Brent Weil MD

Brent R. Weil, MD

Assistant in Surgery

    Contact: 617-355-3039

Medical Services

Specialties

  • General Surgery
  • Pediatrics
  • Circumcision
  • Undescended Testicles
  • Hernia Surgery
  • Hydrocele
  • Umbilical Hernia
  • Thyroglossal Duct Cyst
  • Branchial cleft anomalies

Departments

  • Surgery
  • Hematology / Oncology
To schedule an appointment: Call 617-355-3039 or Request an Appointment
Brent Weil MD

 

Dr. Weil's clinical interests are pediatric surgical oncology, inflammatory bowel disease, pediatric general surgery, and minimally invasive surgery.

Experience and Education

Education

Medical School

Ohio State University School of Medicine, 2002-2006

Columbus , OH

Residency, Surgery

Indiana University School of Medicine, 2007-2012

Indianapolis, IN

Internship, General Surgery

Indiana University School of Medicine, 2006-2007

Indianapolis , IN

Fellowship, Pediatric General Surgery

Boston Children's Hospital, 2013-2015

Boston, MA

Certifications

  • Surgery, Pediatric Surgery

Publications

Publications powered by Harvard Catalyst Profiles
  1. Onwubiko C, Weil BR, Bairdain S, Hall AM, Perkins JM, Thangarajah H, McSweeney ME, Smithers CJ. Primary laparoscopic gastrojejunostomy tubes as a feeding modality in the pediatric population. J Pediatr Surg. 2017 May 20.
  2. Madenci AL, Li GZ, Weil BR, Zurakowski D, Kang PB, Weldon CB. The role of thymectomy in the treatment of juvenile myasthenia gravis: a systematic review. Pediatr Surg Int. 2017 Jun; 33(6):683-694.
  3. Devji TF, Madenci AL, Carpino E, Leahy IC, Samnaliev M, Dearden JL, Weil BR, Weldon CB, Cravero J. Safety and cost-effectiveness of port removal outside of the operating room among pediatric patients. J Pediatr Surg. 2016 Nov; 51(11):1891-1895.
  4. Weil BR, Al-Ibraheemi A, Vargas SO, Rangel SJ. Autoamputation of the appendix presenting as a calcified abdominal mass following necrotizing enterocolitis. Pediatr Dev Pathol. 2016 Mar 28.
  5. Weil BR, Shamberger RC. Commentary on "Simultaneous Resection of High-risk Liver Tumors and Pulmonary Metastases in Children". Ann Surg. 2015 Jul; 262(1):e4.
  6. Brewster BD, Weil BR, Ladd AP. Prospective determination of percutaneous endoscopic gastrostomy complication rates in children: still a safe procedure. Surgery. 2012 Oct; 152(4):714-9; discussion 719-21.
  7. Weil BR, Leys CM, Rescorla FJ. The jury is still out: changes in gastroschisis management over the last decade are associated with both benefits and shortcomings. J Pediatr Surg. 2012 Jan; 47(1):119-24.
  8. Herrmann JL, Fiege JW, Abarbanell AM, Weil BR, Wang Y, Poynter JA, Manukyan MC, Brewster BD, Meldrum DR. TGF-a equalizes age disparities in stem cell-mediated cardioprotection. J Surg Res. 2012 Aug; 176(2):386-94.
  9. Luo Y, Wang Y, Poynter JA, Manukyan MC, Herrmann JL, Abarbanell AM, Weil BR, Meldrum DR. Pretreating mesenchymal stem cells with interleukin-1ß and transforming growth factor-ß synergistically increases vascular endothelial growth factor production and improves mesenchymal stem cell-mediated myocardial protection after acute ischemia. Surgery. 2012 Mar; 151(3):353-63.
  10. Hollander LL, Leys CM, Weil BR, Rescorla FJ. Predictive value of response to steroid therapy on response to splenectomy in children with immune thrombocytopenic purpura. Surgery. 2011 Oct; 150(4):643-8.
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  12. Herrmann JL, Abarbanell AM, Wang Y, Weil BR, Poynter JA, Manukyan MC, Meldrum DR. Transforming growth factor-a enhances stem cell-mediated postischemic myocardial protection. Ann Thorac Surg. 2011 Nov; 92(5):1719-25.
  13. Weil BR, Herrmann JL, Abarbanell AM, Manukyan MC, Poynter JA, Meldrum DR. Intravenous infusion of mesenchymal stem cells is associated with improved myocardial function during endotoxemia. Shock. 2011 Sep; 36(3):235-41.
