John Zupancic, MD, ScD

John Zupancic, MD, MS, ScD

Assistant in Medicine

Associate Professor of Pediatrics, Harvard Medical School

    Contact: 617-667-3276
  • Fax: 617-667-7040

Medical Services


  • Newborn Medicine


  • Medicine
  • Newborn Medicine


  • English
To schedule an appointment: Call 617-667-3276

Experience and Education


Medical School

McMaster University, 1991

Ontario, CAN

Internship, Pediatrics

McMaster University, 1991

Ontario, CAN

Residency, Pediatrics

McMaster University, 1992-1995

Ontario, CAN

Fellowship, Neonatal-Perinatal Medicine

Harvard Neonatal-Perinatal Medicine Training Program, 1995

Boston, MA

Graduate School, ScD, Health Policy

Harvard School of Public Health, 2001

Boston, MA



Publications powered by Harvard Catalyst Profiles
  1. Hay SC, Kirpalani H, Viner C, Soll R, Dukhovny D, Mao WY, Profit J, DeMauro SB, Zupancic JAF. Do trials reduce uncertainty? Assessing impact through cumulative meta-analysis of neonatal RCTs. J Perinatol. 2017 Nov; 37(11):1215-1219.
  2. Ho T, Zupancic JAF, Pursley DM, Dukhovny D. Improving Value in Neonatal Intensive Care. Clin Perinatol. 2017 Sep; 44(3):617-625.
  3. Kunz SN, Zupancic JAF, Rigdon J, Phibbs CS, Lee HC, Gould JB, Leskovec J, Profit J. Network analysis: a novel method for mapping neonatal acute transport patterns in California. J Perinatol. 2017 Jun; 37(6):702-708.
  4. Dukhovny D, Zupancic JAF. Longer and deeper cooling for hypoxic ischemic encephalopathy in neonates does not reduce mortality. Acta Paediatr. 2017 Jul; 106(7):1200.
  5. Hay S, Zupancic JA, Flannery DD, Kirpalani H, Dukhovny D. Should we believe in transfusion-associated enterocolitis? Applying a GRADE to the literature. Semin Perinatol. 2017 Feb; 41(1):80-91.
  6. Caughey AB, Zupancic JA, Greenberg JM, Garfield SS, Thung SF, Iams JD. Clinical and Cost Impact Analysis of a Novel Prognostic Test for Early Detection of Preterm Birth. AJP Rep. 2016 Oct; 6(4):e407-e416.
  7. Mowitz ME, Zupancic JA, Millar D, Kirpalani H, Gaulton JS, Roberts RS, Mao W, Dukhovny D. Prospective economic evaluation alongside the non-invasive ventilation trial. J Perinatol. 2017 Jan; 37(1):61-66.
  8. Dukhovny D, Pursley DM, Kirpalani HM, Horbar JH, Zupancic JA. Evidence, Quality, and Waste: Solving the Value Equation in Neonatology. Pediatrics. 2016 Mar; 137(3):e20150312.
  9. Kirpalani H, Zupancic J. "Waste not, want not", or the cost of doing the wrong thing. J Pediatr (Rio J). 2016 Jan-Feb; 92(1):1-3.
  10. Ho T, Dukhovny D, Zupancic JA, Goldmann DA, Horbar JD, Pursley DM. Choosing Wisely in Newborn Medicine: Five Opportunities to Increase Value. Pediatrics. 2015 Aug; 136(2):e482-9.
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  12. Zupancic JA, Dukhovny D. Resource distribution in neonatology: beyond the Pareto principle. Arch Dis Child Fetal Neonatal Ed. 2015 Nov; 100(6):F472-3.
  13. Kaempf JW, Zupancic JA, Wang L, Grunkemeier GL. A risk-adjusted, composite outcomes score and resource utilization metrics for very low-birth-weight infants. JAMA Pediatr. 2015 May; 169(5):459-65.
  14. Mosquera RA, Avritscher EB, Samuels CL, Harris TS, Pedroza C, Evans P, Navarro F, Wootton SH, Pacheco S, Clifton G, Moody S, Franzini L, Zupancic J, Tyson JE. Effect of an enhanced medical home on serious illness and cost of care among high-risk children with chronic illness: a randomized clinical trial. JAMA. 2014 Dec 24-31; 312(24):2640-8.
