Navil Sethna

Navil Sethna, MC, ChB

Clinical Director of the PPRC; Senior Associate in Pain Medicine; Senior Associate in Perioperative Anesthesia

Associate Professor of Anaesthesia, Harvard Medical School

  • Contact: 617-355-7040

  • Fax: 617-730-0894

Medical Services


  • Anesthesia
  • Pain Management Treatment
  • Spinal Fusion


  • Anesthesiology Perioperative and Pain Medicine


  • English


  • Division of Perioperative Anesthesia
  • Pain Treatment Services
To schedule an appointment: Call 617-355-7040

Experience and Education



University of Baghdad Hospital, Affiliated Teaching Hospitals, 1979-1980

Baghdad,, Iraq

Medical School

University of Baghdad College of Medicine, 1976

Baghdad, Iraq

Residency, Surgery

Al-Quassimi Hospital,

Residency, Department of Accident and Emergency

Al-Quassimi Hospital,

Residency, Surgery

Brookdale Hospital Medical Center, State University of NY,

Brooklyn, NY

Residency, Anesthesia

Brookdale Hospital Medical Center, State University of NY,

Brooklyn, NY

Fellowship, Clinical Trials Research & Clinical Associate in Neurobiology and Anesthesiology Branch

National Institute of Dental Research, National Institute of Health, 1

Fellowship, Pediatric Anesthesia

Boston Children's Hospital, 1982-1983

Boston, MA


  • Pediatric Anesthesia


Research Focus Area
Acute Pain, Chronic Pain and rehabilitation,  Fibrinolytic therapy

For more information, please visit my research profile.


