Jeffrey Goldsmith

Jeffrey Goldsmith, MD

Director, GI Pathology

Assistant Professor of Pathology, Harvard Medical School

  • Contact: 617-667-2586

  • Fax: 617-975-5620

Medical Services

Specialties

  • Gastrointestinal Pathology

Departments

  • Pathology

Programs

  • Center for Pediatric Polyposis
  • Pancreatic Disorders Program
To schedule an appointment: Call 617-667-2586

Experience and Education

Education

Undergraduate Degree, BS

University of Michigan, 1991

Ann Arbor, MI

Medical School

Wayne State University School of Medicine, 1996

Detroit, MI

Residency, Anatomic and Clinical Pathology

University of Pennsylvania Medical Center, 2000

Philadelphia, PA

Fellowship, Gastrointestinal, hepatic and surgical pathology

University of Pennsylvania Medical Center, 2002

Philadelphia, PA

Certifications

  • Anatomic and Clinical Pathology

Publications

Publications powered by Harvard Catalyst Profiles
  1. Adriaanse MP, Leffler DA, Kelly CP, Schuppan D, Najarian RM, Goldsmith JD, Buurman WA, Vreugdenhil AC. Serum I-FABP Detects Gluten Responsiveness in Adult Celiac Disease Patients on a Short-Term Gluten Challenge. Am J Gastroenterol. 2016 Jul; 111(7):1014-22.
  2. Zenlea T, Yee EU, Rosenberg L, Boyle M, Nanda KS, Wolf JL, Falchuk KR, Cheifetz AS, Goldsmith JD, Moss AC. Histology Grade Is Independently Associated With Relapse Risk in Patients With Ulcerative Colitis in Clinical Remission: A Prospective Study. Am J Gastroenterol. 2016 May; 111(5):685-90.
  3. Goldsmith JD, Fitzgibbons PL, Swanson PE. Principles of Analytic Validation of Clinical Immunohistochemistry Assays. Adv Anat Pathol. 2015 Nov; 22(6):384-7.
  4. Pogoriler J, Kamin D, Goldsmith JD. Pediatric non-Helicobacter pylori atrophic gastritis: a case series. Am J Surg Pathol. 2015 Jun; 39(6):786-92.
  5. Thaker AM, Allard F, Goldsmith J, Smith M, Horst D, Tapper EB. Giant Cystic Arteriovenous Malformation of the Mesentery and the Role of Cross-Sectional Imaging in Occult Gastrointestinal Bleeding. ACG Case Rep J. 2015 Apr; 2(3):158-60.
  6. Chou J, Massaad MJ, Cangemi B, Bainter W, Platt C, Badran YR, Raphael BP, Kamin DS, Goldsmith JD, Pai SY, Al-Herz W, Geha RS. A novel mutation in ICOS presenting as hypogammaglobulinemia with susceptibility to opportunistic pathogens. J Allergy Clin Immunol. 2015 Sep; 136(3):794-797.e1.
  7. Shillingford NM, Calicchio ML, Teot LA, Boyd T, Kurek KC, Goldsmith JD, Bousvaros A, Perez-Atayde AR, Kozakewich HP. Villin immunohistochemistry is a reliable method for diagnosing microvillus inclusion disease. Am J Surg Pathol. 2015 Feb; 39(2):245-50.
  8. Torlakovic EE, Nielsen S, Francis G, Garratt J, Gilks B, Goldsmith JD, Hornick JL, Hyjek E, Ibrahim M, Miller K, Petcu E, Swanson PE, Zhou X, Taylor CR, Vyberg M. Standardization of positive controls in diagnostic immunohistochemistry: recommendations from the International Ad Hoc Expert Committee. Appl Immunohistochem Mol Morphol. 2015 Jan; 23(1):1-18.
  9. Senapati GM, Sheiman RG, Almashat S, Goldsmith JD. Pleomorphic liposarcoma of the inferior vena cava. Radiographics. 2015 Jan-Feb; 35(1):269-74.
