Sulpicio Soriano II, MD

Sulpicio Soriano II, MD

BCH Endowed Chair in Pediatric Neuroanesthesia; Senior Associate in Perioperative Anesthesia

Professor of Anaesthesia, Harvard Medical School

  • Contact: 617-355-7737

  • Fax: 617-730-0894

Medical Services

Specialties

  • Neuroanesthesia

Departments

  • Anesthesiology Perioperative and Pain Medicine

Programs

  • Division of Perioperative Anesthesia
To schedule an appointment: Call 617-355-7737

Experience and Education

Education

Medical School

University of Pennsylvania School of Medicine, 1985

Philadelphia, PA

Internship

St. Mary's Hospital and Medical Center, 1985-1986

San Francisco, CA

Residency

University of California Davis Medical Center, 1986-1989

Sacramento, CA

Fellowship

Boston Children's Hospital, 1989-1990

Boston, MA

Certifications

  • Pediatric Anesthesia

Research

Research Focus Area
1. Anesthetic neuromodulation of the developing brain.

2. Neuroimmunology

For more information, please visit my research profile.

Publications

Publications powered by Harvard Catalyst
  1. G Soriano S. Not just neuroanesthesia, but Pediatric neuroanesthesia! Paediatr Anaesth. 2014 Jul; 24(7):645-6.
  2. Goobie SM, Meier PM, Sethna NF, Soriano SG, Zurakowski D, Samant S, Pereira LM. Population pharmacokinetics of tranexamic acid in paediatric patients undergoing craniosynostosis surgery. Clin Pharmacokinet. 2013 Apr; 52(4):267-76.
  3. Shen X, Dong Y, Xu Z, Wang H, Miao C, Soriano SG, Sun D, Baxter MG, Zhang Y, Xie Z. Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment. Anesthesiology. 2013 Mar; 118(3):502-15.
  4. Mashour GA, Avitsian R, Lauer KK, Soriano SG, Sharma D, Koht A, Crosby G. Neuroanesthesiology fellowship training: curricular guidelines from the Society for Neuroscience in Anesthesiology and Critical Care. J Neurosurg Anesthesiol. 2013 Jan; 25(1):1-7.
  5. McCann ME, Soriano SG. Perioperative central nervous system injury in neonates. Br J Anaesth. 2012 Dec; 109 Suppl 1:i60-i67.
  6. Soriano SG. Neurotoxicity of ketamine: known unknowns. Crit Care Med. 2012 Aug; 40(8):2518-9.
  7. Liu JR, Liu Q, Li J, Baek C, Han XH, Athiraman U, Soriano SG. Noxious stimulation attenuates ketamine-induced neuroapoptosis in the developing rat brain. Anesthesiology. 2012 Jul; 117(1):64-71.
  8. McCann ME, Soriano SG. General anesthetics in pediatric anesthesia: influences on the developing brain. Curr Drug Targets. 2012 Jun; 13(7):944-51.
  9. McClain CD, Rockoff MA, Soriano SG. Anesthetic concerns for pediatric patients in an intraoperative MRI suite. Curr Opin Anaesthesiol. 2011 Oct; 24(5):480-6.
  10. Yahalom B, Athiraman U, Soriano SG, Zurakowski D, Carpino EA, Corfas G, Berde CB. Spinal anesthesia in infant rats: development of a model and assessment of neurologic outcomes. Anesthesiology. 2011 Jun; 114(6):1325-35.
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  12. Goobie SM, Meier PM, Pereira LM, McGowan FX, Prescilla RP, Scharp LA, Rogers GF, Proctor MR, Meara JG, Soriano SG, Zurakowski D, Sethna NF. Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology. 2011 Apr; 114(4):862-71.