  14. Manukyan MC, Keck AC, Poynter JA, Wang Y, Weil BR, Abarbanell AM, Herrmann JL, Crowe BJ, Alvernaz C, Meldrum DR. Transforming growth factor-alpha does not protect myocardium during acute ischemia/reperfusion. Surgery. 2011 Aug; 150(2):339-46.
  15. Crowe B, Poynter JA, Manukyan MC, Wang Y, Brewster BD, Herrmann JL, Abarbanell AM, Weil BR, Meldrum DR. Pretreatment with intracoronary mimosine improves postischemic myocardial functional recovery. Surgery. 2011 Aug; 150(2):191-6.
  16. Poynter JA, Manukyan MC, Wang Y, Brewster BD, Herrmann JL, Weil BR, Abarbanell AM, Meldrum DR. Systemic pretreatment with dimethyloxalylglycine increases myocardial HIF-1a and VEGF production and improves functional recovery after acute ischemia/reperfusion. Surgery. 2011 Aug; 150(2):278-83.
  17. Manukyan MC, Alvernaz CH, Poynter JA, Wang Y, Brewster BD, Weil BR, Abarbanell AM, Herrmann JL, Crowe BJ, Keck AC, Meldrum DR. Interleukin-10 protects the ischemic heart from reperfusion injury via the STAT3 pathway. Surgery. 2011 Aug; 150(2):231-9.
  18. Poynter JA, Herrmann JL, Manukyan MC, Wang Y, Abarbanell AM, Weil BR, Brewster BD, Meldrum DR. Intracoronary mesenchymal stem cells promote postischemic myocardial functional recovery, decrease inflammation, and reduce apoptosis via a signal transducer and activator of transcription 3 mechanism. J Am Coll Surg. 2011 Aug; 213(2):253-60.
  19. Herrmann JL, Weil BR, Abarbanell AM, Wang Y, Poynter JA, Manukyan MC, Meldrum DR. IL-6 and TGF-a costimulate mesenchymal stem cell vascular endothelial growth factor production by ERK-, JNK-, and PI3K-mediated mechanisms. Shock. 2011 May; 35(5):512-6.
  20. Manukyan MC, Weil BR, Wang Y, Abarbanell AM, Herrmann JL, Poynter JA, Brewster BD, Meldrum DR. Female stem cells are superior to males in preserving myocardial function following endotoxemia. Am J Physiol Regul Integr Comp Physiol. 2011 Jun; 300(6):R1506-14.
  21. Wang Y, Abarbanell AM, Herrmann JL, Weil BR, Manukyan MC, Poynter JA, Meldrum DR. TLR4 inhibits mesenchymal stem cell (MSC) STAT3 activation and thereby exerts deleterious effects on MSC-mediated cardioprotection. PLoS One. 2010 Dec 03; 5(12):e14206.
  22. Poynter JA, Beckman DJ, Abarbanell AM, Herrmann JL, Manukyan MC, Weil BR, Bumb K, Meldrum DR. Surgical treatment of atrial fibrillation: the time is now. Ann Thorac Surg. 2010 Dec; 90(6):2079-86.
  23. Wang Y, Abarbanell AM, Herrmann JL, Weil BR, Poynter J, Manukyan MC, Crisostomo PR, Meldrum DR. Toll-like receptor signaling pathways and the evidence linking toll-like receptor signaling to cardiac ischemia/reperfusion injury. Shock. 2010 Dec; 34(6):548-57.
  24. Manukyan MC, Weil BR, Wang Y, Abarbanell AM, Herrmann JL, Poynter JA, Meldrum DR. The phosphoinositide-3 kinase survival signaling mechanism in sepsis. Shock. 2010 Nov; 34(5):442-9.
  25. Tan J, Weil BR, Abarbanell AM, Wang Y, Herrmann JL, Dake ML, Meldrum DR. Ablation of TNF-alpha receptors influences mesenchymal stem cell-mediated cardiac protection against ischemia. Shock. 2010 Sep; 34(3):236-42.
  26. Abarbanell AM, Hartley JA, Herrmann JL, Weil BR, Wang Y, Manukyan MC, Poynter JA, Meldrum DR. Exogenous high-mobility group box 1 improves myocardial recovery after acute global ischemia/reperfusion injury. Surgery. 2011 Mar; 149(3):329-35.
  27. Weil BR, Manukyan MC, Herrmann JL, Abarbanell AM, Poynter JA, Wang Y, Meldrum DR. The immunomodulatory properties of mesenchymal stem cells: implications for surgical disease. J Surg Res. 2011 May 01; 167(1):78-86.
  28. Weil BR, Ladd AP, Yoder K. Pericardial effusion and cardiac tamponade associated with central venous catheters in children: an uncommon but serious and treatable condition. J Pediatr Surg. 2010 Aug; 45(8):1687-92.
