Jennifer Mack, MD, MPH

Associate Chief, Population Sciences for Pediatric Hematology/Oncology; Co-Director, Pediatric Hematology/Oncology Fellowship Program

Assistant Professor of Pediatrics - Harvard Medical School

    Contact: 617-632-5430
  • Fax: 617-632-2270

Medical Services


  • Hematology Oncology


  • Hematology / Oncology
  • Medicine


  • Brain Tumor Center
  • Hematology / Oncology
  • Hematology / Oncology
To schedule an appointment: Call 617-632-5430

Experience and Education


Medical School

Harvard Medical School, 1998

Boston, MA

Pediatric Hematology/Oncology; Pediatric Palliative Care

Children's Hospital Boston/Dana Farber Cancer Institute, 2001-2004

Boston, MA


Boston Children's Hospital, 1998-1999

Boston, MA


Boston Children's Hospital/Boston Medical Center, 1999-2001

Boston, MA



Publications powered by Harvard Catalyst Profiles
  1. Pinheiro LC, McFatrich M, Lucas N, Walker JS, Withycombe JS, Hinds PS, Sung L, Tomlinson D, Freyer DR, Mack JW, Baker JN, Reeve BB. Child and adolescent self-report symptom measurement in pediatric oncology research: a systematic literature review. Qual Life Res. 2017 Sep 06.
  2. Ilowite MF, Cronin AM, Kang TI, Mack JW. Disparities in prognosis communication among parents of children with cancer: The impact of race and ethnicity. Cancer. 2017 Oct 15; 123(20):3995-4003.
  3. Mack JW. Pediatric Palliative Care-A Shared Priority. JAMA Oncol. 2017 Sep 01; 3(9):1220-1221.
  4. Tulsky JA, Beach MC, Butow PN, Hickman SE, Mack JW, Morrison RS, Street RL, Sudore RL, White DB, Pollak KI. A Research Agenda for Communication Between Health Care Professionals and Patients Living With Serious Illness. JAMA Intern Med. 2017 Sep 01; 177(9):1361-1366.
  5. Mack JW, Jacobson J, Frank D, Cronin AM, Horvath K, Allen V, Wind J, Schrag D. Evaluation of Patient and Family Outpatient Complaints as a Strategy to Prioritize Efforts to Improve Cancer Care Delivery. Jt Comm J Qual Patient Saf. 2017 Oct; 43(10):498-507.
  6. Sisk BA, Greenzang KA, Kang TI, Mack JW. Longitudinal parental preferences for late effects communication during cancer treatment. Pediatr Blood Cancer. 2018 Jan; 65(1).
  7. Sisk BA, Mack JW, Ashworth R, DuBois J. Communication in pediatric oncology: State of the field and research agenda. Pediatr Blood Cancer. 2018 Jan; 65(1).
  8. Duberstein PR, Chen M, Chapman BP, Hoerger M, Saeed F, Guancial E, Mack JW. Fatalism and educational disparities in beliefs about the curability of advanced cancer. Patient Educ Couns. 2017 Jul 10.
  9. Danaher TS, Brand SR, Pickard LSS, Mack JW, Berry LL. How a Child With Cancer Moved From Vulnerability to Resilience. J Clin Oncol. 2017 Sep 20; 35(27):3169-3171.
  10. Weaver MS, Mack JW. Holding hope. Pediatr Blood Cancer. 2017 Sep; 64(9).
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  12. Sisk BA, Kang TI, Mack JW. Prognostic disclosures over time: Parental preferences and physician practices. Cancer. 2017 Oct 15; 123(20):4031-4038.
  13. Reeve BB, McFatrich M, Pinheiro LC, Freyer DR, Basch EM, Baker JN, Withycombe JS, Sung L, Mack JW, Waldron MK, Mowbray C, Palma D, Hinds PS. Cognitive Interview-Based Validation of the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events in Adolescents with Cancer. J Pain Symptom Manage. 2017 Apr; 53(4):759-766.
  14. Sobota AE, Shah N, Mack JW. Development of quality indicators for transition from pediatric to adult care in sickle cell disease: A modified Delphi survey of adult providers. Pediatr Blood Cancer. 2017 Jun; 64(6).
  15. Brand SR, Fasciano K, Mack JW. Communication preferences of pediatric cancer patients: talking about prognosis and their future life. Support Care Cancer. 2017 Mar; 25(3):769-774.
  16. Mack JW, Ilowite M, Taddei S. Difficult relationships between parents and physicians of children with cancer: A qualitative study of parent and physician perspectives. Cancer. 2017 Feb 15; 123(4):675-681.
  17. Reeve BB, McFatrich M, Pinheiro LC, Weaver MS, Sung L, Withycombe JS, Baker JN, Mack JW, Waldron MK, Gibson D, Tomlinson D, Freyer DR, Mowbray C, Jacobs S, Palma D, Martens CE, Gold SH, Jackson KD, Hinds PS. Eliciting the child's voice in adverse event reporting in oncology trials: Cognitive interview findings from the Pediatric Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events initiative. Pediatr Blood Cancer. 2017 Mar; 64(3).
  18. Mack JW, Cronin AM, Kang TI. Decisional Regret Among Parents of Children With Cancer. J Clin Oncol. 2016 Sep 12.
  19. Sisk BA, Bluebond-Langner M, Wiener L, Mack J, Wolfe J. Prognostic Disclosures to Children: A Historical Perspective. Pediatrics. 2016 Sep; 138(3).
  20. Brand SR, Pickard L, Mack JW, Berry LL. What Adult Cancer Care Can Learn From Pediatrics. J Oncol Pract. 2016 Sep; 12(9):765-7.
  21. Mack JW, Cannavale K, Sattayapiwat O, Cheung B, Chen LH, Cooper RM, Chao CR. Care in the Final Month of Life among Adolescent and Young Adult Cancer Patients in Kaiser Permanente Southern California. J Palliat Med. 2016 Nov; 19(11):1136-1141.
  22. Marron JM, DuBois SG, Glade Bender J, Kim A, Crompton BD, Meyer SC, Janeway KA, Mack JW. Patient/parent perspectives on genomic tumor profiling of pediatric solid tumors: The Individualized Cancer Therapy (iCat) experience. Pediatr Blood Cancer. 2016 Nov; 63(11):1974-82.
  23. Lindley LC, Mixer SJ, Mack JW. Home care for children with multiple complex chronic conditions at the end of life: The choice of hospice versus home health. Home Health Care Serv Q. 2016 Jul-Dec; 35(3-4):101-111.
  24. Walling AM, Keating NL, Kahn KL, Dy S, Mack JW, Malin J, Arora NK, Adams JL, Antonio AL, Tisnado D. Lower Patient Ratings of Physician Communication Are Associated With Unmet Need for Symptom Management in Patients With Lung and Colorectal Cancer. J Oncol Pract. 2016 Jun; 12(6):e654-69.
  25. Greenzang KA, Cronin AM, Mack JW. Parental preparedness for late effects and long-term quality of life in survivors of childhood cancer. Cancer. 2016 Aug 15; 122(16):2587-94.
  26. Nyborn JA, Olcese M, Nickerson T, Mack JW. "Don't Try to Cover the Sky with Your Hands": Parents' Experiences with Prognosis Communication About Their Children with Advanced Cancer. J Palliat Med. 2016 Jun; 19(6):626-31.
  27. Feraco AM, Brand SR, Mack JW, Kesselheim JC, Block SD, Wolfe J. Communication Skills Training in Pediatric Oncology: Moving Beyond Role Modeling. Pediatr Blood Cancer. 2016 Jun; 63(6):966-72.
  28. Lindley LC, Mack JW, Bruce DJ. Clusters of Multiple Complex Chronic Conditions: A Latent Class Analysis of Children at End of Life. J Pain Symptom Manage. 2016 May; 51(5):868-74.