Publications powered by Harvard Catalyst Profiles
  1. Shapiro F, Athiraman U, Clendenin DJ, Hoagland M, Sethna NF. Anesthetic management of 877 pediatric patients undergoing muscle biopsy for neuromuscular disorders: a 20-year review. Paediatr Anaesth. 2016 Jul; 26(7):710-21.
  2. Haché M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. J Child Neurol. 2016 Jun; 31(7):899-906.
  3. Simons LE, Erpelding N, Hernandez JM, Serrano P, Zhang K, Lebel AA, Sethna NF, Berde CB, Prabhu SP, Becerra L, Borsook D. Fear and Reward Circuit Alterations in Pediatric CRPS. Front Hum Neurosci. 2015; 9:703.
  4. Jacob E, Chan VW, Hodge C, Zeltzer L, Zurakowski D, Sethna NF. Sensory and Thermal Quantitative Testing in Children With Sickle Cell Disease. J Pediatr Hematol Oncol. 2015 Apr; 37(3):185-9.
  5. Sethna NF, Yahalom B, Schmidt B, Hall AM, Zurakowski D. The analgesic effect of a vapocoolant stream spray in reducing heat nociception on the glabrous skin of rat pups. Anesth Analg. 2014 Dec; 119(6):1367-72.
  6. Cornelissen L, Donado C, Kim J, Chiel L, Zurakowski D, Logan DE, Meier P, Sethna NF, Blankenburg M, Zernikow B, Sundel RP, Berde CB. Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study. Pediatr Rheumatol Online J. 2014; 12:39.
  7. Becerra L, Sava S, Simons LE, Drosos AM, Sethna N, Berde C, Lebel AA, Borsook D. Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome. Neuroimage Clin. 2014; 6:347-69.
  8. Maxwell LG, Buckley GM, Kudchadkar SR, Ely E, Stebbins EL, Dube C, Morad A, Jastaniah EA, Sethna NF, Yaster M. Pain management following major intracranial surgery in pediatric patients: a prospective cohort study in three academic children's hospitals. Paediatr Anaesth. 2014 Nov; 24(11):1132-40.
  9. Logan DE, Sieberg CB, Conroy C, Smith K, Odell S, Sethna N. Changes in sleep habits in adolescents during intensive interdisciplinary pediatric pain rehabilitation. J Youth Adolesc. 2015 Feb; 44(2):543-55.
  10. Micalizzi RA, Williams LA, Pignataro S, Sethna NF, Zurakowski D. Review of outcomes in pediatric patients undergoing anterior cruciate ligament repairs with regional nerve blocks. J Pediatr Nurs. 2014 Nov-Dec; 29(6):670-8.
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  12. Simons LE, Pielech M, Erpelding N, Linnman C, Moulton E, Sava S, Lebel A, Serrano P, Sethna N, Berde C, Becerra L, Borsook D. The responsive amygdala: treatment-induced alterations in functional connectivity in pediatric complex regional pain syndrome. Pain. 2014 Sep; 155(9):1727-42.
  13. Sieberg CB, Simons LE, Edelstein MR, DeAngelis MR, Pielech M, Sethna N, Hresko MT. Pain prevalence and trajectories following pediatric spinal fusion surgery. J Pain. 2013 Dec; 14(12):1694-702.
  14. Jerome J, Solodiuk JC, Sethna N, McHale J, Berde C. A single institution's effort to translate codeine knowledge into specific clinical practice. J Pain Symptom Manage. 2014 Jul; 48(1):119-26.
  15. Goobie SM, Meier PM, Sethna NF, Soriano SG, Zurakowski D, Samant S, Pereira LM. Population pharmacokinetics of tranexamic acid in paediatric patients undergoing craniosynostosis surgery. Clin Pharmacokinet. 2013 Apr; 52(4):267-76.
  16. Gaughan V, Logan D, Sethna N, Mott S. Parents' perspective of their journey caring for a child with chronic neuropathic pain. Pain Manag Nurs. 2014 Mar; 15(1):246-57.
  17. Logan DE, Carpino EA, Chiang G, Condon M, Firn E, Gaughan VJ, Hogan M, Leslie DS, Olson K, Sager S, Sethna N, Simons LE, Zurakowski D, Berde CB. A day-hospital approach to treatment of pediatric complex regional pain syndrome: initial functional outcomes. Clin J Pain. 2012 Nov-Dec; 28(9):766-74.
  18. Shenkman Z, Johnson VM, Zurakowski D, Arnon S, Sethna NF. Hemodynamic changes during spinal anesthesia in premature infants with congenital heart disease undergoing inguinal hernia correction. Paediatr Anaesth. 2012 Sep; 22(9):865-70.