  15. Profit J, Kowalkowski MA, Zupancic JA, Pietz K, Richardson P, Draper D, Hysong SJ, Thomas EJ, Petersen LA, Gould JB. Baby-MONITOR: a composite indicator of NICU quality. Pediatrics. 2014 Jul; 134(1):74-82.
  16. Unger S, Gibbins S, Zupancic J, O'Connor DL. DoMINO: Donor milk for improved neurodevelopmental outcomes. BMC Pediatr. 2014 May 13; 14:123.
  17. Escobar GJ, Puopolo KM, Wi S, Turk BJ, Kuzniewicz MW, Walsh EM, Newman TB, Zupancic J, Lieberman E, Draper D. Stratification of risk of early-onset sepsis in newborns = 34 weeks' gestation. Pediatrics. 2014 Jan; 133(1):30-6.
  18. Gupta M, Ringer S, Tess A, Hansen A, Zupancic J. Developing a quality and safety curriculum for fellows: lessons learned from a neonatology fellowship program. Acad Pediatr. 2014 Jan-Feb; 14(1):47-53.
  19. Sherenian M, Profit J, Schmidt B, Suh S, Xiao R, Zupancic JA, DeMauro SB. Nurse-to-patient ratios and neonatal outcomes: a brief systematic review. Neonatology. 2013; 104(3):179-83.
  20. Dukhovny D, Dennis CL, Hodnett E, Weston J, Stewart DE, Mao W, Zupancic JA. Prospective economic evaluation of a peer support intervention for prevention of postpartum depression among high-risk women in Ontario, Canada. Am J Perinatol. 2013 Sep; 30(8):631-42.
  21. Profit J, Zupancic JA, Gould JB, Pietz K, Kowalkowski MA, Draper D, Hysong SJ, Petersen LA. Correlation of neonatal intensive care unit performance across multiple measures of quality of care. JAMA Pediatr. 2013 Jan; 167(1):47-54.
  22. Kirpalani H, Zupancic JA. Do transfusions cause necrotizing enterocolitis? The complementary role of randomized trials and observational studies. Semin Perinatol. 2012 Aug; 36(4):269-76.
  23. Profit J, Gould JB, Draper D, Zupancic JA, Kowalkowski MA, Woodard L, Pietz K, Petersen LA. Variations in definitions of mortality have little influence on neonatal intensive care unit performance ratings. J Pediatr. 2013 Jan; 162(1):50-5.e2.
  24. Dennis CL, Ravitz P, Grigoriadis S, Jovellanos M, Hodnett E, Ross L, Zupancic J. The effect of telephone-based interpersonal psychotherapy for the treatment of postpartum depression: study protocol for a randomized controlled trial. Trials. 2012 Apr 19; 13:38.
  25. Guillén U, DeMauro S, Ma L, Zupancic J, Roberts R, Schmidt B, Kirpalani H. Relationship between attrition and neurodevelopmental impairment rates in extremely preterm infants at 18 to 24 months: a systematic review. Arch Pediatr Adolesc Med. 2012 Feb; 166(2):178-84.
  26. Smith VC, Dukhovny D, Zupancic JA, Gates HB, Pursley DM. Neonatal intensive care unit discharge preparedness: primary care implications. Clin Pediatr (Phila). 2012 May; 51(5):454-61.
  27. Dukhovny D, Dukhovny S, Pursley DM, Escobar GJ, McCormick MC, Mao WY, Zupancic JA. The impact of maternal characteristics on the moderately premature infant: an antenatal maternal transport clinical prediction rule. J Perinatol. 2012 Jul; 32(7):532-8.
  28. Guillén Ú, Suh S, Munson D, Posencheg M, Truitt E, Zupancic JA, Gafni A, Kirpalani H. Development and pretesting of a decision-aid to use when counseling parents facing imminent extreme premature delivery. J Pediatr. 2012 Mar; 160(3):382-7.