  29. Sanford E, Wolbrink T, Mack J, Rowe RG. Severe Tumor Lysis Syndrome and Acute Pulmonary Edema Requiring Extracorporeal Membrane Oxygenation Following Initiation of Chemotherapy for Metastatic Alveolar Rhabdomyosarcoma. Pediatr Blood Cancer. 2016 May; 63(5):928-30.
  30. Mack JW, Chen K, Boscoe FP, Gesten FC, Roohan PJ, Schymura MJ, Schrag D. High Intensity of End-of-Life Care Among Adolescent and Young Adult Cancer Patients in the New York State Medicaid Program. Med Care. 2015 Dec; 53(12):1018-26.
  31. Sobota AE, Umeh E, Mack JW. Young Adult Perspectives on a Successful Transition from Pediatric to Adult Care in Sickle Cell Disease. J Hematol Res. 2015 Dec; 2(1):17-24.
  32. Brooks GA, Cronin AM, Uno H, Schrag D, Keating NL, Mack JW. Intensity of Medical Interventions between Diagnosis and Death in Patients with Advanced Lung and Colorectal Cancer: A CanCORS Analysis. J Palliat Med. 2016 Jan; 19(1):42-50.
  33. Mack JW, Cronin A, Fasciano K, Block SD, Keating NL. Cancer treatment decision-making among young adults with lung and colorectal cancer: a comparison with adults in middle age. Psychooncology. 2016 Sep; 25(9):1085-91.
  34. Wiener L, Feudtner C, Hinds P, Wolfe J, Mack J. Deeper Conversations Need Not Wait Until the End. J Clin Oncol. 2015 Nov 20; 33(33):3974.
  35. Mack JW, Chen LH, Cannavale K, Sattayapiwat O, Cooper RM, Chao CR. End-of-Life Care Intensity Among Adolescent and Young Adult Patients With Cancer in Kaiser Permanente Southern California. JAMA Oncol. 2015 Aug; 1(5):592-600.
  36. Kamihara J, Nyborn JA, Olcese ME, Nickerson T, Mack JW. Parental hope for children with advanced cancer. Pediatrics. 2015 May; 135(5):868-74.
  37. Kehl KL, Landrum MB, Arora NK, Ganz PA, van Ryn M, Mack JW, Keating NL. Association of Actual and Preferred Decision Roles With Patient-Reported Quality of Care: Shared Decision Making in Cancer Care. JAMA Oncol. 2015 Apr; 1(1):50-8.
  38. Marron JM, Mack JW. When to say when: How aggressively to care for children with multiply relapsed cancer? Pediatr Blood Cancer. 2015 Jul; 62(7):1119-20.
  39. Hobbs GS, Landrum MB, Arora NK, Ganz PA, van Ryn M, Weeks JC, Mack JW, Keating NL. The role of families in decisions regarding cancer treatments. Cancer. 2015 Apr 01; 121(7):1079-87.
  40. Mack JW, Walling A, Dy S, Antonio AL, Adams J, Keating NL, Tisnado D. Patient beliefs that chemotherapy may be curative and care received at the end of life among patients with metastatic lung and colorectal cancer. Cancer. 2015 Jun 01; 121(11):1891-7.
  41. Keating NL, Kahn KL, Dy SM, Malin J, Arora NK, Mack JW, Adams JL, Antonio AL, Pantoja P, Tisnado DM. Association of lower patient ratings of physician communication with need for symptom management in lung and colorectal cancer patients. J Clin Oncol. 2014 Nov; 32(31_suppl):153.
  42. Lindley LC, Zhou W, Mack JW, Li X. Pediatric hospice and palliative care: designing a mobile app for clinical practice. Comput Inform Nurs. 2014 Jul; 32(7):299-302.
  43. Walling AM, Weeks JC, Kahn KL, Tisnado D, Keating NL, Dy SM, Arora NK, Mack JW, Pantoja PM, Malin JL. Symptom prevalence in lung and colorectal cancer patients. J Pain Symptom Manage. 2015 Feb; 49(2):192-202.
  44. Liu PH, Landrum MB, Weeks JC, Huskamp HA, Kahn KL, He Y, Mack JW, Keating NL. Physicians' propensity to discuss prognosis is associated with patients' awareness of prognosis for metastatic cancers. J Palliat Med. 2014 Jun; 17(6):673-82.
