Abrams MD

Dominic J.R. Abrams, MD MRCP

Associate in Cardiology; Director, Inherited Cardiac Arrhythmias Program

Assistant Professor of Pediatrics, Harvard Medical School

"Working with families in the Inherited Cardiac Arrhythmia Program to define different aspects of inherited cardiac conditions is both an exciting challenge and incredible privilege. Each day brings new situations and different scenarios, but adopting a team approach to each different problem provides great satisfaction and will always be a unique and very humbling experience."

Medical Services

Specialties

  • Cardiac Electrophysiology
  • Arrhythmia
  • Ablation
  • Pacemaker
  • Cardiology

Departments

  • Cardiology
  • Cardiovascular Program

Programs

  • Electrophysiology Service
To schedule an appointment: Call 617-355-6955 or Request an Appointment
Abrams MD

My job as a cardiac electrophysiologist provides an amazing contrast between the varied world of human cardiac genetics and the myriad of different cardiac arrhythmias managed interventionally in the cardiac electrophysiology laboratory. 

From the early days of my medical training, I have been fascinated by the complex relationship between human genetics and the associated clinical conditions - how one simple molecular change can lead to such wide ranging and varied conditions, and how understanding human genetics has helped unlock different biological pathways involved in inherited heart disorders. Working with families in the Inherited Cardiac Arrhythmia Program to define different aspects of inherited cardiac conditions is both an exciting challenge and incredible privilege.  Each day brings new situations and different scenarios, but adopting a team approach to each different problem provides great satisfaction and will always be a unique and very humbling experience.  

 

Equally challenging and satisfying, and yet requiring a complete different approach, is the interventional approach to arrhythmia management.  As a medical student watching a presentation of the treatment of a young patient with highly symptomatic Wolff-Parkinson-White syndrome, and seeing a picture of him on the summit of Mt. Kilimanjaro after a successful ablation was an inspirational and highly motivating experience.  To be able to eliminate symptoms in patients with arrhythmia allowing them to resume a normal quality of life remains as rewarding and satisfying today as performing my first ablation.   

Experience and Education

Education

Medical School

St. Mary's Hospital/Imperial College, 1994

London, UNITED KINGDOM

Internship

St. Mary's Hospital, 1995

London, UNITED KINGDOM

Pediatric Residency

St. Mary’s, St. Thomas’, Northwick Park, Royal Brompton & Harefield Hospitals, 1999

London, UNITED KINGDOM

Cardiac Electrophysiology Fellowship

Royal Brompton & Harefield, St. Bartholomew’s and The Heart/University College Hospitals, 2007

London, UNITED KINGDOM

Certifications

  • Pediatrics, Pediatric Cardiology

Professional History

I received my medical education and post-graduate training in the United Kingdom, specializing in cardiology and electrophysiology.  My fellowships were in both pediatric and adult cardiology, and in 2007 I was appointed as a Consultant Cardiologist and Electrophysiologist at St. Bartholomew’s Hospital, the largest adult electrophysiology center in the UK, and also continued to perform pediatric electrophysiology at Great Ormond Street Hospital.  This dual appointment allowed for detailed evaluation of all family members with varying inherited cardiac condition, including ion channel disorders and cardiomyopathies.  In Boston we have developed a rapid access Inherited Cardiac Arrhythmia Program for all patients with a confirmed or suspected inherited/genetic component to their condition, which runs between Boston Children’s and Brigham & Women’s Hospitals allowing for continued clinical care within the family irrespective of age.  Patients are comprehensively investigated, including clinical and genetic diagnosis and risk stratification, and appropriate management strategies implemented, including cascade screening across extensive families.  We are currently developing a major collaboration with colleagues across New England.  

As an adult and pediatric electrophysiologist I also have extensive experience in the management of arrhythmias in the adult congenital population and this has been a major area of clinical and research activity.

