Current Environment: Production

Medical Services

Specialties

Programs & Services

Languages

  • English
  • Turkish

Education

Medical School

Istanbul School of Medicine

1986, Istanbul, Turkey

Residency

Monmouth Medical Center

1999, Long Branch, NJ

Fellowship

Boston Children's Hospital

2003, Boston, MA

Certifications

  • American Board of Pediatrics (Rheumatology)

Publications

  1. Improvement in dermatomyositis-associated muscle disease with anifrolumab. Br J Dermatol. 2025 May 19; 192(6):1126-1128. View Abstract

  2. EULAR/American College of Rheumatology Classification Criteria for Pediatric Chronic Nonbacterial Osteomyelitis. Arthritis Rheumatol. 2025 May 08. View Abstract

  3. Three-dimensional stereophotogrammetry: an effective tool for detecting disease progression in lupus erythematosus panniculitis. Clin Exp Dermatol. 2025 Mar 26; 50(4):901-903. View Abstract

  4. Sex Differences in B Cells From the Joints of Children With Oligoarticular Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2025 Mar 17. View Abstract

  5. TEMPORARY REMOVAL: EULAR/ACR classification criteria for paediatric chronic nonbacterial osteomyelitis (CNO). Ann Rheum Dis. 2025 Jan 30. View Abstract

  6. Features of hyperinflammation link the biology of Epstein-Barr virus infection and cytokine storm syndromes. J Allergy Clin Immunol. 2025 Apr; 155(4):1346-1356.e9. View Abstract

  7. Comparison of 3D facial photographs and clinical documentation in patients with craniofacial morphea. Skin Health Dis. 2024 Dec; 4(6):e438. View Abstract

  8. Severe Features of Systemic Juvenile Idiopathic Arthritis in Patients With Congenital Heart Disease. J Rheumatol. 2024 Aug 01; 51(8):811-817. View Abstract

  9. Disease-Tailored Brief Intervention for Alcohol Use Among Youths With Chronic Medical Conditions: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2024 07 01; 7(7):e2419858. View Abstract

  10. Capturing the Range of Disease Involvement in Localized Scleroderma: The Localized Scleroderma Total Severity Scale. Arthritis Care Res (Hoboken). 2024 05; 76(5):616-626. View Abstract

  11. Rapid Improvement in Recalcitrant Cutaneous Juvenile Dermatomyositis With Anifrolumab Treatment. JAMA Dermatol. 2024 02 01; 160(2):237-238. View Abstract

  12. Elevation of IL-17 Cytokines Distinguishes Kawasaki Disease From Other Pediatric Inflammatory Disorders. Arthritis Rheumatol. 2024 02; 76(2):285-292. View Abstract

  13. Type I interferon signature and cycling lymphocytes in macrophage activation syndrome. J Clin Invest. 2023 11 15; 133(22). View Abstract

  14. Corrigendum: Increase in pediatric recurrent fever evaluations during the first year of the COVID-19 pandemic in North America. Front Pediatr. 2023; 11:1323946. View Abstract

  15. Use of 3-Dimensional Stereophotogrammetry to Detect Disease Progression in Craniofacial Morphea. JAMA Dermatol. 2023 11 01; 159(11):1232-1239. View Abstract

  16. Development of a Screening Algorithm for Lung Disease in Systemic Juvenile Idiopathic Arthritis. ACR Open Rheumatol. 2023 Oct; 5(10):556-562. View Abstract

  17. Increase in pediatric recurrent fever evaluations during the first year of the COVID-19 pandemic in North America. Front Pediatr. 2023; 11:1240242. View Abstract

  18. Update on autoinflammatory diseases. Curr Opin Rheumatol. 2023 09 01; 35(5):285-292. View Abstract

  19. Feasibility of Conducting Comparative Effectiveness Research and Validation of a Clinical Disease Activity Score for Chronic Nonbacterial Osteomyelitis. J Rheumatol. 2023 10; 50(10):1333-1340. View Abstract

