MEDICAL SERVICES

EDUCATION

Undergraduate Degree

BS
  • Stonehill College , 1995 , Easton , MA

Medical School

  • State University of New York at Buffalo School of Medicine , 1999 , Buffalo , NY

Residency

Internal Medicine
  • Brown University Categorical Internal Medicine , 2002 , Providence , RI

Fellowship

Primary Care Sports Medicine
  • Boston Children's Hospital , 2004 , Boston , MA

Philosophy of Care

My path to becoming a doctor began with a passion for the power of science and innovation.  As I have progressed throughout my career I have come to find that the most important and fulfilling parts of the job are the personal interactions with patients.   As a non-surgical physician, and as a son of two teachers, I am proud to say that my communication skills are my strongest assets.  I know how essential it is to listen and convey a clear explanation and plan of care for every patient I see.

PROFESSIONAL HISTORY

Michael J. O'Brien, MD is a physician in the Sports Medicine Division at Boston Children's Hospital, and an Assistant Professor in Orthopedics at Harvard Medical School. He is the Director of the Sports Concussion Clinic and his clinical interests include concussion management, traumatic brain injury, exercise induced compartment syndrome, and many other sports-related injuries.


Dr. O'Brien is the team physician for the Roxbury Latin School and a staff physician at The Micheli Center for Sports Injury Prevention in Waltham. As a member of the Sports Medicine Division, he is proud to be a longtime part of the medical coverage team for events such as the Boston Marathon finish line and medical tent, the Boston Ballet, Bay State Games, and various synchronized ice skating and track and field championships. Dr. O'Brien lectures at national and international conferences on various sports medicine topics, with particular expertise in the evaluation and management of sports related concussions.

