EDUCATION

Medical School

  • Albert Einstein College of Medicine , 2005 , Bronx , NY

Internship

  • Boston Children's Hospital/Boston Medical Center , 2006 , Boston , MA

Residency

Pediatrics
  • Boston Children's Hospital/Boston Medical Center , Boston , MA

Fellowship

Pediatric Hematology-Oncology
  • Dana-Farber Cancer Institute , 2011 , Boston , MA

PROFESSIONAL HISTORY

I am a Pediatric Oncology physician-scientist with an interest in translational research and a growing expertise in the care of pediatric solid tumor patients. I have followed a unique path, focused initially on the use of imaging to enhance diagnostics and therapeutics in pediatric solid tumor patients, now with an increasing interest in the Ewing sarcoma cell surfaceome and immune environment. My prior work generating a targeted imaging probe to more sensitively and specifically diagnose Ewing sarcoma micro-metastases inspired a growing interest in targeted immunotherapeutics. My subsequent training in cancer immunology, including but not limited to antibody humanization, characterization, and engineering, has generated the skills necessary to pursue novel immunotherapeutics for pediatric patients. In concert with my preclinical training, I have focused on developing clinical solid tumor expertise, recognizing my career goals of becoming a leader in the care of solid tumor patients with a focus on translational research and innovation.

I lead the Dana-Farber/Boston Children’s pediatric Liver Tumor Program, working closely with surgeons, interventional radiologists, and preclinical researchers to bring innovative care to patients with all types of primary liver tumors. I am involved nationally in the Children’s Oncology Group Liver Tumor Committee and internationally with the SIOP Liver Tumor Working Group working to author an upcoming collaborative international clinical trial. My unique split between patient care and research has allowed an opportunity to develop and refine skills in teaching medical students, residents and fellows, training laboratory technicians and post-doctoral fellows, and counseling trainees regarding the intricacies relevant to a career in translational research. With continued support from a multidisciplinary team, I hope to bring the power of cancer imaging and immunotherapy to bear on the diagnosis and treatment of pediatric solid tumor patients.

Research Overview

Currently investigating:

  1. Targeted Immunotherapy for Ewing Sarcoma - The long-term goal of this subset of projects is to develop new, targeted diagnostic and therapeutic options for patients with Ewing sarcoma focused on antibody-specific approaches.
  2. Improved Therapies for Pediatric Hepatocellular Carcinoma (HCC) - The over-arching goal of this group of projects is to better understand the genomic phenotype of pediatric hepatocellular carcinomas while identifying therapies, both standard and immonotherapeutic, that will yield improved outcomes. Dr. O'Neill has also authored the HCC arm of the Pediatric Hepatic International Tumors Trial (PHITT).
  3. Clinical Discovery in Pediatric Hepatoblastoma - Dr. O'Neill's interests in pediatric hepatoblastoma include better understanding the kinetics of alpha feto-protein and improving the treatment of patients with high risk disease. She coordinates the international Online Consultation Forum through SIOP which allows physicians worldwide the opportunity to discuss cases of a difficult nature with international experts. Institutionally, Dr. O'Neill heads the DFCI Liver Tumor Program working jointly with surgeons, preclinical researchers, and clinicians to assure a comprehensive patient-care experience.
  4. Oncology/Interventional Radiology Collaborative - The goal of this working relationship is to prioritize interventional techniques for patients with relapsed/refractory solid tumors and to better document our institutional experiences and outcomes utilizing these approaches.