  20. Incidence and Risk Factors for Eosinophilia and Lung Disease in Biologic-Exposed Children With Systemic Juvenile Idiopathic Arthritis. Arthritis Care Res (Hoboken). 2023 10; 75(10):2063-2072. View Abstract

  21. Gathering expert consensus to inform a proposed trial in chronic nonbacterial osteomyelitis (CNO). Clin Immunol. 2023 06; 251:109344. View Abstract

  22. Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome and Syndrome of Unexplained Recurrent Fevers in Children and Adults. J Allergy Clin Immunol Pract. 2023 06; 11(6):1676-1687. View Abstract

  23. Case report: Novel variants in RELA associated with familial Behcet's-like disease. Front Immunol. 2023; 14:1127085. View Abstract

  24. Botulinum toxin for refractory Raynaud's phenomenon: A "how to" guide for pediatric patients. Pediatr Dermatol. 2023 May-Jun; 40(3):587-589. View Abstract

  25. Construct validity of Patient-Reported Outcomes Measurement Information System Paediatric measures in juvenile idiopathic arthritis and systemic lupus erythematosus: cross-sectional evaluation. BMJ Open. 2023 01 27; 13(1):e063675. View Abstract

  26. Biologics and JAK inhibitors for the treatment of monogenic systemic autoinflammatory diseases in children. J Allergy Clin Immunol. 2023 03; 151(3):607-618. View Abstract

  27. Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis. Front Immunol. 2022; 13:1068399. View Abstract

  28. How Have the Diagnosis and Treatment of Chronic Recurrent Multifocal Osteomyelitis Changed Over Time? J Oral Maxillofac Surg. 2023 02; 81(2):238-247. View Abstract

  29. An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. J Rheumatol. 2022 Sep; 49(9):1042-1051. View Abstract

  30. Features predicting colchicine efficacy in treatment of children with undefined systemic autoinflammatory disease: A retrospective cohort study. Eur J Rheumatol. 2022 07; 9(3):116-121. View Abstract

  31. Pilot use of 3-dimensional photography to aid clinical decision-making in craniofacial morphea. JAAD Case Rep. 2022 Jul; 25:100-103. View Abstract

  32. The 2021 EULAR/American College of Rheumatology points to consider for diagnosis, management and monitoring of the interleukin-1 mediated autoinflammatory diseases: cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic syndrome, mevalonate kinase deficiency, and deficiency of the interleukin-1 receptor antagonist. Ann Rheum Dis. 2022 07; 81(7):907-921. View Abstract

  33. Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and Lupus. Front Immunol. 2022; 13:905109. View Abstract

  34. The 2021 EULAR/American College of Rheumatology Points to Consider for Diagnosis, Management and Monitoring of the Interleukin-1 Mediated Autoinflammatory Diseases: Cryopyrin-Associated Periodic Syndromes, Tumour Necrosis Factor Receptor-Associated Periodic Syndrome, Mevalonate Kinase Deficiency, and Deficiency of the Interleukin-1 Receptor Antagonist. Arthritis Rheumatol. 2022 07; 74(7):1102-1121. View Abstract

  35. Genetic diagnosis of immune dysregulation can lead to targeted therapy for interstitial lung disease: A case series and single center approach. Pediatr Pulmonol. 2022 07; 57(7):1577-1587. View Abstract

  36. Dental Anomalies in Parry-Romberg Syndrome: A 40-Year Retrospective Review. Cleft Palate Craniofac J. 2023 08; 60(8):956-961. View Abstract

  37. Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis. JCI Insight. 2021 09 22; 6(18). View Abstract

  38. Microbiome is not linked to clinical disease severity of familial Mediterranean fever in an international cohort of children. Clin Exp Rheumatol. 2021 Sep-Oct; 39 Suppl 132(5):102-108. View Abstract

  39. Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: A review. World J Otorhinolaryngol Head Neck Surg. 2021 Jul; 7(3):166-173. View Abstract

  40. Establishing core domain sets for Chronic Nonbacterial Osteomyelitis (CNO) and Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO): A report from the OMERACT 2020 special interest group. Semin Arthritis Rheum. 2021 08; 51(4):957-961. View Abstract