  45. Dy SM, Walling AM, Mack JW, Malin JL, Pantoja P, Lorenz KA, Tisnado DM. Evaluating the quality of supportive oncology using patient-reported data. J Oncol Pract. 2014 Jul; 10(4):e223-30.
  46. Mack JW, Joffe S. Communicating about prognosis: ethical responsibilities of pediatricians and parents. Pediatrics. 2014 Feb; 133 Suppl 1:S24-30.
  47. Joffe S, Mack JW. Deliberation and the life cycle of informed consent. Hastings Cent Rep. 2014 Jan-Feb; 44(1):33-5.
  48. Kaye E, Mack JW. Parent perceptions of the quality of information received about a child's cancer. Pediatr Blood Cancer. 2013 Nov; 60(11):1896-901.
  49. Mack JW, Chen K, Boscoe FP, Gesten FC, Roohan PJ, Weeks JC, Schymura MJ, Schrag D. Underuse of hospice care by Medicaid-insured patients with stage IV lung cancer in New York and California. J Clin Oncol. 2013 Jul 10; 31(20):2569-79.
  50. Benoit MM, Vargas SO, Bhattacharyya N, McGill TA, Robson CD, Ferraro N, Didas AE, Labow BI, Upton J, Taghinia A, Meara JG, Marcus KJ, Mack J, Rodriguez-Galindo C, Rahbar R. The presentation and management of mandibular tumors in the pediatric population. Laryngoscope. 2013 Aug; 123(8):2035-42.
  51. Weeks JC, Mack JW, Schrag D. Talking with patients about dying. N Engl J Med. 2013 Jan 31; 368(5):480-1.
  52. Dy SM, Malin J, Mack JW, Kim B, Lorenz K, Tisnado DM. Evaluating the quality of supportive oncology using patient-reported survey data. J Clin Oncol. 2012 Dec; 30(34_suppl):42.
  53. Mack JW, Cronin A, Keating NL, Taback N, Huskamp HA, Malin JL, Earle CC, Weeks JC. Associations between end-of-life discussion characteristics and care received near death: a prospective cohort study. J Clin Oncol. 2012 Dec 10; 30(35):4387-95.
  54. Weeks JC, Catalano PJ, Cronin A, Finkelman MD, Mack JW, Keating NL, Schrag D. Patients' expectations about effects of chemotherapy for advanced cancer. N Engl J Med. 2012 Oct 25; 367(17):1616-25.
  55. Lindley LC, Mixer S, Mack JW. Profit status and delivery of hospice care for infants: the mediating role of pediatric knowledge. J Palliat Med. 2012 Dec; 15(12):1369-73.
  56. Ala L, Mack J, Shaw R, Gasson A, Cogbill E, Marion R, Rahman R, Deibel F, Rathbone N. Selecting ambulatory emergency care (AEC) patients from the medical emergency in-take: the derivation and validation of the Amb score. Clin Med (Lond). 2012 Oct; 12(5):420-6.
  57. Williams DA, Mack J. Enough is indeed enough: ACGME required changes in pediatric training. Pediatr Blood Cancer. 2012 Dec 15; 59(7):1158-9.
  58. Mack JW, Smith TJ. Reasons why physicians do not have discussions about poor prognosis, why it matters, and what can be improved. J Clin Oncol. 2012 Aug 01; 30(22):2715-7.
  59. Volpe D, Harrison S, Damian F, Rachh P, Kahlon PS, Morrissey L, Mack J, Akenroye A, Stack AM. Improving timeliness of antibiotic delivery for patients with fever and suspected neutropenia in a pediatric emergency department. Pediatrics. 2012 Jul; 130(1):e201-10.
  60. Olcese ME, Mack JW. Research participation experiences of parents of children with cancer who were asked about their child's prognosis. J Palliat Med. 2012 Mar; 15(3):269-73.
  61. Mack JW, Cronin A, Taback N, Huskamp HA, Keating NL, Malin JL, Earle CC, Weeks JC. End-of-life care discussions among patients with advanced cancer: a cohort study. Ann Intern Med. 2012 Feb 07; 156(3):204-10.
