Leslie Lehmann

Leslie Lehmann, MD

Director, Clinical Stem Cell Transplantation Program

Assistant Professor of Pediatrics

    Contact: 617-632-4882
  • Fax: 617-632-4410

Medical Services

Specialties

  • Transplant for BM Failure Syndrome
  • Hematopoietic Stem Cell Transplantation for Sickle Cell Disease and Thalassemia
  • Hematopoietic Stem Cell Transplantation
  • Role of Exercise in Hematopoietic Stem Cell Transplantation
  • Second Transplants

Departments

  • Hematology / Oncology
  • Medicine

Programs

  • Lymphoma Program
  • Bone Marrow Failure Program
  • Hematology / Oncology
  • Stem Cell Transplantation
  • Stem Cell Transplantation
  • Hematology / Oncology
To schedule an appointment: Call 617-632-4882 or Request an Appointment

Experience and Education

Education

Duke University School of Medicine,

Durham, NC

Pediatric Hematology/Oncology

Boston Children's Hospital/Dana-Farber Cancer Institute,

Boston, MA

Pediatrics

Duke University School of Medicine,

Durham, NC

Certifications

  • Pediatric Hematology/Oncology, Pediatrics

Publications

Publications powered by Harvard Catalyst Profiles
  1. Shulman DS, Lee MA, Lehmann LE, Margossian SP. Outcomes Following Bone Marrow Transplantation in Children With Accelerated Phase or Blast Crisis Chronic Myelogenous Leukemia in the Era of Tyrosine Kinase Inhibitors. J Pediatr Hematol Oncol. 2016 Nov; 38(8):610-614.
  2. Rowe RG, Guo D, Lee M, Margossian S, London WB, Lehmann L. Cytomegalovirus Infection in Pediatric Hematopoietic Stem Cell Transplantation: Risk Factors for Primary Infection and Cases of Recurrent and Late Infection at a Single Center. Biol Blood Marrow Transplant. 2016 Jul; 22(7):1275-83.
  3. Al-Herz W, Chu JI, van der Spek J, Raghupathy R, Massaad MJ, Keles S, Biggs CM, Cockerton L, Chou J, Dbaibo G, Elisofon SA, Hanna-Wakim R, Kim HB, Lehmann LE, McDonald DR, Notarangelo LD, Veys P, Chatila TA, Geha RS, Gaspar HB, Pai SY. Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2016 Sep; 138(3):852-859.e3.
  4. Ullrich CK, Lehmann L, London WB, Guo D, Sridharan M, Koch R, Wolfe J. End-of-Life Care Patterns Associated with Pediatric Palliative Care among Children Who Underwent Hematopoietic Stem Cell Transplant. Biol Blood Marrow Transplant. 2016 Jun; 22(6):1049-55.
  5. Richardson PG, Riches ML, Kernan NA, Brochstein JA, Mineishi S, Termuhlen AM, Arai S, Grupp SA, Guinan EC, Martin PL, Steinbach G, Krishnan A, Nemecek ER, Giralt S, Rodriguez T, Duerst R, Doyle J, Antin JH, Smith A, Lehmann L, Champlin R, Gillio A, Bajwa R, D'Agostino RB, Massaro J, Warren D, Miloslavsky M, Hume RL, Iacobelli M, Nejadnik B, Hannah AL, Soiffer RJ. Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure. Blood. 2016 Mar 31; 127(13):1656-65.
  6. Stulac S, Mark Munyaneza RB, Chai J, Bigirimana JB, Nyishime M, Tapela N, Chaffee S, Lehmann L, Shulman LN. Initiating Childhood Cancer Treatment in Rural Rwanda: A Partnership-Based Approach. Pediatr Blood Cancer. 2016 May; 63(5):813-7.
  7. Lehmann L, El-Haddad A, Barr RD. Global Approach to Hematologic Malignancies. Hematol Oncol Clin North Am. 2016 Apr; 30(2):417-32.
  8. Elborai Y, Hafez H, Moussa EA, Hammad M, Hussein H, Lehmann L, Elhaddad A. Comparison of toxicity following different conditioning regimens (busulfan/melphalan and carboplatin/etoposide/melphalan) for advanced stage neuroblastoma: Experience of two transplant centers. Pediatr Transplant. 2016 Mar; 20(2):284-9.
  9. Poorvu PD, Barton SE, Duncan CN, London WB, Laufer MR, Lehmann LE, Marcus KJ. Use and Effectiveness of Gonadotropin-Releasing Hormone Agonists for Prophylactic Menstrual Suppression in Postmenarchal Women Who Undergo Hematopoietic Cell Transplantation. J Pediatr Adolesc Gynecol. 2016 Jun; 29(3):265-8.