  19. Haack M, Scott-Sutherland J, Santangelo G, Simpson NS, Sethna N, Mullington JM. Pain sensitivity and modulation in primary insomnia. Eur J Pain. 2012 Apr; 16(4):522-33.
  20. Tassone RF, Seefelder C, Sethna NF. Unilateral hemiparesis with thoracic epidural in an adolescent. Case Rep Anesthesiol. 2012; 2012:732584.
  21. Sethna NF, Berde CB. Sympathetic nerve blocks, pragmatic trials, and responder analysis. Anesthesiology. 2012 Jan; 116(1):12-4.
  22. Goobie SM, Meier PM, Pereira LM, McGowan FX, Prescilla RP, Scharp LA, Rogers GF, Proctor MR, Meara JG, Soriano SG, Zurakowski D, Sethna NF. Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology. 2011 Apr; 114(4):862-71.
  23. Fuzaylov G, Ying B, Tang Y, Sethna NF. Successful resuscitation after inadvertent intravenous injection of bupivacaine in an adolescent. Paediatr Anaesth. 2010 Oct; 20(10):958-9.
  24. Sethna NF, Clendenin D, Athiraman U, Solodiuk J, Rodriguez DP, Zurakowski D. Incidence of epidural catheter-associated infections after continuous epidural analgesia in children. Anesthesiology. 2010 Jul; 113(1):224-32.
  25. Clendenin DJ, Athiraman U, Zurakowski D, Shapiro F, Sethna NF. Accuracy of preoperative electrocardiographic and chest radiographic screening for prediction of left ventricular dysfunction in patients with suspected neuromuscular disorders. Anesth Analg. 2010 Apr 1; 110(4):1116-20.
  26. Ellinas H, Sethna NF. Ganglion impar block for management of chronic coccydynia in an adolescent. Paediatr Anaesth. 2009 Nov; 19(11):1137-8.
  27. Lin YC, Tassone RF, Jahng S, Rahbar R, Holzman RS, Zurakowski D, Sethna NF. Acupuncture management of pain and emergence agitation in children after bilateral myringotomy and tympanostomy tube insertion. Paediatr Anaesth. 2009 Nov; 19(11):1096-101.
  28. Meier PM, Zurakowski D, Berde CB, Sethna NF. Lumbar sympathetic blockade in children with complex regional pain syndromes: a double blind placebo-controlled crossover trial. Anesthesiology. 2009 Aug; 111(2):372-80.
  29. Graham RJ, Athiraman U, Laubach AE, Sethna NF. Anesthesia and perioperative medical management of children with spinal muscular atrophy. Paediatr Anaesth. 2009 Nov; 19(11):1054-63.
  30. Salloum ML, Eberlin KR, Sethna N, Hamdan US. Combined use of infraorbital and external nasal nerve blocks for effective perioperative pain control during and after cleft lip repair. Cleft Palate Craniofac J. 2009 Nov; 46(6):629-35.
  31. McGrath PJ, Walco GA, Turk DC, Dworkin RH, Brown MT, Davidson K, Eccleston C, Finley GA, Goldschneider K, Haverkos L, Hertz SH, Ljungman G, Palermo T, Rappaport BA, Rhodes T, Schechter N, Scott J, Sethna N, Svensson OK, Stinson J, von Baeyer CL, Walker L, Weisman S, White RE, Zajicek A, Zeltzer L. Core outcome domains and measures for pediatric acute and chronic/recurrent pain clinical trials: PedIMMPACT recommendations. J Pain. 2008 Sep; 9(9):771-83.
  32. Shapiro F, Zurakowski D, Sethna NF. Tranexamic acid diminishes intraoperative blood loss and transfusion in spinal fusions for duchenne muscular dystrophy scoliosis. Spine (Phila Pa 1976). 2007 Sep 15; 32(20):2278-83.
  33. Sethna NF, Meier PM, Zurakowski D, Berde CB. Cutaneous sensory abnormalities in children and adolescents with complex regional pain syndromes. Pain. 2007 Sep; 131(1-2):153-61.
  34. Mason KP, Michna E, Zurakowski D, Burrows PE, Pirich MA, Carrier M, Fontaine PJ, Sethna NF. Value of bispectral index monitor in differentiating between moderate and deep Ramsay Sedation Scores in children. Paediatr Anaesth. 2006 Dec; 16(12):1226-31.
  35. Meier PM, Alexander ME, Sethna NF, De Jong-De Vos Van Steenwijk CC, Zurakowski D, Berde CB. Complex regional pain syndromes in children and adolescents: regional and systemic signs and symptoms and hemodynamic response to tilt table testing. Clin J Pain. 2006 May; 22(4):399-406.