CERTIFICATIONS

  • American Board of Internal Medicine

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Howell DR, O'Brien MJ, Raghuram A, Shah AS, Meehan WP. Near Point of Convergence and Gait Deficits in Adolescents After Sport-Related Concussion. Clin J Sport Med. 2018 05; 28(3):262-267. View abstract
  2. Howell DR, O'Brien MJ, Fraser J, Meehan WP. Continuing Play, Symptom Severity, and Symptom Duration After Concussion in Youth Athletes. Clin J Sport Med. 2018 Jan 15. View abstract
  3. Deal JB, Smith E, Heard W, O'Brien MJ, Savoie FH. Platelet-Rich Plasma for Primary Treatment of Partial Ulnar Collateral Ligament Tears: MRI Correlation With Results. Orthop J Sports Med. 2017 Nov; 5(11):2325967117738238. View abstract
  4. O'Brien MJ, Howell DR, Pepin MJ, Meehan WP. Sport-Related Concussions: Symptom Recurrence After Return to Exercise. Orthop J Sports Med. 2017 Oct; 5(10):2325967117732516. View abstract
  5. Smith JS, Ramchandran S, Lafage V, Shaffrey CI, Ailon T, Klineberg E, Protopsaltis T, Schwab FJ, O'Brien M, Hostin R, Gupta M, Mundis G, Hart R, Kim HJ, Passias PG, Scheer JK, Deviren V, Burton DC, Eastlack R, Bess S, Albert TJ, Riew KD, Ames CP. Prospective Multicenter Assessment of Early Complication Rates Associated With Adult Cervical Deformity Surgery in 78 Patients. Neurosurgery. 2016 09; 79(3):378-88. View abstract
  6. Rush LN, Lake N, Stiefel EC, Hobgood ER, Ramsey JR, O'Brien MJ, Field LD, Savoie FH. Comparison of Short-term Complications Between 2 Methods of Coracoclavicular Ligament Reconstruction: A Multicenter Study. Orthop J Sports Med. 2016 Jul; 4(7):2325967116658419. View abstract
  7. Louis DN, O'Brien MJ, Young RH. The flowering of pathology as a medical discipline in Boston, 1892-c.1950: W.T. Councilman, FB Mallory, JH Wright, SB Wolbach and their descendants. Mod Pathol. 2016 09; 29(9):944-61. View abstract
  8. Howell DR, O'Brien MJ, Beasley MA, Mannix RC, Meehan WP. Initial somatic symptoms are associated with prolonged symptom duration following concussion in adolescents. Acta Paediatr. 2016 Sep; 105(9):e426-32. View abstract
  9. Smith JS, Lafage V, Shaffrey CI, Schwab F, Lafage R, Hostin R, O'Brien M, Boachie-Adjei O, Akbarnia BA, Mundis GM, Errico T, Kim HJ, Protopsaltis TS, Hamilton DK, Scheer JK, Sciubba D, Ailon T, Fu KM, Kelly MP, Zebala L, Line B, Klineberg E, Gupta M, Deviren V, Hart R, Burton D, Bess S, Ames CP. Outcomes of Operative and Nonoperative Treatment for Adult Spinal Deformity: A Prospective, Multicenter, Propensity-Matched Cohort Assessment With Minimum 2-Year Follow-up. Neurosurgery. 2016 06; 78(6):851-61. View abstract
  10. Howell DR, O'Brien M, Raghuram A, Meehan WP. Adolescents With Convergence Insufficiency Exhibit Gait Stability Deficits Acutely After Concussion: 2907 June 3 2: 00 PM - 2: 15 PM. Med Sci Sports Exerc. 2016 May; 48(5 Suppl 1):814-5. View abstract
  11. Herrera VL, Colby AH, Tan GA, Moran AM, O'Brien MJ, Colson YL, Ruiz-Opazo N, Grinstaff MW. Evaluation of expansile nanoparticle tumor localization and efficacy in a cancer stem cell-derived model of pancreatic peritoneal carcinomatosis. Nanomedicine (Lond). 2016 May; 11(9):1001-15. View abstract
  12. Kriz PK, Stein C, Kent J, Ruggieri D, Dolan E, O'Brien M, Meehan WP. Physical Maturity and Concussion Symptom Duration among Adolescent Ice Hockey Players. J Pediatr. 2016 Apr; 171:234-9.e1-2. View abstract
