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Jing Chen, PhD

Department: Ophthalmology
Hospital Title: Research Associate
Academic Title: Assistant Professor of Ophthalmology
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Dr. Jing Chen received her PhD from Boston University and completed her postdoctoral fellowship training in Ophthalmology at Boston Children’s Hospital (BCH) / Harvard Medical School. Since then Dr. Chen was recruited as a faculty member in Ophthalmology Department at BCH and Harvard Medical School, and is also an associate at the BCH Manton Center for Orphan Disease Research.

Dr. Chen’s primary interests are retinal vascular biology and pathologic vascular eye diseases, including retinopathy of prematurity, age-related macular degeneration, diabetic retinopathy, and rare orphan eye diseases: familiar exudative vitreoretinopathy (FEVR) and Norrie disease. Her lab studies animal models of these diseases to investigate disease pathogenesis and develop potential therapeutics. She has published numerous papers and lectured nationally and internationally on vascular eye disorders and angiogenesis research. Her current research projects include: 1) Wnt signaling in controlling vascular growth and permeability in retinopathy; 2) lipid sensing nuclear receptor mediated ocular neovascularization and inflammation; 3) microRNA regulation of pathologic vascular growth in eye diseases.

Selected Publications:

Chen J, Michan S, Juan AM, Hurst CG, Hatton CJ, Pei DT, Joyal J, Evans LP, Cui Z, Stahl A, Sapieha P, Sinclair DA, Smith LE. Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis. 2013 Oct;16(4):985-92. PMID: 23912262. (cover article)

Chen J, Stahl A, Krah NM, Seaward MR, Joyal J-S, Juan AM, Hatton CJ, Aderman CM, Dennison RJ, Willett KL, Sapieha P, Smith LE. Retinal Expression of Wnt-Pathway Mediated Genes in Low-Density Lipoprotein Receptor-Related Protein 5 (Lrp5) Knockout Mice. PLoS One. 2012;7(1):e30203. Epub 2012 Jan 17. PMID: 22272305.

Chen J, Stahl A, Krah NM, Seaward MR, Dennison RJ, Sapieha P, Hua J, Hatton CJ, Juan AM, Aderman CM, Willett KL, Guerin KI, Mammoto A, Campbell M, Smith LE. Wnt signaling mediates pathologic vascular growth in proliferative retinopathy. Circulation. 2011 Oct 25;124(17):1871-81. PMID: 21969016.

Chen J, Connor KM, Aderman CM, Willett KL, Aspegren OP, Smith LE. Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy. Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1329-35. PMID: 18952918. (cover article)

Chen J, Connor KM, Aderman CM, Smith LE. Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest. 2008 Feb 1;118(2):526-533.  PMID: 18219289. (cover article).

 
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