  13. Yuki K, Soriano SG, Shimaoka M. Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesth Analg. 2011 Apr; 112(4):830-8.
  14. Meier PM, Goobie SM, DiNardo JA, Proctor MR, Zurakowski D, Soriano SG. Endoscopic strip craniectomy in early infancy: the initial five years of anesthesia experience. Anesth Analg. 2011 Feb; 112(2):407-14.
  15. Dearling JL, Park EJ, Dunning P, Baker A, Fahey F, Treves ST, Soriano SG, Shimaoka M, Packard AB, Peer D. Detection of intestinal inflammation by MicroPET imaging using a (64)Cu-labeled anti-beta(7) integrin antibody. Inflamm Bowel Dis. 2010 Sep; 16(9):1458-66.
  16. Yuki K, Astrof NS, Bracken C, Soriano SG, Shimaoka M. Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1. Anesthesiology. 2010 Sep; 113(3):600-9.
  17. Soriano SG, Liu Q, Li J, Liu JR, Han XH, Kanter JL, Bajic D, Ibla JC. Ketamine activates cell cycle signaling and apoptosis in the neonatal rat brain. Anesthesiology. 2010 May; 112(5):1155-63.
  18. Soriano SG. Thinking about the neurotoxic effects of sedatives on the developing brain. Pediatr Crit Care Med. 2010 Mar; 11(2):306-7.
  19. Davidyuk G, Soriano SG, Goumnerova L, Mizrahi-Arnaud A. Acute intraoperative neurogenic pulmonary edema during endoscopic ventriculoperitoneal shunt revision. Anesth Analg. 2010 Feb 1; 110(2):594-5.
  20. Soriano SG. Thinking about the neurotoxic effects of sedatives on the developing brain. Pediatric Critical Care Medicine. 2010; in press.
  21. Dearling JLJ, Park EJ, Dunning P, Fahey F, Treves ST, Soriano SG, Shimaoka M, Parkard AB, Peer D. Detection of intestinal inflammation by PET imaging using a 64Cu-labeled anti-ƒÒ7 integrin antibody. Inflammatory Bowel Disease. 2010; in press.
  22. McCann ME, Soriano SG. Is anesthesia bad for the newborn brain? Anesthesiol Clin. 2009 Jun; 27(2):269-84.
  23. McCann ME, Bellinger DC, Davidson AJ, Soriano SG. Clinical research approaches to studying pediatric anesthetic neurotoxicity. Neurotoxicology. 2009 Sep; 30(5):766-71.
  24. Ibla JC, Hayashi H, Bajic D, Soriano SG. Prolonged exposure to ketamine increases brain derived neurotrophic factor levels in developing rat brains. Curr Drug Saf. 2009 Jan; 4(1):11-6.
  25. Vavilala, M.S. and Soriano, S.G. Anesthesia for Pediatric Neurosurgery and Traumatic Brain Injury. Smith's Anesthesia for Infants and Children. 2009.
  26. Yuki K, Astrof NS, Bracken C, Yo R, Silkworth W, Soriano SG Shimaoka M . The volatile anesthetic agent isoflurane perturbs the conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB. 2008; 22(12):4109-16.
  27. Soriano SG, Rockoff MA. . Pediatric Neuroanesthesia, Winn R (ed). Youman's Neurological Surgery. 2008.
  28. Soriano, S.G. SNACC: Basic and Clinical Neurosciences in Perfect Harmony. ASA Newsletter. 2008; 72(9):48-49.
  29. Yuki K, Astrof NS, Bracken C, Yoo R, Silkworth W, Soriano SG, Shimaoka M. The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB J. 2008 Dec; 22(12):4109-16.
  30. Loepke AW, McGowan FX, Soriano SG. CON: The toxic effects of anesthetics in the developing brain: the clinical perspective. Anesth Analg. 2008 Jun; 106(6):1664-9.