  13. Meehan WP, O'Brien MJ, Geminiani E, Mannix R. Initial symptom burden predicts duration of symptoms after concussion. J Sci Med Sport. 2016 Sep; 19(9):722-5. View abstract
  14. Savoie FH, O'Brien MJ. The Subscapularis-Sparing Approach in Humeral Head Replacement. Bull Hosp Jt Dis (2013). 2015 Dec; 73 Suppl 1:S148-53. View abstract
  15. Shapiro MC, Wong B, O'Brien MJ, Salama A. Mandibular Destruction Secondary to Invasion by Carcinoma Cuniculatum. J Oral Maxillofac Surg. 2015 Dec; 73(12):2343-51. View abstract
  16. Schroy PC, Wong JB, O'Brien MJ, Chen CA, Griffith JL. A Risk Prediction Index for Advanced Colorectal Neoplasia at Screening Colonoscopy. Am J Gastroenterol. 2015 Jul; 110(7):1062-71. View abstract
  17. O'Brien MJ, Zhao Q, Yang S. Colorectal serrated pathway cancers and precursors. Histopathology. 2015 Jan; 66(1):49-65. View abstract
  18. Qazi TM, O'Brien MJ, Farraye FA, Gould RW, Chen CA, Schroy PC. Epidemiology of goblet cell and microvesicular hyperplastic polyps. Am J Gastroenterol. 2014 Dec; 109(12):1922-32. View abstract
  19. Rodriguez-Diaz E, Huang Q, Cerda SR, O'Brien MJ, Bigio IJ, Singh SK. Endoscopic histological assessment of colonic polyps by using elastic scattering spectroscopy. Gastrointest Endosc. 2015 Mar; 81(3):539-47. View abstract
  20. O'Brien MJ, Meehan WP. Evaluating the risks and benefits of participation in high-school football. Virtual Mentor. 2014 Jul 01; 16(7):526-33. View abstract
  21. Rodriguez-Diaz E, Atkinson C, Jepeal LI, Berg A, Huang CS, Cerda SR, O'Brien MJ, Bigio IJ, Farraye FA, Singh SK. Elastic scattering spectroscopy as an optical marker of inflammatory bowel disease activity and subtypes. Inflamm Bowel Dis. 2014 Jun; 20(6):1029-36. View abstract
  22. Kim HJ, Boachie-Adjei O, Shaffrey CI, Schwab F, Lafage V, Bess S, Gupta MC, Smith JS, Deviren V, Akbarnia B, Mundis GM, O'Brien M, Hostin R, Ames C. Upper thoracic versus lower thoracic upper instrumented vertebrae endpoints have similar outcomes and complications in adult scoliosis. Spine (Phila Pa 1976). 2014 Jun 01; 39(13):E795-9. View abstract
  23. Drew DA, Devers TJ, O'Brien MJ, Horelik NA, Levine J, Rosenberg DW. HD chromoendoscopy coupled with DNA mass spectrometry profiling identifies somatic mutations in microdissected human proximal aberrant crypt foci. Mol Cancer Res. 2014 Jun; 12(6):823-9. View abstract
  24. Bess S, Line BG, Lafage V, Schwab F, Shaffrey CI, Hart RA, Boachie-Adjei O, Akbarnia BA, Ames CP, Burton DC, Deverin V, Fu KM, Gupta M, Hostin R, Kebaish K, Klineberg E, Mundis G, O'Brien M, Shelokov A, Smith JS. Does recombinant human bone morphogenetic protein-2 use in adult spinal deformity increase complications and are complications associated with location of rhBMP-2 use? A prospective, multicenter study of 279 consecutive patients. Spine (Phila Pa 1976). 2014 Feb 01; 39(3):233-42. View abstract
  25. Iagulli ND, Field LD, Hobgood ER, Hurt JA, Charles R, O'Brien MJ, Savoie FH. Surface Replacement Arthroplasty of the Humeral Head in Young, Active Patients: Midterm Results. Orthop J Sports Med. 2014 Jan; 2(1):2325967113519407. View abstract
  26. Brown NJ, Mannix RC, O'Brien MJ, Gostine D, Collins MW, Meehan WP. Effect of cognitive activity level on duration of post-concussion symptoms. Pediatrics. 2014 Feb; 133(2):e299-304. View abstract
