Edward Yang MD

Edward Yang, MD, PhD

Attending Radiologist; Director of Neuro MR

Instructor in Radiology, Harvard Medical School

Medical Services

Specialties

  • Neuroradiology

Departments

  • Radiology

Languages

  • English

Programs

  • Computed Tomography (CT)
  • Magnetic Resonance Imaging (MRI)
  • Neuroradiology
  • Epilepsy Center
  • Brain Development and Genetics Clinic
To schedule an appointment: Call 617-919-7365
Edward Yang MD

 

I enjoy visual puzzles, thinking about the brain, and helping patients. So pediatric neuroradiology is the perfect field for me because I get to immerse myself in all three activities on a daily basis. It is a particular privilege to work here at Boston Children’s Hospital since we have the technology, resources, and collective clinical expertise to ensure that our patients obtain the highest quality care possible. Our hospital is also fortunate to see rare conditions in sufficient frequency that we can contribute to improved diagnosis, therapy, and overall understanding of a wide array of childhood diseases affecting the brain, spine, and head/neck.

Experience and Education

Education

Undergraduate

Stanford University, 1996

Stanford, CA

Graduate School, PhD Molecular Cell Biology

Rockefeller University, 2003

New York, NY

Medical School

Weill Cornell Medical College of Cornell University, 2004

New York, NY

Internship, Internal Medicine

Brigham & Women's Hospital, 2004-2005

Boston, MA

Residency, Diagnostic Radiology

Hospital of the University of Pennsylvania, 2005-2009

Philadelphia, PA

Fellowship, Neuroradiology

Hospital of the University of Pennsylvania, 2009-2010

Philadelphia, PA

Fellowship, Pediatric Neuroradiology

The Children's Hospital of Philadelphia, 2010-2011

Philadelphia, PA

Certifications

  • American Board of Radiology, Neuroradiology

Professional History

Dr. Yang obtained a B.S. in Chemistry from Stanford University in 1996. He subsequently enrolled in the Medical Scientist Training Program at the Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program in New York, obtaining a Ph.D. in Molecular Cell Biology from Rockefeller University in 2003 and a M.D. from Cornell University in 2004. After completing a medical internship at Brigham & Women’s Hospital in 2005, he completed a residency in Diagnostic Radiology (2009) and a fellowship in Neuroradiology (2010) at the Hospital of the University of Pennsylvania. Following an additional fellowship in Pediatric Neuroradiology at The Children’s Hospital of Philadelphia, he served as Assistant Professor and Director of Pediatric Neuroradiology, University of Chicago Pritzker School of Medicine, Chicago, IL. He has been an Attending Neuroradiologist at Boston Children’s Hospital since 2013. He has a special interest in genetic conditions affecting the central nervous system and congenital brain malformations.