  31. Loepke AW, Soriano SG. An assessment of the effects of general anesthetics on developing brain structure and neurocognitive function. Anesth Analg. 2008 Jun; 106(6):1681-707.
  32. Soriano SG, Piva S. Central nervous system inflammation. Eur J Anaesthesiol Suppl. 2008; 42:154-9.
  33. McClain CD and Soriano SG. Pediatric Neuroanesthesia. Pediatric Anesthesia, Principles and Practice, Bissonnette, B. (ed.). 2008.
  34. McClain CD and Soriano SG. The Central Nervous System: Pediatric Neuroanesthesia. A Practical Approach to Pediatric Anesthesia, Holzman RS, Mancuso T, Polaner D (eds.). 2008.
  35. Soriano SG and McManus ML. Anesthetic considerations and postoperative ICU care. Pediatric Epilepsy Surgery: Preoperative Assessment and Surgical Treatment, Cataltepe O and Jallo G (eds.). 2008.
  36. Soriano SG and McManus, ML. Pediatric Neuroanesthesia. Anesthesia and Neurosurgery, Cottrell J and Young W eds. 2008.
  37. Recognition and Alleviation of Pain in Laboratory Animals. 2008.
  38. Soriano SG, Rockoff MA. Pediatric Neuroanesthesia. Anesthesia for Neurosurgery in Principles and Practice of Pediatric Neurosurgery Albright AL, Pollack IF, and Adelson D (eds.). 2008.
  39. McClain CD, Soriano SG, Rockoff MA. Pediatric Neuroanesthesia. A Practice of Anesthesia for Infants and Children Cote CJ and Lerman J(eds.). 2008.
  40. Soriano SG, Eldredge EA, Rockoff MA. Pediatric neuroanesthesia. Neuroimaging Clin N Am. 2007 May; 17(2):259-67.
  41. McClain CD, Soriano SG, Goumnerova LC, Black PM, Rockoff MA. Detection of unanticipated intracranial hemorrhage during intraoperative magnetic resonance image-guided neurosurgery. Report of two cases. J Neurosurg. 2007 May; 106(5 Suppl):398-400.
  42. Bilotta F, Ferri F, Soriano SG, Favaro R, Annino L, Rosa G. Lidocaine pretreatment for the prevention of propofol-induced transient motor disturbances in children during anesthesia induction: a randomized controlled trial in children undergoing invasive hematologic procedures. Paediatr Anaesth. 2006 Dec; 16(12):1232-7.
  43. Soriano SG, Bozza P. Anesthesia for epilepsy surgery in children. Childs Nerv Syst. 2006 Aug; 22(8):834-43.
  44. Anand KJ, Aranda JV, Berde CB, Buckman S, Capparelli EV, Carlo W, Hummel P, Johnston CC, Lantos J, Tutag-Lehr V, Lynn AM, Maxwell LG, Oberlander TF, Raju TN, Soriano SG, Taddio A, Walco GA. Summary proceedings from the neonatal pain-control group. Pediatrics. 2006 Mar; 117(3 Pt 2):S9-S22.
  45. Subramaniam B, Soriano SG, Michael Scott R, Kussman BD. Anesthetic management of pial synangiosis and intracranial hemorrhage with a Fontan circulation. Paediatr Anaesth. 2006 Jan; 16(1):72-6.
  46. Soriano SG, Loepke AW. Let's not throw the baby out with the bath water: potential neurotoxicity of anesthetic drugs in infants and children. J Neurosurg Anesthesiol. 2005 Oct; 17(4):207-9.
  47. Wang YF, Gwathmey JK, Zhang G, Soriano SG, He S, Wang Y. Cerebrospinal fluid may mediate CNS ischemic injury. Cerebrospinal Fluid Res. 2005 Sep 20; 2:7.
  48. Soriano SG, Anand KJ. Anesthetics and brain toxicity. Curr Opin Anaesthesiol. 2005 Jun; 18(3):293-7.