  41. Comprehensive analysis of ADA2 genetic variants and estimation of carrier frequency driven by a function-based approach. J Allergy Clin Immunol. 2022 01; 149(1):379-387. View Abstract

  42. Multiple Emergency Department Visits for a Diagnosis of Kawasaki Disease: An Examination of Risk Factors and Outcomes. J Pediatr. 2021 05; 232:127-132.e3. View Abstract

  43. Distinct clinical and immunological features of SARS-CoV-2-induced multisystem inflammatory syndrome in children. J Clin Invest. 2020 11 02; 130(11):5942-5950. View Abstract

  44. Burden of illness in hereditary periodic fevers: a multinational observational patient diary study. Clin Exp Rheumatol. 2020 Sep-Oct; 38 Suppl 127(5):26-34. View Abstract

  45. Safety Protocols for Adolescent Substance Use Research in Clinical Settings. J Adolesc Health. 2021 05; 68(5):999-1005. View Abstract

  46. Common genetic susceptibility loci link PFAPA syndrome, Behçet's disease, and recurrent aphthous stomatitis. Proc Natl Acad Sci U S A. 2020 06 23; 117(25):14405-14411. View Abstract

  47. Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group. Pediatr Rheumatol Online J. 2020 Apr 15; 18(1):31. View Abstract

  48. Inflammatory manifestations in patients with Shwachman-Diamond syndrome: A novel phenotype. Am J Med Genet A. 2020 07; 182(7):1754-1760. View Abstract

  49. Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis. JCI Insight. 2020 03 26; 5(6). View Abstract

  50. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis. Ann Rheum Dis. 2020 02; 79(2):225-231. View Abstract

  51. Initial Results from a Pilot Comparative Effectiveness Study of 3 Methotrexate-based Consensus Treatment Plans for Juvenile Localized Scleroderma. J Rheumatol. 2020 08 01; 47(8):1242-1252. View Abstract

  52. Developing comparative effectiveness studies for a rare, understudied pediatric disease: lessons learned from the CARRA juvenile localized scleroderma consensus treatment plan pilot study. Pediatr Rheumatol Online J. 2019 Jul 15; 17(1):43. View Abstract

  53. Risk Model Development and Validation for Prediction of Coronary Artery Aneurysms in Kawasaki Disease in a North American Population. J Am Heart Assoc. 2019 06 04; 8(11):e011319. View Abstract

  54. Screening and Counseling for Alcohol Use in Adolescents With Chronic Medical Conditions in the Ambulatory Setting. J Adolesc Health. 2019 06; 64(6):804-806. View Abstract

  55. Classification criteria for autoinflammatory recurrent fevers. Ann Rheum Dis. 2019 08; 78(8):1025-1032. View Abstract

  56. Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Pediatr Rheumatol Online J. 2019 Feb 14; 17(1):7. View Abstract

  57. Vasculitis in Systemic Autoinflammatory Diseases. Front Pediatr. 2018; 6:377. View Abstract

  58. Using Smartphone Crowdsourcing to Redefine Normal and Febrile Temperatures in Adults: Results from the Feverprints Study. J Gen Intern Med. 2018 12; 33(12):2046-2047. View Abstract

  59. Impact of biologics on disease course in systemic onset juvenile idiopathic arthritis. Clin Rheumatol. 2018 Dec; 37(12):3263-3273. View Abstract

  60. In silico validation of the Autoinflammatory Disease Damage Index. Ann Rheum Dis. 2018 11; 77(11):1599-1605. View Abstract

  61. Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and/or With Active Spinal Lesions. Arthritis Care Res (Hoboken). 2018 08; 70(8):1228-1237. View Abstract

  62. De novo ATP1A3 and compound heterozygous NLRP3 mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome. Mol Genet Metab Rep. 2018 Sep; 16:23-29. View Abstract

  63. An international delphi survey for the definition of the variables for the development of new classification criteria for periodic fever aphtous stomatitis pharingitis cervical adenitis (PFAPA). Pediatr Rheumatol Online J. 2018 Apr 18; 16(1):27. View Abstract

