"I provide families with a compassionate and comprehensive understanding of their child’s condition."

EDUCATION

Medical Degree
  • University of Alabama at Birmingham , Birmingham , AL

Internship

and Residency
  • Boston Combined Residency Program, Boston Children's Hospital and Boston Medical Center , Boston , MA

Graduate Degree

in Pediatric Neurology
  • Boston Children's Hospital , Boston , MA

Fellowship

in Neurogenetics - Epilepsy Genetics
  • Boston Children's Hospital , Boston , MA

Medicine is the intersection between science and humanity.

My passion is bridging this gap. At the bedside, I provide families with a compassionate and comprehensive understanding of their child’s condition, and at the bench I utilize novel scientific techniques to better understand the developing brain.

PROFESSIONAL HISTORY

My passion in child neurology is caring for patients with infantile spasms, neurogenetic conditions, and studying the underlying molecular basis for neurologic disorders. My graduate work identified misregulation of glycogen synthase kinase-3 as a potential target for therapeutic intervention in Fragile X syndrome. Since joining Boston Children’s Hospital, my work with Ann Poduri, MD, has contributed to a recent Nature paper identifying the specific de novo mutations in patients with epileptic encephalopathy. My current work involves studying several genes involved in infantile spasms, epileptic encephalopathy, and neurodevelopmental disorders. My priority is to understand how mutations in components of critical molecular pathways contribute to neurodevelopmental disorders, and to identify targets for therapeutic intervention.

 

Dr. Yuska serves as an expert for the Department of Neurology for Boston Children's Hospital Precision Medicine Service. For more information about the Precision Medicine Service please visit bostonchildrens.org/precisionmed.

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Harini C, Sharda S, Bergin AM, Poduri A, Yuskaitis CJ, Peters JM, Rakesh K, Kapur K, Pearl PL, Prabhu SP. Detailed Magnetic Resonance Imaging (MRI) Analysis in Infantile Spasms. J Child Neurol. 2018 May; 33(6):405-412. View abstract
  2. Yuskaitis CJ, Jones BM, Wolfson RL, Super CE, Dhamne SC, Rotenberg A, Sabatini DM, Sahin M, Poduri A. A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility. Neurobiol Dis. 2018 Mar; 111:91-101. View abstract
  3. Agulnik A, Kelly DP, Bruccoleri R, Yuskaitis C, Ebrahimi-Fakhari D, Sahin M, Burns MM, Kohane DS. Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose. Pediatrics. 2017 May; 139(5). View abstract
  4. Johnson EL, Yuskaitis CJ, Rondeau MW, Klein JP. A Tangled Web. Neurohospitalist. 2015 Oct; 5(4):253-4. View abstract
  5. Yuskaitis CJ, Parviz M, Loui P, Wan CY, Pearl PL. Neural Mechanisms Underlying Musical Pitch Perception and Clinical Applications Including Developmental Dyslexia. Curr Neurol Neurosci Rep. 2015 Aug; 15(8):51. View abstract
  6. Winden KD, Yuskaitis CJ, Poduri A. Megalencephaly and Macrocephaly. Semin Neurol. 2015 Jun; 35(3):277-87. View abstract
  7. Poduri A, Heinzen EL, Chitsazzadeh V, Lasorsa FM, Elhosary PC, LaCoursiere CM, Martin E, Yuskaitis CJ, Hill RS, Atabay KD, Barry B, Partlow JN, Bashiri FA, Zeidan RM, Elmalik SA, Kabiraj MM, Kothare S, Stödberg T, McTague A, Kurian MA, Scheffer IE, Barkovich AJ, Palmieri F, Salih MA, Walsh CA. SLC25A22 is a novel gene for migrating partial seizures in infancy. Ann Neurol. 2013 Dec; 74(6):873-82. View abstract
  8. Allen AS, Berkovic SF, Cossette P, Delanty N, Dlugos D, Eichler EE, Epstein MP, Glauser T, Goldstein DB, Han Y, Heinzen EL, Hitomi Y, Howell KB, Johnson MR, Kuzniecky R, Lowenstein DH, Lu YF, Madou MR, Marson AG, Mefford HC, Esmaeeli Nieh S, O'Brien TJ, Ottman R, Petrovski S, Poduri A, Ruzzo EK, Scheffer IE, Sherr EH, Yuskaitis CJ, Abou-Khalil B, Alldredge BK, Bautista JF, Berkovic SF, Boro A, Cascino GD, Consalvo D, Crumrine P, Devinsky O, Dlugos D, Epstein MP, Fiol M, Fountain NB, French J, Friedman D, Geller EB, Glauser T, Glynn S, Haut SR, Hayward J, Helmers SL, Joshi S, Kanner A, Kirsch HE, Knowlton RC, Kossoff EH, Kuperman R, Kuzniecky R, Lowenstein DH, McGuire SM, Motika PV, Novotny EJ, Ottman R, Paolicchi JM, Parent JM, Park K, Poduri A, Scheffer IE, Shellhaas RA, Sherr EH, Shih JJ, Singh R, Sirven J, Smith MC, Sullivan J, Lin Thio L, Venkat A, Vining EP, Von Allmen GK, Weisenberg JL, Widdess-Walsh P, Winawer MR. De novo mutations in epileptic encephalopathies. Nature. 2013 Sep 12; 501(7466):217-21. View abstract
  9. Yuskaitis CJ, Beurel E, Jope RS. Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome. Biochim Biophys Acta. 2010 Nov; 1802(11):1006-12. View abstract
  10. Mines MA, Yuskaitis CJ, King MK, Beurel E, Jope RS. GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism. PLoS One. 2010 Mar 16; 5(3):e9706. View abstract
  11. Yuskaitis CJ, Mines MA, King MK, Sweatt JD, Miller CA, Jope RS. Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome. Biochem Pharmacol. 2010 Feb 15; 79(4):632-46. View abstract
  12. Yuskaitis CJ, Jope RS. Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity. Cell Signal. 2009 Feb; 21(2):264-73. View abstract
  13. Min WW, Yuskaitis CJ, Yan Q, Sikorski C, Chen S, Jope RS, Bauchwitz RP. Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential. Neuropharmacology. 2009 Feb; 56(2):463-72. View abstract
  14. Jope RS, Yuskaitis CJ, Beurel E. Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res. 2007 Apr-May; 32(4-5):577-95. View abstract