  10. Stulac S, Binagwaho A, Tapela NM, Wagner CM, Muhimpundu MA, Ngabo F, Nsanzimana S, Kayonde L, Bigirimana JB, Lessard AJ, Lehmann L, Shulman LN, Nutt CT, Drobac P, Mpunga T, Farmer PE. Capacity building for oncology programmes in sub-Saharan Africa: the Rwanda experience. Lancet Oncol. 2015 Aug; 16(8):e405-13.
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  12. Mehta PA, Zhang MJ, Eapen M, He W, Seber A, Gibson B, Camitta BM, Kitko CL, Dvorak CC, Nemecek ER, Frangoul HA, Abdel-Azim H, Kasow KA, Lehmann L, Gonzalez Vicent M, Diaz Pérez MA, Ayas M, Qayed M, Carpenter PA, Jodele S, Lund TC, Leung WH, Davies SM. Transplantation Outcomes for Children with Hypodiploid Acute Lymphoblastic Leukemia. Biol Blood Marrow Transplant. 2015 Jul; 21(7):1273-7.
  13. Shulman DS, London WB, Guo D, Duncan CN, Lehmann LE. Incidence and causes of hospital readmission in pediatric patients after hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2015 May; 21(5):913-9.
  14. Huang JT, Duncan CN, Boyer D, Khosravi H, Lehmann LE, Saavedra A. Nail dystrophy, edema, and eosinophilia: harbingers of severe chronic GVHD of the skin in children. Bone Marrow Transplant. 2014 Dec; 49(12):1521-7.
  15. Madenci AL, Lehmann LE, Weldon CB. Surgical consultation and intervention during pediatric hematopoietic stem cell transplantation. Pediatr Transplant. 2014 Dec; 18(8):875-81.
  16. Pai SY, de Boer H, Massaad MJ, Chatila TA, Keles S, Jabara HH, Janssen E, Lehmann LE, Hanna-Wakim R, Dbaibo G, McDonald DR, Al-Herz W, Geha RS. Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency. J Allergy Clin Immunol. 2014 Jul; 134(1):221-3.
  17. Cohen LE, Gordon JH, Popovsky EY, Gunawardene S, Duffey-Lind E, Lehmann LE, Diller LR. Late effects in children treated with intensive multimodal therapy for high-risk neuroblastoma: high incidence of endocrine and growth problems. Bone Marrow Transplant. 2014 Apr; 49(4):502-8.
  18. Bitan M, He W, Zhang MJ, Abdel-Azim H, Ayas MF, Bielorai B, Carpenter PA, Cairo MS, Diaz MA, Horan JT, Jodele S, Kitko CL, Schultz KR, Kletzel M, Kasow KA, Lehmann LE, Mehta PA, Shah N, Pulsipher MA, Prestidge T, Seber A, Shenoy S, Woolfrey AE, Yu LC, Davies SM. Transplantation for children with acute myeloid leukemia: a comparison of outcomes with reduced intensity and myeloablative regimens. Blood. 2014 Mar 6; 123(10):1615-20.
  19. Hitzler JK, He W, Doyle J, Cairo M, Camitta BM, Chan KW, Diaz Perez MA, Fraser C, Gross TG, Horan JT, Kennedy-Nasser AA, Kitko C, Kurtzberg J, Lehmann L, O'Brien T, Pulsipher MA, Smith FO, Zhang MJ, Eapen M, Carpenter PA. Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome. Pediatr Blood Cancer. 2014 Jun; 61(6):1126-8.
  20. Meserve EE, Lehmann LE, Perez-Atayde AR, Labelle JL. Cyclophosphamide-associated cardiotoxicity in a child after stem cell transplantation for ß-thalassemia major: case report and review of the literature. Pediatr Dev Pathol. 2014 Jan-Feb; 17(1):50-4.
  21. Croteau SE, Luo HY, Lehmann LE, Chui DH, Neufeld EJ. Novel dominant ß-thalassemia: Hb Boston-Kuwait [codon 139/140(+T)]. Pediatr Blood Cancer. 2013 Oct; 60(10):E131-4.
  22. Duncan CN, Lehmann LE, Cheifetz IM, Greathouse K, Haight AE, Hall MW, Herschberger A, Hill KS, Moffet JR, Morrison RR, Norris AL, Petrovic A, Spear DA, Steiner ME, Talano JA, Tamburro RF, Wagner J, McArthur J. Clinical outcomes of children receiving intensive cardiopulmonary support during hematopoietic stem cell transplant. Pediatr Crit Care Med. 2013 Mar; 14(3):261-7.