  10. Harris RM, Stillman IE, Goldsmith JD, Qian Q, Kirby JE. Pathological rib fracture and soft tissue mass simulating malignancy--Cryptococcus, an unsuspected culprit. Diagn Microbiol Infect Dis. 2015 Mar; 81(3):189-91.
  11. Show all
  12. Arnason T, Brown IS, Goldsmith JD, Anderson W, O'Brien BH, Wilson C, Winter H, Lauwers GY. Collagenous gastritis: a morphologic and immunohistochemical study of 40 patients. Mod Pathol. 2015 Apr; 28(4):533-44.
  13. Manfredi MA, Jiang H, Borges LF, Deutsch AJ, Goldsmith JD, Lightdale JR. Good agreement between endoscopic findings and biopsy reports supports limited tissue sampling during pediatric colonoscopy. J Pediatr Gastroenterol Nutr. 2014 Jun; 58(6):773-8.
  14. Alter RY, Wamsley CC, Mullen JT, Haile WZ, Goldsmith JD, Kasper EM. Peripheral nerve fibromyxoid sarcoma. J Neurosurg. 2014 Sep; 121(3):576-9.
  15. Fitzgibbons PL, Bradley LA, Fatheree LA, Alsabeh R, Fulton RS, Goldsmith JD, Haas TS, Karabakhtsian RG, Loykasek PA, Marolt MJ, Shen SS, Smith AT, Swanson PE. Principles of analytic validation of immunohistochemical assays: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center. Arch Pathol Lab Med. 2014 Nov; 138(11):1432-43.
  16. Almashat SJ, Duan L, Goldsmith JD. Non-reflux esophagitis: a review of inflammatory diseases of the esophagus exclusive of reflux esophagitis. Semin Diagn Pathol. 2014 Mar; 31(2):89-99.
  17. Lin YC, Goldsmith JD, Gebhardt MG, Wu JS. Bursal synovial chondromatosis formation following osteochondroma resection. Skeletal Radiol. 2014 Jul; 43(7):997-1000.
  18. Mohseni M, Sun J, Lau A, Curtis S, Goldsmith J, Fox VL, Wei C, Frazier M, Samson O, Wong KK, Wong KK, Kim C, Camargo FD. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. Nat Cell Biol. 2014 Jan; 16(1):108-17.
  19. Lee CH, Wu JS, Goldsmith JD, Kung JW. Reply to the letter to the editor: in response to "Lipomatosis of the sciatic nerve secondary to compression by a desmoid tumor". Skeletal Radiol. 2014 Feb; 43(2):131-2.
  20. Yee EU, Goldsmith JD. Diarrheal Illness in the Pediatric Population: A Review of Neonatal Enteropathies and Childhood Idiopathic Inflammatory Bowel Disease. Surg Pathol Clin. 2013 Sep; 6(3):523-43.
  21. Didolkar MM, Anderson ME, Hochman MG, Rissmiller JG, Goldsmith JD, Gebhardt MG, Wu JS. Image guided core needle biopsy of musculoskeletal lesions: are nondiagnostic results clinically useful? Clin Orthop Relat Res. 2013 Nov; 471(11):3601-9.
  22. Lee CH, Wu JS, Goldsmith JD, Kung JW. Lipomatosis of the sciatic nerve secondary to compression by a desmoid tumor. Skeletal Radiol. 2013 Dec; 42(12):1751-4.
  23. Ohla V, Ciarlini PD, Goldsmith JD, Kasper EM. Cellular myxoma of the lumbar spine. Surg Neurol Int. 2013; 4:82.
  24. Chen X, Yang G, Song JH, Xu H, Li D, Goldsmith J, Zeng H, Parsons-Wingerter PA, Reinecker HC, Kelly CP. Probiotic yeast inhibits VEGFR signaling and angiogenesis in intestinal inflammation. PLoS One. 2013; 8(5):e64227.