Publications

Publications powered by Harvard Catalyst Profiles
  1. De Ferrari GM, Dusi V, Spazzolini C, Bos JM, Abrams DJ, Berul CI, Crotti L, Davis AM, Eldar M, Kharlap M, Khoury A, Krahn AD, Leenhardt A, Moir CR, Odero A, Olde Nordkamp L, Paul T, Rosés I Noguer F, Shkolnikova M, Till J, Wilde AA, Ackerman MJ, Schwartz PJ. Clinical Management of Catecholaminergic Polymorphic Ventricular Tachycardia: The Role of Left Cardiac Sympathetic Denervation. Circulation. 2015 Jun 23; 131(25):2185-93.
  2. DeWitt ES, Triedman JK, Cecchin F, Mah DY, Abrams DJ, Walsh EP, Gauvreau K, Alexander ME. Time dependence of risks and benefits in pediatric primary prevention implantable cardioverter-defibrillator therapy. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1057-63.
  3. Giudici V, Spanaki A, Hendry J, Mead-Regan S, Field E, Zuccotti GV, Abrams D, Lowe M, Kaski JP. Sudden arrhythmic death syndrome: diagnostic yield of comprehensive clinical evaluation of pediatric first-degree relatives. Pacing Clin Electrophysiol. 2014 Dec; 37(12):1681-5.
  4. Sawhney V, Brouilette S, Abrams D, Schilling R, O'Brien B. Current genomics in cardiovascular medicine. Curr Genomics. 2012 Sep; 13(6):446-62.
  5. Page SP, Archbold A, Abrams DJ. Chest pain and ST elevation. BMJ. 2012; 344:e4323.
  6. Cabral RM, Tattersall D, Patel V, McPhail GD, Hatzimasoura E, Abrams DJ, South AP, Kelsell DP. The DSPII splice variant is crucial for desmosome-mediated adhesion in HaCaT keratinocytes. J Cell Sci. 2012 Jun 15; 125(Pt 12):2853-61.
  7. Abrams D. Wherein lies children's intergroup bias? Egocentrism, social understanding, and social projection. Child Dev. 2011 Sep-Oct; 82(5):1579-93.
  8. Cabral RM, Wan H, Cole CL, Abrams DJ, Kelsell DP, South AP. Identification and characterization of DSPIa, a novel isoform of human desmoplakin. Cell Tissue Res. 2010 Jul; 341(1):121-9.
  9. Abrams DJ, Perkin MA, Skinner JR. Long QT syndrome. BMJ. 2010; 340:b4815.
  10. Opel A, Murray S, Kamath N, Dhinoja M, Abrams D, Sporton S, Schilling R, Earley M. Cryoablation versus radiofrequency ablation for treatment of atrioventricular nodal reentrant tachycardia: cryoablation with 6-mm-tip catheters is still less effective than radiofrequency ablation. Heart Rhythm. 2010 Mar; 7(3):340-3.
  11. Show all
  12. Hunter RJ, Diab I, Thomas G, Duncan E, Abrams D, Dhinoja M, Sporton S, Earley MJ, Schilling RJ. Validation of a classification system to grade fractionation in atrial fibrillation and correlation with automated detection systems. Europace. 2009 Dec; 11(12):1587-96.
  13. Abrams DJ, Earley MJ, Sporton SC, Kistler PM, Gatzoulis MA, Mullen MJ, Till JA, Cullen S, Walker F, Lowe MD, Deanfield JE, Schilling RJ. Comparison of noncontact and electroanatomic mapping to identify scar and arrhythmia late after the Fontan procedure. Circulation. 2007 Apr 3; 115(13):1738-46.
  14. Kistler PM, Rajappan K, Jahngir M, Earley MJ, Harris S, Abrams D, Gupta D, Liew R, Ellis S, Sporton SC, Schilling RJ. The impact of CT image integration into an electroanatomic mapping system on clinical outcomes of catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2006 Oct; 17(10):1093-101.
  15. Abrams DJ, Earley MJ, Sporton SC, Schilling RJ. Successful ablation of atrioventricular nodal reentry tachycardia following the atriopulmonary Fontan procedure. Europace. 2006 Oct; 8(10):907-10.
  16. Earley MJ, Abrams DJ, Sporton SC, Schilling RJ. Validation of the noncontact mapping system in the left atrium during permanent atrial fibrillation and sinus rhythm. J Am Coll Cardiol. 2006 Aug 1; 48(3):485-91.
  17. Earley MJ, Showkathali R, Alzetani M, Kistler PM, Gupta D, Abrams DJ, Horrocks JA, Harris SJ, Sporton SC, Schilling RJ. Radiofrequency ablation of arrhythmias guided by non-fluoroscopic catheter location: a prospective randomized trial. Eur Heart J. 2006 May; 27(10):1223-9.