  27. Deshpande A, Nelson D, Corless CL, Deshpande V, O'Brien MJ. Leiomyoma of the gastrointestinal tract with interstitial cells of Cajal: a mimic of gastrointestinal stromal tumor. Am J Surg Pathol. 2014 Jan; 38(1):72-7. View abstract
  28. Meehan WP, Mannix RC, O'Brien MJ, Collins MW. The prevalence of undiagnosed concussions in athletes. Clin J Sport Med. 2013 Sep; 23(5):339-42. View abstract
  29. Hart R, McCarthy I, O'brien M, Bess S, Line B, Adjei OB, Burton D, Gupta M, Ames C, Deviren V, Kebaish K, Shaffrey C, Wood K, Hostin R. Identification of decision criteria for revision surgery among patients with proximal junctional failure after surgical treatment of spinal deformity. Spine (Phila Pa 1976). 2013 Sep 01; 38(19):E1223-7. View abstract
  30. Schroy PC, Coe A, Chen CA, O'Brien MJ, Heeren TC. Prevalence of advanced colorectal neoplasia in white and black patients undergoing screening colonoscopy in a safety-net hospital. Ann Intern Med. 2013 Jul 02; 159(1):13-20. View abstract
  31. Mannix R, O'Brien MJ, Meehan WP. The epidemiology of outpatient visits for minor head injury: 2005 to 2009. Neurosurgery. 2013 Jul; 73(1):129-34; discussion 134. View abstract
  32. Gibson S, Nigrovic LE, O'Brien M, Meehan WP. The effect of recommending cognitive rest on recovery from sport-related concussion. Brain Inj. 2013; 27(7-8):839-42. View abstract
  33. Hostin R, McCarthy I, O'Brien M, Bess S, Line B, Boachie-Adjei O, Burton D, Gupta M, Ames C, Deviren V, Kebaish K, Shaffrey C, Wood K, Hart R. Incidence, mode, and location of acute proximal junctional failures after surgical treatment of adult spinal deformity. Spine (Phila Pa 1976). 2013 May 20; 38(12):1008-15. View abstract
  34. Agarwal S, Stucchi AF, Dendrinos K, Cerda S, O'Brien MJ, Becker JM, Heeren T, Farraye FA. Is pyloric gland metaplasia in ileal pouch biopsies a marker for Crohn's disease? Dig Dis Sci. 2013 Oct; 58(10):2918-25. View abstract
  35. Gillespie E, Leeman SE, Watts LA, Coukos JA, O'Brien MJ, Cerda SR, Farraye FA, Stucchi AF. Plasminogen activator inhibitor-1 is increased in colonic epithelial cells from patients with colitis-associated cancer. J Crohns Colitis. 2013 Jun; 7(5):403-11. View abstract
  36. Gillespie E, Leeman SE, Watts LA, Coukos JA, O'Brien MJ, Cerda SR, Farraye FA, Stucchi AF, Becker JM. Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer. Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17420-5. View abstract
  37. Huang CS, Farraye FA, Yang S, O'Brien MJ. The clinical significance of serrated polyps. Am J Gastroenterol. 2011 Feb; 106(2):229-40; quiz 241. View abstract
  38. Hetzel JT, Huang CS, Coukos JA, Omstead K, Cerda SR, Yang S, O'Brien MJ, Farraye FA. Variation in the detection of serrated polyps in an average risk colorectal cancer screening cohort. Am J Gastroenterol. 2010 Dec; 105(12):2656-64. View abstract
  39. Savoie FH, VanSice W, O'Brien MJ. Arthroscopic tennis elbow release. J Shoulder Elbow Surg. 2010 Mar; 19(2 Suppl):31-6. View abstract
  40. Lambert R, Kudo SE, Vieth M, Allen JI, Fujii H, Fujii T, Kashida H, Matsuda T, Mori M, Saito H, Shimoda T, Tanaka S, Watanabe H, Sung JJ, Feld AD, Inadomi JM, O'Brien MJ, Lieberman DA, Ransohoff DF, Soetikno RM, Zauber A, Teixeira CR, Rey JF, Jaramillo E, Rubio CA, Van Gossum A, Jung M, Jass JR, Triadafilopoulos G. Pragmatic classification of superficial neoplastic colorectal lesions. Gastrointest Endosc. 2009 Dec; 70(6):1182-99. View abstract
