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Nicholas Stylopoulos
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Nicholas Stylopoulos, MD

Department: Medicine
Research Centers: Endocrinology Research Center
Hospital Title: Medical Staff
Academic Title: Assistant Professor in Pediatrics, Harvard Medical School
Research Area: Metabolism

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Research Overview

Nicholas Stylopoulos is a Principal investigator at the Division of Endocrinology and an Assistant Professor at Harvard Medical School. His laboratory is part of the Center for Basic and Translational Obesity Research and focuses on the mechanisms by which weight loss surgery affects energy balance.

The Center for Basic and Translational Obesity Research is an exciting new research program at the Division of Endocrinology at Children’s Hospital Boston and Harvard Medical School, whose goal is to improve our understanding of how people become obese or suffer from complications of obesity, and to help translate research findings into better treatments. The Director of the Center is Dr. Joel Hirschhorn. Dr. Nada Kalaany is a Principal Investigator at the Center.

Stylopoulos laboratory uses many gastrointestinal weight loss surgery rodent models to study weight loss procedures (e.g., Roux-en-Y gastric bypass, sleeve gastrectomy, gastric banding and other). These models represent a powerful, novel, translational and clinically relevant model system to study regulation of energy balance and metabolic function. They offer a unique opportunity to unravel mechanisms underlying the beneficial effects of surgery on body weight, metabolism, glucose homeostasis, inflammation and cancer.

By “reverse engineering” the mechanisms by which weight loss surgery induces weight loss and resolution of diabetes and other metabolic complications, we will be able to develop less invasive approaches that will utilize the same effective mechanisms without the invasiveness of surgery. Thus, we will eventually “bypass the bypass” and we will be able to increase the number of treatment options and offer less-invasive options that will allow the widespread use in many categories of patients with obesity, including children and adolescents.


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