EDUCATION

Graduate School
  • University of Toronto - Ph.D. , Toronto , Canada

Medical School

  • The Fourth Military Medical University , Xian City, P.R. China

Internship

Pediatrics
  • Bridgeport Hospital, Yale University

Graduate Degree

Pediatrics
  • New York University Medical Center

Fellowship

Neonatal -Perinatal Medicine
  • Harvard Neonatal-Perinatal Medicine Fellowship Training Program , Boston , MA

CERTIFICATIONS

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Ackerman SD, Luo R, Poitelon Y, Mogha A, Harty BL, D'Rozario M, Sanchez NE, Lakkaraju AKK, Gamble P, Li J, Qu J, MacEwan MR, Ray WZ, Aguzzi A, Feltri ML, Piao X, Monk KR. GPR56/ADGRG1 regulates development and maintenance of peripheral myelin. J Exp Med. 2018 Mar 05; 215(3):941-961. View abstract
  2. Mehta P, Küspert M, Bale T, Brownstein CA, Towne MC, De Girolami U, Shi J, Beggs AH, Darras BT, Wegner M, Piao X, Agrawal PB. Novel mutation in CNTNAP1 results in congenital hypomyelinating neuropathy. Muscle Nerve. 2017 May; 55(5):761-765. View abstract
  3. Mehta P, Piao X. Adhesion G-protein coupled receptors and extracellular matrix proteins: Roles in myelination and glial cell development. Dev Dyn. 2017 04; 246(4):275-284. View abstract
  4. Mogha A, Harty BL, Carlin D, Joseph J, Sanchez NE, Suter U, Piao X, Cavalli V, Monk KR. Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair. J Neurosci. 2016 Dec 07; 36(49):12351-12367. View abstract
  5. Salzman GS, Ackerman SD, Ding C, Koide A, Leon K, Luo R, Stoveken HM, Fernandez CG, Tall GG, Piao X, Monk KR, Koide S, Araç D. Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains. Neuron. 2016 Sep 21; 91(6):1292-1304. View abstract
  6. Langenhan T, Piao X, Monk KR. Adhesion G protein-coupled receptors in nervous system development and disease. Nat Rev Neurosci. 2016 09; 17(9):550-61. View abstract
  7. Sigoillot SM, Monk KR, Piao X, Selimi F, Harty BL. Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination. Handb Exp Pharmacol. 2016; 234:275-298. View abstract
  8. Chen P, Piao X, Bonaldo P. Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury. Acta Neuropathol. 2015 Nov; 130(5):605-18. View abstract
  9. Schöneberg T, Liebscher I, Luo R, Monk KR, Piao X. Tethered agonists: a new mechanism underlying adhesion G protein-coupled receptor activation. J Recept Signal Transduct Res. 2015 Jun; 35(3):220-3. View abstract
  10. Petersen SC, Luo R, Liebscher I, Giera S, Jeong SJ, Mogha A, Ghidinelli M, Feltri ML, Schöneberg T, Piao X, Monk KR. The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211. Neuron. 2015 Feb 18; 85(4):755-69. View abstract
  11. Rao TN, Marks-Bluth J, Sullivan J, Gupta MK, Chandrakanthan V, Fitch SR, Ottersbach K, Jang YC, Piao X, Kulkarni RN, Serwold T, Pimanda JE, Wagers AJ. High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice. Stem Cell Res. 2015 May; 14(3):307-22. View abstract
  12. Ackerman SD, Garcia C, Piao X, Gutmann DH, Monk KR. The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Ga12/13 and RhoA. Nat Commun. 2015 Jan 21; 6:6122. View abstract
  13. Giera S, Deng Y, Luo R, Ackerman SD, Mogha A, Monk KR, Ying Y, Jeong SJ, Makinodan M, Bialas AR, Chang BS, Stevens B, Corfas G, Piao X. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun. 2015 Jan 21; 6:6121. View abstract
  14. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol Rev. 2015; 67(2):338-67. View abstract
