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David Nathan
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David G. Nathan, MD

Department: Medicine
Research Centers: Cancer and Blood Diseases Research Center
Hospital Title: President Emeritus, Dana-Farber Cancer Institute
Academic Title: Robert A. Stranahan Distinguished Professor of Pediatrics
Research Area: Gene transfer for anemia


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Research Overview

Dr. Nathan no longer operates a research laboratory. Most of his academic effort is devoted to teaching students, house staff and fellows, mentoring young faculty members, and writing text book chapters, books and short articles. He continues his interest in the congenital and acquired bone marrow failure syndromes and the hemoglobinopathies. He has recently received three program project grants of which he is the PI devoted to an entirely new treatment of sickle cell crisis based on interference with iNKT cell function. He remains involved in policies concerning clinical research.

About David Nathan

David Nathan received an MD from Harvard Medical School. He completed an internship and residency at Brigham and Women's Hospital and a fellowship at the National Cancer Institute.

David Nathan received an MD from Harvard Medical School. He completed an internship and residency at Brigham and Women's Hospital and a fellowship at the National Cancer Institute.

He is the recipient of numerous awards, including the National Medal of Science, 1990; the American Philosophical Society, 1999; the Annual Award for Excellence in Clinical Research, NIH, 1996; the Henry Stratton Medal, American Society of Hematology, 1995; the John Howland Medal of the American Pediatric Society, 2003; the George Kober Medal of the Association of American Physicians, 2006; John Stearns Medal for Life Time Achievement in Medicine, 2009; Harvard University Honorary Doctor of Science, 2010; and the Wallace H. Coulter Award, American Society of Hematology, 2011.

Key Publications

  • Gazda H, Lipton JM, Willig TN, Ball S, Niemeyer CM, Tchernia G, Mohandas N, Daly MJ, Ploszynska A, Orfali KA, Vlachos A, Glader BE, Rokicka-Milewska R, Ohara A, Baker D, Pospisilova D, Webber A, Viskochil DH, Nathan DG, Beggs AH, Sieff CA. Evidence for linkage of familial Diamond-Blackfan anemia to chromosome 8p23.3-p22 and for non-19q non-8p disease. Blood 2001; 97: 2145-2150.

  • Nathan DG. Acceptance of the 2006 Kober medal. J Clin Invest. 2007 Apr;117(4):1107-13.

  • Nathan DG. The several Cs of translational clinical research. J Clin Invest. 2005 Apr;115(4):795-7.

  • Cunningham MJ, Nathan DG. New developments in iron chelators. Curr Opin Hematol. 2005 Mar;12(2):129-34.

  • Gazda HT, Grabowska A, Merida-Long LB, Latawiec E, Schneider HE, Lipton JM, Vlachos A, Atsidaftos E, Ball SE, Orfali KA, Niewiadomska E, Da Costa L, Tchernia G, Niemeyer C, Meerpohl JJ, Stahl J, Schratt G, Glader B, Backer K, Wong C, Nathan DG, Beggs AH, Sieff CA. Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia. AM J Hum Genet. 2006 DEC; 79(6):1110-8. Epub 2006 Nov 2

  • Sankaran VG, Nathan DG. Thalassemia: an overview of 50 years of clinical research. Hematol Oncol Clin North Am 2010 Dec:24(6):1005-1020.

  • Bunn HF, Nathan DG, Dover GJ, et al. Pulmonary hypertension and nitric oxide depletion in sickle cell disease. Blood 2010 Aug:116(5):687-692.
  • Field JJ, Nathan DG, Linden J. Targeting iNKT cells for the treatment of sickle cell  disease Clin Immunol. Clin Immunol 2011, 140(2):177-183.
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