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Tanvi Sharma, MD
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Tanvi Sharma, MD

Department: Medicine
Research Centers:
Hospital Title: Assistant in Medicine
Academic Title: Assistant Professor of Pediatrics, Harvard Medical School
Research Area: Pediatric HIV Prevention, Care and Treatment
Immunocompromised infectious diseases
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Research Overview

Dr. Sharma’s research focuses on metabolic complications related to antiretroviral medications in children and adolescents with HIV infection.  As children who were perinatally-infected with HIV are getting older and remaining healthier since they have been receiving anti-HIV therapy for many years, we are now beginning to see changes in body composition, an increased risk of diabetes, and increasing risk of other cardiovascular complications in these children.  Dr. Sharma’s research entails evaluating the mechanisms by which these abnormalities occur, and whether life-saving antiretroviral medications may also contribute to some of these complications.  In addition, Dr. Sharma conducts research evaluating infectious complications such as viral infections in pediatric transplant recipients.

About Tanvi Sharma

Dr. Sharma received her medical degree from the University of Miami Miller School of Medicine. She completed her residency training in pediatrics and fellowship in pediatric infectious diseases and immunology at the University of Miami/Jackson Memorial Medical Center in Miami, Florida.  Dr. Sharma joined the faculty in the Division of Infectious Diseases at Children’s Hospital Boston in 2007.  She currently serves as the Program Director for the pediatric infectious diseases fellowship training program here at Children’s.

Key Publications

1.      Sharma TS, Kinnamon DD, Duggan C, Weinberg GA, Furuta L, Bechard L, Nicchitta J, Gorbach SL, Miller TL.  Changes in Macronutrient Intake Among HIV-infected Children Between 1995 and 2004.  American Journal of Clinical Nutrition, 2008;88:384-91.

2.       Sharma TS, Hughes J, Murillo A, Riley J, Soares A, Little F, Mitchell CD, Hanekom WA.  CD8+ T-cell Interleukin 7 Receptor Alpha Expression as a Potential Indicator of Disease Status in HIV-Infected Children.  PLoS ONE, 2008;3(12):e3986.

3.       Sharma TS, Bechard LJ, Feldman HA, Venick R, Gura K, Gordon CM, Guinan EC, Duggan C.  Effect of titrated parenteral nutrition on body composition after hematopoietic stem cell transplantation in children: a blinded, randomized, multi-center trial.  American Journal of Clinical Nutrition 2012;95 342-351

4.      Sharma N, Willen E, Garcia A, Sharma TS.  Attitudes toward transitioning in youth with perinatally-acquired HIV and their family caregivers.  Journal of the Association of Nurses in AIDS Care.  2013.

5.      Sharma TS, Jacobson DL, Anderson L, Gerschenson M, Van Dyke RB, McFarland EJ, & Miller TL for the Pediatric HIV/AIDS Cohort Study.  The relationship between mitochondrial dysfunction and insulin resistance in HIV-infected children receiving antiretroviral therapy.  AIDS Research and Human Retroviruses 2013.

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