My research seeks to understand the biological relationships between the circadian clock and diseases of the developing brain.

MEDICAL SERVICES

Departments

Programs

Languages

  • English

EDUCATION

Undergraduate Degree

  • Brown University , Providence , RI

Medical School

  • Albert Einstein College of Medicine , Bronx , NY

Internship

Pediatrics
  • Children's Hospital of Montefiore , 2004 , Bronx , NY

Residency

Neurology
  • Boston Children's Hospital , 2005 , Boston , MA

Fellowship

Sleep Medicine
  • Boston Children's Hospital / Beth Israel Deaconess Medical Center , 2008 , Boston , MA

PROFESSIONAL HISTORY

As a child neurologist and sleep physician, I am especially aware of the importance of sleep in children with neurological disease. My research seeks to understand the biological relationships between the circadian clock and diseases of the developing brain.

We have identified the core circadian clock protein BMAL1 as a regulator of protein synthesis. BMAL1 promotes circadian rhythms in protein synthesis as a substrate of the mechanistic target of rapamycin (mTOR) pathway, a critical gauge of nutritive status and stress in all cells, including the brain.

We have characterized a novel, potentially modifiable, link between the biological timing system and cellular signaling. Corroborating these findings, we have found strong phenotypes in mouse models of the mTOR-opathy Tuberous Sclerosis Complex. Using a combination of mouse behavior, cell biology, biochemistry, and proteomic approaches, my research investigates how circadian timing mechanisms are disrupted in disease.

My teaching activities include supervision of medical students, neurology residents, sleep medicine fellows, graduate students, and post-doctoral fellows. My educational role straddles both clinical and basic scientific domains and have widely at local, national, and international venues. 

CERTIFICATIONS

  • American Board of Psychiatry and Neurology, Child and Adolescent Neurology
  • American Board of Psychiatry and Neurology, Sleep Medicine