  15. Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2014 Dec; 1333:43-64. View abstract
  16. White JP, Wrann CD, Rao RR, Nair SK, Jedrychowski MP, You JS, Martínez-Redondo V, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X, Spiegelman BM. G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):15756-61. View abstract
  17. Luo R, Jeong SJ, Yang A, Wen M, Saslowsky DE, Lencer WI, Araç D, Piao X. Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation. PLoS One. 2014; 9(6):e100043. View abstract
  18. Bae BI, Tietjen I, Atabay KD, Evrony GD, Johnson MB, Asare E, Wang PP, Murayama AY, Im K, Lisgo SN, Overman L, Šestan N, Chang BS, Barkovich AJ, Grant PE, Topçu M, Politsky J, Okano H, Piao X, Walsh CA. Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. Science. 2014 Feb 14; 343(6172):764-8. View abstract
  19. Wu MP, Doyle JR, Barry B, Beauvais A, Rozkalne A, Piao X, Lawlor MW, Kopin AS, Walsh CA, Gussoni E. G-protein coupled receptor 56 promotes myoblast fusion through serum response factor- and nuclear factor of activated T-cell-mediated signalling but is not essential for muscle development in vivo. FEBS J. 2013 Dec; 280(23):6097-113. View abstract
  20. Jeong SJ, Luo R, Singer K, Giera S, Kreidberg J, Kiyozumi D, Shimono C, Sekiguchi K, Piao X. GPR56 functions together with a3ß1 integrin in regulating cerebral cortical development. PLoS One. 2013; 8(7):e68781. View abstract
  21. Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T. Dissecting signaling and functions of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2012 Dec; 1276:1-25. View abstract
  22. Singer K, Luo R, Jeong SJ, Piao X. GPR56 and the developing cerebral cortex: cells, matrix, and neuronal migration. Mol Neurobiol. 2013 Feb; 47(1):186-96. View abstract
  23. Jeong SJ, Luo R, Li S, Strokes N, Piao X. Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex. J Comp Neurol. 2012 Sep 01; 520(13):2930-40. View abstract
  24. Luo R, Jin Z, Deng Y, Strokes N, Piao X. Disease-associated mutations prevent GPR56-collagen III interaction. PLoS One. 2012; 7(1):e29818. View abstract
  25. Jeong SJ, Li S, Luo R, Strokes N, Piao X. Loss of Col3a1, the gene for Ehlers-Danlos syndrome type IV, results in neocortical dyslamination. PLoS One. 2012; 7(1):e29767. View abstract
  26. Luo R, Jeong SJ, Jin Z, Strokes N, Li S, Piao X. G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12925-30. View abstract
  27. Luo R, Yang HM, Jin Z, Halley DJ, Chang BS, MacPherson L, Brueton L, Piao X. A novel GPR56 mutation causes bilateral frontoparietal polymicrogyria. Pediatr Neurol. 2011 Jul; 45(1):49-53. View abstract
  28. Strokes N, Piao X. Adhesion-GPCRs in the CNS. Adv Exp Med Biol. 2010; 706:87-97. View abstract
  29. Yang YX, Guo J, Jin Z, Yoon SY, Choi JY, Wang MH, Piao XS, Kim BW, Chae BJ. Lysine restriction and realimentation affected growth, blood profiles and expression of genes related to protein and fat metabolism in weaned pigs. J Anim Physiol Anim Nutr (Berl). 2009 Dec; 93(6):732-43. View abstract
  30. Jin Z, Luo R, Piao X. GPR56 and its related diseases. Prog Mol Biol Transl Sci. 2009; 89:1-13. View abstract
  31. Koirala S, Jin Z, Piao X, Corfas G. GPR56-regulated granule cell adhesion is essential for rostral cerebellar development. J Neurosci. 2009 Jun 10; 29(23):7439-49. View abstract