  62. Mack JW, Feudtner C, Hinds PS. Communication and decision support for children with advanced cancer and their families. Am Soc Clin Oncol Educ Book. 2012; 637-43.
  63. Mack JW, Cronin A, Taback N, Huskamp H, Keating NL, Malin J, Earle C, Weeks JC. Discussions about end-of-life care planning between physicians and patients with stage IV lung or colorectal cancer. J Clin Oncol. 2011 May 20; 29(15_suppl):6026.
  64. Mack JW, Wolfe J, Cook EF, Grier HE, Cleary PD, Weeks JC. Parents' roles in decision making for children with cancer in the first year of cancer treatment. J Clin Oncol. 2011 May 20; 29(15):2085-90.
  65. Williams DA, Porter ES, Lux SE, Grier HE, Mack JW, Orkin SH. Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute. Am J Hematol. 2010 Oct; 85(10):793-4.
  66. Wright AA, Mack JW, Kritek PA, Balboni TA, Massaro AF, Matulonis UA, Block SD, Prigerson HG. Influence of patients' preferences and treatment site on cancer patients' end-of-life care. Cancer. 2010 Oct 01; 116(19):4656-63.
  67. Mack JW, Paulk ME, Viswanath K, Prigerson HG. Racial disparities in the outcomes of communication on medical care received near death. Arch Intern Med. 2010 Sep 27; 170(17):1533-40.
  68. Lannen P, Wolfe J, Mack J, Onelov E, Nyberg U, Kreicbergs U. Absorbing information about a child's incurable cancer. Oncology. 2010; 78(3-4):259-66.
  69. Mack JW, Weeks JC, Wright AA, Block SD, Prigerson HG. End-of-life discussions, goal attainment, and distress at the end of life: predictors and outcomes of receipt of care consistent with preferences. J Clin Oncol. 2010 Mar 01; 28(7):1203-8.
  70. Robson CD, Rahbar R, Vargas SO, Marcus KJ, Mack JW, Licameli GR, Grier HE. Sinonasal and laryngeal carcinoma in children: correlation of imaging characteristics with clinicopathologic and cytogenetic features. AJNR Am J Neuroradiol. 2010 Feb; 31(2):257-61.
  71. Mack JW, Block SD, Nilsson M, Wright A, Trice E, Friedlander R, Paulk E, Prigerson HG. Measuring therapeutic alliance between oncologists and patients with advanced cancer: the Human Connection Scale. Cancer. 2009 Jul 15; 115(14):3302-11.
  72. Mack JW, Wolfe J, Cook EF, Grier HE, Cleary PD, Weeks JC. Peace of mind and sense of purpose as core existential issues among parents of children with cancer. Arch Pediatr Adolesc Med. 2009 Jun; 163(6):519-24.
  73. Wright AA, Mack JW, Trice ED, Balboni TA, Block SD, Prigerson HG. Personalized end-of-life care: Associations between patient preferences and treatment intensity near death. J Clin Oncol. 2009 May 20; 27(15_suppl):6516.
  74. Wright AA, Zhang B, Ray A, Mack JW, Trice E, Balboni T, Mitchell SL, Jackson VA, Block SD, Maciejewski PK, Prigerson HG. Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment. JAMA. 2008 Oct 08; 300(14):1665-73.
  75. Mack JW, Joffe S, Hilden JM, Watterson J, Moore C, Weeks JC, Wolfe J. Parents' views of cancer-directed therapy for children with no realistic chance for cure. J Clin Oncol. 2008 Oct 10; 26(29):4759-64.
  76. Jackson VA, Mack J, Matsuyama R, Lakoma MD, Sullivan AM, Arnold RM, Weeks JC, Block SD. A qualitative study of oncologists' approaches to end-of-life care. J Palliat Med. 2008 Jul; 11(6):893-906.
