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Edward Y Lee
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Edward Y. Lee, MD, MPH

Department: Radiology
Research Centers: Radiology Research Center
Hospital Title: Chief, Divison of Thoracic Imaging Director, Magnetic Resonance Imaging
Academic Title: Associate Professor of Radiology, Harvard Medical School
Research Area: MDCT and MRI for pediatric pulmonary imaging
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Research Overview

Dr. Edward Lee’s clinical expertise and innovations have been achieved by successfully combining his clinical research and teaching in the field of pediatric thoracic imaging to improve the ability of radiologists to non-invasively diagnose a variety of pediatric thoracic anomalies and abnormalities particularly with multidetector CT (MDCT) and magnetic resonance imaging (MRI). His role as the Chief of Thoracic Imaging Division and Director of MRI in the Departments of Radiology has provided him with the opportunity to develop a unique niche in the field of pediatric thoracic imaging - an area arguably underdeveloped both in terms of technologic innovation and patient therapies.

LungsHis primary research activities have focused on the development and application of advanced CT and MRI imaging methods, aimed at improving diagnostic capabilities, therapeutic options and patient outcomes in pediatric patients with various anomalies and abnormalities of the large airways, lungs and mediastinal vessels. Dr. Edward Lee has extensively researched MDCT in order to evaluate pediatric patients with congenital mediastinal vascular and lung anomalies with Heart2D and 3D imaging. His publications as a first author on this topic were among the first in the medical literature to scientifically evaluate the efficacy of this technique in diagnosing pediatric patients with congenital mediastinal vascular and lung anomalies. Dr. Edward Lee’s work helped to establish 2D and 3D imaging with MDCT as a standard of care for the imaging evaluation of children with various congenital mediastinal vascular and lung anomalies.


He has also developed and introduced a new MDCT technique, which has become the primary non-invasive imaging method to assess dynamic central airway diseases such as tracheobronchomalacia in infants and children  By showing that MDCT has comparable accuracy to bronchoscopy, this work has had an important clinical impact in both radiology and pulmonary medicine by obviating invasive procedures such as bronchoscopy in pediatric patients for assessing tracheobronchomalacia. He has written the techniques and guidelines related to the clinical use of dynamic MDCT for evaluating tracheobronchomalacia in infants and children.

Furthermore, Dr. Edward Lee is acknowledged as the first investigator to evaluate pulmonary embolism in pediatric patients with MDCT. His work on this topic has provided seminal information regarding direct and indirect CT imaging findings, role of 2D imaging for accurate diagnosis, and clinically valuable risk factor assessment for pulmonary embolism in pediatric patients, which helps facilitate prompt diagnosis and optimal patient care.

In addition to Dr. Lee’s work on MDCT, his current work is in testing the technical feasibility and clinical applicability of MRI using hyperpolarized gases (e.g., 3He) and innovative motion-robust-high-resolution MR technique to better visualize the central airways and lungs, which is supported by research grants from the Society for Pediatric Radiology (SPR), Association of University Radiologists and GE Health Care (GERRAF) and the Society of Thoracic Radiology (STR).

About Edward Lee

Dr. Edward Lee is an associate professor of radiology at Harvard Medical School. He received his A.B. and M.D. from the University of Chicago (Phi Beta Kappa and Swift Scholar) and his M.P.H. from Harvard University (Student Marshal), followed by an internship at Harvard Medical Center (BIDM / BWH / DFCI) and radiology residency at Mallincrodt Institute of Radiology / Washington University Medical Center. After completing a pediatric radiology fellowship as a chief fellow at Children’s Hospital Boston and Harvard Medical School in 2006, he joined the Departments of Radiology and Medicine, Division of Pulmonary Medicine as a clinician-researcher whose academic focus is on developing non-invasive imaging methods that will improve the clinical care of pediatric patients diagnosed with thoracic anomalies and abnormalities. Since Dr. Lee was appointed as the Chief of Thoracic Imaging Division in 2010 and Director of MRI in 2012, he has provided integrated image performance and interpretation across modalities for congenital and acquired pediatric thoracic disorders at Boston Children’s Hospital.

Dr. Lee has more than 110 peer-reviewed journal articles, 40 review articles or book chapters, and two books related to pediatric chest imaging.

He was the recipient of RSNA Eyler Editorial Fellowship in 2010. He is the winner of the prestigious Caffey’s Awards from SPR in both Best Clinical Scientific Research and Best Educational Exhibit Presentation categories. Additionally, as an assistant editor of the pediatric section of the American Journal of Roentgenology (AJR) and European Journal of Radiology (EJR); editorial board member of nine journals; and reviewer of 25 journals; Dr. Lee has also helped guide and establish the educational and scientific direction and growth in his academic specialty – pediatric thoracic imaging – at academic and medical institutions around the world.

