Juan Ibla MD

Juan Ibla, MD

Senior Associate in Cardiac Anesthesia

Assistant Professor in Anaesthesia, Harvard Medical School

  • Contact: 617-355-7737

  • Fax: 617-730-0894

Medical Services

Specialties

  • Anesthesia

Departments

  • Anesthesiology Perioperative and Pain Medicine
To schedule an appointment: Call 617-355-7737

Experience and Education

Education

Medical School

Colombian School of Medicine, 1991

Bogota, Colombia

Fellowship, Pediatric Anesthesia and Critical Care

Boston Children's Hospital, 2000-2001

Boston, MA

Fellowship, Research

Boston Children's Hospital, 2001-2002

Boston, MA

Internship, Surgical

Boston University, 1996-1997

Boston, MA

Residency, Anesthesia

Brigham and Women's Hospital, 1997-2000

Boston, MA

Certifications

  • Anesthesia

Research

Pulmonary Biology, Lung Transplantatio

Publications

Publications powered by Harvard Catalyst
  1. Liu JR, Liu Q, Khoury J, Li YJ, Han XH, Li J, Ibla JC. Hypoxic preconditioning decreases nuclear factor ?B activity via Disrupted in Schizophrenia-1. Int J Biochem Cell Biol. 2016 Jan; 70:140-8.
  2. Wang RF, Zhang LH, Shan LH, Sun WG, Chai CC, Wu HM, Ibla JC, Wang LF, Liu JR. Effects of the fibroblast activation protein on the invasion and migration of gastric cancer. Exp Mol Pathol. 2013 Dec; 95(3):350-56.
  3. Dong HW, Zhang S, Sun WG, Liu Q, Ibla JC, Soriano SG, Han XH, Liu LX, Li MS, Liu JR. ß-Ionone arrests cell cycle of gastric carcinoma cancer cells by a MAPK pathway. Arch Toxicol. 2013 Oct; 87(10):1797-808.
  4. Ibla JC, Khoury J. Methods to assess tissue permeability. Methods Mol Biol. 2013; 1066:81-8.
  5. Liu Q, Dong HW, Sun WG, Liu M, Ibla JC, Liu LX, Parry JW, Han XH, Li MS, Liu JR. Apoptosis initiation of ß-ionone in SGC-7901 gastric carcinoma cancer cells via a PI3K-AKT pathway. Arch Toxicol. 2013 Mar; 87(3):481-90.
  6. Soriano SG, Liu Q, Li J, Liu JR, Han XH, Kanter JL, Bajic D, Ibla JC. Ketamine activates cell cycle signaling and apoptosis in the neonatal rat brain. Anesthesiology. 2010 May; 112(5):1155-63.
  7. Jia-Ren Liu, Juan C. Ibla, Qian Liu, Xiaohui Han, Joseph Khoury. Disrupted in Schizophrenia-1 (DISC1)Regulates ATM-mediated NFkappaB Activation during Hypoxia and Re-oxygenation. FASEB meeting. 2010.
  8. Soriano SG, Liu JR, Liu Q, Bajic D and Ibla JC. Dexmedetomidine is less pro-apoptotic than ketamine in the neonatal rat brain. ASA. 2009.
  9. Liu Q, Li J, Khoury J, Colgan SP, Ibla JC. Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation. J Biol Chem. 2009 May 15; 284(20):13686-95.
  10. Liu Q, Li J, Khoury J, Colgan SP and Ibla JC. Adenosine signaling mediates small ubiquitin-like protein (sumo-1) modification of IKappaBalpha during hypoxia and re-oxygenation. In press, Journal of Biological Chemistry. 2009.
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  12. Ibla JC. Anesthesia for Pediatric Thoracic Surgery. Springer Science and Business Media ( Phillip Hartigan). 2009.
  13. Ibla JC, Hayashi H, Bajic D and Soriano SG. Prolonged exposure to ketamine increases brain derived neurotrophic factor levels in developing rat brains. 2009; 4(1):11-16.
  14. Ibla JC, Hayashi H, Bajic D, Soriano SG. Prolonged exposure to ketamine increases brain derived neurotrophic factor levels in developing rat brains. Curr Drug Saf. 2009 Jan; 4(1):11-6.
  15. Soriano Sg, Li J, Liu Q, Athimaran U, Ibla JC. Noxious Stimulation Attenuates Ketamine and Isoflurane-Induced Neuroapoptosis in the P7 Rat Brain. ASA, 2008. 2008.
  16. Soriano SG, Li J, Liu Q, Kanter J, Ibla JC. Ketamine Activates Cell Cycle Events and Apoptosis in the Neonatal Rat Brain. ASA, 2008. 2008.