  29. Weil BR, Manukyan MC, Herrmann JL, Wang Y, Abarbanell AM, Poynter JA, Meldrum DR. Mesenchymal stem cells attenuate myocardial functional depression and reduce systemic and myocardial inflammation during endotoxemia. Surgery. 2010 Aug; 148(2):444-52.
  30. Weil BR, Manukyan MC, Herrmann JL, Wang Y, Abarbanell AM, Poynter JA, Meldrum DR. Signaling via GPR30 protects the myocardium from ischemia/reperfusion injury. Surgery. 2010 Aug; 148(2):436-43.
  31. Herrmann JL, Abarbanell AM, Weil BR, Manukyan MC, Poynter JA, Brewster BJ, Wang Y, Meldrum DR. Optimizing stem cell function for the treatment of ischemic heart disease. J Surg Res. 2011 Mar; 166(1):138-45.
  32. Kelly ML, Wang M, Crisostomo PR, Abarbanell AM, Herrmann JL, Weil BR, Meldrum DR. TNF receptor 2, not TNF receptor 1, enhances mesenchymal stem cell-mediated cardiac protection following acute ischemia. Shock. 2010 Jun; 33(6):602-7.
  33. Herrmann JL, Abarbanell AM, Weil BR, Wang Y, Poynter JA, Manukyan MC, Meldrum DR. Postinfarct intramyocardial injection of mesenchymal stem cells pretreated with TGF-alpha improves acute myocardial function. Am J Physiol Regul Integr Comp Physiol. 2010 Jul; 299(1):R371-8.
  34. Weil BR, Andreoli SP, Billmire DF. Bleeding risk for surgical dialysis procedures in children with hemolytic uremic syndrome. Pediatr Nephrol. 2010 Sep; 25(9):1693-8.
  35. Herrmann JL, Abarbanell AM, Weil BR, Manukyan MC, Poynter JA, Wang Y, Coffey AC, Meldrum DR. Gender dimorphisms in progenitor and stem cell function in cardiovascular disease. J Cardiovasc Transl Res. 2010 Apr; 3(2):103-13.
  36. Abarbanell AM, Wang Y, Herrmann JL, Weil BR, Poynter JA, Manukyan MC, Meldrum DR. Toll-like receptor 2 mediates mesenchymal stem cell-associated myocardial recovery and VEGF production following acute ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2010 May; 298(5):H1529-36.
  37. Herrmann JL, Wang Y, Abarbanell AM, Weil BR, Tan J, Meldrum DR. Preconditioning mesenchymal stem cells with transforming growth factor-alpha improves mesenchymal stem cell-mediated cardioprotection. Shock. 2010 Jan; 33(1):24-30.
  38. Herrmann JL, Abarbanell AM, Weil BR, Wang Y, Wang M, Tan J, Meldrum DR. Cell-based therapy for ischemic heart disease: a clinical update. Ann Thorac Surg. 2009 Nov; 88(5):1714-22.
  39. Weil BR, Meldrum DR. What's new in Shock, October 2009? Shock. 2009 Oct; 32(4):345-7.
  40. Abarbanell AM, Coffey AC, Fehrenbacher JW, Beckman DJ, Herrmann JL, Weil B, Meldrum DR. Proinflammatory cytokine effects on mesenchymal stem cell therapy for the ischemic heart. Ann Thorac Surg. 2009 Sep; 88(3):1036-43.
  41. Wang Y, Weil BR, Herrmann JL, Abarbanell AM, Tan J, Markel TA, Kelly ML, Meldrum DR. MEK, p38, and PI-3K mediate cross talk between EGFR and TNFR in enhancing hepatocyte growth factor production from human mesenchymal stem cells. Am J Physiol Cell Physiol. 2009 Nov; 297(5):C1284-93.
  42. Herrmann JL, Markel TA, Abarbanell AM, Weil BR, Wang M, Wang Y, Tan J, Meldrum DR. Proinflammatory stem cell signaling in cardiac ischemia. Antioxid Redox Signal. 2009 Aug; 11(8):1883-96.
  43. Weil BR, Markel TA, Herrmann JL, Abarbanell AM, Meldrum DR. Mesenchymal stem cells enhance the viability and proliferation of human fetal intestinal epithelial cells following hypoxic injury via paracrine mechanisms. Surgery. 2009 Aug; 146(2):190-7.
  44. Vornehm ND, Wang M, Abarbanell A, Herrmann J, Weil B, Tan J, Wang Y, Kelly M, Meldrum DR. Acute postischemic treatment with estrogen receptor-alpha agonist or estrogen receptor-beta agonist improves myocardial recovery. Surgery. 2009 Aug; 146(2):145-54.
  45. Abarbanell AM, Herrmann JL, Weil BR, Wang Y, Tan J, Moberly SP, Fiege JW, Meldrum DR. Animal models of myocardial and vascular injury. J Surg Res. 2010 Aug; 162(2):239-49.