CERTIFICATIONS

  • American Board of Pediatrics, General Pediatrics
  • American Board of Pediatrics, Pediatric Hematology and Oncology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Ramos-Gonzalez G, LaQuaglia M, O'Neill AF, Elisofon S, Zurakowski D, Kim HB, Vakili K. Long-term outcomes of liver transplantation for hepatoblastoma: A single-center 14-year experience. Pediatr Transplant. 2018 Jun 11; e13250. View abstract
  2. Ballinger ML, Best A, Mai PL, Khincha PP, Loud JT, Peters JA, Achatz MI, Chojniak R, Balieiro da Costa A, Santiago KM, Garber J, O'Neill AF, Eeles RA, Evans DG, Bleiker E, Sonke GS, Ruijs M, Loo C, Schiffman J, Naumer A, Kohlmann W, Strong LC, Bojadzieva J, Malkin D, Rednam SP, Stoffel EM, Koeppe E, Weitzel JN, Slavin TP, Nehoray B, Robson M, Walsh M, Manelli L, Villani A, Thomas DM, Savage SA. Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging: A Meta-analysis. JAMA Oncol. 2017 12 01; 3(12):1634-1639. View abstract
  3. O'Neill AF, Voss SD, Jagannathan JP, Kamihara J, Nibecker C, Itriago-Araujo E, Masciari S, Parker E, Barreto M, London WB, Garber JE, Diller L. Screening with whole-body magnetic resonance imaging in pediatric subjects with Li-Fraumeni syndrome: A single institution pilot study. Pediatr Blood Cancer. 2018 Feb; 65(2). View abstract
  4. O'Neill AF, Towbin AJ, Krailo MD, Xia C, Gao Y, McCarville MB, Meyers RL, McGahren ED, Tiao GM, Dunn SP, Langham MR, Weldon CB, Finegold MJ, Ranganathan S, Furman WL, Malogolowkin M, Rodriguez-Galindo C, Katzenstein HM. Characterization of Pulmonary Metastases in Children With Hepatoblastoma Treated on Children's Oncology Group Protocol AHEP0731 (The Treatment of Children With All Stages of Hepatoblastoma): A Report From the Children's Oncology Group. J Clin Oncol. 2017 Oct 20; 35(30):3465-3473. View abstract
  5. Pogoriler J, O'Neill AF, Voss SD, Shamberger RC, Perez-Atayde AR. Hepatocellular Carcinoma in Fanconi-Bickel Syndrome. Pediatr Dev Pathol. 2018 Jan-Feb; 21(1):84-90. View abstract
  6. Trobaugh-Lotrario AD, Meyers RL, O'Neill AF, Feusner JH. Unresectable hepatoblastoma: current perspectives. Hepat Med. 2017; 9:1-6. View abstract
  7. O'Neill AF, Hanto DW, Katzenstein HM. Cause and effect: the etiology of pediatric hepatocellular carcinoma and the role for liver transplantation. Pediatr Transplant. 2016 11; 20(7):878-879. View abstract
  8. O'Neill AF, Qin L, Wen PY, de Groot JF, Van den Abbeele AD, Yap JT. Demonstration of DCE-MRI as an early pharmacodynamic biomarker of response to VEGF Trap in glioblastoma. J Neurooncol. 2016 12; 130(3):495-503. View abstract
  9. O'Neill AF, Adil EA, Irace AL, Neff L, Davis IJ, Perez-Atayde AR, Voss SD, Weinberg O, Rahbar R. Post-transplant lymphoproliferative disorder of the pediatric airway: Presentation and management. Int J Pediatr Otorhinolaryngol. 2016 Jul; 86:218-23. View abstract
  10. O'Neill AF, Dearling JL, Wang Y, Tupper T, Sun Y, Aster JC, Calicchio ML, Perez-Atayde AR, Packard AB, Kung AL. Targeted imaging of Ewing sarcoma in preclinical models using a 64Cu-labeled anti-CD99 antibody. Clin Cancer Res. 2014 Feb 01; 20(3):678-87. View abstract
  11. Stewart AK, Shmukler BE, Vandorpe DH, Rivera A, Heneghan JF, Li X, Hsu A, Karpatkin M, O'Neill AF, Bauer DE, Heeney MM, John K, Kuypers FA, Gallagher PG, Lux SE, Brugnara C, Westhoff CM, Alper SL. Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Am J Physiol Cell Physiol. 2011 Dec; 301(6):C1325-43. View abstract
  12. Lin HW, O'Neill A, Rahbar R, Skinner ML. Ludwig's angina following frenuloplasty in an adolescent. Int J Pediatr Otorhinolaryngol. 2009 Sep; 73(9):1313-5. View abstract
  13. Lin HW, O'Neill A, Cunningham MJ. Ludwig's angina in the pediatric population. Clin Pediatr (Phila). 2009 Jul; 48(6):583-7. View abstract
  14. Satwani P, Ayello J, Ven C, O'Neill AF, Simpson LL, Baxi L, Cairo MS. Immaturity of IL-18 gene expression and protein production in cord blood (CB) versus peripheral blood (PB) mononuclear cells and differential effects in natural killer (NK) cell development and function. Br J Haematol. 2005 Jul; 130(2):284-92. View abstract
  15. Guest RD, Hawkins RE, Kirillova N, Cheadle EJ, Arnold J, O'Neill A, Irlam J, Chester KA, Kemshead JT, Shaw DM, Embleton MJ, Stern PL, Gilham DE. The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens. J Immunother. 2005 May-Jun; 28(3):203-11. View abstract
  16. Hirata K, Dufour JF, Shibao K, Knickelbein R, O'Neill AF, Bode HP, Cassio D, St-Pierre MV, Larusso NF, Leite MF, Nathanson MH. Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms. Hepatology. 2002 Aug; 36(2):284-96. View abstract
  17. O'Neill AF, Hagar RE, Zipfel WR, Nathanson MH, Ehrlich BE. Regulation of the type III InsP(3) receptor by InsP(3) and calcium. Biochem Biophys Res Commun. 2002 Jun 14; 294(3):719-25. View abstract
  18. Hirata K, Pusl T, O'Neill AF, Dranoff JA, Nathanson MH. The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes. Gastroenterology. 2002 Apr; 122(4):1088-100. View abstract
  19. Dranoff JA, O'Neill AF, Franco AM, Cai SY, Connolly GC, Ballatori N, Boyer JL, Nathanson MH. A primitive ATP receptor from the little skate Raja erinacea. J Biol Chem. 2000 Sep 29; 275(39):30701-6. View abstract
  20. Nathanson MH, O'Neill AF, Burgstahler AD. Primitive organization of cytosolic Ca(2+) signals in hepatocytes from the little skate Raja erinacea. J Exp Biol. 1999 Nov; 202(Pt 22):3049-56. View abstract