  64. The safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade: an international survey. Pediatr Rheumatol Online J. 2018 Mar 21; 16(1):19. View Abstract

  65. Adding patient-reported outcomes to a multisite registry to quantify quality of life and experiences of disease and treatment for youth with juvenile idiopathic arthritis. J Patient Rep Outcomes. 2018; 2. View Abstract

  66. Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. J Exp Med. 2017 Jul 03; 214(7):1937-1947. View Abstract

  67. Predicting Coronary Artery Aneurysms in Kawasaki Disease at a North American Center: An Assessment of Baseline z Scores. J Am Heart Assoc. 2017 May 31; 6(6). View Abstract

  68. Physicians' perspectives on the diagnosis and management of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. Rheumatol Int. 2017 Jun; 37(6):883-889. View Abstract

  69. Physicians' Perspectives on the Diagnosis and Treatment of Chronic Nonbacterial Osteomyelitis. Int J Rheumatol. 2017; 2017:7694942. View Abstract

  70. Periodic Fever, Aphthosis, Pharyngitis, and Adenitis Syndrome: Analysis of Patients From Two Geographic Areas. Arthritis Care Res (Hoboken). 2016 12; 68(12):1859-1865. View Abstract

  71. Development of the autoinflammatory disease damage index (ADDI). Ann Rheum Dis. 2017 May; 76(5):821-830. View Abstract

  72. Diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS). Ann Rheum Dis. 2017 Jun; 76(6):942-947. View Abstract

  73. Systemic onset juvenile idiopathic arthritis and exposure to fine particulate air pollution. Clin Exp Rheumatol. 2016 Sep-Oct; 34(5):946-952. View Abstract

  74. Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2016 07; 68(7):1758-68. View Abstract

  75. A Screening Tool for Assessing Alcohol Use Risk among Medically Vulnerable Youth. PLoS One. 2016; 11(5):e0156240. View Abstract

  76. A81: spectrum of mevalonate kinase deficiency: is colitis more common than we think? Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S114. View Abstract

  77. A119: deep sequencing analysis of the T regulatory and T effector repertoire in juvenile idiopathic arthritis. Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S156. View Abstract

  78. A121: in search of infectious triggers of periodic Fever, aphthous stomatitis, pharyngitis and adenitis syndrome. Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S158. View Abstract

  79. Autoinflammatory diseases in pediatrics. Dermatol Clin. 2013 Jul; 31(3):481-94. View Abstract

  80. Urine proteomics for discovery of improved diagnostic markers of Kawasaki disease. EMBO Mol Med. 2013 Feb; 5(2):210-20. View Abstract

  81. Pediatric chronic nonbacterial osteomyelitis. Pediatrics. 2012 Nov; 130(5):e1190-7. View Abstract

  82. Long-term surgical outcomes of adenotonsillectomy for PFAPA syndrome. Arch Otolaryngol Head Neck Surg. 2012 Oct; 138(10):902-6. View Abstract

  83. Multiple juvenile idiopathic arthritis subtypes demonstrate proinflammatory IgG glycosylation. Arthritis Rheum. 2012 Sep; 64(9):3025-33. View Abstract

  84. Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma. Arthritis Care Res (Hoboken). 2012 Aug; 64(8):1175-85. View Abstract

  85. A novel missense mutation in MVK associated with MK deficiency and dyserythropoietic anemia. Pediatrics. 2010 Apr; 125(4):e964-8. View Abstract

  86. Drug-induced autoimmunity. Curr Opin Rheumatol. 2009 Sep; 21(5):547-51. View Abstract

  87. Complete and sustained remission of juvenile dermatomyositis resulting from aggressive treatment. Arthritis Rheum. 2009 Jun; 60(6):1825-1830. View Abstract

  88. NOD2-associated diseases: Bridging innate immunity and autoinflammation. Clin Immunol. 2010 Mar; 134(3):251-61. View Abstract