  32. Yang YX, Guo J, Yoon SY, Jin Z, Choi JY, Piao XS, Kim BW, Ohh SJ, Wang MH, Chae BJ. Early energy and protein reduction: effects on growth, blood profiles and expression of genes related to protein and fat metabolism in broilers. Br Poult Sci. 2009 Mar; 50(2):218-27. View abstract
  33. Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes RO, Walsh CA, Corfas G, Piao X. GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci. 2008 May 28; 28(22):5817-26. View abstract
  34. Liu P, Piao XS, Kim SW, Wang L, Shen YB, Lee HS, Li SY. Effects of chito-oligosaccharide supplementation on the growth performance, nutrient digestibility, intestinal morphology, and fecal shedding of Escherichia coli and Lactobacillus in weaning pigs. J Anim Sci. 2008 Oct; 86(10):2609-18. View abstract
  35. Jin Z, Tietjen I, Bu L, Liu-Yesucevitz L, Gaur SK, Walsh CA, Piao X. Disease-associated mutations affect GPR56 protein trafficking and cell surface expression. Hum Mol Genet. 2007 Aug 15; 16(16):1972-85. View abstract
  36. Xianhua Piao and Christopher A. Walsh. GPR56 and Bilateral Frontoparietal Polymicrogyria. Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis. C.J. Epstein, R.P. Erickson, and A. Wynshaw-Boris eds. 2007; 1309-1312. View abstract
  37. Xianhua Piao. White Matter Injury. Primary Care of the Premature Infant. Brodsky D and Quellette MA eds. 2007. View abstract
  38. Zhaohui Jin, Ian Tietjen, Lihong Bu, Liqun Liu-Yesucevitz, Shantanu K. Gaur, Christopher A. Walsh, and Xianhua Piao. Disease-associated mutations affect intracellular traffic and function of GPR56. Pediatric Academic Societies 2007 Annual Meeting, May 3-8, 2007, Toronto, Canada. 2007. View abstract
  39. Zhaohui Jin, Ian Tietjen, Lihong Bu, Liqun Liu-Yesucevitz, Shantanu K. Gaur, Christopher A. Walsh, and Xianhua Piao. Posttranslational Modification of G Protein-coupled Receptor 56 (GPR56) is Essential for Its Function. G Protein-Coupled Receptors: Evolving Concepts and New Techniques (C1), Keystone, Colorado, February, 2006. 2006. View abstract
  40. Lihong Bu, Lei Xu, Anthony D. Hill, Liqun Liu-Yesucevitz, Richard O. Hynes, Christopher A. Walsh, and Xianhua Piao. Loss of GPR56 Function Leads to Cortical Lamination Defects. Gordon Conference—Neural Development, 2006, Salve Regina University, Newport, RI. 2006. View abstract
  41. Piao X, Chang BS, Bodell A, Woods K, Benzeev B, Topcu M, Guerrini R, Goldberg-Stern H, Sztriha L, Dobyns WB, Barkovich AJ, Walsh CA. Genotype-phenotype analysis of human frontoparietal polymicrogyria syndromes. Ann Neurol. 2005 Nov; 58(5):680-7. View abstract
  42. Xianhua Piao. The GPR56 Gene. International Symposium on Polymicrogyria Syndromes and Epilepsy. 2005. View abstract
  43. Xianhua Piao, Bernard S. Chang, Adria Bodell, Katherine Woods, BFPP clinical collaborative group, and Christopher A. Walsh. Mutations in GPR56 define classic Bilateral Frontoparietal Polymicrogyria (BFPP) syndrome. Pediatric Academic Societies 2005 Annual Meeting, Washington DC, May, 2005. 2005. View abstract
  44. Piao X, Walsh CA. A novel signaling mechanism in brain development. Pediatr Res. 2004 Sep; 56(3):309-10. View abstract
  45. Chang BS, Piao X, Giannini C, Cascino GD, Scheffer I, Woods CG, Topcu M, Tezcan K, Bodell A, Leventer RJ, Barkovich AJ, Grant PE, Walsh CA. Bilateral generalized polymicrogyria (BGP): a distinct syndrome of cortical malformation. Neurology. 2004 May 25; 62(10):1722-8. View abstract