  17. Juan C. Ibla, Joseph Khoury, Andrew Neish and Sean P. Colgan. Pulmonary anti-inflammatory adaptation to hypoxia through adenosine-mediated Cullin-1 Deneddylation. ASA, San Francisco CA. 2007.
  18. Juan C. Ibla. Central Venous Access in the Neonate. 2007.
  19. Eckle T, Füllbier L, Wehrmann M, Khoury J, Mittelbronn M, Ibla J, Rosenberger P, Eltzschig HK. Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury. J Immunol. 2007 Jun 15; 178(12):8127-37.
  20. Ibla JC, Khoury J, Neish AS and Colgan SP. Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. FASEB meeting, 2007. Washington DC. 2007.
  21. Eckle T, Fullbier L, Wehrmann M, Khoury J, Ibla J, Rosenberg P and Eltzschig KH. Identification of ecto-nucleotidases CD39 and CD73 in innate protection during acute lung injury. J Immunol, In press. 2007.
  22. Khoury J, Ibla JC, Neish AS, Colgan SP. Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. J Clin Invest. 2007 Mar; 117(3):703-11.
  23. Juan C. Ibla and John H. Arnold. Mechanical Ventilation of the Neonate. Cambridge Press. 2007.
  24. Neukirchner G, Kim HG, Kang V, Okada N and Ibla JC. Early tracheal extubation after liver or multivisceral transplantation in infant and toddler recipients: Is it safe?. ASA. 2006.
  25. Ibla JC, Khoury J, Kong T, Robinson A and Colgan SP. Transcriptional Repression of Na-K-2Cl-cotransporter NKCC1 by Hypoxia Inducible Factor-1. AJP. Cell Physiol. 2006; 291:C282-C289.
  26. Khoury J, Ibla JC, Colgan SP. Identification of Molecular Anti-inflammatory Mechanisms of Adenosine: Cullin-1 Denedddylation during Hypoxic Preconditioning. 8th International Symposium on Adenosine and Adenine Nucleotides. 2006.
  27. Eltzschig HK, Faigle M, Knapp S, Karhausen J, Ibla J, Rosenberger P, Odegard KC, Laussen PC, Thompson LF, Colgan SP. Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. Blood. 2006 Sep 1; 108(5):1602-10.
  28. Eltzschig HK, Faigle M, Knapp S, Karhausen J, Ibla J, Rosenberger P, Odegard KC, Laussen PC, Thompson LF, Colgan SP. Endothelial Catabolism of Extracellular Adenosine during Hypoxia: Role of Surface Adenosine Deaminase and CD26. Blood. Epub ahead of print. 2006.
  29. Colgan SP, Khoury J, Robinson A, Kong T, Ibla JC. HIF-dependent Repression of Na-K-2Clcotransporter (NKCC1) in Hypoxia. FASEB meeting 2006. San Francisco CA. 2006.
  30. Ibla JC, Khoury J, Kong T, Robinson A, Colgan SP. Transcriptional repression of Na-K-2Cl cotransporter NKCC1 by hypoxia-inducible factor-1. Am J Physiol Cell Physiol. 2006 Aug; 291(2):C282-9.
  31. Kovatsis PG, Dumont RS, Ibla JC, Kang BV, Koka BV, Kussman BD, Myers LB, Okada NA, Seefelder C. Anesthetic Management of a Patient with Hepatopulmonary Syndrome, Prolonged QTc Interval and Panhypopituitarism for Liver Transplantation. Society of Pediatric Anesthesia meeting. 2006.
  32. Ibla JC, Khoury J. Methods to assess tissue permeability. Methods Mol Biol. 2006; 341:111-7.
  33. Khoury J, Ibla JC, Kong T, Robinson A, Colgan Sp. Transcriptional Repression of Na-K-2Cl-cotransporter (NKCC1) by Hypoxia Inducible Factor 1. Keystone Symposia. 2005.
  34. Kang VB, Soriano SG, Madril DR and Ibla JC. Anesthesia for Emergent non-cardiac Surgery in neonates with Unpalliated Hypoplastic Left Heart Syndrome. SPA/AAP. 2005.
  35. Juan C. Ibla, M.D. and Joseph Khoury,Ph.D. Methods in Molecular Biology. Methods to Assess Tissue Permeability. Cell-Cell Interactions. 2005; 341:111-117.
  36. Thompson LF, Eltzschig HK, Ibla JC, Van De Wiele CJ, Resta R, Morote-Garcia JC, Colgan SP. Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med. 2004 Dec 6; 200(11):1395-405.