Dr. Lee is currently one of the most sought-after internationally known pediatric radiology speakers in the field of pediatric thoracic imaging. He has served either as a visiting professor or as an invited speaker on various topics related to related to pediatric thoracic imaging education more than 20 different countries in the Americas, Europe, Middle East, Asia, and Africa.

His lecture topics include:

  1. Multidetector CT Evaluation of Congenital Lung Anomalies in Children

  2. Multidetector CT Evaluation of Central Airway Anomalies and Abnormalities in Pediatric Patients 

  3. Interstitial Lung Disease in Infants: New Classification, Imaging Findings and Pathological Correlation

  4. CT and MRI Evaluation of Mediastinal Vascular Anomalies in Children 

  5. CT Evaluation of Non-vascular Mediastinal Masses in Children: Step by Step Approach to Diagnosis 

  6. Chest Trauma in Children: Current Imaging Guidelines, Techniques, and Imaging Findings 

  7. Chest Sonography in Children: Practical Imaging Approach

  8. Imaging Evaluation of Chest Wall Lesions in Pediatric Patients

  9. Multimodality Imaging Evaluation of Pediatric Congenital Heart Disease 

  10. Interactive Pediatric Chest Cases


Key Publications

  • Lee EY, Zucker EJ, Restrepo R, Daltro P, Boiselle PM. Advanced large airway CT imaging in children: evolution from axial to 4D assessment. Pediatr Radiol. 2013; 43(3): 285 - 297.
  • Lee EY. Interstitial lung disease in infants: new classification system, imaging technique, and clinical presentation and imaging findings. Pediatr Radiol. 2013; 43(1): 3 - 13. 
  • Lee EY, Neuman MI, Lee N, Johnson VM, Tracy DA, Zurakowski D, Boiselle PM. Pulmonary embolism detected by MDCT pulmonary angiography in older children and young adults; risk factor assessment. AJR Am J Roentgenol. 2012; 198(6): 1431-1437.
  • Lee EY, Zurakowski D, Bastos MA, Stark C, Carrier M, Mason KP. Evaluation of image quality and patient safety: paired inspiratory and expiratory MDCT assessment of tracheobronchomalacia in pediatric patients under general anesthesia with breath-hold technique. J Med Imaging Radiat Oncol. 2012; 56(2): 151 – 157.
  • Lee EY, Tse SKS, Zurakowski D, Johnson VM, Lee N, Tracy, DA, Boiselle PM. Multidetector CT pulmonary angiography: thromboembolic risk factors and implications for appropriate use in children. Radiology. 2012; 262(1): 242 – 251.
  • Lee EY, Restrepo R, Dillman JR, Ridge CA, Hammer MR, Boiselle PM. Imaging evaluation of pediatric trachea and bronchi: systemic review and updates. Semin Roentgenol. 2012: 47 (2): 182 – 196.
  • Lee EY, Browne LP, Lam W. Noninvasive magnetic resonance imaging of thoracic large vessels in children. Semin Roentgenol. 2012:47 (1): 45 – 55.
  • Lee EY, Greenberg SB, Boiselle PM. Multidetector CT of the pediatric large airway disease: State of the Art. Radiol Clin North Am. 2011; 49(5): 869 – 893.
  • Lee EY, Dorkin H, Vargas SO. Congenital pulmonary malformations in pediatric patients: review and update on etiology, classification, and imaging findings. Radiol Clin North Am. 2011; 49(5): 921-948.
  • Lee EY, Zucker E, Tsai J, Tracy DA, Cleveland RH, Zurakowski D, Boiselle PM. Pulmonary MDCT angiography: value of multiplanar reformatted images in detecting pulmonary embolism in children. AJR Am J Roentgenol. 2011; 197: 1460 – 1465. 
  • Lee EY, Tracy DA, Mahmood SA, Weldon CB, Zurakowski D, Boiselle PM. Preoperative MDCT evaluation of congenital lung anomalies in children: comparison of axial, multiplanar, and 3D images. AJR Am J Roentgenol. 2011; 196(5): 1040 - 1046.
