Isaac Ely Stillman, MD

Consultant Renal Pathologist

Associate Professor of Pathology, Harvard Medical School

    Contact: 617-667-4344
  • Fax: 617-975-5620

Medical Services


  • Anatomic Pathology


To schedule an appointment: Call 617-667-4344

Experience and Education


Undergraduate Degree

Yeshiva College, Yeshiva University, 1983

New York, NY

Medical School

Albert Einstein College of Medicine of Yeshiva University, 1987

Bronx, NY

Internship, Internal Medicine

Booth Memorial Medical Center, 1988

Flushing, NY

Residency, Anatomic Pathology

Beth Israel Hospital, 1991

Boston, MA

Fellowship, Surgical and Renal Pathology

Beth Israel Hospital, 1992

Boston, MA


  • American Board of Pathology, Pathology - Anatomic


Research interests include: Experimental and Translational Renal Pathology, Acute Renal Failure, Diabetes, Angiogenic Factors

Isaac Ely Stillman, MD PubMed articles


Publications powered by Harvard Catalyst Profiles
  1. Kota SK, Pernicone E, Leaf DE, Stillman IE, Waikar SS, Kota SB. BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI. J Am Soc Nephrol. 2017 Dec; 28(12):3473-3478.
  2. Zhao Y, Bucur O, Irshad H, Chen F, Weins A, Stancu AL, Oh EY, DiStasio M, Torous V, Glass B, Stillman IE, Schnitt SJ, Beck AH, Boyden ES. Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy. Nat Biotechnol. 2017 Aug; 35(8):757-764.
  3. Cardenas-Gonzalez M, Srivastava A, Pavkovic M, Bijol V, Rennke HG, Stillman IE, Zhang X, Parikh S, Rovin BH, Afkarian M, de Boer IH, Himmelfarb J, Waikar SS, Vaidya VS. Identification, Confirmation, and Replication of Novel Urinary MicroRNA Biomarkers in Lupus Nephritis and Diabetic Nephropathy. Clin Chem. 2017 Sep; 63(9):1515-1526.
  4. Qi W, Keenan HA, Li Q, Ishikado A, Kannt A, Sadowski T, Yorek MA, Wu IH, Lockhart S, Coppey LJ, Pfenninger A, Liew CW, Qiang G, Burkart AM, Hastings S, Pober D, Cahill C, Niewczas MA, Israelsen WJ, Tinsley L, Stillman IE, Amenta PS, Feener EP, Vander Heiden MG, Stanton RC, King GL. Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nat Med. 2017 Jun; 23(6):753-762.
  5. Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Zhang L, Kyttaris VC, Tsokos GC, Stillman IE, Ichimura T, Bonventre JV, Libby P, Shi GP. CD74 Deficiency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice. J Immunol. 2017 Apr 01; 198(7):2568-2577.
  6. Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Kyttaris VC, Stillman IE, Gelb B, Libby P, Tsokos GC, Shi GP. Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Faslpr Mice. J Immunol. 2017 Mar 01; 198(5):1846-1854.
  7. Zsengellér ZK, Rajakumar A, Hunter JT, Salahuddin S, Rana S, Stillman IE, Ananth Karumanchi S. Trophoblast mitochondrial function is impaired in preeclampsia and correlates negatively with the expression of soluble fms-like tyrosine kinase 1. Pregnancy Hypertens. 2016 Oct; 6(4):313-319.
  8. Burke SD, Zsengellér ZK, Khankin EV, Lo AS, Rajakumar A, DuPont JJ, McCurley A, Moss ME, Zhang D, Clark CD, Wang A, Seely EW, Kang PM, Stillman IE, Jaffe IZ, Karumanchi SA. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia. J Clin Invest. 2016 Jul 01; 126(7):2561-74.
  9. Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM. PGC1a drives NAD biosynthesis linking oxidative metabolism to renal protection. Nature. 2016 Mar 24; 531(7595):528-32.
  10. Reimold FR, Balasubramanian S, Doroquez DB, Shmukler BE, Zsengeller ZK, Saslowsky D, Thiagarajah JR, Stillman IE, Lencer WI, Wu BL, Villalpando-Carrion S, Alper SL. Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W. Front Physiol. 2015; 6:179.
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  12. Erpenbeck L, Demers M, Zsengellér ZK, Gallant M, Cifuni SM, Stillman IE, Karumanchi SA, Wagner DD. ADAMTS13 Endopeptidase Protects against Vascular Endothelial Growth Factor Inhibitor-Induced Thrombotic Microangiopathy. J Am Soc Nephrol. 2016 Jan; 27(1):120-31.