  36. Sethna NF, McGowan FX. Do results from studies of a simulated epidural test dose improve our ability to detect unintentional epidural vascular puncture in children? Paediatr Anaesth. 2005 Sep; 15(9):711-5.
  37. Houck CS, Sethna NF. Transdermal analgesia with local anesthetics in children: review, update and future directions. Expert Rev Neurother. 2005 Sep; 5(5):625-34.
  38. Sethna NF, Zurakowski D, Brustowicz RM, Bacsik J, Sullivan LJ, Shapiro F. Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery. Anesthesiology. 2005 Apr; 102(4):727-32.
  39. Sethna NF, Verghese ST, Hannallah RS, Solodiuk JC, Zurakowski D, Berde CB. A randomized controlled trial to evaluate S-Caine patch for reducing pain associated with vascular access in children. Anesthesiology. 2005 Feb; 102(2):403-8.
  40. Shapiro F, Sethna N. Blood loss in pediatric spine surgery. Eur Spine J. 2004 Oct; 13 Suppl 1:S6-17.
  41. Berde CB, Sethna NF. Analgesics for the treatment of pain in children. N Engl J Med. 2002 Oct 3; 347(14):1094-103.
  42. Lee BH, Scharff L, Sethna NF, McCarthy CF, Scott-Sutherland J, Shea AM, Sullivan P, Meier P, Zurakowski D, Masek BJ, Berde CB. Physical therapy and cognitive-behavioral treatment for complex regional pain syndromes. J Pediatr. 2002 Jul; 141(1):135-40.
  43. Palmer GM, Sundel R, Berde CB, Sethna NF. Prolonged sensory and motor deficit following short-term lumbar epidural analgesia in a patient with mixed connective tissue disease. J Pain Symptom Manage. 2002 Feb; 23(2):89-92.
  44. McCann ME, Sethna NF, Mazoit JX, Sakamoto M, Rifai N, Hope T, Sullivan L, Auble SG, Berde CB. The pharmacokinetics of epidural ropivacaine in infants and young children. Anesth Analg. 2001 Oct; 93(4):893-7.
  45. Meier PM, Berde CB, DiCanzio J, Zurakowski D, Sethna NF. Quantitative assessment of cutaneous thermal and vibration sensation and thermal pain detection thresholds in healthy children and adolescents. Muscle Nerve. 2001 Oct; 24(10):1339-45.
  46. Palmer GM, Davidson AJ, Sethna N, Laussen P. Use of the Bispectral Index monitor to aid titration of propofol during a drug-assisted interview. Paediatr Anaesth. 2001 Mar; 11(2):245-8.
  47. Sethna NF, Sullivan L, Retik A, McGowan FX, Zurakowski D. Efficacy of simulated epinephrine-containing epidural test dose after intravenous atropine during isoflurane anesthesia in children. Reg Anesth Pain Med. 2000 Nov-Dec; 25(6):566-72.
  48. Park JM, Houck CS, Sethna NF, Sullivan LJ, Atala A, Borer JG, Cilento BG, Diamond DA, Peters CA, Retik AB, Bauer SB. Ketorolac suppresses postoperative bladder spasms after pediatric ureteral reimplantation. Anesth Analg. 2000 Jul; 91(1):11-5.
  49. Dionne RA, Max MB, Gordon SM, Parada S, Sang C, Gracely RH, Sethna NF, MacLean DB. The substance P receptor antagonist CP-99,994 reduces acute postoperative pain. Clin Pharmacol Ther. 1998 Nov; 64(5):562-8.
  50. Sethna N. Regional anesthesia and analgesia. Semin Perinatol. 1998 Oct; 22(5):380-9.
  51. Sethna NF, Liu M, Gracely R, Bennett GJ, Max MB. Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects. Anesth Analg. 1998 Jun; 86(6):1250-6.
  52. Ririe DG, Shapiro F, Sethna NF. The response of patients with Duchenne's muscular dystrophy to neuromuscular blockade with vecuronium. Anesthesiology. 1998 Feb; 88(2):351-4.
  53. Kussman BD, Sethna NF. Pethidine-associated seizure in a healthy adolescent receiving pethidine for postoperative pain control. Paediatr Anaesth. 1998; 8(4):349-52.
  54. Ririe DG, Ririe KL, Sethna NF, Fox L. Unexpected interaction of methylphenidate (Ritalin) with anaesthetic agents. Paediatr Anaesth. 1997; 7(1):69-72.
  55. Houck CS, Wilder RT, McDermott JS, Sethna NF, Berde CB. Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system. J Pediatr. 1996 Aug; 129(2):292-6.