  41. Khalid O, Radaideh S, Cummings OW, O'Brien MJ, Goldblum JR, Rex DK. Reinterpretation of histology of proximal colon polyps called hyperplastic in 2001. World J Gastroenterol. 2009 Aug 14; 15(30):3767-70. View abstract
  42. O'Brien M, Curtis C, D'Hemecourt P, Proctor M. Case report: a case of persistent back pain and constipation in a 5-year-old boy. Phys Sportsmed. 2009 Apr; 37(1):133-7. View abstract
  43. Kovacheva VP, Davison JM, Mellott TJ, Rogers AE, Yang S, O'Brien MJ, Blusztajn JK. Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival. FASEB J. 2009 Apr; 23(4):1054-63. View abstract
  44. Kudo Se, Lambert R, Allen JI, Fujii H, Fujii T, Kashida H, Matsuda T, Mori M, Saito H, Shimoda T, Tanaka S, Watanabe H, Sung JJ, Feld AD, Inadomi JM, O'Brien MJ, Lieberman DA, Ransohoff DF, Soetikno RM, Triadafilopoulos G, Zauber A, Teixeira CR, Rey JF, Jaramillo E, Rubio CA, Van Gossum A, Jung M, Vieth M, Jass JR, Hurlstone PD. Nonpolypoid neoplastic lesions of the colorectal mucosa. Gastrointest Endosc. 2008 Oct; 68(4 Suppl):S3-47. View abstract
  45. O'Brien MJ. 5 approaches to leading successful organizational change. Healthc Financ Manage. 2008 Sep; 62(9):138, 140. View abstract
  46. O'Brien M. Leading innovation in a risk-averse healthcare environment. Healthc Financ Manage. 2008 Aug; 62(8):112-4. View abstract
  47. Kokkotou E, Moss AC, Torres D, Karagiannides I, Cheifetz A, Liu S, O'Brien M, Maratos-Flier E, Pothoulakis C. Melanin-concentrating hormone as a mediator of intestinal inflammation. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10613-8. View abstract
  48. Gay J, Kokkotou E, O'Brien M, Pothoulakis C, Karalis KP. Corticotropin-releasing hormone deficiency is associated with reduced local inflammation in a mouse model of experimental colitis. Endocrinology. 2008 Jul; 149(7):3403-9. View abstract
  49. O'Brien M. Easing tensions between systems and hospitals for better performance. Trustee. 2008 Apr; 61(4):32-3. View abstract
  50. Kokkotou E, Moss AC, Michos A, Espinoza D, Cloud JW, Mustafa N, O'Brien M, Pothoulakis C, Kelly CP. Comparative efficacies of rifaximin and vancomycin for treatment of Clostridium difficile-associated diarrhea and prevention of disease recurrence in hamsters. Antimicrob Agents Chemother. 2008 Mar; 52(3):1121-6. View abstract
  51. O'Brien MJ. Hyperplastic and serrated polyps of the colorectum. Gastroenterol Clin North Am. 2007 Dec; 36(4):947-68, viii. View abstract
  52. Connelly M, O'Brien M. Beyond the hierarchy. Seven innovations have enabled this executive team to become more productive. Health Prog. 2007 Nov-Dec; 88(6):60-3. View abstract
  53. Glatz K, Pritt B, Glatz D, Hartmann A, O'Brien MJ, Blaszyk H. A multinational, internet-based assessment of observer variability in the diagnosis of serrated colorectal polyps. Am J Clin Pathol. 2007 Jun; 127(6):938-45. View abstract
  54. Rosenberg DW, Yang S, Pleau DC, Greenspan EJ, Stevens RG, Rajan TV, Heinen CD, Levine J, Zhou Y, O'Brien MJ. Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans. Cancer Res. 2007 Apr 15; 67(8):3551-4. View abstract
  55. Connelly MD, O'Brien MJ. Reorganize for effective communication. Changing expectations to get more accomplished. Healthc Exec. 2007 Mar-Apr; 22(2):54, 56-7. View abstract