  13. Harris RM, Stillman IE, Goldsmith JD, Qian Q, Kirby JE. Pathological rib fracture and soft tissue mass simulating malignancy--Cryptococcus, an unsuspected culprit. Diagn Microbiol Infect Dis. 2015 Mar; 81(3):189-91.
  14. Holwerda KM, Burke SD, Faas MM, Zsengeller Z, Stillman IE, Kang PM, van Goor H, McCurley A, Jaffe IZ, Karumanchi SA, Lely AT. Hydrogen sulfide attenuates sFlt1-induced hypertension and renal damage by upregulating vascular endothelial growth factor. J Am Soc Nephrol. 2014 Apr; 25(4):717-25.
  15. McMahon K, Karumanchi SA, Stillman IE, Cummings P, Patton D, Easterling T. Does soluble fms-like tyrosine kinase-1 regulate placental invasion? Insight from the invasive placenta. Am J Obstet Gynecol. 2014 Jan; 210(1):68.e1-4.
  16. Guerrero J, Mallur P, Folch E, Keyes C, Stillman IE, Gangadharan SP, Majid A. Necrotizing tracheitis secondary to corynebacterium species presenting with central airway obstruction. Respir Care. 2014 Jan; 59(1):e5-8.
  17. Ujire MP, Curry MP, Stillman IE, Hanto DW, Mandelbrot DA. A simultaneous liver-kidney transplant recipient with IgA nephropathy limited to native kidneys and BK virus nephropathy limited to the transplant kidney. Am J Kidney Dis. 2013 Aug; 62(2):331-4.
  18. Reimold FR, Braun N, Zsengellér ZK, Stillman IE, Karumanchi SA, Toka HR, Latus J, Fritz P, Biegger D, Segerer S, Alscher MD, Bhasin MK, Alper SL. Transcriptional patterns in peritoneal tissue of encapsulating peritoneal sclerosis, a complication of chronic peritoneal dialysis. PLoS One. 2013; 8(2):e56389.
  19. Baradhi KM, Gary Abuelo J, Stillman IE. The Case: diabetic nephropathy in a nondiabetic smoker? Kidney Int. 2012 Nov; 82(10):1141-2.
  20. McMahon GM, Datta D, Bruneau S, Kann M, Khalid M, Ho J, Seto T, Kreidberg JA, Stillman IE, Briscoe DM. Constitutive activation of the mTOR signaling pathway within the normal glomerulus. Biochem Biophys Res Commun. 2012 Aug 24; 425(2):244-9.
  21. Mukhopadhyay P, Horváth B, Zsengeller Z, Bátkai S, Cao Z, Kechrid M, Holovac E, Erdelyi K, Tanchian G, Liaudet L, Stillman IE, Joseph J, Kalyanaraman B, Pacher P. Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially targeted antioxidants. Free Radic Biol Med. 2012 Sep 01; 53(5):1123-38.
  22. Zsengellér ZK, Ellezian L, Brown D, Horváth B, Mukhopadhyay P, Kalyanaraman B, Parikh SM, Karumanchi SA, Stillman IE, Pacher P. Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity. J Histochem Cytochem. 2012 Jul; 60(7):521-9.
  23. Rajakumar A, Cerdeira AS, Rana S, Zsengeller Z, Edmunds L, Jeyabalan A, Hubel CA, Stillman IE, Parikh SM, Karumanchi SA. Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia. Hypertension. 2012 Feb; 59(2):256-64.
  24. Stillman IE, Karumanchi SA. Vasculitis is an antiangiogenic state. J Am Soc Nephrol. 2012 Jan; 23(1):8-10.
  25. Bixel K, Silasi M, Zelop CM, Lim KH, Zsengeller Z, Stillman IE, Rana S. Placental origins of angiogenic dysfunction in mirror syndrome. Hypertens Pregnancy. 2012; 31(2):211-7.
  26. Mukhopadhyay P, Horváth B, Zsengellér Z, Zielonka J, Tanchian G, Holovac E, Kechrid M, Patel V, Stillman IE, Parikh SM, Joseph J, Kalyanaraman B, Pacher P. Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. Free Radic Biol Med. 2012 Jan 15; 52(2):497-506.
  27. Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM. PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest. 2011 Oct; 121(10):4003-14.
  28. Silasi M, Rana S, Powe C, Cohen B, Lim KH, Zsengellér ZK, Karumanchi SA, Stillman IE. Placental expression of angiogenic factors in Trisomy 13. Am J Obstet Gynecol. 2011 Jun; 204(6):546.e1-4.
  29. Hasnain W, Stillman IE, Bayliss GP. Minimal-change renal disease and Graves' disease: a case report and literature review. NDT Plus. 2011 Apr; 4(2):96-8.