  56. Collins JJ, Grier HE, Sethna NF, Wilder RT, Berde CB. Regional anesthesia for pain associated with terminal pediatric malignancy. Pain. 1996 Apr; 65(1):63-9.
  57. Soriano SG, Sethna NF, Scott RM. Anesthetic management of children with moyamoya syndrome. Anesth Analg. 1993 Nov; 77(5):1066-70.
  58. Sethna NF, Berde CB. Venous air embolism during identification of the epidural space in children. Anesth Analg. 1993 May; 76(5):925-7.
  59. Henderson K, Sethna NF, Berde CB. Continuous caudal anesthesia for inguinal hernia repair in former preterm infants. J Clin Anesth. 1993 Mar-Apr; 5(2):129-33.
  60. Perillo M, Sethna NF, Berde CB. Intravenous isoproterenol as a marker for epidural test-dosing in children. Anesth Analg. 1993 Jan; 76(1):178-81.
  61. Sethna NF, Sockin SM, Holzman RS, Slater JE. Latex anaphylaxis in a child with a history of multiple anesthetic drug allergies. Anesthesiology. 1992 Aug; 77(2):372-5.
  62. Shapiro F, Sethna N, Colan S, Wohl ME, Specht L. Spinal fusion in Duchenne muscular dystrophy: a multidisciplinary approach. Muscle Nerve. 1992 May; 15(5):604-14.
  63. Sethna NF, Berde CB. Pediatric regional anesthesia equipment. Int Anesthesiol Clin. 1992; 30(3):163-76.
  64. Irazuzta JE, Berde CB, Sethna NF. Laser Doppler measurements of skin blood flow before, during, and after lumbar sympathetic blockade in children and young adults with reflex sympathetic dystrophy syndrome. J Clin Monit. 1992 Jan; 8(1):16-9.
  65. Sethna NF, Berde CB. Continuous subarachnoid analgesia in two adolescents with severe scoliosis and impaired pulmonary function. Reg Anesth. 1991 Nov-Dec; 16(6):333-6.
  66. Cooper MG, Sethna NF. Epidural analgesia in patients with congenital lumbosacral spinal anomalies. Anesthesiology. 1991 Aug; 75(2):370-4.
  67. Berde CB, Beyer JE, Bournaki MC, Levin CR, Sethna NF. Comparison of morphine and methadone for prevention of postoperative pain in 3- to 7-year-old children. J Pediatr. 1991 Jul; 119(1 Pt 1):136-41.
  68. Berde CB, Lehn BM, Yee JD, Sethna NF, Russo D. Patient-controlled analgesia in children and adolescents: a randomized, prospective comparison with intramuscular administration of morphine for postoperative analgesia. J Pediatr. 1991 Mar; 118(3):460-6.
  69. Berde CB, Sethna NF, Fisher DE, Kahn CH, Chandler P, Grier HE. Celiac plexus blockade for a 3-year-old boy with hepatoblastoma and refractory pain. Pediatrics. 1990 Nov; 86(5):779-81.
  70. Berde CB, Sethna NF, Conrad LS, Hershenson MB, Shillito J. Subarachnoid bupivacaine analgesia for seven months for a patient with a spinal cord tumor. Anesthesiology. 1990 Jun; 72(6):1094-6.
  71. Pascucci RC, Hershenson MB, Sethna NF, Loring SH, Stark AR. Chest wall motion of infants during spinal anesthesia. J Appl Physiol (1985). 1990 May; 68(5):2087-91.
  72. Anderson CT, Berde CB, Sethna NF, Pribaz JJ. Meningococcal purpura fulminans: treatment of vascular insufficiency in a 2-yr-old child with lumbar epidural sympathetic blockade. Anesthesiology. 1989 Sep; 71(3):463-4.
  73. Berde CB, Sethna NF, Levin L, Retik A, Millis M, Lillehei C, Micheli L. Regional analgesia on pediatric medical and surgical wards. Intensive Care Med. 1989; 15 Suppl 1:S40-3.
  74. Berde C, Sethna NF, Masek B, Fosburg M, Rocklin S. Pediatric pain clinics: recommendations for their development. Pediatrician. 1989; 16(1-2):94-102.
  75. Sethna NF, Rockoff MA, Worthen HM, Rosnow JM. Anesthesia-related complications in children with Duchenne muscular dystrophy. Anesthesiology. 1988 Mar; 68(3):462-5.
  76. Sethna NF, Rockoff MA. Cardiac arrest following inhalation induction of anaesthesia in a child with Duchenne's muscular dystrophy. Can Anaesth Soc J. 1986 Nov; 33(6):799-802.
To schedule an appointment: Call 617-355-7040


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