  46. Piao X, Hill RS, Bodell A, Chang BS, Basel-Vanagaite L, Straussberg R, Dobyns WB, Qasrawi B, Winter RM, Innes AM, Voit T, Ross ME, Michaud JL, Déscarie JC, Barkovich AJ, Walsh CA. G protein-coupled receptor-dependent development of human frontal cortex. Science. 2004 Mar 26; 303(5666):2033-6. View abstract
  47. Xianhua Piao, Randall Collura, Alice S. Bailey, David Reich, Maryellen Ruvolo, and Christopher A. Walsh. Evolutionarily dynamic G-protein-coupled receptor regulates the development of human cerebral cortex. The American Society of Human Genetics 2004 Annual Meeting. 2004. View abstract
  48. Chang BS, Piao X, Bodell A, Basel-Vanagaite L, Straussberg R, Dobyns WB, Qasrawi B, Winter RM, Innes AM, Voit T, Grant PE, Barkovich AJ, Walsh CA. Bilateral frontoparietal polymicrogyria: clinical and radiological features in 10 families with linkage to chromosome 16. Ann Neurol. 2003 May; 53(5):596-606. View abstract
  49. Piao X, Basel-Vanagaite L, Straussberg R, Grant PE, Pugh EW, Doheny K, Doan B, Hong SE, Shugart YY, Walsh CA. An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21. Am J Hum Genet. 2002 Apr; 70(4):1028-33. View abstract
  50. Bennett DC, Trayner ID, Piao X, Easty DJ, Klüppel M, Alexander WS, Wagner EF, Bernstein A. recessive spotting: a linked locus that interacts with W/Kit but is not allelic. Genes Cells. 1998 Apr; 3(4):235-44. View abstract
  51. Piao X, Paulson R, van der Geer P, Pawson T, Bernstein A. Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14665-9. View abstract
  52. Piao X, Bernstein A. A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenicity, and differentiation of mast cells. Blood. 1996 Apr 15; 87(8):3117-23. View abstract
  53. Xianhua Piao. Ph.D. Dissertation: Oncogenic Property of the Kit Receptor and Its Activating Mutant Allele. 1996. View abstract
  54. Xu WM, Piao XH, Addy L, Jamal M, Minden MD, Messner HA. Minimal residual disease in bone marrow transplant recipients with chronic myeloid leukemia. Bone Marrow Transplant. 1994 Aug; 14(2):299-306. View abstract
  55. Piao X, Curtis JE, Minkin S, Minden MD, Bernstein A. Expression of the Kit and KitA receptor isoforms in human acute myelogenous leukemia. Blood. 1994 Jan 15; 83(2):476-81. View abstract
  56. Bai Y, Piao XH, Luo QL, Mao BZ. Monoclonal antibody 55 (CD10) and complement used for purging autologous bone marrow in common acute lymphoblastic leukemia. Chin Med J (Engl). 1990 May; 103(5):385-90. View abstract
  57. Bai Y, Lu S, and Piao XH. Killing of Acute Lymphoblastic Leukemic Cells with Cytotoxic Monoclonal Antibody CD7. Chinese Journal of Hematology. 1990; 11:519-524. View abstract
  58. Mao BZ, Luo QL, Bai Y, Piao XH, and Zhang ZH. In Vitro Autologous Bone Marrow Purging and Phase I Clinical Trial. Journal of Clinical Medicine. 1989; 14:434-439. View abstract
  59. Piao XH and Bai Y. Separation, Purging, and Preservation of Bone Marrow Cells in Autologous Bone Marrow Transplantation. Journal of Clinical Hematology. 1988; 1(1):22-29. View abstract
  60. Piao XH, Liu Y, Bai Y. Elimination of Leukemic Cells from Bone Marrow with Monoclonal Antibody. Chinese Journal of Hematology. 1988; 9:331-333. View abstract
  61. Xianhua Piao. M.Sc. Thesis: In Vitro Purging and Autologous Bone Marrow Transplantation in Common Acute Lymphoblastic Leukemia Patients. 1987. View abstract