  • Lee EY, Tracy DA, Eisenberg RL, Arellano CM, Mahmood SA, Cleveland RH, Zurakwoski D, Boiselle PM. Screening of asymptomatic children for tuberculosis: is a lateral chest radiograph routinely indicated? Acad Radiol. 2011; 18(2): 184 - 190.
  • Lee EY, Khatwa U, McAdam AJ, Bastos M. Mahmood SA, Ervoes JP, Boiselle PM. Streptococcus milleri group pleuropulmonary infection in children: computed tomographic findings and clinical features. J Comput Assist Tomogr. 2010; 34(6): 927 - 932.
  • Lee EY, Zurakowski D, Boiselle PM. Pulmonary embolism in pediatric patients: survey of CT pulmonary angiography practices and policies. Acad Radiol. 2010; 17(12) 1543 - 1549.
  • Lee EY, Kritsaneepaiboon S, Arellano CM, Grace RF, Zurakowski D, Boiselle PM. Unsuspected pulmonary emboli in pediatric oncology patients: detection with MDCT. AJR Am J Roentgenol. 2010; 194(5): 1216 - 1222.
  • Lee EY, Tracy DA, Bastos M, Casey AM, Zurakowski D, Boiselle PM. Expiratory volumetric MDCT evaluation of air trapping in pediatric patients with and without tracheomalacia. AJR Am J Roentgenol. 2010; 194(5): 1210 - 1215.
  • Lee EY, Boiselle PM, Shamberger RC. Multidetector computed tomography and 3-dimensional imaging: preoperative evaluation of thoracic vascular and tracheobronchial anomalies and abnormalities in pediatric patients. J Pediatr Surg. 2010; 45(4): 811 - 821.
  • Lee EY, Strauss KJ, Tracy DA, Bastos M, Zurakowski D, Boiselle PM. Comparison of standard-dose and reduced-dose expiratory MDCT techniques for assessment of tracheomalacia in children. Acad Radiol. 2010; 17(4): 504 - 510.
  • Lee EY, McAdam AJ, Chaudry G, Fishman MP, Zurakowski D, Boiselle PM. Swine-origin influenza A (H1N1) viral infection in children: initial chest radiographic findings. Radiology. 2010; 254(3): 934 - 941.
  • Lee EY, Zurakowski D, Diperna S, d'Almeida Bastos M, Strauss KJ, Boiselle PM. Parenchymal and pleural abnormalities in children with and without pulmonary embolism at MDCT pulmonary angiography. Pediatr Radiol. 2010; 40(2): 173 - 181.
  • Lee EY, Kritsaneepaiboon S, Zurakowski D, Arellano CM, Strauss KJ, Boiselle PM. Beyond the pulmonary arteries: alternative diagnoses in children with MDCT pulmonary angiography negative for pulmonary embolism. AJR Am J Roentgenol. 2009; 193(3): 888 - 894.
  • Lee EY, Boiselle PM. Tracheobronchomalacia in Infants and Children: Multidetector CT Evaluation. Radiology 2009; 252(1): 7 - 22.
  • Lee EY, Sun Y, Zurakowski D, Hatabu H, Khatwa U, Albert MS. Hyperpolarized 3He MR Imaging of the Lung: Normal Range of Ventilation Defects and PFT Correlation in Young Adults. J Thorac Imaging 2009; 24(2): 110 - 114.
  • Lee EY, Litmanovich D, Boiselle PM. Multidetector CT Evaluation of Tracheobronchomalacia. Radiol Clin North Am 2009; 47(2): 261-269.
  • Lee EY, Zurakowski D, Waltz DA, Mason KP, Riaz F, Ralph A, Boiselle PM. MDCT evaluation of the prevalence of tracheomalacia in children with mediastinal aortic vascular anomalies. J Thorac Imaging 2008; 23(4):258-265.
  • Lee EY, Boiselle PM, Cleveland RH. MDCT Evaluation of Congenital Lung Anomalies. Radiology 2008; 247(3): 632-648.
  • Lee EY, Siegel MJ, Hildebolt CF, Gutierrez FR, Fallah JH, Bhalla S. Evaluation of thoracic aortic anomalies in pediatric patients and young adults: Comparison of axial, multiplanar, and 3D images. AJR Am J Roentgenol. 2004; 183: 777-784.
  • Lee EY, Siegel MJ, Chu CM, Gutierrez FR, Kort HW. Amplatzer Atrial Septal Defect Occluder for Pediatric Patients: Radiologic Appearance. Radiology 2004; 233(2): 471 - 476.
  • Lee EY, Siegel MJ, Sierra LM, Foglia RP. Evaluation of Angioarchitecture of Pulmonary Sequestration in Pediatric Patients Using 3D MDCT Angiography. AJR Am J Roentgenol. 2004; 183(1): 183 - 188.

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