  77. Mack JW, Nilsson M, Balboni T, Friedlander RJ, Block SD, Trice E, Prigerson HG. Peace, Equanimity, and Acceptance in the Cancer Experience (PEACE): validation of a scale to assess acceptance and struggle with terminal illness. Cancer. 2008 Jun; 112(11):2509-17.
  78. Mack JW, Wolfe J, Cook EF, Grier HE, Cleary PD, Weeks JC. Peace of mind and sense of purpose as core existential issues among parents of children with cancer. J Clin Oncol. 2008 May 20; 26(15_suppl):9518.
  79. Mack JW, Wolfe J, Cook EF, Grier HE, Cleary PD, Weeks JC. Hope and prognostic disclosure. J Clin Oncol. 2007 Dec 10; 25(35):5636-42.
  80. Santucci G, Mack JW. Common gastrointestinal symptoms in pediatric palliative care: nausea, vomiting, constipation, anorexia, cachexia. Pediatr Clin North Am. 2007 Oct; 54(5):673-89, x.
  81. Mack JW, Co JP, Goldmann DA, Weeks JC, Cleary PD. Quality of health care for children: role of health and chronic illness in inpatient care experiences. Arch Pediatr Adolesc Med. 2007 Sep; 161(9):828-34.
  82. Mack JW, Cook EF, Wolfe J, Grier HE, Cleary PD, Weeks JC. Understanding of prognosis among parents of children with cancer: parental optimism and the parent-physician interaction. J Clin Oncol. 2007 Apr 10; 25(11):1357-62.
  83. Mack JW, Wolfe J, Grier HE, Cleary PD, Weeks JC. Communication about prognosis between parents and physicians of children with cancer: parent preferences and the impact of prognostic information. J Clin Oncol. 2006 Nov 20; 24(33):5265-70.
  84. Mack JW, Cook EF, Wolfe J, Grier HE, Cleary PD, Weeks JC. Understanding of prognosis among parents of children with cancer: Parental optimism and the role of the parent-physician interaction. J Clin Oncol. 2006 Jun 20; 24(18_suppl):6033.
  85. Rahbar R, Grimmer JF, Vargas SO, Robson CD, Mack JW, Perez-Atayde AR, Marcus KJ, Grier HE, Healy GB, McGill TJ. Mucoepidermoid carcinoma of the parotid gland in children: A 10-year experience. Arch Otolaryngol Head Neck Surg. 2006 Apr; 132(4):375-80.
  86. Mack JW, Wolfe J. Early integration of pediatric palliative care: for some children, palliative care starts at diagnosis. Curr Opin Pediatr. 2006 Feb; 18(1):10-4.
  87. Houlahan KE, Branowicki PA, Mack JW, Dinning C, McCabe M. Can end of life care for the pediatric patient suffering with escalating and intractable symptoms be improved? J Pediatr Oncol Nurs. 2006 Jan-Feb; 23(1):45-51.
  88. Mack JW, Hilden JM, Watterson J, Moore C, Turner B, Grier HE, Weeks JC, Wolfe J. Parent and physician perspectives on quality of care at the end of life in children with cancer. J Clin Oncol. 2005 Dec 20; 23(36):9155-61.
  89. Mack JW, Hilden JM, Watterson J, Grier HE, Weeks JC, Wolfe J. Factors associated with the quality of care at the end of life in children with cancer. J Clin Oncol. 2004 Jul 15; 22(14_suppl):8529.
  90. Mack JW, Grier HE. The Day One Talk. J Clin Oncol. 2004 Feb 01; 22(3):563-6.
  91. Godambe SA, Mack JW, Chung DS, Lindeman R, Lillehei CW, Colin AA. Iatrogenic pleuropulmonary charcoal instillation in a teenager. Pediatr Pulmonol. 2003 Jun; 35(6):490-3.
  92. Porter DK, Van Every MJ, Anthracite RF, Mack JW. Massive hemoptysis in cystic fibrosis. Arch Intern Med. 1983 Feb; 143(2):287-90.
  93. Mack JW, Fry MB, McIntosh DA. Pulmonary hypertension in systemic lupus erythematosus. N Engl J Med. 1973 Jul 19; 289(3):157-8.
To schedule an appointment: Call 617-632-5430


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