The goals of Dr. Fishman's research include:
To effect permanent luminal obliteration of vascular malformations
using tissue engineering and angiogenesis inhibition to enhance existing
To clarify the subtypes of pediatric liver hemangiomas, predict their natural history, and optimize their management.
To develop mechanisms to enlarge short segments of esophagus and intestine.
The translational implications of Dr. Fishman's work:
Vascular malformations can often be controlled or nearly obliterated
with intravascular sclerotherapy or embolization of the luminal spaces.
However, recanalization and clinical recurrence are commonplace. We hope
to make luminal obliteration permanent, eliminating the need for
repeated procedures and deforming surgical procedures.
Liver hemangiomas, previously believed to be homogeneous, occur in
several types and patterns.
Clarifying their phenotypes and behaviors
will facilitate improved survival and avoid needless morbidity.
Infants born with esophageal atresia have a disrupted, often very
short esophagus. When the two ends cannot be brought together, the
esophagus is often surgically replaced with other, less adequate organs.
Facilitating growth of the shortened esophagus may allow the native
esophageal tissues to be connected, eliminating the need for replacement
with colon or stomach.
About Steven Fishman
Dr. Fishman completed his residency in general surgery at the Hospital
of the University of Pennsylvania. He was a Pediatric Surgical Fellow at
Children's Hospital Boston.