Publications

Publications powered by Harvard Catalyst Profiles
  1. Yang E, Storey A, Olson HE, Soul J, Estroff JA, Trenor CC, Cooper BK, Smith ER, Orbach DB. Imaging features and prognostic factors in fetal and postnatal torcular dural sinus malformations, part I: review of experience at Boston Children's Hospital. J Neurointerv Surg. 2017 Sep 30.
  2. Yang E, Storey A, Olson HE, Soul J, Estroff JA, Trenor CC, Cooper BK, Smith ER, Orbach DB. Imaging features and prognostic factors in fetal and postnatal torcular dural sinus malformations, part II: synthesis of the literature and patient management. J Neurointerv Surg. 2017 Sep 30.
  3. Ramkissoon SH, Bandopadhayay P, Hwang J, Ramkissoon LA, Greenwald NF, Schumacher SE, O'Rourke R, Pinches N, Ho P, Malkin H, Sinai C, Filbin M, Plant A, Bi WL, Chang MS, Yang E, Wright KD, Manley PE, Ducar M, Alexandrescu S, Lidov H, Delalle I, Goumnerova LC, Church AJ, Janeway KA, Harris MH, MacConaill LE, Folkerth RD, Lindeman NI, Stiles CD, Kieran MW, Ligon AH, Santagata S, Dubuc AM, Chi SN, Beroukhim R, Ligon KL. Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. Neuro Oncol. 2017 Jul 01; 19(7):986-996.
  4. Yang E, Chu WCW, Lee EY. A Practical Approach to Supratentorial Brain Malformations: What Radiologists Should Know. Radiol Clin North Am. 2017 Jul; 55(4):609-627.
  5. Al-Ghamdi F, Anselm I, Yang E, Ghosh PS. Brain involvement in Charcot-Marie-Tooth disease due to ganglioside-induced differentiation associated-protein 1 mutation. Neuromuscul Disord. 2017 Sep; 27(9):848-851.
  6. Im K, Guimaraes A, Kim Y, Cottrill E, Gagoski B, Rollins C, Ortinau C, Yang E, Grant PE. Quantitative Folding Pattern Analysis of Early Primary Sulci in Human Fetuses with Brain Abnormalities. AJNR Am J Neuroradiol. 2017 Jul; 38(7):1449-1455.
  7. Walsh BH, Neil J, Morey J, Yang E, Silvera MV, Inder TE, Ortinau C. The Frequency and Severity of Magnetic Resonance Imaging Abnormalities in Infants with Mild Neonatal Encephalopathy. J Pediatr. 2017 Aug; 187:26-33.e1.
  8. Marami B, Mohseni Salehi SS, Afacan O, Scherrer B, Rollins CK, Yang E, Estroff JA, Warfield SK, Gholipour A. Temporal slice registration and robust diffusion-tensor reconstruction for improved fetal brain structural connectivity analysis. Neuroimage. 2017 Aug 01; 156:475-488.
  9. Gholipour A, Rollins CK, Velasco-Annis C, Ouaalam A, Akhondi-Asl A, Afacan O, Ortinau CM, Clancy S, Limperopoulos C, Yang E, Estroff JA, Warfield SK. A normative spatiotemporal MRI atlas of the fetal brain for automatic segmentation and analysis of early brain growth. Sci Rep. 2017 Mar 28; 7(1):476.
  10. Olson HE, Kelly M, LaCoursiere CM, Pinsky R, Tambunan D, Shain C, Ramgopal S, Takeoka M, Libenson MH, Julich K, Loddenkemper T, Marsh ED, Segal D, Koh S, Salman MS, Paciorkowski AR, Yang E, Bergin AM, Sheidley BR, Poduri A. Genetics and genotype-phenotype correlations in early onset epileptic encephalopathy with burst suppression. Ann Neurol. 2017 Mar; 81(3):419-429.
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  12. Peyton C, Yang E, Msall ME, Adde L, Støen R, Fjørtoft T, Bos AF, Einspieler C, Zhou Y, Schreiber MD, Marks JD, Drobyshevsky A. White Matter Injury and General Movements in High-Risk Preterm Infants. AJNR Am J Neuroradiol. 2017 Jan; 38(1):162-169.
  13. Rodan LH, El Achkar CM, Berry GT, Poduri A, Prabhu SP, Yang E, Anselm I. De Novo TUBB2A Variant Presenting With Anterior Temporal Pachygyria. J Child Neurol. 2017 Jan; 32(1):127-131.
  14. Peyton C, Yang E, Kocherginsky M, Adde L, Fjørtoft T, Støen R, Bos AF, Einspieler C, Schreiber MD, Msall ME. Relationship between white matter pathology and performance on the General Movement Assessment and the Test of Infant Motor Performance in very preterm infants. Early Hum Dev. 2016 Apr; 95:23-7.
  15. Chang PT, Yang E, Swenson DW, Lee EY. Pediatric Emergency Magnetic Resonance Imaging: Current Indications, Techniques, and Clinical Applications. Magn Reson Imaging Clin N Am. 2016 May; 24(2):449-80.
