I have had two major professional interests, pediatric cardiac intensive care and the pulmonary circulation, especially pulmonary hypertension. Being a member of the first cohort of pediatric cardiologists who took a special interest in critical care as it applies to pediatric patients with cardiac disease, I have been an active worker in the development of the field, and had deep involvement in a variety of domains. I look forward to continuing to provide clinical care in the CICU, and to helping to train pediatric cardiologists and others interested the critically ill cardiac patient.
My second major clinical and academic focus is the pulmonary circulation, especially pathological pulmonary vasoconstriction and remodeling. Earlier in my career, this interest took expression primarily in laboratory investigation of the pharmacology of the pulmonary vascular bed, and how mechanical forces impact pulmonary vascular smooth muscle growth and matrix protein expression. I left laboratory investigations as I moved my focus into the clinical and administrative arena. I have participated in the design and execution of a prospective, industry-sponsored clinical trial of sildenafil for pediatric pulmonary hypertension, and treated many patients for this affliction using conventional therapy.