  46. Weil BR, Markel TA, Herrmann JL, Abarbanell AM, Kelly ML, Meldrum DR. Stem cells in sepsis. Ann Surg. 2009 Jul; 250(1):19-27.
  47. Wang M, Tan J, Coffey A, Fehrenbacher J, Weil BR, Meldrum DR. Signal transducer and activator of transcription 3-stimulated hypoxia inducible factor-1alpha mediates estrogen receptor-alpha-induced mesenchymal stem cell vascular endothelial growth factor production. J Thorac Cardiovasc Surg. 2009 Jul; 138(1):163-71, 171.e1.
  48. Wang M, Wang Y, Abarbanell A, Tan J, Weil B, Herrmann J, Meldrum DR. Both endogenous and exogenous testosterone decrease myocardial STAT3 activation and SOCS3 expression after acute ischemia and reperfusion. Surgery. 2009 Aug; 146(2):138-44.
  49. Wang Y, Wang M, Abarbanell AM, Weil BR, Herrmann JL, Tan J, Novotny NM, Coffey AC, Meldrum DR. MEK mediates the novel cross talk between TNFR2 and TGF-EGFR in enhancing vascular endothelial growth factor (VEGF) secretion from human mesenchymal stem cells. Surgery. 2009 Aug; 146(2):198-205.
  50. Weil BR, Abarbanell AM, Herrmann JL, Wang Y, Meldrum DR. High glucose concentration in cell culture medium does not acutely affect human mesenchymal stem cell growth factor production or proliferation. Am J Physiol Regul Integr Comp Physiol. 2009 Jun; 296(6):R1735-43.
  51. Zeller CN, Wang Y, Markel TA, Weil B, Abarbanell A, Herrmann JL, Kelly ML, Coffey A, Meldrum DR. Role of tumor necrosis factor receptor 1 in sex differences of stem cell mediated cardioprotection. Ann Thorac Surg. 2009 Mar; 87(3):812-9.
  52. Wang M, Wang Y, Weil B, Abarbanell A, Herrmann J, Tan J, Kelly M, Meldrum DR. Estrogen receptor beta mediates increased activation of PI3K/Akt signaling and improved myocardial function in female hearts following acute ischemia. Am J Physiol Regul Integr Comp Physiol. 2009 Apr; 296(4):R972-8.
  53. Lahm T, Crisostomo PR, Markel TA, Wang M, Wang Y, Weil B, Meldrum DR. Exogenous estrogen rapidly attenuates pulmonary artery vasoreactivity and acute hypoxic pulmonary vasoconstriction. Shock. 2008 Dec; 30(6):660-7.
  54. Wang Y, Crisostomo PR, Wang M, Weil B, Abarbanell A, Poynter J, Manukyan MC, Meldrum DR. Nitric oxide suppresses the secretion of vascular endothelial growth factor and hepatocyte growth factor from human mesenchymal stem cells. Shock. 2008 Nov; 30(5):527-31.
  55. Sharma R, Markel TA, Wang Y, Crisostomo PR, Wang M, Sando IC, Weil BR, Meldrum DR. Proestrus female rats are more resistant to right ventricular pressure overload. Shock. 2008 Sep; 30(3):318-23.
  56. Weil BR, Howard TJ, Zyromski NJ. Spontaneous duodenal hematoma: a rare cause of upper gastrointestinal tract obstruction. Arch Surg. 2008 Aug; 143(8):794-6.
  57. Lahm T, Crisostomo PR, Markel TA, Wang M, Weil BR, Novotny NM, Meldrum DR. The effects of estrogen on pulmonary artery vasoreactivity and hypoxic pulmonary vasoconstriction: potential new clinical implications for an old hormone. Crit Care Med. 2008 Jul; 36(7):2174-83.
  58. Ray R, Herring CM, Markel TA, Crisostomo PR, Wang M, Weil B, Lahm T, Meldrum DR. Deleterious effects of endogenous and exogenous testosterone on mesenchymal stem cell VEGF production. Am J Physiol Regul Integr Comp Physiol. 2008 May; 294(5):R1498-503.
  59. Palomera S, Baron C, Weil B, Lang P. Comparison between allogeneic and xenogeneic lymphocyte reactivity. Transplant Proc. 1996 Oct; 28(5):2915-6.
  60. Baron C, Lang P, Bierre V, Rostoker G, Weil B. Split tolerance in chimeric GVH mice. Transpl Int. 1994; 7 Suppl 1:S606-10.
  61. Laurent J, Philippon C, Lagrue G, Laurent G, Weil B, Rostoker G. Proteinuria selectivity index--prognostic value in lipoid nephrosis and related diseases. Nephron. 1993; 65(2):185-9.
To schedule an appointment: Call 617-355-3039 or Request an Appointment

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