  25. Rosenberg L, Nanda KS, Zenlea T, Gifford A, Lawlor GO, Falchuk KR, Wolf JL, Cheifetz AS, Goldsmith JD, Moss AC. Histologic markers of inflammation in patients with ulcerative colitis in clinical remission. Clin Gastroenterol Hepatol. 2013 Aug; 11(8):991-6.
  26. Rosenberg L, Lawlor GO, Zenlea T, Goldsmith JD, Gifford A, Falchuk KR, Wolf JL, Cheifetz AS, Robson SC, Moss AC. Predictors of endoscopic inflammation in patients with ulcerative colitis in clinical remission. Inflamm Bowel Dis. 2013 Mar-Apr; 19(4):779-84.
  27. Kelly AD, Haibe-Kains B, Janeway KA, Hill KE, Howe E, Goldsmith J, Kurek K, Perez-Atayde AR, Francoeur N, Fan JB, April C, Schneider H, Gebhardt MC, Culhane A, Quackenbush J, Spentzos D. MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32. Genome Med. 2013; 5(1):2.
  28. Anderson ME, Goldsmith JD, Hochman MG, Taghinia A. Orthopaedic case of the month: pulsatile soft tissue mass. Clin Orthop Relat Res. 2012 Nov; 470(11):3275-9.
  29. Fountzilas E, Kelly AD, Perez-Atayde AR, Goldsmith J, Konstantinopoulos PA, Francoeur N, Correll M, Rubio R, Hu L, Gebhardt MC, Quackenbush J, Spentzos D. A microRNA activity map of human mesenchymal tumors: connections to oncogenic pathways; an integrative transcriptomic study. BMC Genomics. 2012; 13:332.
  30. Yaziji H, Eisen R, Wick M, Swanson P, Badve S, Cartun R, Haas T, Marolt M, Hicks D, Martin A, Barry T, Alsabeh R, Taylor J, Fulton R, Goldsmith J, Shen S, Taylor C. Immunohistochemistry cocktails are here to stay: Center of Medicare and Medicaid Services should revise its new reimbursement policy. Appl Immunohistochem Mol Morphol. 2012 Jul; 20(4):331-3.
  31. Nadig SN, Pedrosa I, Goldsmith JD, Callery MP, Vollmer CM. Clinical implications of mucinous nonneoplastic cysts of the pancreas. Pancreas. 2012 Apr; 41(3):441-6.
  32. Carbo AR, Blanco PG, Graeme-Cooke F, Misdraji J, Kappler S, Shaffer K, Goldsmith JD, Berzin T, Leffler D, Najarian R, Sepe P, Kaplan J, Pitman M, Goldman H, Pelletier S, Hayward JN, Shields HM. Revitalizing pathology laboratories in a gastrointestinal pathophysiology course using multimedia and team-based learning techniques. Pathol Res Pract. 2012 May 15; 208(5):300-5.
  33. Lin MM, Goldsmith JD, Resch SC, DeAngelis JP, Ramappa AJ. Histologic examinations of arthroplasty specimens are not cost-effective: a retrospective cohort study. Clin Orthop Relat Res. 2012 May; 470(5):1452-60.
  34. Kelly AD, Breitkopf SB, Yuan M, Goldsmith J, Spentzos D, Asara JM. Metabolomic profiling from formalin-fixed, paraffin-embedded tumor tissue using targeted LC/MS/MS: application in sarcoma. PLoS One. 2011; 6(10):e25357.
  35. Roshan B, Leffler DA, Jamma S, Dennis M, Sheth S, Falchuk K, Najarian R, Goldsmith J, Tariq S, Schuppan D, Kelly CP. The incidence and clinical spectrum of refractory celiac disease in a north american referral center. Am J Gastroenterol. 2011 May; 106(5):923-8.
  36. Goldsmith JD, Allred DC, Beasley MB, Eisen R, Fulton RS, Gown AM, Hammond ME. Fixation time does not affect expression of HER2/neu. Am J Clin Pathol. 2011 Mar; 135(3):484; author reply 485.