  29. Puopolo KM, Draper D, Wi S, Newman TB, Zupancic J, Lieberman E, Smith M, Escobar GJ. Estimating the probability of neonatal early-onset infection on the basis of maternal risk factors. Pediatrics. 2011 Nov; 128(5):e1155-63.
  30. Kamholz KL, Dukhovny D, Kirpalani H, Whyte RK, Roberts RS, Wang N, Mao W, Zupancic JA. Economic evaluation alongside the Premature Infants in Need of Transfusion randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2012 Mar; 97(2):F93-8.
  31. Guillen U, DeMauro S, Ma L, Zupancic J, Wang E, Gafni A, Kirpalani H. Survival rates in extremely low birthweight infants depend on the denominator: avoiding potential for bias by specifying denominators. Am J Obstet Gynecol. 2011 Oct; 205(4):329.e1-7.
  32. Profit J, Gould JB, Zupancic JA, Stark AR, Wall KM, Kowalkowski MA, Mei M, Pietz K, Thomas EJ, Petersen LA. Formal selection of measures for a composite index of NICU quality of care: Baby-MONITOR. J Perinatol. 2011 Nov; 31(11):702-10.
  33. Belfort MB, Zupancic JA, Riera KM, Turner JH, Prosser LA. Health state preferences associated with weight status in children and adolescents. BMC Pediatr. 2011 Feb 07; 11:12.
  34. McCormick MC, Litt JS, Smith VC, Zupancic JA. Prematurity: an overview and public health implications. Annu Rev Public Health. 2011; 32:367-79.
  35. Eichenwald EC, Zupancic JA, Mao WY, Richardson DK, McCormick MC, Escobar GJ. Variation in diagnosis of apnea in moderately preterm infants predicts length of stay. Pediatrics. 2011 Jan; 127(1):e53-8.
  36. Dukhovny D, Lorch SA, Schmidt B, Doyle LW, Kok JH, Roberts RS, Kamholz KL, Wang N, Mao W, Zupancic JA. Economic evaluation of caffeine for apnea of prematurity. Pediatrics. 2011 Jan; 127(1):e146-55.
  37. Profit J, Lee D, Zupancic JA, Papile L, Gutierrez C, Goldie SJ, Gonzalez-Pier E, Salomon JA. Clinical benefits, costs, and cost-effectiveness of neonatal intensive care in Mexico. PLoS Med. 2010 Dec 14; 7(12):e1000379.
  38. Profit J, Petersen LA, McCormick MC, Escobar GJ, Coleman-Phox K, Zheng Z, Pietz K, Zupancic JA. Patient-to-nurse ratios and outcomes of moderately preterm infants. Pediatrics. 2010 Feb; 125(2):320-6.
  39. Dammann O, Shah B, Naples M, Bednarek F, Zupancic J, Allred EN, Leviton A. Interinstitutional variation in prediction of death by SNAP-II and SNAPPE-II among extremely preterm infants. Pediatrics. 2009 Nov; 124(5):e1001-6.
  40. Zupancic JA, Hibbs AM, Palermo L, Truog WE, Cnaan A, Black DM, Ballard PL, Wadlinger SR, Ballard RA. Economic evaluation of inhaled nitric oxide in preterm infants undergoing mechanical ventilation. Pediatrics. 2009 Nov; 124(5):1325-32.
  41. Smith VC, Young S, Pursley DM, McCormick MC, Zupancic JA. Are families prepared for discharge from the NICU? J Perinatol. 2009 Sep; 29(9):623-9.
  42. McBride JA, Parad RB, Davis JM, Zheng Z, Zupancic JA. Economic evaluation of recombinant human copper zinc superoxide dismutase administered at birth to premature infants. J Perinatol. 2009 May; 29(5):364-71.
  43. Aslam M, Burris HH, Zupancic JA. Are we satisfied with the way we review an article? Adv Neonatal Care. 2009 Feb; 9(1):40-2.
  44. Dennis CL, Hodnett E, Kenton L, Weston J, Zupancic J, Stewart DE, Kiss A. Effect of peer support on prevention of postnatal depression among high risk women: multisite randomised controlled trial. BMJ. 2009 Jan 15; 338:a3064.
  45. Kamholz KL, Cole CH, Gray JE, Zupancic JA. Cost-effectiveness of early treatment for retinopathy of prematurity. Pediatrics. 2009 Jan; 123(1):262-9.