  23. Hitzler JK, He W, Doyle J, Cairo M, Camitta BM, Chan KW, Diaz Perez MA, Fraser C, Gross TG, Horan JT, Kennedy-Nasser AA, Kitko C, Kurtzberg J, Lehmann L, O'Brien T, Pulsipher MA, Smith FO, Zhang MJ, Eapen M, Carpenter PA. Outcome of transplantation for acute myelogenous leukemia in children with Down syndrome. Biol Blood Marrow Transplant. 2013 Jun; 19(6):893-7.
  24. Richardson PG, Corbacioglu S, Ho VT, Kernan NA, Lehmann L, Maguire C, Maglio M, Hoyle M, Sardella M, Giralt S, Holler E, Carreras E, Niederwieser D, Soiffer R. Drug safety evaluation of defibrotide. Expert Opin Drug Saf. 2013 Jan; 12(1):123-36.
  25. Lo MS, Lee GM, Gunawardane N, Burchett SK, Lachenauer CS, Lehmann LE. The impact of RSV, adenovirus, influenza, and parainfluenza infection in pediatric patients receiving stem cell transplant, solid organ transplant, or cancer chemotherapy. Pediatr Transplant. 2013 Mar; 17(2):133-43.
  26. Elborai Y, Uwumugambi A, Lehmann L. Hematopoietic stem cell transplantation for thalassemia. Immunotherapy. 2012 Sep; 4(9):947-56.
  27. Treister N, Duncan C, Cutler C, Lehmann L. How we treat oral chronic graft-versus-host disease. Blood. 2012 Oct 25; 120(17):3407-18.
  28. Corbacioglu S, Kernan N, Lehmann L, Brochstein J, Revta C, Grupp S, Martin P, Richardson PG. Defibrotide for the treatment of hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation. Expert Rev Hematol. 2012 Jun; 5(3):291-302.
  29. Nahata L, Cohen LE, Lehmann LE, Yu RN. Semen analysis in adolescent cancer patients prior to bone marrow transplantation: when is it too late for fertility preservation? Pediatr Blood Cancer. 2013 Jan; 60(1):129-32.
  30. Lightdale JR, Randolph AG, Tran CM, Jiang H, Colon A, Houlahan K, Billet A, Sloan S, Lehmann LE. Impact of a conservative red blood cell transfusion strategy in children undergoing hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2012 May; 18(5):813-7.
  31. Oshrine B, Lehmann LE, Duncan CN. Safety and utility of liver biopsy after pediatric hematopoietic stem cell transplantation. J Pediatr Hematol Oncol. 2011 Apr; 33(3):e92-7.
  32. Daly KP, Colan SD, Blume ED, Margossian R, Gauvreau K, Duncan C, Lehmann LE, Chen MH. Changes in echocardiographic measures of systolic and diastolic function in children 1 year after hematopoietic SCT. Bone Marrow Transplant. 2011 Dec; 46(12):1532-9.
  33. Smith AR, Majhail NS, MacMillan ML, DeFor TE, Jodele S, Lehmann LE, Krance R, Davies SM. Hematopoietic cell transplantation comorbidity index predicts transplantation outcomes in pediatric patients. Blood. 2011 Mar 3; 117(9):2728-34.
  34. Duncan CN, Vrooman L, Apfelbaum EM, Whitley K, Bechard L, Lehmann LE. 25-hydroxy vitamin D deficiency following pediatric hematopoietic stem cell transplant. Biol Blood Marrow Transplant. 2011 May; 17(5):749-53.
  35. Duncan CN, Barry EV, Lehmann LE. Tolerability of pravastatin in pediatric hematopoietic stem cell transplant patients with bronchiolitis obliterans. J Pediatr Hematol Oncol. 2010 Apr; 32(3):185-8.
  36. Ullrich CK, Dussel V, Hilden JM, Sheaffer JW, Lehmann L, Wolfe J. End-of-life experience of children undergoing stem cell transplantation for malignancy: parent and provider perspectives and patterns of care. Blood. 2010 May 13; 115(19):3879-85.
  37. Kheir JN, Lawlor MW, Ahn ES, Lehmann L, Riviello JJ, Silvera VM, McManus M, Folkerth RD. Neuropathology of a fatal case of posterior reversible encephalopathy syndrome. Pediatr Dev Pathol. 2010 Sep-Oct; 13(5):397-403.
  38. Jacobsohn DA, Gilman AL, Rademaker A, Browning B, Grimley M, Lehmann L, Nemecek ER, Thormann K, Schultz KR, Vogelsang GB. Evaluation of pentostatin in corticosteroid-refractory chronic graft-versus-host disease in children: a Pediatric Blood and Marrow Transplant Consortium study. Blood. 2009 Nov 12; 114(20):4354-60.