  37. Bergquist ER, Wu JS, Goldsmith JD, Anderson ME. Orthopaedic case of the month: ankle pain and swelling in a 23-year-old man. Clin Orthop Relat Res. 2010 Sep; 468(9):2556-60.
  38. Fox VL, Perros S, Jiang H, Goldsmith JD. Juvenile polyps: recurrence in patients with multiple and solitary polyps. Clin Gastroenterol Hepatol. 2010 Sep; 8(9):795-9.
  39. Qiu L, Pleskow DK, Chuttani R, Vitkin E, Leyden J, Ozden N, Itani S, Guo L, Sacks A, Goldsmith JD, Modell MD, Hanlon EB, Itzkan I, Perelman LT. Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett's esophagus. Nat Med. 2010 May; 16(5):603-6, 1p following 606.
  40. Konstantinopoulos PA, Fountzilas E, Goldsmith JD, Bhasin M, Pillay K, Francoeur N, Libermann TA, Gebhardt MC, Spentzos D. Analysis of multiple sarcoma expression datasets: implications for classification, oncogenic pathway activation and chemotherapy resistance. PLoS One. 2010; 5(4):e9747.
  41. Kung JW, Brown A, Kruskal JB, Goldsmith JD, Pedrosa I. Heterotopic pancreas: typical and atypical imaging findings. Clin Radiol. 2010 May; 65(5):403-7.
  42. McMahon CJ, Vollmer CM, Goldsmith J, Brown A, Pleskow D, Pedrosa I. An unusual variant of anomalous pancreaticobiliary junction in a patient with pancreas divisum diagnosed with secretin-magnetic resonance cholangiopancreatography. Pancreas. 2010 Jan; 39(1):101-4.
  43. Turner MS, Goldsmith JD. Best practices in diagnostic immunohistochemistry: spindle cell neoplasms of the gastrointestinal tract. Arch Pathol Lab Med. 2009 Sep; 133(9):1370-4.
  44. Chen X, Fruehauf J, Goldsmith JD, Xu H, Katchar KK, Koon HW, Zhao D, Kokkotou EG, Pothoulakis C, Kelly CP. Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice. Gastroenterology. 2009 Sep; 137(3):914-23.
  45. Pedrosa I, Lafornara M, Pandharipande PV, Goldsmith JD, Rofsky NM. Pregnant patients suspected of having acute appendicitis: effect of MR imaging on negative laparotomy rate and appendiceal perforation rate. Radiology. 2009 Mar; 250(3):749-57.
  46. Goldsmith JD, Siegal GP, Suster S, Wheeler TM, Brown RW. Reporting guidelines for clinical laboratory reports in surgical pathology. Arch Pathol Lab Med. 2008 Oct; 132(10):1608-16.
  47. Chen X, Katchar K, Goldsmith JD, Nanthakumar N, Cheknis A, Gerding DN, Kelly CP. A mouse model of Clostridium difficile-associated disease. Gastroenterology. 2008 Dec; 135(6):1984-92.
  48. Najarian RM, Hait EJ, Leichtner AM, Glickman JN, Antonioli DA, Goldsmith JD. Clinical significance of colonic intraepithelial lymphocytosis in a pediatric population. Mod Pathol. 2009 Jan; 22(1):13-20.
  49. Wu JS, Goldsmith JD, Horwich PJ, Shetty SK, Hochman MG. Bone and soft-tissue lesions: what factors affect diagnostic yield of image-guided core-needle biopsy? Radiology. 2008 Sep; 248(3):962-70.
  50. Oble DA, Mino-Kenudson M, Goldsmith J, Hodi FS, Seliem RM, Dranoff G, Mihm M, Hasserjian R, Lauwers GY. Alpha-CTLA-4 mAb-associated panenteritis: a histologic and immunohistochemical analysis. Am J Surg Pathol. 2008 Aug; 32(8):1130-7.
