Amy Hughes MD

Amy Hughes, MD

Associate in Otolaryngology

Clinical Instructor of Otology and Laryngology, Harvard Medical School

    Contact: 617-355-6462
  • Fax: 617-730-0337

Medical Services


  • Otolaryngology
  • Branchial cleft anomalies
  • Thyroglossal Duct Cyst


  • Otolaryngology and Communication Enhancement


  • English
To schedule an appointment: Call 617-355-6462 or Request an Appointment

Experience and Education


Medical School

Loyola University-Stritch School of Medicine, 2004-2008

Maywood, IL


University of Connecticut, 2008-2009

Farmington, CT


University of Connecticut, 2009-2013

Farmington, CT


Boston Children's Hospital, 2013-2014

Boston, MA


  • American Board of Otolaryngology

Professional History

Amy L. Hughes, M.D. is a graduate of Boston College and Loyola University-Stritch School of Medicine. She completed otolaryngology training at the University of Connecticut and completed her fellowship in pediatric otolaryngology at Boston Children’s Hospital in 2014.

Her principal clinical interests are in the management of salivary gland disorders and the management of drooling.  She has participated in national and international training courses on sialendoscopy, a technology that allows us to examine our patient’s salivary ducts for blockages such as stones or narrowed areas called strictures.  She would also like to start a multi-disciplinary clinic to improve management of drooling in our complex patients.


Publications powered by Harvard Catalyst Profiles
  1. Hughes A, Choi S. Does intraglandular injection of botulinum toxin improve pediatric sialorrhea? Laryngoscope. 2017 Dec 15.
  2. Hughes AL, Roberson D, Bannos C, Trudell EK, Vernacchio L. Appropriateness of Tympanostomy Tubes in the Boston Metropolitan Area: Are the AAO-HNSF Guidelines Being Met? Otolaryngol Head Neck Surg. 2017 Dec; 157(6):1041-1047.
  3. Hughes A, Danehy A, Adil E. Case 226: Oval Window Atresia. Radiology. 2016 Feb; 278(2):626-31.
  4. Hughes A, Danehy A, Adil E. Case 226. Radiology. 2015 Oct; 277(1):294-7.
  5. Hughes AL, Yang E, Vargas SO. A pediatric soft palate mass. Pleomorphic adenoma. JAMA Otolaryngol Head Neck Surg. 2015 Apr; 141(4):391-2.
  6. Hughes A, Adil EA. What is the role of endoscopic sinus surgery in adult patients with cystic fibrosis? Laryngoscope. 2015 Sep; 125(9):2018-20.
  7. Gantwerker EA, Hughes AL, Silvera VM, Vargas SO, Rahbar R. Management of a large antenatally recognized foregut duplication cyst of the tongue causing respiratory distress at birth. JAMA Otolaryngol Head Neck Surg. 2014 Nov; 140(11):1065-9.
  8. Hughes AL, Hussain N, Pafford R, Parham K. Dexamethasone otoprotection in a multidose cisplatin ototoxicity mouse model. Otolaryngol Head Neck Surg. 2014 Jan; 150(1):115-20.
  9. Chen ZW, Hughes AL, Ghim SH, Letvin NL, Watkins DI. Two more chimpanzee Patr-A locus alleles related to the HLA-A1/A3/A11 family. Immunogenetics. 1993; 38(3):238-40.
  10. Chen ZW, Shen L, Miller MD, Ghim SH, Hughes AL, Letvin NL. Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag. J Immunol. 1992 Dec 15; 149(12):4060-6.
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  12. Chen ZW, McAdam SN, Hughes AL, Dogon AL, Letvin NL, Watkins DI. Molecular cloning of orangutan and gibbon MHC class I cDNA. The HLA-A and -B loci diverged over 30 million years ago. J Immunol. 1992 Apr 15; 148(8):2547-54.
  13. Levinson G, Hughes AL, Letvin NL. Sequence and diversity of rhesus monkey T-cell receptor beta chain genes. Immunogenetics. 1992; 35(2):75-88.
  14. Zhou LJ, Ord DC, Hughes AL, Tedder TF. Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain. J Immunol. 1991 Aug 15; 147(4):1424-32.
  15. Miller MD, Yamamoto H, Hughes AL, Watkins DI, Letvin NL. Definition of an epitope and MHC class I molecule recognized by gag-specific cytotoxic T lymphocytes in SIVmac-infected rhesus monkeys. J Immunol. 1991 Jul 01; 147(1):320-9.
  16. Watkins DI, Chen ZW, Garber TL, Hughes AL, Letvin NL. Segmental exchange between MHC class I genes in a higher primate: recombination in the gorilla between the ancestor of a human non-functional gene and an A locus gene. Immunogenetics. 1991; 34(3):185-91.
  17. Watkins DI, Garber TL, Chen ZW, Toukatly G, Hughes AL, Letvin NL. Unusually limited nucleotide sequence variation of the expressed major histocompatibility complex class I genes of a New World primate species (Saguinus oedipus). Immunogenetics. 1991; 33(2):79-89.
  18. Watkins DI, Chen ZW, Hughes AL, Lagos A, Lewis AM, Shadduck JA, Letvin NL. Syrian hamsters express diverse MHC class I gene products. J Immunol. 1990 Nov 15; 145(10):3483-90.
  19. Watkins DI, Chen ZW, Hughes AL, Evans MG, Tedder TF, Letvin NL. Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes. Nature. 1990 Jul 05; 346(6279):60-3.
  20. Watkins DI, Chen ZW, Hughes AL, Hodi FS, Letvin NL. Genetically distinct cell populations in naturally occurring bone marrow-chimeric primates express similar MHC class I gene products. J Immunol. 1990 May 15; 144(10):3726-35.
  21. Watkins DI, Letvin NL, Hughes AL, Tedder TF. Molecular cloning of cDNA that encode MHC class I molecules from a New World primate (Saguinus oedipus). Natural selection acts at positions that may affect peptide presentation to T cells. J Immunol. 1990 Feb 01; 144(3):1136-43.
To schedule an appointment: Call 617-355-6462 or Request an Appointment


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