF, Perry SB, Castaneda AR, Lock JE. Severe congenital mitral stenosis in infants. Circulation. 1994 May; 89(5):2099-106.
  42. Nishimoto K, Keane JF, Jonas RA. Dilation of intra-atrial baffle fenestrations: results in vivo and in vitro. Cathet Cardiovasc Diagn. 1994 Jan; 31(1):73-8.
  43. Fishberger SB, Bridges ND, Keane JF, Hanley FL, Jonas RA, Mayer JE, Castaneda AR, Lock JE. Intraoperative device closure of ventricular septal defects. Circulation. 1993 Nov; 88(5 Pt 2):II205-9.
  44. Perry SB, van der Velde ME, Bridges ND, Keane JF, Lock JE. Transcatheter closure of atrial and ventricular septal defects. Herz. 1993 Apr; 18(2):135-42.
  45. Keane JF, Driscoll DJ, Gersony WM, Hayes CJ, Kidd L, O'Fallon WM, Pieroni DR, Wolfe RR, Weidman WH. Second natural history study of congenital heart defects. Results of treatment of patients with aortic valvar stenosis. Circulation. 1993 Feb; 87(2 Suppl):I16-27.
  46. Bridges ND, Mayer JE, Lock JE, Jonas RA, Hanley FL, Keane JF, Perry SB, Castaneda AR. Effect of baffle fenestration on outcome of the modified Fontan operation. Circulation. 1992 Dec; 86(6):1762-9.
  47. Hourihan M, Perry SB, Mandell VS, Keane JF, Rome JJ, Bittl JA, Lock JE. Transcatheter umbrella closure of valvular and paravalvular leaks. J Am Coll Cardiol. 1992 Nov 15; 20(6):1371-7.
  48. Perry SB, Rome J, Keane JF, Baim DS, Lock JE. Transcatheter closure of coronary artery fistulas. J Am Coll Cardiol. 1992 Jul; 20(1):205-9.
  49. Di Donato RM, Wernovsky G, Jonas RA, Mayer JE, Keane JF, Castañeda AR. Corrected transposition in situs inversus. Biventricular repair of associated cardiac anomalies. Circulation. 1991 Nov; 84(5 Suppl):III193-9.
  50. Bridges ND, Perry SB, Parness I, Keane JF, Lock JE. Transcatheter closure of a large patent ductus arteriosus with the clamshell septal umbrella. J Am Coll Cardiol. 1991 Nov 1; 18(5):1297-302.
  51. Flanagan MF, Hourihan M, Keane JF. Incidence of renal dysfunction in adults with cyanotic congenital heart disease. Am J Cardiol. 1991 Aug 1; 68(4):403-6.
  52. Bridges ND, Perry SB, Keane JF, Goldstein SA, Mandell V, Mayer JE, Jonas RA, Casteneda AR, Lock JE. Preoperative transcatheter closure of congenital muscular ventricular septal defects. N Engl J Med. 1991 May 9; 324(19):1312-7.
  53. Bridges ND, Jonas RA, Mayer JE, Flanagan MF, Keane JF, Castaneda AR. Bidirectional cavopulmonary anastomosis as interim palliation for high-risk Fontan candidates. Early results. Circulation. 1990 Nov; 82(5 Suppl):IV170-6.
  54. Rome JJ, Keane JF, Perry SB, Spevak PJ, Lock JE. Double-umbrella closure of atrial defects. Initial clinical applications. Circulation. 1990 Sep; 82(3):751-8.
  55. Spevak PJ, Bass JL, Ben-Shachar G, Hesslein P, Keane JF, Perry S, Pyles L, Lock JE. Balloon angioplasty for congenital mitral stenosis. Am J Cardiol. 1990 Aug 15; 66(4):472-6.
  56. Rhodes LA, Keane JF, Keane JP, Fellows KE, Jonas RA, Castaneda AR, Nadas AS. Long follow-up (to 43 years) of ventricular septal defect with audible aortic regurgitation. Am J Cardiol. 1990 Aug 1; 66(3):340-5.
  57. Rothman A, Perry SB, Keane JF, Lock JE. Early results and follow-up of balloon angioplasty for branch pulmonary artery stenoses. J Am Coll Cardiol. 1990 Apr; 15(5):1109-17.
  58. Rothman A, Perry SB, Keane JF, Lock JE. Balloon dilation of branch pulmonary artery stenosis. Semin Thorac Cardiovasc Surg. 1990 Jan; 2(1):46-54.
