Jonathan Lipton MD

Jonathan Lipton, MD, PhD

Assistant in Neurology

Instructor of Neurology, Harvard Medical School

  • Contact: 781-216-2570

  • Fax: 781-216-2518

"My research seeks to understand the biological relationships between the circadian clock and diseases of the developing brain."

Medical Services

Specialties

  • Sleep Disorders

Departments

  • Neurology

Languages

  • English

Programs

  • Pediatric Sleep Disorders Center
To schedule an appointment: Call 781-216-2570 or Request an Appointment

Experience and Education

Education

Undergraduate

Brown University,

Providence, Rhode Island

Graduate

Albert Einstein College of Medicine, 2003

Bronx, New York

Medical School

Albery Einstein College of Medicine,

Bronx, New York

Internship

Pediatrics-Children's Hospital of Montefiore, 2004

Bronx, New York

Residency

Neurology - Boston Children's Hospital, 2005

Boston, Massachusetts

Fellowship

Sleep Medicine-Boston Children's Hospital & Beth Israel Deaconess Medical Center, 2008

Boston, Massachusetts

Certifications

  • Neurology with special qualifications in child neurology, Sleep Medicine

  • Neurology) American Board of Psychiatry and Neurology

Professional History

As a child neurologist and sleep physician, I am especially aware of the importance of sleep in children with neurological disease. My research seeks to understand the biological relationships between the circadian clock and diseases of the developing brain.

We have identified the core circadian clock protein BMAL1 as a regulator of protein synthesis. BMAL1 promotes circadian rhythms in protein synthesis as a substrate of the mechanistic target of rapamycin (mTOR) pathway, a critical gauge of nutritive status and stress in all cells, including the brain.

We have characterized a novel, potentially modifiable, link between the biological timing system and cellular signaling. Corroborating these findings, we have found strong phenotypes in mouse models of the mTOR-opathy Tuberous Sclerosis Complex. Using a combination of mouse behavior, cell biology, biochemistry, and proteomic approaches, my research investigates how circadian timing mechanisms are disrupted in disease.

My teaching activities include supervision of medical students, neurology residents, sleep medicine fellows, graduate students, and post-doctoral fellows. My educational role straddles both clinical and basic scientific domains and have widely at local, national, and international venues. 

Publications

Publications powered by Harvard Catalyst
  1. Lipton JO, Yuan ED, Boyle LM, Ebrahimi-Fakhari D, Kwiatkowski E, Nathan A, Güttler T, Davis F, Asara JM, Sahin M. The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation. Cell. 2015 May 21; 161(5):1138-51.
  2. Lipton JO, Sahin M. The neurology of mTOR. Neuron. 2014 Oct 22; 84(2):275-91.
  3. Olson H, Shen Y, Avallone J, Sheidley BR, Pinsky R, Bergin AM, Berry GT, Duffy FH, Eksioglu Y, Harris DJ, Hisama FM, Ho E, Irons M, Jacobsen CM, James P, Kothare S, Khwaja O, Lipton J, Loddenkemper T, Markowitz J, Maski K, Megerian JT, Neilan E, Raffalli PC, Robbins M, Roberts A, Roe E, Rollins C, Sahin M, Sarco D, Schonwald A, Smith SE, Soul J, Stoler JM, Takeoka M, Tan WH, Torres AR, Tsai P, Urion DK, Weissman L, Wolff R, Wu BL, Miller DT, Poduri A. Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014 Jun; 75(6):943-58.
  4. Lipton J, Sahin M. Fragile X syndrome therapeutics: translation, meet translational medicine. Neuron. 2013 Jan 23; 77(2):212-3.
  5. Lipton J, Rivkin MJ. 16p11.2-related paroxysmal kinesigenic dyskinesia and dopa-responsive parkinsonism in a child. Neurology. 2009 Aug 11; 73(6):479-80.
  6. Lipton J, Megerian JT, Kothare SV, Cho YJ, Shanahan T, Chart H, Ferber R, Adler-Golden L, Cohen LE, Czeisler CA, Pomeroy SL. Melatonin deficiency and disrupted circadian rhythms in pediatric survivors of craniopharyngioma. Neurology. 2009 Jul 28; 73(4):323-5.
  7. Lipton J, Becker RE, Kothare SV. Insomnia of childhood. Curr Opin Pediatr. 2008 Dec; 20(6):641-9.
  8. Lipton J, Joffe S, Ullrich NJ. CNS relapse of acute myelogenous leukemia masquerading as pseudotumor cerebri. Pediatr Neurol. 2008 Nov; 39(5):355-7.
  9. Jonathan Lipton and Michael J. Rivkin. Kawasaki disease: cerebrovascular and neurologic complication. Uncommon Causes of Stroke. 2008.
  10. Lipton, J. and Rivkin, M.J. Kawasaki disease: cerebrovascular and neurologic complications. Uncommon Causes of Stroke (editor LR Caplan). 2008.
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  12. Jonathan O. Lipton, Yoon-Jae Cho, Jonathan T. Megerian, Theresa Shanahan, Laurie Cohen, Richard Ferber, Charles Czeisler, Sanjeev V. Kothare, Scott L. Pomeroy. Disruption of Circadian Melatonin Secretion in Pediatric Craniopharyngioma Survivors with Hypersomnolence. Sleep (Abstract). 2008.
  13. Lipton, J. . Mating worms and the cystic kidney: C. elegans as a model for renal disease. Pediatric Nephrology. 2005; 20:1531-36.
  14. Lipton, J. , Kleemann, G., Ghosh, R., Lints, R., Emmons, S.W. . Mate searching in Caenorhabditis elegans: a genetic model for sex drive in a simple in vertebrate. Journal of Neuroscience. 2004; 24:7427-34.
  15. Emmons, S.W. and Lipton, J. The genetic basis of male mating behavior. Journal of Neurobiology. 2003; 54:93-110.
  16. Jonathan Oren Lipton. Genetics of Sexually Motivated Behavior in Caenorhabditis elegans. 2003.
To schedule an appointment: Call 781-216-2570 or Request an Appointment

Locations

We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”
- Sandra L. Fenwick, President and CEO

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