  49. Berde CB, Jaksic T, Lynn AM, Maxwell LG, Soriano SG, Tibboel D. Anesthesia and analgesia during and after surgery in neonates. Clin Ther. 2005 Jun; 27(6):900-21.
  50. Anand KJ, Aranda JV, Berde CB, Buckman S, Capparelli EV, Carlo WA, Hummel P, Lantos J, Johnston CC, Lehr VT, Lynn AM, Maxwell LG, Oberlander TF, Raju TN, Soriano SG, Taddio A, Walco GA. Analgesia and anesthesia for neonates: study design and ethical issues. Clin Ther. 2005 Jun; 27(6):814-43.
  51. Soriano SG, Anand KJ, Rovnaghi CR, Hickey PR. Of mice and men: should we extrapolate rodent experimental data to the care of human neonates? Anesthesiology. 2005 Apr; 102(4):866-8; author reply 868-9.
  52. Soriano, S.G. Society of Neurosurgical Anesthesia and Critical Care (SNACC) Problem-based learning discussion: 3 month old boy with saggital craniosynostosis SNACC Website http://www.snacc.org/ed/casedisc/Craniosynostosis.pdf. 2005.
  53. Anand KJ, Soriano SG. Anesthetic agents and the immature brain: are these toxic or therapeutic? Anesthesiology. 2004 Aug; 101(2):527-30.
  54. Wise-Faberowski L, Soriano SG, Ferrari L, McManus ML, Wolfsdorf JI, Majzoub J, Scott RM, Truog R, Rockoff MA. Perioperative management of diabetes insipidus in children. J Neurosurg Anesthesiol. 2004 Jul; 16(3):220-5.
  55. Davidson A, Soriano S. Does anaesthesia harm the developing brain--evidence or speculation? Paediatr Anaesth. 2004 Mar; 14(3):199-200.
  56. Scott RM, Smith JL, Robertson RL, Madsen JR, Soriano SG, Rockoff MA. Long-term outcome in children with moyamoya syndrome after cranial revascularization by pial synangiosis. J Neurosurg. 2004 Feb; 100(2 Suppl Pediatrics):142-9.
  57. Wise-Faberowski L, Soriano SG, Ferrari L, McManus ML, Wolfsdorf JI, Majzoub J, Scott RM, Truog R, Rockoff MA. Perioperative management of diabetes insipidus in children [corrected]. J Neurosurg Anesthesiol. 2004 Jan; 16(1):14-9.
  58. Soriano SG, Martyn JA. Antiepileptic-induced resistance to neuromuscular blockers: mechanisms and clinical significance. Clin Pharmacokinet. 2004; 43(2):71-81.
  59. Soriano SG , Domino KM. Society for Neurosurgical Anesthesia and Critical Care (SNACC) Bibliography, SNACC website: http://www.snacc.org/ed/bib/StartBIB.html. 2004.
  60. Soriano SG, Eldredge EA, Rockoff MA. Pediatric Neuroanesthesia. Youman's Neurological Surgery Winn HR (ed.). 2004; 3187-3197.
  61. Cheng MA, Soriano SG, Vavilala MS, Domino KB. Society of Neurosurgical Anesthesia and Critical Care (SNACC) newsletter: report of the 2002 annual meeting, Orlando, Florida. J Neurosurg Anesthesiol. 2003 Apr; 15(2):165-7.
  62. Hayashi H, Dikkes P, Soriano SG. Repeated administration of ketamine may lead to neuronal degeneration in the developing rat brain. Paediatr Anaesth. 2002 Nov; 12(9):770-4.
  63. Shenkman Z, Rockoff MA, Eldredge EA, Korf BR, Black PM, Soriano SG. Anaesthetic management of children with tuberous sclerosis. Paediatr Anaesth. 2002 Oct; 12(8):700-4.
  64. Soriano SG, Eldredge EA, Rockoff MA. Pediatric neuroanesthesia. Anesthesiol Clin North America. 2002 Jun; 20(2):389-404.
