Lab Web Site: Pu Lab
Dr. Pu's laboratory is interested in the regulation of gene expression in heart development and heart failure. They use conditional gene knockout and overexpression approaches to manipulate gene expression in mice and in primary cultured cells. They are currently investigating the tissue-specific function of the transcription factor Gata4. They are also studying the effect of microRNAs on gene expression, heart development, and heart function.
Goals of Dr. Pu's research include:
- to understand the transcriptional network regulating heart development
- to understand the contribution of microRNAs to regulating heart development and heart function
- to understand genetic contributions to congenital heart disease
About William Pu
William Pu received an MD from Harvard Medical School. He completed his internship, residency and a cardiology fellowship at Boston Children's Hospital.
- Bisping, E. et al. Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure. Proc Natl Acad Sci U S A (2006).
- Rivera-Feliciano, J. et al. Development of heart valves requires Gata4 expression in endothelial-derived cells. Development 133, 3607-3618 (2006).
- Zeisberg, E. M. et al. Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest 115, 1522-1531 (2005).