Jonathan Lipton MD

Jonathan Lipton, MD, PhD

Assistant in Neurology

Instructor of Neurology, Harvard Medical School

  • Contact: 781-216-2570

  • Fax: 781-216-2518

"My research seeks to understand the biological relationships between the circadian clock and diseases of the developing brain."

Medical Services

Specialties

  • Sleep Disorders

Departments

  • Neurology

Languages

  • English

Programs

  • Pediatric Sleep Disorders Center
To schedule an appointment: Call 781-216-2570 or Request an Appointment

Experience and Education

Education

Undergraduate

Brown University,

Providence, Rhode Island

Graduate

Albert Einstein College of Medicine, 2003

Bronx, New York

Medical School

Albery Einstein College of Medicine,

Bronx, New York

Internship

Pediatrics-Children's Hospital of Montefiore, 2004

Bronx, New York

Residency

Neurology - Boston Children's Hospital, 2005

Boston, Massachusetts

Fellowship

Sleep Medicine-Boston Children's Hospital & Beth Israel Deaconess Medical Center, 2008

Boston, Massachusetts

Certifications

  • Neurology with special qualifications in child neurology, Sleep Medicine

  • Neurology) American Board of Psychiatry and Neurology

Professional History

As a child neurologist and sleep physician, I am especially aware of the importance of sleep in children with neurological disease. My research seeks to understand the biological relationships between the circadian clock and diseases of the developing brain.

We have identified the core circadian clock protein BMAL1 as a regulator of protein synthesis. BMAL1 promotes circadian rhythms in protein synthesis as a substrate of the mechanistic target of rapamycin (mTOR) pathway, a critical gauge of nutritive status and stress in all cells, including the brain.

We have characterized a novel, potentially modifiable, link between the biological timing system and cellular signaling. Corroborating these findings, we have found strong phenotypes in mouse models of the mTOR-opathy Tuberous Sclerosis Complex. Using a combination of mouse behavior, cell biology, biochemistry, and proteomic approaches, my research investigates how circadian timing mechanisms are disrupted in disease.

My teaching activities include supervision of medical students, neurology residents, sleep medicine fellows, graduate students, and post-doctoral fellows. My educational role straddles both clinical and basic scientific domains and have widely at local, national, and international venues. 

To schedule an appointment: Call 781-216-2570 or Request an Appointment

Locations

The future of pediatrics will be forged by thinking differently, breaking paradigms and joining together in a shared vision of tackling the toughest challenges before us.”
- Sandra L. Fenwick, President and CEO

Boston Children's Hospital 300 Longwood Avenue, Boston, MA 02115 617-355-6000 | 800-355-7944

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