  37. Ibla JC, Eltzschig HK, Resta R, Colgan SP and Thompson LF. Critical Role for ecto-5'nucleotidase in pulmonary vascular permeability during hypoxia. ASA. 2004.
  38. Eltzschig HK, Thompson LF, Karhausen J, Cotta RJ, Ibla JC, Robson SC, Colgan SP. Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood. 2004 Dec 15; 104(13):3986-92.
  39. Ibla JC, Eltzschig HK, Jacobson K, Enjoyoji K, Robson S and Colgan SP. The dynamic influences of hypoxia on extracellular nucleotide metabolism and nucleoside signalling. Purines 2004. 2004.
  40. Ibla JC, Hayashi H and Soriano SG. Prolonged Ketamine Administration increases brain derived neurotrophic factor in developing rat brains. 2003.
  41. Eltzschig HK, Ibla JC, Furuta GT, Leonard MO, Jacobson KA, Enjyoji K, Robson SC, Colgan SP. Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med. 2003 Sep 1; 198(5):783-96.
  42. Karhausen J, Ibla JC, Colgan SP. Implications of hypoxia on mucosal barrier function. Cell Mol Biol (Noisy-le-grand). 2003 Feb; 49(1):77-87.
  43. Ibla JC, Shamberger RC, DiCanzio J, Zurakowski D, Koka BV, Lillehei CW. Lung growth after reduced size transplantation in a sheep model. Transplantation. 1999 Jan 27; 67(2):233-40.
  44. Nobuhara KK, DiFiore JW, Ibla JC, Siddiqui AM, Ferretti ML, Fauza DO, Schnitzer JJ, Wilson JM. Insulin-like growth factor-I gene expression in three models of accelerated lung growth. J Pediatr Surg. 1998 Jul; 33(7):1057-60; discussion 1061.
  45. Tsakayannis DE, Siddiqui AM, Kozakewich H, Nobuhara KK, Ibla JC, Perry SD, Lillehei CW. The use of expandable metallic stents for acute tracheal stenosis in the growing lamb. J Pediatr Surg. 1998 Jul; 33(7):1038-41; discussion 1041-2.
  46. Ibla JC, Shamberger RC, DiCanzio J, Zurakowski D, Koka VB and Lillehei CW. Lung growth following reduced-size lung transplantation in a sheep model. 1998.
  47. Doctor A, Ibla JC, Grenier BM, Zurakowski D, Ferretti ML, Thompson JE, Lillehei CW, Arnold JH. Pulmonary blood flow distribution during partial liquid ventilation. J Appl Physiol (1985). 1998 May; 84(5):1540-50.
  48. Nobuhara KK, DiFiore JW, Ibla JC, Siddiqui AM, Ferreti M, Schitnzer JJ and Wilson JM. Insulin like growth factor I gene expression in three models of accelerated lung growth. 1997.
  49. Tsakayannis DE, Siddiqui AM, Ibla JC, Kozakewich H, Nobuhara KK, Perry S and Lillehei CW. The use of expandable metallic stents for acute tracheal stenosis in the growing lamb. 1997.
  50. Ibla JC, Arnold JH, Thompson JE, Breuer CK, Benjamin PK, Lillehei CW. Effects of nitric oxide on hyperinflation-induced pulmonary hypertension in the isolated-perfused lung. Crit Care Med. 1996 Aug; 24(8):1388-95.
  51. Nobuhara JJ, Slavin R, Ibla JC, Fauza DO, Fackler JC, Wilson JM. Continuos intrapulmonary distention with perfluorocarbon does not result in postnatal lung growth in adult sheep. 1996.
  52. Doctor A, Ibla JC, Grenier B, Thompson J, Lillehei CW and Arnold JH. Redistribution of pulmonary blood flow during partial liquid ventilation. 1996.
  53. Forbess JM, Ibla JC, Lidov HG, Cioffi MA, Hiramatsu T, Laussen P, Miura T, Jonas RA. University of Wisconsin cerebroplegia in a piglet survival model of circulatory arrest. Ann Thorac Surg. 1995 Dec; 60(6 Suppl):S494-500.
  54. Ibla JC, Arnold JH, Thompson JE, Breuer CK, Benjamin PK and Lillehei CW. The effect of nitric oxide on overdistention pulmonary hypertension in the isolated sheep lung model. 1995.
  55. Ibla JC, Rodriguez G, Pacheco C. Limb fractures associated with craneoencephalic trauma. 1991.
To schedule an appointment: Call 617-355-7737

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