  39. Kesselheim JC, Lehmann LE, Styron NF, Joffe S. Is blood thicker than water?: ethics of hematopoietic stem cell donation by biological siblings of adopted children. Arch Pediatr Adolesc Med. 2009 May; 163(5):413-6.
  40. Peritz DC, Duncan C, Kurek K, Perez-Atayde AR, Lehmann LE. Visceral varicella zoster virus (VZV) after allogeneic hematopoietic stem cell transplant (HSCT) in pediatric patients with chronic graft-versus-host disease (cGVHD). J Pediatr Hematol Oncol. 2008 Dec; 30(12):931-4.
  41. Grewal SS, Hunt JP, O'Connor SC, Gianturco LE, Richardson MW, Lehmann LE. Helicobacter pylori associated gastric Burkitt lymphoma. Pediatr Blood Cancer. 2008 Apr; 50(4):888-90.
  42. Duncan CN, Buonanno MR, Barry EV, Myers K, Peritz D, Lehmann L. Bronchiolitis obliterans following pediatric allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2008 Jun; 41(11):971-5.
  43. Al-Mohaya M, Treister N, Al-Khadra O, Lehmann L, Padwa B, Woo SB. Calcineurin inhibitor-associated oral inflammatory polyps after transplantation. J Oral Pathol Med. 2007 Oct; 36(9):570-4.
  44. Guinan EC, Kalish LA, Berry WS, McDaniel S, Lehmann LE, Diller LR. A novel pattern of transaminase elevation associated with autologous transplant for neuroblastoma. Pediatr Transplant. 2006 Sep; 10(6):669-76.
  45. Ullrich NJ, Marcus K, Pomeroy SL, Turner CD, Zimmerman M, Lehmann LE, Scott RM, Goumnerova L, Gillan E, Kieran MW, Chi SN. Transverse myelitis after therapy for primitive neuroectodermal tumors. Pediatr Neurol. 2006 Aug; 35(2):122-5.
  46. Lehmann L, Wagner J, Metzler M. Estrogenic and clastogenic potential of the mycotoxin alternariol in cultured mammalian cells. Food Chem Toxicol. 2006 Mar; 44(3):398-408.
  47. Treister NS, Woo SB, O'Holleran EW, Lehmann LE, Parsons SK, Guinan EC. Oral chronic graft-versus-host disease in pediatric patients after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2005 Sep; 11(9):721-31.
  48. Schumacher DM, Wagner J, Metzler M, Lehmann L. Influence of decreased intracellular glutathione level on the mutagenicity of patulin in cultured mouse lymphoma cells. Mycotoxin Res. 2005 Jun; 21(2):150-2.
  49. Lehmann L, Esch HL, Wagner J, Rohnstock L, Metzler M. Estrogenic and genotoxic potential of equol and two hydroxylated metabolites of Daidzein in cultured human Ishikawa cells. Toxicol Lett. 2005 Jul 28; 158(1):72-86.
  50. Bourquin JP, Thornley I, Neuberg D, Brennan L, Kung A, Clark J, Lehmann L, Guinan EC. Favorable outcome of allogeneic hematopoietic stem cell transplantation for relapsed or refractory acute promyelocytic leukemia in childhood. Bone Marrow Transplant. 2004 Nov; 34(9):795-8.
  51. Treister N, Lehmann LE, Cherrick I, Guinan EC, Woo SB. Dyskeratosis congenita vs. chronic graft versus host disease: report of a case and a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Nov; 98(5):566-71.
  52. Thornley I, Lehmann LE, Sung L, Holmes C, Spear JM, Brennan L, Vangel M, Bechard LJ, Richardson P, Duggan C, Guinan EC. A multiagent strategy to decrease regimen-related toxicity in children undergoing allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2004 Sep; 10(9):635-44.
  53. Levy O, Teixeira-Pinto A, White ML, Carroll SF, Lehmann L, Wypij D, Guinan E. Endotoxemia and elevation of lipopolysaccharide-binding protein after hematopoietic stem cell transplantation. Pediatr Infect Dis J. 2003 Nov; 22(11):978-81.