  56. Katchar K, Kelly CP, Keates S, O'brien MJ, Keates AC. MIP-3alpha neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inflammation in mice. Am J Physiol Gastrointest Liver Physiol. 2007 May; 292(5):G1263-71. View abstract
  57. Jass JR, O'Brien MJ, Riddell RH, Snover DC. Recommendations for the reporting of surgically resected specimens of colorectal carcinoma. Hum Pathol. 2007 Apr; 38(4):537-545. View abstract
  58. Schwartz SA, Taljanovic MS, Smyth S, O'Brien MJ, Rogers LF. CT findings of rupture, impending rupture, and contained rupture of abdominal aortic aneurysms. AJR Am J Roentgenol. 2007 Jan; 188(1):W57-62. View abstract
  59. O'Brien MJ, Bloom A, LaBerge JM, Roberts JP, Rosenthal P, Kerlan RK. SIR 2006 Annual Meeting Film Panel Case: Budd-Chiari syndrome in a patient with Cogan syndrome. J Vasc Interv Radiol. 2006 Dec; 17(12):1881-3. View abstract
  60. O'Brien MJ, Yang S, Mack C, Xu H, Huang CS, Mulcahy E, Amorosino M, Farraye FA. Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points. Am J Surg Pathol. 2006 Dec; 30(12):1491-501. View abstract
  61. Jass JR, O'Brien MJ, Riddell RH, Snover DC. Recommendations for the reporting of surgically resected specimens of colorectal carcinoma. Virchows Arch. 2007 Jan; 450(1):1-13. View abstract
  62. Gay J, Kokkotou E, O'Brien M, Pothoulakis C, Karalis KP. Interleukin-6 genetic ablation protects from trinitrobenzene sulfonic acid-induced colitis in mice. Putative effect of antiinflammatory cytokines. Neuroimmunomodulation. 2006; 13(2):114-21. View abstract
  63. Dwarka D, Schwartz SA, Smyth SH, O'Brien MJ. Bradyarrhythmias during use of the AngioJet system. J Vasc Interv Radiol. 2006 Oct; 17(10):1693-5. View abstract
  64. Zeineldin R, Last JA, Slade AL, Ista LK, Bisong P, O'Brien MJ, Brueck SR, Sasaki DY, Lopez GP. Using bicellar mixtures to form supported and suspended lipid bilayers on silicon chips. Langmuir. 2006 Sep 12; 22(19):8163-8. View abstract
  65. Kokkotou E, Torres D, Moss AC, O'Brien M, Grigoriadis DE, Karalis K, Pothoulakis C. Corticotropin-releasing hormone receptor 2-deficient mice have reduced intestinal inflammatory responses. J Immunol. 2006 Sep 01; 177(5):3355-61. View abstract
  66. Stucchi A, Reed K, O'Brien M, Cerda S, Andrews C, Gower A, Bushell K, Amar S, Leeman S, Becker J. A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC. Inflamm Bowel Dis. 2006 Jul; 12(7):581-7. View abstract
  67. Chen X, Kokkotou EG, Mustafa N, Bhaskar KR, Sougioultzis S, O'Brien M, Pothoulakis C, Kelly CP. Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis. J Biol Chem. 2006 Aug 25; 281(34):24449-54. View abstract
  68. Rex DK, Kahi CJ, Levin B, Smith RA, Bond JH, Brooks D, Burt RW, Byers T, Fletcher RH, Hyman N, Johnson D, Kirk L, Lieberman DA, Levin TR, O'Brien MJ, Simmang C, Thorson AG, Winawer SJ. Guidelines for colonoscopy surveillance after cancer resection: a consensus update by the American Cancer Society and the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2006 May; 130(6):1865-71. View abstract
  69. Winawer SJ, Zauber AG, Fletcher RH, Stillman JS, O'Brien MJ, Levin B, Smith RA, Lieberman DA, Burt RW, Levin TR, Bond JH, Brooks D, Byers T, Hyman N, Kirk L, Thorson A, Simmang C, Johnson D, Rex DK. Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society. Gastroenterology. 2006 May; 130(6):1872-85. View abstract