  59. Zeevi B, Keane JF, Castaneda AR, Perry SB, Lock JE. Neonatal critical valvar aortic stenosis. A comparison of surgical and balloon dilation therapy. Circulation. 1989 Oct; 80(4):831-9.
  60. Zeevi B, Keane JF, Perry SB, Lock JE. Balloon dilation of postoperative right ventricular outflow obstructions. J Am Coll Cardiol. 1989 Aug; 14(2):401-8; discussion 409-12.
  61. Perry SB, Zeevi B, Keane JF, Lock JE. Interventional catheterization of left heart lesions, including aortic and mitral valve stenosis and coarctation of the aorta. Cardiol Clin. 1989 May; 7(2):341-9.
  62. Lock JE, Rome JJ, Davis R, Van Praagh S, Perry SB, Van Praagh R, Keane JF. Transcatheter closure of atrial septal defects. Experimental studies. Circulation. 1989 May; 79(5):1091-9.
  63. Perry SB, Radtke W, Fellows KE, Keane JF, Lock JE. Coil embolization to occlude aortopulmonary collateral vessels and shunts in patients with congenital heart disease. J Am Coll Cardiol. 1989 Jan; 13(1):100-8.
  64. Pasquini L, Sanders SP, Parness I, Colan S, Keane JF, Mayer JE, Kratz C, Foran RB, Marino B, Van Praagh S, et al. Echocardiographic and anatomic findings in atrioventricular discordance with ventriculoarterial concordance. Am J Cardiol. 1988 Dec 1; 62(17):1256-62.
  65. Shamberger RC, Welch KJ, Castaneda AR, Keane JF, Fyler DC. Anterior chest wall deformities and congenital heart disease. J Thorac Cardiovasc Surg. 1988 Sep; 96(3):427-32.
  66. Zeevi B, Perry SB, Keane JF, Mandell VS, Lock JE. Interventional cardiac procedures in neonates and infants: state of the art. Clin Perinatol. 1988 Sep; 15(3):633-58.
  67. Sholler GF, Keane JF, Perry SB, Sanders SP, Lock JE. Balloon dilation of congenital aortic valve stenosis. Results and influence of technical and morphological features on outcome. Circulation. 1988 Aug; 78(2):351-60.
  68. Arnold LW, Keane JF, Kan JS, Fellows KE, Lock JE. Transient unilateral pulmonary edema after successful balloon dilation of peripheral pulmonary artery stenosis. Am J Cardiol. 1988 Aug 1; 62(4):327-30.
  69. Lock JE, Block PC, McKay RG, Baim DS, Keane JF. Transcatheter closure of ventricular septal defects. Circulation. 1988 Aug; 78(2):361-8.
  70. Sholler GF, Colan SD, Sanders SP, Keane JF. Noninvasive estimation of the left ventricular pressure waveform throughout ejection in young patients with aortic stenosis. J Am Coll Cardiol. 1988 Aug; 12(2):492-7.
  71. Wernovsky G, Hougen TJ, Walsh EP, Sholler GF, Colan SD, Sanders SP, Parness IA, Keane JF, Mayer JE, Jonas RA, et al. Midterm results after the arterial switch operation for transposition of the great arteries with intact ventricular septum: clinical, hemodynamic, echocardiographic, and electrophysiologic data. Circulation. 1988 Jun; 77(6):1333-44.
  72. Perry SB, Keane JF, Lock JE. Interventional catheterization in pediatric congenital and acquired heart disease. Am J Cardiol. 1988 May 9; 61(14):109G-117G.
  73. Wessel DL, Keane JF, Parness I, Lock JE. Outpatient closure of the patent ductus arteriosus. Circulation. 1988 May; 77(5):1068-71.
  74. Walsh EP, Rockenmacher S, Keane JF, Hougen TJ, Lock JE, Castaneda AR. Late results in patients with tetralogy of Fallot repaired during infancy. Circulation. 1988 May; 77(5):1062-7.
  75. Zeevi B, Keane JF, Fellows KE, Lock JE. Balloon dilation of critical pulmonary stenosis in the first week of life. J Am Coll Cardiol. 1988 Apr; 11(4):821-4.
  76. Fellows KE, Radtke W, Keane JF, Lock JE. Acute complications of catheter therapy for congenital heart disease. Am J Cardiol. 1987 Sep 15; 60(8):679-83.
  77. Nussbaum AR, Newman B, Freed MD, Keane JF, Teele RL, Fellows KE, Lebowitz RL. Nonutility of cineurograms in children with congenital heart disease. Am J Cardiol. 1987 Sep 15; 60(8):684-7.
To schedule an appointment: Call 617-355-7866


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