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Archer TC, Ehrenberger T, Mundt F, Gold MP, Krug K, Mah CK, Mahoney EL, Daniel CJ, LeNail A, Ramamoorthy D, Mertins P, Mani DR, Zhang H, Gillette MA, Clauser K, Noble M, Tang LC, Pierre-François J, Silterra J, Jensen J, Tamayo P, Korshunov A, Pfister SM, Kool M, Northcott PA, Sears RC, Lipton JO, Carr SA, Mesirov JP, Pomeroy SL, Fraenkel E. Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups. Cancer Cell. 2018 Sep 10; 34(3):396-410.e8. View abstract
  2. Kelly E, Schaeffer SM, Dhamne SC, Lipton JO, Lindemann L, Honer M, Jaeschke G, Super CE, Lammers SH, Modi ME, Silverman JL, Dreier JR, Kwiatkowski DJ, Rotenberg A, Sahin M. mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex. Neuropsychopharmacology. 2018 May; 43(6):1457-1465. View abstract
  3. Lipton JO, Boyle LM, Yuan ED, Hochstrasser KJ, Chifamba FF, Nathan A, Tsai PT, Davis F, Sahin M. Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy. Cell Rep. 2017 07 25; 20(4):868-880. View abstract
  4. Scammell TE, Arrigoni E, Lipton JO. Neural Circuitry of Wakefulness and Sleep. Neuron. 2017 Feb 22; 93(4):747-765. View abstract
  5. Ebrahimi-Fakhari D, Saffari A, Wahlster L, DiNardo A, Turner D, Lewis TL, Conrad C, Rothberg JM, Lipton JO, Kölker S, Hoffmann GF, Han MJ, Polleux F, Sahin M. Impaired Mitochondrial Dynamics And Mitophagy In Neuronal Models Of Tuberous Sclerosis Complex. Cell Rep. 2016 11 15; 17(8):2162. View abstract
  6. Ebrahimi-Fakhari D, Saffari A, Wahlster L, Di Nardo A, Turner D, Lewis TL, Conrad C, Rothberg JM, Lipton JO, Kölker S, Hoffmann GF, Han MJ, Polleux F, Sahin M. Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex. Cell Rep. 2016 10 18; 17(4):1053-1070. View abstract
  7. Sun Y, Lipton JO, Boyle LM, Madsen JR, Goldenberg MC, Pascual-Leone A, Sahin M, Rotenberg A. Direct current stimulation induces mGluR5-dependent neocortical plasticity. Ann Neurol. 2016 08; 80(2):233-46. View abstract
  8. Lipton JO, Yuan ED, Boyle LM, Ebrahimi-Fakhari D, Kwiatkowski E, Nathan A, Güttler T, Davis F, Asara JM, Sahin M. The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation. Cell. 2015 May 21; 161(5):1138-1151. View abstract
  9. Lipton JO, Sahin M. The neurology of mTOR. Neuron. 2014 Oct 22; 84(2):275-91. View abstract
  10. Olson H, Shen Y, Avallone J, Sheidley BR, Pinsky R, Bergin AM, Berry GT, Duffy FH, Eksioglu Y, Harris DJ, Hisama FM, Ho E, Irons M, Jacobsen CM, James P, Kothare S, Khwaja O, Lipton J, Loddenkemper T, Markowitz J, Maski K, Megerian JT, Neilan E, Raffalli PC, Robbins M, Roberts A, Roe E, Rollins C, Sahin M, Sarco D, Schonwald A, Smith SE, Soul J, Stoler JM, Takeoka M, Tan WH, Torres AR, Tsai P, Urion DK, Weissman L, Wolff R, Wu BL, Miller DT, Poduri A. Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014 Jun; 75(6):943-58. View abstract
  11. Lipton J, Sahin M. Fragile X syndrome therapeutics: translation, meet translational medicine. Neuron. 2013 Jan 23; 77(2):212-3. View abstract
  12. Lipton J, Rivkin MJ. 16p11.2-related paroxysmal kinesigenic dyskinesia and dopa-responsive parkinsonism in a child. Neurology. 2009 Aug 11; 73(6):479-80. View abstract
  13. Lipton J, Megerian JT, Kothare SV, Cho YJ, Shanahan T, Chart H, Ferber R, Adler-Golden L, Cohen LE, Czeisler CA, Pomeroy SL. Melatonin deficiency and disrupted circadian rhythms in pediatric survivors of craniopharyngioma. Neurology. 2009 Jul 28; 73(4):323-5. View abstract
  14. Lipton J, Becker RE, Kothare SV. Insomnia of childhood. Curr Opin Pediatr. 2008 Dec; 20(6):641-9. View abstract
  15. Lipton J, Joffe S, Ullrich NJ. CNS relapse of acute myelogenous leukemia masquerading as pseudotumor cerebri. Pediatr Neurol. 2008 Nov; 39(5):355-7. View abstract
  16. Jonathan Lipton and Michael J. Rivkin. Kawasaki disease: cerebrovascular and neurologic complication. Uncommon Causes of Stroke. 2008. View abstract
  17. Lipton, J. and Rivkin, M.J. Kawasaki disease: cerebrovascular and neurologic complications. Uncommon Causes of Stroke (editor LR Caplan). 2008. View abstract
  18. Jonathan O. Lipton, Yoon-Jae Cho, Jonathan T. Megerian, Theresa Shanahan, Laurie Cohen, Richard Ferber, Charles Czeisler, Sanjeev V. Kothare, Scott L. Pomeroy. Disruption of Circadian Melatonin Secretion in Pediatric Craniopharyngioma Survivors with Hypersomnolence. Sleep (Abstract). 2008. View abstract
  19. Lipton, J. . Mating worms and the cystic kidney: C. elegans as a model for renal disease. Pediatric Nephrology. 2005; 20:1531-36. View abstract
  20. Lipton, J. , Kleemann, G., Ghosh, R., Lints, R., Emmons, S.W. . Mate searching in Caenorhabditis elegans: a genetic model for sex drive in a simple in vertebrate. Journal of Neuroscience. 2004; 24:7427-34. View abstract
  21. Emmons, S.W. and Lipton, J. The genetic basis of male mating behavior. Journal of Neurobiology. 2003; 54:93-110. View abstract
  22. Jonathan Oren Lipton. Genetics of Sexually Motivated Behavior in Caenorhabditis elegans. 2003. View abstract