  54. Goldberg JM, Silverman LB, Levy DE, Dalton VK, Gelber RD, Lehmann L, Cohen HJ, Sallan SE, Asselin BL. Childhood T-cell acute lymphoblastic leukemia: the Dana-Farber Cancer Institute acute lymphoblastic leukemia consortium experience. J Clin Oncol. 2003 Oct 1; 21(19):3616-22.
  55. Thornley I, Lehmann L, Ferguson WS, Davis I, Forman EN, Guinan EC. Homozygous alpha-thalassemia treated with intrauterine transfusions and postnatal hematopoietic stem cell transplantation. Bone Marrow Transplant. 2003 Aug; 32(3):341-2.
  56. Duggan C, Bechard L, Donovan K, Vangel M, O'Leary A, Holmes C, Lehmann L, Guinan E. Changes in resting energy expenditure among children undergoing allogeneic stem cell transplantation. Am J Clin Nutr. 2003 Jul; 78(1):104-9.
  57. Levy O, Sisson RB, Fryer HE, Goldmann D, Valore E, Ganz T, White ML, Carroll SF, Lehmann L, Guinan EC. Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils. Transplantation. 2002 May 15; 73(9):1522-6.
  58. Pfeifer W, Levi E, Petrogiannis-Haliotis T, Lehmann L, Wang Z, Kadin ME. A murine xenograft model for human CD30+ anaplastic large cell lymphoma. Successful growth inhibition with an anti-CD30 antibody (HeFi-1). Am J Pathol. 1999 Oct; 155(4):1353-9.
  59. Parsons SK, Neault MW, Lehmann LE, Brennan LL, Eickhoff CE, Kretschmar CS, Diller LR. Severe ototoxicity following carboplatin-containing conditioning regimen for autologous marrow transplantation for neuroblastoma. Bone Marrow Transplant. 1998 Oct; 22(7):669-74.
  60. Lehmann LE, Guinan EC, Halpern SL, Donovan MJ, Bierer BE, Parsons SK. Isolated testicular relapse in an adolescent 5 years following allogeneic bone marrow transplantation for acute myelogenous leukemia. Bone Marrow Transplant. 1997 Apr; 19(8):849-51.
  61. Parsons SK, Castellino SM, Lehmann LE, Eickhoff CE, Tarbell NJ, Sallan SE, Weinstein HJ, Billett AL. Relapsed acute lymphoblastic leukemia: similar outcomes for autologous and allogeneic marrow transplantation in selected children. Bone Marrow Transplant. 1996 May; 17(5):763-8.
  62. Kern E, Lehmann L, Eckert E, Höcht B. [Mesenteric plication by the Childs-Phillips method for the prevention and therapy of small intestine obstructions. Experiences in 148 cases]. Chirurg. 1980 May; 51(5):308-12.
  63. Lehmann LE, Anupindi S, Harris NL. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 18-2003. A 15-year-old girl with pain in the left leg and back, pruritus, and thoracic lymphadenopathy. N Engl J Med. 2003 Jun 12; 348(24):2443-51.
  64. Hacein-Bey-Abina S, Pai SY, Gaspar HB, Armant M, Berry CC, Blanche S, Bleesing J, Blondeau J, de Boer H, Buckland KF, Caccavelli L, Cros G, De Oliveira S, Fernández KS, Guo D, Harris CE, Hopkins G, Lehmann LE, Lim A, London WB, van der Loo JC, Malani N, Male F, Malik P, Marinovic MA, McNicol AM, Moshous D, Neven B, Oleastro M, Picard C, Ritz J, Rivat C, Schambach A, Shaw KL, Sherman EA, Silberstein LE, Six E, Touzot F, Tsytsykova A, Xu-Bayford J, Baum C, Bushman FD, Fischer A, Kohn DB, Filipovich AH, Notarangelo LD, Cavazzana M, Williams DA, Thrasher AJ. A modified ?-retrovirus vector for X-linked severe combined immunodeficiency. N Engl J Med. 2014 Oct 9; 371(15):1407-17.
  65. Bona K, London WB, Guo D, Abel G, Lehmann L, Wolfe J. Prevalence and impact of financial hardship among New England pediatric stem cell transplantation families. Biol Blood Marrow Transplant. 2015 Feb; 21(2):312-8.
  66. Madenci AL, Stetson A, Weldon CB, Lehmann LE. Safety of peritoneal and pleural drain placement in pediatric stem cell transplant recipients with severe veno-occlusive disease. Pediatr Transplant. 2016 Aug; 20(5):687-91.
To schedule an appointment: Call 617-632-4882 or Request an Appointment

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