Michael Silverman’s research explores the interactions between the immune system and commensal microbes. The two goals of his research are to define the mechanisms by which commensal microbes influence the development of a normal and abnormal immune system and to develop approaches for therapeutic interventions to prevent and treat immune system disorders such as autoimmune disease. To address these goals, he studies the interaction of the gut commensal microbes and autoimmune diabetes in the non-obese diabetic mouse model.
About Michael Silverman
Dr. Silverman received an undergraduate degree in biology from Cornell University in 1998. He subsequently joined the MD, PhD program at the University of Pennsylvania School of Medicine in 1999. During his graduate studies with Dr. Gary Koretzky, he explored mechanisms of signal transduction in mast cells. He completed his residency in pediatrics in 2010 at the Boston Combined Residency Program and fellowship in pediatric infectious disease at Boston Children’s Hospital in 2013. Dr. Silverman then joined the laboratory of Drs. Diane Mathis and Christophe Benoist in 2011 to study the interaction of host microbiota and the immune system. Upon completion of his fellowship in 2013, he joined the faculty of the division of infectious disease at Boston Children’s Hospital.
Silverman MA, Neale MC, Sullivan PF, Harris-Kerr C, Wormley B, Sadek H, Ma Y, Kendler KS, Straub RE. 2000. Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence. Am J Med Genet 96: 646-53
Koretzky GA, Abtahian F, Silverman MA. 2006. SLP76 and SLP65: complex regulation of signaling in lymphocytes and beyond. Nat Rev Immunol 6: 67-78
Silverman MA, Shoag J, Wu J, Koretzky GA. 2006. Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. Mol Cell Biol 26: 1826-38
Silverman MA, Misasi J, Smole S, Feldman HA, Cohan AB, Santagata S, McManus M, Ahmed AA. Pediatric Eastern Equine encephalitis in Massachusetts and New Hampshire, 1970-2010. Emerging Infectious Diseases 2013 Feb;19(2):194-201. PMCID: PMC3559032.