  18. Kistler PM, Earley MJ, Harris S, Abrams D, Ellis S, Sporton SC, Schilling RJ. Validation of three-dimensional cardiac image integration: use of integrated CT image into electroanatomic mapping system to perform catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2006 Apr; 17(4):341-8.
  19. Abrams D, Rigby ML. Transhepatic pulmonary artery stenting via a short intravascular sheath following neonatal repair of truncus arteriosus. Catheter Cardiovasc Interv. 2005 Oct; 66(2):277-80.
  20. Abrams D, Schilling R. Mechanism and mapping of atrial arrhythmia in the modified Fontan circulation. Heart Rhythm. 2005 Oct; 2(10):1138-44.
  21. Earley MJ, Abrams DJ, Staniforth AD, Sporton SC, Schilling RJ. Catheter ablation of permanent atrial fibrillation: medium term results. Heart. 2006 Feb; 92(2):233-8.
  22. Cotton DJ, Powderly WG, Feinberg J, Abrams DI, Chaisson RE, Wheat LJ, Finkelstein DM, Tallman V, Zimmer B, Berzon R, et al. Guidelines for the design and conduct of AIDS clinical trials. AIDS Clinical Trials Group. Clin Infect Dis. 1993 Jun; 16(6):816-22; discussion 823-4.
  23. Jacobson MA, Abrams DI, Volberding PA, Bacchetti P, Wilber J, Chaisson RE, Crowe S, Howard W, Moss A. Serum beta 2-microglobulin decreases in patients with AIDS or ARC treated with azidothymidine. J Infect Dis. 1989 Jun; 159(6):1029-36.
  24. Blaydon DC, Biancheri P, Di WL, Plagnol V, Cabral RM, Brooke MA, van Heel DA, Ruschendorf F, Toynbee M, Walne A, O'Toole EA, Martin JE, Lindley K, Vulliamy T, Abrams DJ, MacDonald TT, Harper JI, Kelsell DP. Inflammatory skin and bowel disease linked to ADAM17 deletion. N Engl J Med. 2011 Oct 20; 365(16):1502-8.
  25. Abrams DJ, Rigby ML, Daubeney PE. Images in cardiovascular medicine. Membranous pulmonary atresia treated by radiofrequency-assisted balloon pulmonary valvotomy. Circulation. 2003 Apr 22; 107(15):e98-9.
  26. Abrams DJ, Kirkby C, Page SP, Earley MJ, Nitiou D, Kelsell DP, Schilling RJ. Evolution of Electrocardiographic and Structural Features Over 3 Decades in Arrhythmogenic Cardiomyopathy. Circulation. 2015 Jun 23; 131(25):2233-5.
  27. Finlay M, Sawhney V, Schilling R, Thomas G, Duncan E, Hunter R, Virdi G, Abrams D, Sporton S, Dhinoja M, Earley M. Uninterrupted warfarin for periprocedural anticoagulation in catheter ablation of typical atrial flutter: a safe and cost-effective strategy. J Cardiovasc Electrophysiol. 2010 Feb; 21(2):150-4.
  28. Kistler PM, Ho SY, Rajappan K, Morper M, Harris S, Abrams D, Sporton SC, Schilling RJ. Electrophysiologic and anatomic characterization of sites resistant to electrical isolation during circumferential pulmonary vein ablation for atrial fibrillation: a prospective study. J Cardiovasc Electrophysiol. 2007 Dec; 18(12):1282-8.
  29. Diab IG, Hunter RJ, Kamdar R, Berriman T, Duncan E, Richmond L, Baker V, Abrams D, Earley MJ, Sporton S, Schilling RJ. Does ventricular dyssynchrony on echocardiography predict response to cardiac resynchronisation therapy? A randomised controlled study. Heart. 2011 Sep; 97(17):1410-6.
  30. Page SP, Siddiqui MS, Finlay M, Hunter RJ, Abrams DJ, Dhinoja M, Earley MJ, Sporton SC, Schilling RJ. Catheter ablation for atrial fibrillation on uninterrupted warfarin: can it be done without echo guidance? J Cardiovasc Electrophysiol. 2011 Mar; 22(3):265-70.
  31. Abrams DJ, Kilner P, Till JA, Shore DF, Sethia B, Franklin RC, Magee AG. Prolapse of the antero-superior leaflet of the tricuspid valve secondary to congenital anomalies of the valvar and sub-valvar apparatus: a rare cause of severe tricuspid regurgitation. Cardiol Young. 2005 Aug; 15(4):417-21.
  32. Abrams DJ, Macrae CA. Long QT syndrome. Circulation. 2014 Apr 8; 129(14):1524-9.
To schedule an appointment: Call 617-355-6955 or Request an Appointment

Locations

We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”
- Sandra L. Fenwick, President and CEO

Boston Children's Hospital 300 Longwood Avenue, Boston, MA 02115 617-355-6000 | 800-355-7944

Close