  46. Zupancic JA. The economics of elective cesarean section. Clin Perinatol. 2008 Sep; 35(3):591-9, xii.
  47. Williams C, Munson D, Zupancic J, Kirpalani H. Supporting bereaved parents: practical steps in providing compassionate perinatal and neonatal end-of-life care. A North American perspective. Semin Fetal Neonatal Med. 2008 Oct; 13(5):335-40.
  48. Gray J, Geva A, Zheng Z, Zupancic JA. CoolSim: using industrial modeling techniques to examine the impact of selective head cooling in a model of perinatal regionalization. Pediatrics. 2008 Jan; 121(1):28-36.
  49. Profit J, Zupancic JA, Gould JB, Petersen LA. Implementing pay-for-performance in the neonatal intensive care unit. Pediatrics. 2007 May; 119(5):975-82.
  50. Profit J, McCormick MC, Escobar GJ, Richardson DK, Zheng Z, Coleman-Phox K, Roberts R, Zupancic JA. Neonatal intensive care unit census influences discharge of moderately preterm infants. Pediatrics. 2007 Feb; 119(2):314-9.
  51. Vanpée M, Walfridsson-Schultz U, Katz-Salamon M, Zupancic JA, Pursley D, Jónsson B. Resuscitation and ventilation strategies for extremely preterm infants: a comparison study between two neonatal centers in Boston and Stockholm. Acta Paediatr. 2007 Jan; 96(1):10-6; discussion 8-9.
  52. Zupancic JA, Richardson DK, Horbar JD, Carpenter JH, Lee SK, Escobar GJ. Revalidation of the Score for Neonatal Acute Physiology in the Vermont Oxford Network. Pediatrics. 2007 Jan; 119(1):e156-63.
  53. Janssen PA, Still DK, Klein MC, Singer J, Carty EA, Liston RM, Zupancic JA. Early labor assessment and support at home versus telephone triage: a randomized controlled trial. Obstet Gynecol. 2006 Dec; 108(6):1463-9.
  54. Escobar GJ, McCormick MC, Zupancic JA, Coleman-Phox K, Armstrong MA, Greene JD, Eichenwald EC, Richardson DK. Unstudied infants: outcomes of moderately premature infants in the neonatal intensive care unit. Arch Dis Child Fetal Neonatal Ed. 2006 Jul; 91(4):F238-44.
  55. Zupancic JA, Richardson DK, O'Brien BJ, Cronin CG, Schmidt B, Roberts R, Weinstein MC. Retrospective economic evaluation of a controlled trial of indomethacin prophylaxis for patent ductus arteriosus in premature infants. Early Hum Dev. 2006 Feb; 82(2):97-103.
  56. Profit J, Zupancic JA, McCormick MC, Richardson DK, Escobar GJ, Tucker J, Tarnow-Mordi W, Parry G. Moderately premature infants at Kaiser Permanente Medical Care Program in California are discharged home earlier than their peers in Massachusetts and the United Kingdom. Arch Dis Child Fetal Neonatal Ed. 2006 Jul; 91(4):F245-50.
  57. Bastek TK, Richardson DK, Zupancic JA, Burns JP. Prenatal consultation practices at the border of viability: a regional survey. Pediatrics. 2005 Aug; 116(2):407-13.
  58. Smith VC, Zupancic JA, McCormick MC, Croen LA, Greene J, Escobar GJ, Richardson DK. Trends in severe bronchopulmonary dysplasia rates between 1994 and 2002. J Pediatr. 2005 Apr; 146(4):469-73.
  59. Escobar GJ, Shaheen SM, Breed EM, Botas C, Greene JD, Yoshida CK, Zupancic J, Newman TB. Richardson score predicts short-term adverse respiratory outcomes in newborns &gt/=34 weeks gestation. J Pediatr. 2004 Dec; 145(6):754-60.
  60. Smith VC, Zupancic JA, McCormick MC, Croen LA, Greene J, Escobar GJ, Richardson DK. Rehospitalization in the first year of life among infants with bronchopulmonary dysplasia. J Pediatr. 2004 Jun; 144(6):799-803.