  89. Chronic minocycline-induced autoimmunity in children. J Pediatr. 2008 Sep; 153(3):314-9. View Abstract

  90. B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE. J Allergy Clin Immunol. 2008 Jan; 121(1):191-196.e2. View Abstract

  91. Vasculitis in children. Rheum Dis Clin North Am. 2007 Aug; 33(3):555-83. View Abstract

  92. Update on pediatric vasculitis. Curr Opin Pediatr. 2005 Dec; 17(6):695-702. View Abstract

  93. Coronary artery dilation among patients presenting with systemic-onset juvenile idiopathic arthritis. Pediatrics. 2005 Jul; 116(1):e89-93. View Abstract

  94. Vasculitis in children. Pediatr Clin North Am. 2005 Apr; 52(2):547-75, vii. View Abstract

  95. TACI and BAFF-R mediate isotype switching in B cells. J Exp Med. 2005 Jan 03; 201(1):35-9. View Abstract

  96. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol. 2004 Mar; 16(3):395-404. View Abstract

  97. Impaired IgA class switching in APRIL-deficient mice. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3903-8. View Abstract

  98. Emergency Department management of Lyme disease. Clinical Pediatric Emergency Medicine. 2004; 5(1):54-62.

  99. Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. J Exp Med. 2003 Oct 20; 198(8):1189-200. View Abstract

  100. The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. Immunity. 2002 Sep; 17(3):265-76. View Abstract

  101. Successful treatment of retroperitoneal fibrosis with tamoxifen in a child. J Rheumatol. 2001 Jul; 28(7):1693-5. View Abstract

  102. “ Periodic Fever Disorders.”. International Seminars in Pediatric Gastroenterology and Nutrition. 2000; 9(3):9-15.

  103. Cross-reactions of anti-immunoglobulin sera with synthetic T-cell receptor beta peptides: mapping on a 3-dimension model. Adv Exp Med Biol. 1994; 347:93-8. View Abstract

  104. Light and heavy chains specifying a human IgM kappa autoantibody to a T-cell receptor V beta-antigen. Immunol Lett. 1993 Nov; 38(3):223-7. View Abstract

  105. Reactions of anti-immunoglobulin sera with synthetic T cell receptor peptides: implications for the three-dimensional structure and function of the TCR beta chain. Int Immunol. 1993 May; 5(5):491-502. View Abstract

  106. Lack of preferential V beta usage in synovial T cells of rheumatoid arthritis patients. Immunol Res. 1993; 12(1):12-20. View Abstract

  107. Human autoantibodies reactive with synthetic autoantigens from T-cell receptor beta chain. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3325-9. View Abstract

  108. Antigenic mapping of a human lambda light chain: correlation with three dimensional structure. J Protein Chem. 1992 Apr; 11(2):129-37. View Abstract

  109. T-cell receptors of man and mouse studied with antibodies against synthetic peptides. Exp Clin Immunogenet. 1992; 9(2):95-108. View Abstract

  110. Antigenic mapping of light chains and T cell receptor beta chains. Adv Exp Med Biol. 1991; 303:235-42. View Abstract

  111. "Cross-reactions of anti immunoglobulin sera with T cell receptor-beta peptides: mapping on a 3- dimensional model. Proceedings of the Seventh International Symposium on Immunobiology of Proteins and Peptides. 1991.

  112. "Antigenic mapping of light chains and Tcell receptor b chain". Proceedings of the Sixth International Symposium on Immunobiology of Proteins and Peptides. 1991; 235-242.

  113. "Urinary tract infection caused by Corynebacterium jeikeium ( Corynebacterium Group JK) " . Turkish J. of Infection. 1989; 3(4):465-472.

  114. "Cases of urinary tract infections caused by Salmonella thyphymurium". Turkish J. of Infection. 1989; 3(2):201-208.

  115. Leptospirosis: A case report". Turkish J. of Infection. 1989; 3(3):373-380.

  116. "Corynebacterium Group D2 infection: A case report". Turkish J. of Infection. 1989; 3(4):450-463.
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