  30. Kanter D, Lindheimer MD, Wang E, Borromeo RG, Bousfield E, Karumanchi SA, Stillman IE. Angiogenic dysfunction in molar pregnancy. Am J Obstet Gynecol. 2010 Feb; 202(2):184.e1-5.
  31. Xu Y, Zhang Z, Hu J, Stillman IE, Leopold JA, Handy DE, Loscalzo J, Stanton RC. Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria. FASEB J. 2010 Feb; 24(2):609-16.
  32. Stillman IE, Pavlakis M. Allograft biopsies: studying them for all they're worth. J Am Soc Nephrol. 2009 Nov; 20(11):2282-4.
  33. Crispín JC, Oukka M, Bayliss G, Cohen RA, Van Beek CA, Stillman IE, Kyttaris VC, Juang YT, Tsokos GC. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol. 2008 Dec 15; 181(12):8761-6.
  34. Mutter WP, Stillman IE, Dahl NK. Thrombotic microangiopathy and renal failure exacerbated by epsilon-aminocaproic acid. Am J Kidney Dis. 2009 Feb; 53(2):346-50.
  35. Cohen RA, Bayliss G, Crispin JC, Kane-Wanger GF, Van Beek CA, Kyttaris VC, Avalos I, Yu CY, Tsokos GC, Stillman IE. T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis. Clin Immunol. 2008 Jul; 128(1):1-7.
  36. Shan HY, Rana S, Epstein FH, Stillman IE, Karumanchi SA, Williams ME. Use of circulating antiangiogenic factors to differentiate other hypertensive disorders from preeclampsia in a pregnant woman on dialysis. Am J Kidney Dis. 2008 Jun; 51(6):1029-32.
  37. Stillman IE, Lima EQ, Burdmann EA. Renal biopsies in acute kidney injury: who are we missing? Clin J Am Soc Nephrol. 2008 May; 3(3):647-8.
  38. Maki T, Carville A, Stillman IE, Sato K, Kodaka T, Minamimura K, Ogawa N, Kanamoto A, Gottschalk R, Monaco AP, Marr-Belvin A, Westmoreland SV, Sehgal P. SV40 infection associated with rituximab treatment after kidney transplantation in nonhuman primates. Transplantation. 2008 Mar 27; 85(6):893-902.
  39. Rosen S, Stillman IE. Acute tubular necrosis is a syndrome of physiologic and pathologic dissociation. J Am Soc Nephrol. 2008 May; 19(5):871-5.
  40. Bodyak N, Ayus JC, Achinger S, Shivalingappa V, Ke Q, Chen YS, Rigor DL, Stillman I, Tamez H, Kroeger PE, Wu-Wong RR, Karumanchi SA, Thadhani R, Kang PM. Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):16810-5.
  41. Egbuna O, Pavlakis M, Stillman IE. Acute crescentic glomerulonephritis in a renal allograft: an unusual complication of fungal infection. Am J Kidney Dis. 2007 Sep; 50(3):468-70.
  42. Stillman IE, Karumanchi SA. The glomerular injury of preeclampsia. J Am Soc Nephrol. 2007 Aug; 18(8):2281-4.
  43. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, Stillman IE, Roberts D, D'Amore PA, Epstein FH, Sellke FW, Romero R, Sukhatme VP, Letarte M, Karumanchi SA. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med. 2006 Jun; 12(6):642-9.
  44. Karumanchi SA, Stillman IE. In vivo rat model of preeclampsia. Methods Mol Med. 2006; 122:393-9.
  45. Karumanchi SA, Maynard SE, Stillman IE, Epstein FH, Sukhatme VP. Preeclampsia: a renal perspective. Kidney Int. 2005 Jun; 67(6):2101-13.
  46. Avihingsanon Y, Ma N, Pavlakis M, Chon WJ, Uknis ME, Monaco AP, Ferran C, Stillman I, Schachter AD, Mottley C, Zheng XX, Strom TB. On the intraoperative molecular status of renal allografts after vascular reperfusion and clinical outcomes. J Am Soc Nephrol. 2005 Jun; 16(6):1542-8.
  47. Karumanchi SA, Epstein FH, Stillman IE. Is loss of podocyte foot processes necessary for the induction of proteinuria? Am J Kidney Dis. 2005 Feb; 45(2):436.
  48. Lam C, Stillman IE, Steinman TI. The many faces of HIV nephropathy: results of the disease and consequences of treatment. J Nephrol. 2005 Jan-Feb; 18(1):106-10.
  49. Axthelm MK, Koralnik IJ, Dang X, Wüthrich C, Rohne D, Stillman IE, Letvin NL. Meningoencephalitis and demyelination are pathologic manifestations of primary polyomavirus infection in immunosuppressed rhesus monkeys. J Neuropathol Exp Neurol. 2004 Jul; 63(7):750-8.