  65. Soriano SG, Amaravadi LS, Wang YF, Zhou H, Yu GX, Tonra JR, Fairchild-Huntress V, Fang Q, Dunmore JH, Huszar D, Pan Y. Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury. J Neuroimmunol. 2002 Apr; 125(1-2):59-65.
  66. Soriano SG, Cowan DB, Proctor MR, Scott RM. Levels of soluble adhesion molecules are elevated in the cerebrospinal fluid of children with moyamoya syndrome. Neurosurgery. 2002 Mar; 50(3):544-9.
  67. Soriano SG, McCann ME, Laussen PC. Neuroanesthesia. Innovative techniques and monitoring. Anesthesiol Clin North America. 2002 Mar; 20(1):137-51.
  68. Goobie SM, Soriano SG, Zurakowski D, McGowan FX, Rockoff MA. Hemostatic changes in pediatric neurosurgical patients as evaluated by thrombelastograph. Anesth Analg. 2001 Oct; 93(4):887-92.
  69. Logigian EL, Soriano SG, Herrmann DN, Madsen JR. Gentle dorsal root retraction and dissection can cause areflexia: implications for intraoperative monitoring during "selective" partial dorsal rhizotomy. Muscle Nerve. 2001 Oct; 24(10):1352-8.
  70. Soriano SG, Sullivan LJ, Venkatakrishnan K, Greenblatt DJ, Martyn JA. Pharmacokinetics and pharmacodynamics of vecuronium in children receiving phenytoin or carbamazepine for chronic anticonvulsant therapy. Br J Anaesth. 2001 Feb; 86(2):223-9.
  71. Eldredge EA, Soriano SG, Rockoff MA. Pediatric Neuroanesthesia. A Practice of Anesthesia for Infants and Children Cote CJ (ed.). 2001; 493-521.
  72. Soriano SG, Eldredge EA, Wang FK, Kull L, Madsen JR, Black PM, Riviello JJ, Rockoff MA. The effect of propofol on intraoperative electrocorticography and cortical stimulation during awake craniotomies in children. Paediatr Anaesth. 2000; 10(1):29-34.
  73. Soriano SG, Kaus SJ, Sullivan LJ, Martyn JA. Onset and duration of action of rocuronium in children receiving chronic anticonvulsant therapy. Paediatr Anaesth. 2000; 10(2):133-6.
  74. Soriano SG, Wang YF, Wagner DD, Frenette PS. P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury. Brain Res. 1999 Jul 24; 835(2):360-4.
  75. Soriano SG, Coxon A, Wang YF, Frosch MP, Lipton SA, Hickey PR, Mayadas TN. Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury. Stroke. 1999 Jan; 30(1):134-9.
  76. Rockoff MA, Soriano SG, Eldredge EA. Anesthesia for Pediatric Neurosurgery. Pediatric Anesthesia Volume VII, Miller RD (series editor) Atlas of Anesthesia, Greeley WJ (volume ed.). 1999; 7:7-11.
  77. McManus ML, Soriano SG. Rebound swelling of astroglial cells exposed to hypertonic mannitol. Anesthesiology. 1998 Jun; 88(6):1586-91.
  78. Wang YF, Tsirka SE, Strickland S, Stieg PE, Soriano SG, Lipton SA. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat Med. 1998 Feb; 4(2):228-31.
  79. Soriano SG, Wang YF, Lipton SA, Dikkes P, Gutierrez-Ramos JC, Hickey PR. ICAM-1 dependent pathway is not involved in the development of neuronal apoptosis after transient focal cerebral ischemia. Brain Res. 1998 Jan 12; 780(2):337-41.
  80. Soriano SG, Kim C, Jones DT. Surgical airway, rigid bronchoscopy, and transtracheal jet ventilation in the pediatric patient. Anesthesiol Clin of North America. 1998; 16:827-838.