  16. O'Rawe JA, Wu Y, Dörfel MJ, Rope AF, Au PY, Parboosingh JS, Moon S, Kousi M, Kosma K, Smith CS, Tzetis M, Schuette JL, Hufnagel RB, Prada CE, Martinez F, Orellana C, Crain J, Caro-Llopis A, Oltra S, Monfort S, Jiménez-Barrón LT, Swensen J, Ellingwood S, Smith R, Fang H, Ospina S, Stegmann S, Den Hollander N, Mittelman D, Highnam G, Robison R, Yang E, Faivre L, Roubertie A, Rivière JB, Monaghan KG, Wang K, Davis EE, Katsanis N, Kalscheuer VM, Wang EH, Metcalfe K, Kleefstra T, Innes AM, Kitsiou-Tzeli S, Rosello M, Keegan CE, Lyon GJ. TAF1 Variants Are Associated with Dysmorphic Features, Intellectual Disability, and Neurological Manifestations. Am J Hum Genet. 2015 Dec 03; 97(6):922-32.
  17. Al-Maawali A, Barry BJ, Rajab A, El-Quessny M, Seman A, Coury SN, Barkovich AJ, Yang E, Walsh CA, Mochida GH, Stoler JM. Novel loss-of-function variants in DIAPH1 associated with syndromic microcephaly, blindness, and early onset seizures. Am J Med Genet A. 2016 Feb; 170A(2):435-40.
  18. Rehder R, Yang E, Cohen AR. Variation of the slope of the tentorium during childhood. Childs Nerv Syst. 2016 Mar; 32(3):441-50.
  19. Hughes AL, Yang E, Vargas SO. A pediatric soft palate mass. Pleomorphic adenoma. JAMA Otolaryngol Head Neck Surg. 2015 Apr; 141(4):391-2.
  20. Yang E, Prabhu SP. Imaging manifestations of the leukodystrophies, inherited disorders of white matter. Radiol Clin North Am. 2014 Mar; 52(2):279-319.
  21. Hansford BG, Albert D, Yang E. Classic neuroimaging findings of nonketotic hyperglycemia on computed tomography and magnetic resonance imaging with absence of typical movement disorder symptoms (hemichorea-hemiballism). J Radiol Case Rep. 2013 Aug; 7(8):1-9.
  22. Yang E, Nucifora PG, Melhem ER. Diffusion MR imaging: basic principles. Neuroimaging Clin N Am. 2011 Feb; 21(1):1-25, vii.
  23. Sadzak I, Schiff M, Gattermeier I, Glinitzer R, Sauer I, Saalmüller A, Yang E, Schaljo B, Kovarik P. Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):8944-9.
  24. Ray R, Loughead J, Wang Z, Detre J, Yang E, Gur R, Lerman C. Neuroimaging, genetics and the treatment of nicotine addiction. Behav Brain Res. 2008 Nov 21; 193(2):159-69.
  25. Yang E, Altes T, Anupindi SA. Early Mycoplasma pneumoniae infection presenting as multiple pulmonary masses: an unusual presentation in a child. Pediatr Radiol. 2008 Apr; 38(4):477-80.
  26. Zakharova N, Lymar ES, Yang E, Malik S, Zhang JJ, Roeder RG, Darnell JE. Distinct transcriptional activation functions of STAT1alpha and STAT1beta on DNA and chromatin templates. J Biol Chem. 2003 Oct 31; 278(44):43067-73.
  27. Yang E, van Nimwegen E, Zavolan M, Rajewsky N, Schroeder M, Magnasco M, Darnell JE. Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes. Genome Res. 2003 Aug; 13(8):1863-72.
  28. Yang E, Lerner L, Besser D, Darnell JE. Independent and cooperative activation of chromosomal c-fos promoter by STAT3. J Biol Chem. 2003 May 02; 278(18):15794-9.
  29. Yang E, Henriksen MA, Schaefer O, Zakharova N, Darnell JE. Dissociation time from DNA determines transcriptional function in a STAT1 linker mutant. J Biol Chem. 2002 Apr 19; 277(16):13455-62.
  30. Yang E, Wen Z, Haspel RL, Zhang JJ, Darnell JE. The linker domain of Stat1 is required for gamma interferon-driven transcription. Mol Cell Biol. 1999 Jul; 19(7):5106-12.
  31. Castro A, Sengupta TK, Ruiz DC, Yang E, Ivashkiv LB. IL-4 selectively inhibits IL-2-triggered Stat5 activation, but not proliferation, in human T cells. J Immunol. 1999 Feb 01; 162(3):1261-9.
  32. Friedli AC, Yang E, and Marder SR. A convenient synthetic entry into aldehydes with extended conjugation. Tetrahedron. 1997; 53:2717-2730.
  33. Marder SR, Tiemann BG, Friedli AC, Yang E, and Cheng LT. Large first hyperpolarizabilities of push pull polyenes with strong acceptors . Nonlinear Optics. 1995; 9:213-221.
To schedule an appointment: Call 617-919-7365

Locations

Boston Children’s is so much more than a hospital—it’s a community of researchers, clinicians, administrators, support staff, innovators, teachers, patients and families, all working together to make the impossible possible. ”
- Sandra L. Fenwick, President and CEO

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300 Longwood Avenue, Boston, MA 02115
For Patients: 617-355-6000
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