  70. Rex DK, Kahi CJ, Levin B, Smith RA, Bond JH, Brooks D, Burt RW, Byers T, Fletcher RH, Hyman N, Johnson D, Kirk L, Lieberman DA, Levin TR, O'Brien MJ, Simmang C, Thorson AG, Winawer SJ. Guidelines for colonoscopy surveillance after cancer resection: a consensus update by the American Cancer Society and US Multi-Society Task Force on Colorectal Cancer. CA Cancer J Clin. 2006 May-Jun; 56(3):160-7; quiz 185-6. View abstract
  71. Winawer SJ, Zauber AG, Fletcher RH, Stillman JS, O'brien MJ, Levin B, Smith RA, Lieberman DA, Burt RW, Levin TR, Bond JH, Brooks D, Byers T, Hyman N, Kirk L, Thorson A, Simmang C, Johnson D, Rex DK. Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society. CA Cancer J Clin. 2006 May-Jun; 56(3):143-59; quiz 184-5. View abstract
  72. Taljanovic MS, Hunter TB, Freundlich IM, Mar WA, Smyth SH, O'Brien MJ. Misplaced devices in the chest, abdomen, and pelvis: Part II. Semin Ultrasound CT MR. 2006 Apr; 27(2):98-110. View abstract
  73. Taljanovic MS, Hunter TB, Freundlich IM, Mar WA, Smyth SH, O'Brien MJ. Misplaced devices in the chest, abdomen, and pelvis: Part I. Semin Ultrasound CT MR. 2006 Apr; 27(2):78-97. View abstract
  74. Karagiannides I, Kokkotou E, Tansky M, Tchkonia T, Giorgadze N, O'Brien M, Leeman SE, Kirkland JL, Pothoulakis C. Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5207-12. View abstract
  75. Yantiss RK, Farraye FA, O'Brien MJ, Fruin AB, Stucchi AF, Becker JM, Reddy SI, Odze RD. Prognostic significance of superficial fissuring ulceration in patients with severe "indeterminate" colitis. Am J Surg Pathol. 2006 Feb; 30(2):165-70. View abstract
  76. Nunes D, Fleming C, Offner G, O'Brien M, Tumilty S, Fix O, Heeren T, Koziel M, Graham C, Craven DE, Stuver S, Horsburgh CR. HIV infection does not affect the performance of noninvasive markers of fibrosis for the diagnosis of hepatitis C virus-related liver disease. J Acquir Immune Defic Syndr. 2005 Dec 15; 40(5):538-44. View abstract
  77. Reed KL, Fruin AB, Gower AC, Gonzales KD, Stucchi AF, Andry CD, O'Brien M, Becker JM. NF-kappaB activation precedes increases in mRNA encoding neurokinin-1 receptor, proinflammatory cytokines, and adhesion molecules in dextran sulfate sodium-induced colitis in rats. Dig Dis Sci. 2005 Dec; 50(12):2366-78. View abstract
  78. Garcia AL, Ista LK, Petsev DN, O'Brien MJ, Bisong P, Mammoli AA, Brueck SR, López GP. Electrokinetic molecular separation in nanoscale fluidic channels. Lab Chip. 2005 Nov; 5(11):1271-6. View abstract
  79. Rhee SH, Im E, Riegler M, Kokkotou E, O'brien M, Pothoulakis C. Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13610-5. View abstract
  80. Taljanovic MS, Hunter TB, O'Brien MJ, Schwartz SA. Gallery of medical devices: part 2: devices of the head, neck, spine, chest, and abdomen. Radiographics. 2005 Jul-Aug; 25(4):1119-32. View abstract
  81. Yang S, Farraye FA, Mack C, Posnik O, O'Brien MJ. BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am J Surg Pathol. 2004 Nov; 28(11):1452-9. View abstract
  82. Huang CS, O'brien MJ, Yang S, Farraye FA. Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway. Am J Gastroenterol. 2004 Nov; 99(11):2242-55. View abstract
  83. O'brien MJ, Winawer SJ, Zauber AG, Bushey MT, Sternberg SS, Gottlieb LS, Bond JH, Waye JD, Schapiro M. Flat adenomas in the National Polyp Study: is there increased risk for high-grade dysplasia initially or during surveillance? Clin Gastroenterol Hepatol. 2004 Oct; 2(10):905-11. View abstract
