- General Renal Program
Heidelberg University Medical School, 1982
Marburg University Children's Hospital, 1982-1985
Fellowship, Pediatric Nephrology
Marburg University Children's Hospital, 1985-1987
Yale University School of Medicine, 1987-1990
New Haven, CT
Dr. Hildebrandt’s research work is concerned with the identification and functional characterization of recessive single-gene causes of kidney diseases in children. His group has identified over 20 novel kidney disease genes and delineated the related pathogenesis. This work implicated the primary cilium and centrosomes in nephronophthisis, thereby contributing to the identification of “ciliopathies” as a new class of human disease. Gene identification also extends to nephrotic syndrome and congenital malformations of the kidney and urinary tract. His lab studies the function of newly identified disease genes in disease models of mice and zebrafish as well as in cell-based systems. His work was involved in the early development of efficient methods for gene identification by combining homozygosity mapping with total human exome resequencing. Recently, his lab discovered that DNA damage repair plays a role in the pathogenesis of ciliopathies (Chaki et al. Cell150:533-48, 2012; Zhou et al., Nat Genet 44:910-15; editorial p. 836-8). The research work of his lab has been supported solely by peer-reviewed research grants, mostly from the NIH, the HHMI, the Doris Duke Charitable Foundation, the March of Dimes, the Thrasher Research Foundation, and formerly the German Research Foundation. He has published over 220 original articles, many of them in high-ranking journals.