  61. Dhillon AS, Albersheim SG, Alsaad S, Pargass NS, Zupancic JA. Internet use and perceptions of information reliability by parents in a neonatal intensive care unit. J Perinatol. 2003 Jul-Aug; 23(5):420-4.
  62. Zupancic JA, Richardson DK, O'Brien BJ, Eichenwald EC, Weinstein MC. Cost-effectiveness analysis of predischarge monitoring for apnea of prematurity. Pediatrics. 2003 Jan; 111(1):146-52.
  63. Zupancic JA, Richardson DK, O'Brien BJ, Schmidt B, Weinstein MC. Daily cost prediction model in neonatal intensive care. Int J Technol Assess Health Care. 2003; 19(2):330-8.
  64. Zupancic JA, Richardson DK. Characterization of neonatal personnel time inputs and prediction from clinical variables--a time and motion study. J Perinatol. 2002 Dec; 22(8):658-63.
  65. Zupancic JA, Kirpalani H, Barrett J, Stewart S, Gafni A, Streiner D, Beecroft ML, Smith P. Characterising doctor-parent communication in counselling for impending preterm delivery. Arch Dis Child Fetal Neonatal Ed. 2002 Sep; 87(2):F113-7.
  66. Lee SK, Zupancic JA, Sale J, Pendray M, Whyte R, Brabyn D, Walker R, Whyte H. Cost-effectiveness and choice of infant transport systems. Med Care. 2002 Aug; 40(8):705-16.
  67. Lee SK, Zupancic JA, Pendray M, Thiessen P, Schmidt B, Whyte R, Shorten D, Stewart S. Transport risk index of physiologic stability: a practical system for assessing infant transport care. J Pediatr. 2001 Aug; 139(2):220-6.
  68. Richardson DK, Zupancic JA, Escobar GJ, Ogino M, Pursley DM, Mugford M. A critical review of cost reduction in neonatal intensive care. II. Strategies for reduction. J Perinatol. 2001 Mar; 21(2):121-7.
  69. Richardson DK, Zupancic JA, Escobar GJ, Ogino M, Pursley DM, Mugford M. A critical review of cost reduction in neonatal intensive care. I. The structure of costs. J Perinatol. 2001 Mar; 21(2):107-15.
  70. Zupancic JA, Richardson DK, Lee K, McCormick MC. Economics of prematurity in the era of managed care. Clin Perinatol. 2000 Jun; 27(2):483-97.
  71. Zupancic JA, Triedman JK, Alexander M, Walsh EP, Richardson DK, Berul CI. Cost-effectiveness and implications of newborn screening for prolongation of QT interval for the prevention of sudden infant death syndrome. J Pediatr. 2000 Apr; 136(4):481-9.
  72. Zupancic JA, Richardson DK. Characterization of the triage process in neonatal intensive care. Pediatrics. 1998 Dec; 102(6):1432-6.
  73. Zupancic JA, Gillie P, Streiner DL, Watts JL, Schmidt B. Informed consent for randomised controlled trials in neonates. Arch Dis Child Fetal Neonatal Ed. 1998 Mar; 78(2):F156-7.
  74. Zupancic JA, Gillie P, Streiner DL, Watts JL, Schmidt B. Determinants of parental authorization for involvement of newborn infants in clinical trials. Pediatrics. 1997 Jan; 99(1):E6.
  75. Zupancic JA, Pennie RA, Issenman R. Intussusception in a child with cytomegalovirus infection. Pediatr Infect Dis J. 1994 Jun; 13(6):548-9.
  76. Sherkin-Langer F, Langer JC, Zupancic J, Winthrop AL, Issenman RM. Home esophageal self-dilatation in children. Gastroenterol Nurs. 1993 Aug; 16(1):5-8.
  77. Zupancic JA. Dangerous economics: resource allocation in the NICU. CMAJ. 1992 Mar 15; 146(6):1073-6.
To schedule an appointment: Call 617-667-3276


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