  50. Charytan D, Torre A, Khurana M, Nicastri A, Stillman IE, Kalluri R. Allograft rejection and glomerular basement membrane antibodies in Alport's syndrome. J Nephrol. 2004 May-Jun; 17(3):431-5.
  51. Saurborn DP, Kruskal JB, Stillman IE, Parangi S. Best cases from the AFIP: paraganglioma of the organs of Zuckerkandl. Radiographics. 2003 Sep-Oct; 23(5):1279-86.
  52. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003 Mar; 111(5):649-58.
  53. Mix TC, Stillman IE, McNamara A, Steinman TI. A 57-year-old woman with gross hematuria and bilateral renal masses: an unusual presentation of acute interstitial nephritis. Am J Kidney Dis. 2002 Mar; 39(3):653-8.
  54. Maeshima Y, Colorado PC, Torre A, Holthaus KA, Grunkemeyer JA, Ericksen MB, Hopfer H, Xiao Y, Stillman IE, Kalluri R. Distinct antitumor properties of a type IV collagen domain derived from basement membrane. J Biol Chem. 2000 Jul 14; 275(28):21340-8.
  55. Gertig DM, Stillman IE, Byrne C, Spiegelman D, Schnitt SJ, Connolly JL, Colditz GA, Hunter DJ. Association of age and reproductive factors with benign breast tissue composition. Cancer Epidemiol Biomarkers Prev. 1999 Oct; 8(10):873-9.
  56. Ananth S, Knebelmann B, Grüning W, Dhanabal M, Walz G, Stillman IE, Sukhatme VP. Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma. Cancer Res. 1999 May 01; 59(9):2210-6.
  57. Muruve DA, Barnes MJ, Stillman IE, Libermann TA. Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo. Hum Gene Ther. 1999 Apr 10; 10(6):965-76.
  58. Dhanabal M, Ramchandran R, Volk R, Stillman IE, Lombardo M, Iruela-Arispe ML, Simons M, Sukhatme VP. Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma. Cancer Res. 1999 Jan 01; 59(1):189-97.
  59. Meisels IS, Stillman IE, Kuhlik AB. Anti-glomerular basement membrane disease and dual positivity for antineutrophil cytoplasmic antibody in a patient with membranous nephropathy. Am J Kidney Dis. 1998 Oct; 32(4):646-8.
  60. Greenfeld Z, Stillman IE, Brezis M, Rosen S. Medullary injury in the ageing rat kidney: functional-morphometric correlations. Eur J Clin Invest. 1997 Apr; 27(4):346-51.
  61. Stillman IE, English J, Burdmann EA, Andoh TF, Franschini N, Bennett WM, Rosen S. Prednisone alters the histopathology of chronic cyclosporine nephropathy. Exp Nephrol. 1997 Jan-Feb; 5(1):61-8.
  62. Jacobs TW, Prioleau JE, Stillman IE, Schnitt SJ. Loss of tumor marker-immunostaining intensity on stored paraffin slides of breast cancer. J Natl Cancer Inst. 1996 Aug 07; 88(15):1054-9.
  63. Stillman IE, Andoh TF, Burdmann EA, Bennett WM, Rosen S. FK506 nephrotoxicity: morphologic and physiologic characterization of a rat model. Lab Invest. 1995 Dec; 73(6):794-803.
  64. Stillman IE, Brezis M, Heyman SN, Epstein FH, Spokes K, Rosen S. Effects of salt depletion on the kidney: changes in medullary oxygenation and thick ascending limb size. J Am Soc Nephrol. 1994 Feb; 4(8):1538-45.
  65. Rosen S, Brezis M, Stillman I. The pathology of nephrotoxic injury: a reappraisal. Miner Electrolyte Metab. 1994; 20(4):174-80.
  66. Heyman SN, Stillman IE, Brezis M, Epstein FH, Spokes K, Rosen S. Chronic amphotericin nephropathy: morphometric, electron microscopic, and functional studies. J Am Soc Nephrol. 1993 Jul; 4(1):69-80.
  67. Breall JA, Grossman W, Stillman IE, Gianturco LE, Kim D. Atherectomy of the subclavian artery for patients with symptomatic coronary-subclavian steal syndrome. J Am Coll Cardiol. 1993 Jun; 21(7):1564-7.
  68. Schnitt SJ, Stillman IE, Owings DV, Kishimoto C, Dvorak HF, Abelmann WH. Myocardial fibrin deposition in experimental viral myocarditis that progresses to dilated cardiomyopathy. Circ Res. 1993 Apr; 72(4):914-20.
  69. Stillman IE, Brezis M, Greenfeld Z, Ransil BJ, Heyman SN, Rosen S. Cyclosporine nephropathy: morphometric analysis of the medullary thick ascending limb. Am J Kidney Dis. 1992 Aug; 20(2):162-7.
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