  51. Tummala S, Sheth SG, Goldsmith JD, Goldar-Najafi A, Murphy CK, Osburne MS, Mullin S, Buxton D, Wagner DA, Kelly CP. Quantifying gastric Helicobacter pylori infection: a comparison of quantitative culture, urease breath testing, and histology. Dig Dis Sci. 2007 Feb; 52(2):396-401.
  52. Krasinskas AM, Goldsmith JD, Burke A, Furth EE. Abnormal intrahepatic portal vasculature in native and allograft liver biopsies: a comparative analysis. Am J Surg Pathol. 2005 Oct; 29(10):1382-8.
  53. Kwon JH, Keates AC, Anton PM, Botero M, Goldsmith JD, Kelly CP. Topical antisense oligonucleotide therapy against LIX, an enterocyte-expressed CXC chemokine, reduces murine colitis. Am J Physiol Gastrointest Liver Physiol. 2005 Dec; 289(6):G1075-83.
  54. Johnson TR, Pedrosa I, Goldsmith J, Dewolf WC, Rofsky NM. Magnetic resonance imaging findings in solitary fibrous tumor of the kidney. J Comput Assist Tomogr. 2005 Jul-Aug; 29(4):481-3.
  55. Baroni RH, Pedrosa I, Tavernaraki E, Goldsmith J, Rofsky NM. Pancreatic sarcoidosis: MRI features. J Magn Reson Imaging. 2004 Nov; 20(5):889-93.
  56. Witkiewicz A, Goldsmith J, Pantanowitz L. Carotid body tumor (paraganglioma). Ear Nose Throat J. 2004 Jun; 83(6):384-5.
  57. Bates RC, Goldsmith JD, Bachelder RE, Brown C, Shibuya M, Oettgen P, Mercurio AM. Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids. Curr Biol. 2003 Sep 30; 13(19):1721-7.
  58. Pedrosa I, Guarise A, Goldsmith J, Procacci C, Rofsky NM. The interrupted rim sign in acute cholecystitis: a method to identify the gangrenous form with MRI. J Magn Reson Imaging. 2003 Sep; 18(3):360-3.
  59. Goldsmith JD. Cystic neoplasms of the pancreas. Am J Clin Pathol. 2003 Jun; 119 Suppl:S3-16.
  60. Goldsmith JD, Pawel B, Goldblum JR, Pasha TL, Roberts S, Nelson P, Khurana JS, Barr FG, Zhang PJ. Detection and diagnostic utilization of placental alkaline phosphatase in muscular tissue and tumors with myogenic differentiation. Am J Surg Pathol. 2002 Dec; 26(12):1627-33.
  61. Gupta AK, McKenna WG, Weber CN, Feldman MD, Goldsmith JD, Mick R, Machtay M, Rosenthal DI, Bakanauskas VJ, Cerniglia GJ, Bernhard EJ, Weber RS, Muschel RJ. Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction. Clin Cancer Res. 2002 Mar; 8(3):885-92.
  62. Ladanyi M, Antonescu CR, Leung DH, Woodruff JM, Kawai A, Healey JH, Brennan MF, Bridge JA, Neff JR, Barr FG, Goldsmith JD, Brooks JS, Goldblum JR, Ali SZ, Shipley J, Cooper CS, Fisher C, Skytting B, Larsson O. Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients. Cancer Res. 2002 Jan 1; 62(1):135-40.
  63. Goldsmith JD, van de Rijn M, Syed N. Orbital hemangiopericytoma and solitary fibrous tumor: a morphologic continuum. Int J Surg Pathol. 2001 Oct; 9(4):295-302.
  64. Goldsmith JD, Lai ML, Daniele GM, Tomaszewski JE, LiVolsi VA. Amyloid goiter: report of two cases and review of the literature. Endocr Pract. 2000 Jul-Aug; 6(4):318-23.
To schedule an appointment: Call 617-667-2586

Locations

We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”
- Sandra L. Fenwick, President and CEO

Boston Children's Hospital 300 Longwood Avenue, Boston, MA 02115 617-355-6000 | 800-355-7944

Close