  84. Anton PM, O'Brien M, Kokkotou E, Eisenstein B, Michaelis A, Rothstein D, Paraschos S, Kelly CP, Pothoulakis C. Rifalazil treats and prevents relapse of clostridium difficile-associated diarrhea in hamsters. Antimicrob Agents Chemother. 2004 Oct; 48(10):3975-9. View abstract
  85. Labelle H, Roussouly P, Berthonnaud E, Transfeldt E, O'Brien M, Chopin D, Hresko T, Dimnet J. Spondylolisthesis, pelvic incidence, and spinopelvic balance: a correlation study. Spine (Phila Pa 1976). 2004 Sep 15; 29(18):2049-54. View abstract
  86. O'Brien M, Abeles J. Beyond "best intentions". Health Prog. 2004 Sep-Oct; 85(5):47-50, 60. View abstract
  87. Yantiss RK, Sapp HL, Farraye FA, El-Zammar O, O'Brien MJ, Fruin AB, Stucchi AF, Brien TP, Becker JM, Odze RD. Histologic predictors of pouchitis in patients with chronic ulcerative colitis. Am J Surg Pathol. 2004 Aug; 28(8):999-1006. View abstract
  88. Anton PM, Gay J, Mykoniatis A, Pan A, O'Brien M, Brown D, Karalis K, Pothoulakis C. Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation. Proc Natl Acad Sci U S A. 2004 Jun 01; 101(22):8503-8. View abstract
  89. Rabinovich E, Sviminoshvilli T, O'Brien MJ, Brueck SR, Lopez GP. Dual closed-loop, optoelectronic, auto-oscillatory detection circuit for monitoring fluorescence lifetime-based chemical sensors and biosensors. J Biomed Opt. 2004 May-Jun; 9(3):609-17. View abstract
  90. O'Brien MJ, Yang S, Clebanoff JL, Mulcahy E, Farraye FA, Amorosino M, Swan N. Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype. Am J Surg Pathol. 2004 Apr; 28(4):423-34. View abstract
  91. Lyman RL, O'Brien MJ. Nomothetic science and idiographic history in twentieth-century Americanist anthropology. J Hist Behav Sci. 2004; 40(1):77-96. View abstract
  92. Savidge TC, Pan WH, Newman P, O'brien M, Anton PM, Pothoulakis C. Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine. Gastroenterology. 2003 Aug; 125(2):413-20. View abstract
  93. Stucchi AF, Shebani KO, Leeman SE, Wang CC, Reed KL, Fruin AB, Gower AC, McClung JP, Andry CD, O'Brien MJ, Pothoulakis C, Becker JM. A neurokinin 1 receptor antagonist reduces an ongoing ileal pouch inflammation and the response to a subsequent inflammatory stimulus. Am J Physiol Gastrointest Liver Physiol. 2003 Dec; 285(6):G1259-67. View abstract
  94. Fruin AB, El-Zammer O, Stucchi AF, O'Brien M, Becker JM. Colonic metaplasia in the ileal pouch is associated with inflammation and is not the result of long-term adaptation. J Gastrointest Surg. 2003 Feb; 7(2):246-53; discussion 253-4. View abstract
  95. O'Brien MJ, Lyman RL, Saab Y, Saab E, Darwent J, Glover DS. Two issues in archaeological phylogenetics: taxon construction and outgroup selection. J Theor Biol. 2002 Mar 21; 215(2):133-50. View abstract
  96. Zauber AG, O'Brien MJ, Winawer SJ. On finding flat adenomas: is the search worth the gain? Gastroenterology. 2002 Mar; 122(3):839-40. View abstract
  97. O'Brien MJ, Pérez-Luna VH, Brueck SR, López GP. A surface plasmon resonance array biosensor based on spectroscopic imaging. Biosens Bioelectron. 2001 Jan; 16(1-2):97-108. View abstract
  98. Vaidya R, Tender LM, Bradley G, O'Brien MJ, Cone M, López GP. Computer-controlled laser ablation: a convenient and versatile tool for micropatterning biofunctional synthetic surfaces for applications in biosensing and tissue engineering. Biotechnol Prog. 1998 May-Jun; 14(3):371-7. View abstract