  81. Holzman RS, van der Velde ME, Kaus SJ, Body SC, Colan SD, Sullivan LJ, Soriano SG. Sevoflurane depresses myocardial contractility less than halothane during induction of anesthesia in children. Anesthesiology. 1996 Dec; 85(6):1260-7.
  82. Furst SR, Sullivan LJ, Soriano SG, McDermott JS, Adelson PD, Rockoff MA. Effects of ondansetron on emesis in the first 24 hours after craniotomy in children. Anesth Analg. 1996 Aug; 83(2):325-8.
  83. Soriano SG, Lipton SA, Wang YF, Xiao M, Springer TA, Gutierrez-Ramos JC, Hickey PR. Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury. Ann Neurol. 1996 May; 39(5):618-24.
  84. Soriano SG, McManus ML, Sullivan LJ, Rockoff MA, Black PM, Burrows FA. Cerebral blood flow velocity after mannitol infusion in children. Can J Anaesth. 1996 May; 43(5 Pt 1):461-6.
  85. Logigian EL, Shefner JM, Goumnerova L, Scott RM, Soriano SG, Madsen J. The critical importance of stimulus intensity in intraoperative monitoring for partial dorsal rhizotomy. Muscle Nerve. 1996 Apr; 19(4):415-22.
  86. Lund DP, Soriano SG, Fauza D, Bower L, Jonas R, Hansen DD, Wilson J. Resection of a massive sacrococcygeal teratoma using hypothermic hypoperfusion: a novel use of extracorporeal membrane oxygenation. J Pediatr Surg. 1995 Nov; 30(11):1557-9.
  87. Eldredge EA, Soriano SG, Rockoff MA. Neuroanesthesia. Neurosurg Clin N Am. 1995 Jul; 6(3):505-20.
  88. Stokes MA, Soriano SG, Tarbell NJ, Loeffler JS, Alexander E, Black PM, Rockoff MA. Anesthesia for stereotactic radiosurgery in children. J Neurosurg Anesthesiol. 1995 Apr; 7(2):100-8.
  89. Soriano SG, Logigian EL, Scott RM, Prahl PA, Madsen JR. Nitrous oxide depresses the H-reflex in children with cerebral palsy. Anesth Analg. 1995 Feb; 80(2):239-41.
  90. Soriano SG, McManus ML, Sullivan LJ, Scott RM, Rockoff MA. Doppler sensor placement during neurosurgical procedures for children in the prone position. J Neurosurg Anesthesiol. 1994 Jul; 6(3):153-5.
  91. Logigian EL, Wolinsky JS, Soriano SG, Madsen JR, Scott RM. H reflex studies in cerebral palsy patients undergoing partial dorsal rhizotomy. Muscle Nerve. 1994 May; 17(5):539-49.
  92. Soriano SG, Sethna NF, Scott RM. Anesthetic management of children with moyamoya syndrome. Anesth Analg. 1993 Nov; 77(5):1066-70.
  93. Hanowell LH, Soriano S, Bennett HL. EEG power changes are more sensitive than spectral edge frequency variation for detection of cerebral ischemia during carotid artery surgery: a prospective assessment of processed EEG monitoring. J Cardiothorac Vasc Anesth. 1992 Jun; 6(3):292-4.
  94. Soriano S, Rockoff M. Posterior fossa craniotomy. Common problems in pediatric anesthesia Stehling L, (ed.). 1992; 307-315.
  95. Koka BV, Soriano SG. Neonatal surgical emergencies. Seminars in Anesthesia. 1992; 9:309-316.
  96. Hanowell LH, Kanefield JK, Soriano SG. A recommendation for reduced lidocaine dosage during intravenous regional bretylium treatment of reflex sympathetic dystrophy. Anesthesiology. 1989 Nov; 71(5):811-2.
  97. Kaplan F, Soriano S, Fallon M, Haddad J. Osteomalacia in a night nurse. Clinical Orthopedics. 1986; 205:216-221..
To schedule an appointment: Call 617-355-7737

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