Terry Buchmiller's investigations utilize fetal models for in utero
studies of congenital abnormalities. Areas of interest include the
surgical implantation of amniotic fluid catheters for supplementation
studies in two different arenas.
The first involves a fetal rabbit model of in uterine growth
retardation (IUGR). Experimental amniotic fluid supplementation with
hormones including EGF and gastrin has successfully reversed IUGR by
increasing small intestinal nutrient absorption.
Current studies are
underway to elucidate the molecular events controlling these mechanisms.
The second involves a large animal model in which we have created
mid-gestational obstructive uropathy by both urachal and bladder outlet
ligation in fetal sheep, resulting in Potter’s syndrome with subsequent
oligohydramnios and pulmonary hypoplasia. Implanted amniotic fluid
catheters are used to reconstitute the amniotic fluid during the
remainder of gestation. We have reversed the detrimental effects on
pulmonary growth by this intra-amniotic supplementation. Additionally we
have examined the working collaborative with Dr. Dario Fauza in
examining the effect on renal function and potential predictive urinary
markers of renal dysfunction.
Major research goals:
Understand the mechanisms underlying fetal small bowel nutrient transport and motility.
Define the role of epidermal growth factor in fetal gut development.
Design in utero treatments for intrauterine growth retardation utilizing amniotic fluid supplementation.
Validate a fetal model of obstructive uropathy with resultant
pulmonary hypoplasia which is reversible with amniotic fluid
About Terry Buchmiller
- MD, University of California, Davis
- Intern in Surgery, UCLA Medical Center, Los Angeles, CA
- Resident in Surgery, UCLA Medical Center, Los Angeles, CA
- Research Fellow, Division of Pediatric Surgery, UCLA Medical Center, Los Angeles, CA
- Associate Chief Resident in Pediatric Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA
- Chief Resident in Pediatric Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA