Holcombe Grier

Holcombe E. Grier, MD

Consultant; Assistant in Medicine

Professor of Pediatrics, Harvard Medical School

  • Contact: 617-632-3971

  • Fax: 617-632-5710

Medical Services

Specialties

  • Ewing Sarcoma
  • Osteosarcoma
  • Rhabdomyosarcoma
  • Soft Tissue Sarcoma

Departments

  • Hematology / Oncology

Programs

  • Solid Tumor Program
To schedule an appointment: Call 617-632-3971 or Request an Appointment

Experience and Education

Education

Undergraduate Degree

Trinity College, 1972

Hartford, CT

Medical School

University of Pennsylvania School of Medicine, 1976

Philadelphia, PA

Internship

North Carolina Memorial Hospital, 1976-1977

Chapel Hill, NC

Residency

North Carolina Memorial Hospital, 1977-1980

Chapel Hill, NC

Fellowship, Pediatric Hematology/Oncology

Boston Children's Hospital / Dana-Farber Cancer Institute, 1981-1983

Boston, MA

Certifications

  • Pediatrics, Pediatric Hematology/Oncology, Internal Medicine

Professional History

Dr. Grier received his MD from the University of Pennsylvania in 1976, and then trained in pediatrics, internal medicine, and infectious disease at the University of North Carolina. He joined Dana-Farber Cancer Institute in 1984. He is a Past President of the American Society of Pediatric Hematology/Oncology and is a member of the steering committee for Bone Tumors in the Children’s Oncology Group.

Research

Sarcomas, Other Solid Tumors Detection and treatment of Ewing sarcoma, rhabdomyosarcoma, osteosarcoma, neuroblastoma and other pediatric soft tissue tumors 

Publications

Publications powered by Harvard Catalyst Profiles
  1. Wilejto M, Grier H, Shaikh F. Completion of Therapy Talk. J Oncol Pract. 2016 Sep; 12(9):769-71.
  2. Lagmay JP, Krailo MD, Dang H, Kim A, Hawkins DS, Beaty O, Widemann BC, Zwerdling T, Bomgaars L, Langevin AM, Grier HE, Weigel B, Blaney SM, Gorlick R, Janeway KA. Outcome of Patients With Recurrent Osteosarcoma Enrolled in Seven Phase II Trials Through Children's Cancer Group, Pediatric Oncology Group, and Children's Oncology Group: Learning From the Past to Move Forward. J Clin Oncol. 2016 Sep 1; 34(25):3031-8.
  3. Cash T, McIlvaine E, Krailo MD, Lessnick SL, Lawlor ER, Laack N, Sorger J, Marina N, Grier HE, Granowetter L, Womer RB, DuBois SG. Comparison of clinical features and outcomes in patients with extraskeletal versus skeletal localized Ewing sarcoma: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2016 Oct; 63(10):1771-9.
  4. Daw NC, Laack NN, McIlvaine EJ, Krailo M, Womer RB, Granowetter L, Grier HE, Marina NM, Bernstein ML, Gebhardt MC, Marcus KJ, Advani SM, Healey JH, Letson GD, Gorlick RG, Randall RL. Local Control Modality and Outcome for Ewing Sarcoma of the Femur: A Report From the Children's Oncology Group. Ann Surg Oncol. 2016 Oct; 23(11):3541-7.
  5. Vo KT, Edwards JV, Epling CL, Sinclair E, Hawkins DS, Grier HE, Janeway KA, Barnette P, McIlvaine E, Krailo MD, Barkauskas DA, Matthay KK, Womer RB, Gorlick RG, Lessnick SL, Mackall CL, DuBois SG. Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group. Clin Cancer Res. 2016 Jul 15; 22(14):3643-50.
  6. Marina N, Granowetter L, Grier HE, Womer RB, Randall RL, Marcus KJ, McIlvaine E, Krailo M. Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children's Oncology Group Report. Sarcoma. 2015; 2015:927123.
  7. Schwartz CL, Wexler LH, Krailo MD, Teot LA, Devidas M, Steinherz LJ, Goorin AM, Gebhardt MC, Healey JH, Sato JK, Meyers PA, Grier HE, Bernstein ML, Lipshultz SE. Intensified Chemotherapy With Dexrazoxane Cardioprotection in Newly Diagnosed Nonmetastatic Osteosarcoma: A Report From the Children's Oncology Group. Pediatr Blood Cancer. 2016 Jan; 63(1):54-61.
  8. Karski EE, McIlvaine E, Segal MR, Krailo M, Grier HE, Granowetter L, Womer RB, Meyers PA, Felgenhauer J, Marina N, DuBois SG. Identification of Discrete Prognostic Groups in Ewing Sarcoma. Pediatr Blood Cancer. 2016 Jan; 63(1):47-53.
  9. Hettmer S, Teot LA, Kozakewich H, Werger AM, Davies KJ, Fletcher CD, Grier HE, Rodriguez-Galindo C, Wagers AJ. Myogenic tumors in nevoid Basal cell carcinoma syndrome. J Pediatr Hematol Oncol. 2015 Mar; 37(2):147-9.
  10. DuBois SG, Krailo MD, Gebhardt MC, Donaldson SS, Marcus KJ, Dormans J, Shamberger RC, Sailer S, Nicholas RW, Healey JH, Tarbell NJ, Randall RL, Devidas M, Meyer JS, Granowetter L, Womer RB, Bernstein M, Marina N, Grier HE. Comparative evaluation of local control strategies in localized Ewing sarcoma of bone: a report from the Children's Oncology Group. Cancer. 2015 Feb 1; 121(3):467-75.
  11. Show all
  12. Meyer WH, Grier HE. Comparing oxazaphosphorines for treating Ewing sarcoma: is the answer important two decades later? J Clin Oncol. 2014 Aug 10; 32(23):2401-2.
  13. Gorlick S, Barkauskas DA, Krailo M, Piperdi S, Sowers R, Gill J, Geller D, Randall RL, Janeway K, Schwartz C, Grier H, Meyers PA, Gorlick R, Bernstein M, Marina N. HER-2 expression is not prognostic in osteosarcoma; a Children's Oncology Group prospective biology study. Pediatr Blood Cancer. 2014 Sep; 61(9):1558-64.
  14. Kenney LB, Duffey-Lind E, Ebb D, Sklar CA, Grier H, Diller L. Impaired testicular function after an ifosfamide-containing regimen for pediatric osteosarcoma: a case series and review of the literature. J Pediatr Hematol Oncol. 2014 Apr; 36(3):237-40.
  15. Hettmer S, Teot LA, van Hummelen P, MacConaill L, Bronson RT, Dall'Osso C, Mao J, McMahon AP, Gruber PJ, Grier HE, Rodriguez-Galindo C, Fletcher CD, Wagers AJ. Mutations in Hedgehog pathway genes in fetal rhabdomyomas. J Pathol. 2013 Sep; 231(1):44-52.
  16. Skapek SX, Anderson JR, Hill DA, Henry D, Spunt SL, Meyer W, Kao S, Hoffer FA, Grier HE, Hawkins DS, Raney RB. Safety and efficacy of high-dose tamoxifen and sulindac for desmoid tumor in children: results of a Children's Oncology Group (COG) phase II study. Pediatr Blood Cancer. 2013 Jul; 60(7):1108-12.
  17. Womer RB, West DC, Krailo MD, Dickman PS, Pawel BR, Grier HE, Marcus K, Sailer S, Healey JH, Dormans JP, Weiss AR. Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group. J Clin Oncol. 2012 Nov 20; 30(33):4148-54.
  18. Ebb D, Meyers P, Grier H, Bernstein M, Gorlick R, Lipshultz SE, Krailo M, Devidas M, Barkauskas DA, Siegal GP, Ferguson WS, Letson GD, Marcus K, Goorin A, Beardsley P, Marina N. Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group. J Clin Oncol. 2012 Jul 10; 30(20):2545-51.
  19. Janeway KA, Barkauskas DA, Krailo MD, Meyers PA, Schwartz CL, Ebb DH, Seibel NL, Grier HE, Gorlick R, Marina N. Outcome for adolescent and young adult patients with osteosarcoma: a report from the Children's Oncology Group. Cancer. 2012 Sep 15; 118(18):4597-605.
  20. Dubois SG, Shusterman S, Ingle AM, Ahern CH, Reid JM, Wu B, Baruchel S, Glade-Bender J, Ivy P, Grier HE, Adamson PC, Blaney SM. Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a children's oncology group study. Clin Cancer Res. 2011 Aug 1; 17(15):5113-22.
  21. Mack JW, Wolfe J, Cook EF, Grier HE, Cleary PD, Weeks JC. Parents' roles in decision making for children with cancer in the first year of cancer treatment. J Clin Oncol. 2011 May 20; 29(15):2085-90.
  22. DuBois SG, Stempak D, Wu B, Mokhtari RB, Nayar R, Janeway KA, Goldsby R, Grier HE, Baruchel S. Circulating endothelial cells and circulating endothelial precursor cells in patients with osteosarcoma. Pediatr Blood Cancer. 2012 Feb; 58(2):181-4.
  23. Williams DA, Porter ES, Lux SE, Grier HE, Mack JW, Orkin SH. Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute. Am J Hematol. 2010 Oct; 85(10):793-4.
  24. Debelenko LV, Perez-Atayde AR, Dubois SG, Grier HE, Pai SY, Shamberger RC, Kozakewich HP. p53+/mdm2- atypical lipomatous tumor/well-differentiated liposarcoma in young children: an early expression of Li-Fraumeni syndrome. Pediatr Dev Pathol. 2010 May-Jun; 13(3):218-24.
  25. Janeway KA, Grier HE. Sequelae of osteosarcoma medical therapy: a review of rare acute toxicities and late effects. Lancet Oncol. 2010 Jul; 11(7):670-8.
  26. Laufer MR, Upton J, Schuster SR, Grier H, Emans SJ, Diller L. Ovarian tissue autologous transplantation to the upper extremity for girls receiving abdominal/pelvic radiation: 20-year follow-up of reproductive endocrine function. J Pediatr Adolesc Gynecol. 2010 Apr; 23(2):107-10.
  27. Robson CD, Rahbar R, Vargas SO, Marcus KJ, Mack JW, Licameli GR, Grier HE. Sinonasal and laryngeal carcinoma in children: correlation of imaging characteristics with clinicopathologic and cytogenetic features. AJNR Am J Neuroradiol. 2010 Feb; 31(2):257-61.
  28. Klimo P, Codd PJ, Grier H, Goumnerova LC. Primary pediatric intraspinal sarcomas. Report of 3 cases. J Neurosurg Pediatr. 2009 Sep; 4(3):222-9.
  29. Mack JW, Wolfe J, Cook EF, Grier HE, Cleary PD, Weeks JC. Peace of mind and sense of purpose as core existential issues among parents of children with cancer. Arch Pediatr Adolesc Med. 2009 Jun; 163(6):519-24.
  30. DuBois SG, Grier HE. Chemotherapy: The role of ifosfamide and etoposide in Ewing sarcoma. Nat Rev Clin Oncol. 2009 May; 6(5):251-3.
  31. Granowetter L, Womer R, Devidas M, Krailo M, Wang C, Bernstein M, Marina N, Leavey P, Gebhardt M, Healey J, Shamberger RC, Goorin A, Miser J, Meyer J, Arndt CA, Sailer S, Marcus K, Perlman E, Dickman P, Grier HE. Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumors: a Children's Oncology Group Study. J Clin Oncol. 2009 May 20; 27(15):2536-41.
  32. Lewis MJ, DuBois SG, Fligor B, Li X, Goorin A, Grier HE. Ototoxicity in children treated for osteosarcoma. Pediatr Blood Cancer. 2009 Mar; 52(3):387-91.
  33. DuBois SG, Krailo MD, Lessnick SL, Smith R, Chen Z, Marina N, Grier HE, Stegmaier K. Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2009 Mar; 52(3):324-7.
  34. Leavey PJ, Mascarenhas L, Marina N, Chen Z, Krailo M, Miser J, Brown K, Tarbell N, Bernstein ML, Granowetter L, Gebhardt M, Grier HE. Prognostic factors for patients with Ewing sarcoma (EWS) at first recurrence following multi-modality therapy: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2008 Sep; 51(3):334-8.
  35. DuBois SG, Perez-Atayde AR, McLean TW, Grier HE. Late recurrence of ewing sarcoma during pregnancy: a report of 2 cases. J Pediatr Hematol Oncol. 2008 Sep; 30(9):716-8.
  36. Meyer JS, Nadel HR, Marina N, Womer RB, Brown KL, Eary JF, Gorlick R, Grier HE, Randall RL, Lawlor ER, Lessnick SL, Schomberg PJ, Kailo MD. Imaging guidelines for children with Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group Bone Tumor Committee. Pediatr Blood Cancer. 2008 Aug; 51(2):163-70.
  37. Wolfe J, Hammel JF, Edwards KE, Duncan J, Comeau M, Breyer J, Aldridge SA, Grier HE, Berde C, Dussel V, Weeks JC. Easing of suffering in children with cancer at the end of life: is care changing? J Clin Oncol. 2008 Apr 1; 26(10):1717-23.
  38. Meyers PA, Schwartz CL, Krailo MD, Healey JH, Bernstein ML, Betcher D, Ferguson WS, Gebhardt MC, Goorin AM, Harris M, Kleinerman E, Link MP, Nadel H, Nieder M, Siegal GP, Weiner MA, Wells RJ, Womer RB, Grier HE. Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology Group. J Clin Oncol. 2008 Feb 1; 26(4):633-8.
  39. Mack JW, Wolfe J, Cook EF, Grier HE, Cleary PD, Weeks JC. Hope and prognostic disclosure. J Clin Oncol. 2007 Dec 10; 25(35):5636-42.
  40. Miser JS, Goldsby RE, Chen Z, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, Gebhardt MC, Dickman PS, Perlman EJ, Meyers PA, Donaldson SS, Moore SG, Rausen AR, Vietti TJ, Grier HE. Treatment of metastatic Ewing sarcoma/primitive neuroectodermal tumor of bone: evaluation of increasing the dose intensity of chemotherapy--a report from the Children's Oncology Group. Pediatr Blood Cancer. 2007 Dec; 49(7):894-900.
  41. Schwartz CL, Gorlick R, Teot L, Krailo M, Chen Z, Goorin A, Grier HE, Bernstein ML, Meyers P. Multiple drug resistance in osteogenic sarcoma: INT0133 from the Children's Oncology Group. J Clin Oncol. 2007 May 20; 25(15):2057-62.
  42. DuBois SG, Elterman K, Grier HE. Early lymphocyte recovery in Ewing sarcoma. J Pediatr Hematol Oncol. 2007 May; 29(5):351-2.
  43. Mack JW, Cook EF, Wolfe J, Grier HE, Cleary PD, Weeks JC. Understanding of prognosis among parents of children with cancer: parental optimism and the parent-physician interaction. J Clin Oncol. 2007 Apr 10; 25(11):1357-62.
  44. Skapek SX, Ferguson WS, Granowetter L, Devidas M, Perez-Atayde AR, Dehner LP, Hoffer FA, Speights R, Gebhardt MC, Dahl GV, Grier HE. Vinblastine and methotrexate for desmoid fibromatosis in children: results of a Pediatric Oncology Group Phase II Trial. J Clin Oncol. 2007 Feb 10; 25(5):501-6.
  45. Parsons SK, Saiki-Craighill S, Mayer DK, Sullivan AM, Jeruss S, Terrin N, Tighiouart H, Nakagawa K, Iwata Y, Hara J, Grier HE, Block S. Telling children and adolescents about their cancer diagnosis: Cross-cultural comparisons between pediatric oncologists in the US and Japan. Psychooncology. 2007 Jan; 16(1):60-8.
  46. Mack JW, Wolfe J, Grier HE, Cleary PD, Weeks JC. Communication about prognosis between parents and physicians of children with cancer: parent preferences and the impact of prognostic information. J Clin Oncol. 2006 Nov 20; 24(33):5265-70.
  47. Bhatia S, Krailo MD, Chen Z, Burden L, Askin FB, Dickman PS, Grier HE, Link MP, Meyers PA, Perlman EJ, Rausen AR, Robison LL, Vietti TJ, Miser JS. Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: A report from the Children's Oncology Group. Blood. 2007 Jan 1; 109(1):46-51.
  48. Yock TI, Krailo M, Fryer CJ, Donaldson SS, Miser JS, Chen Z, Bernstein M, Laurie F, Gebhardt MC, Grier HE, Tarbell NJ. Local control in pelvic Ewing sarcoma: analysis from INT-0091--a report from the Children's Oncology Group. J Clin Oncol. 2006 Aug 20; 24(24):3838-43.
  49. Rahbar R, Grimmer JF, Vargas SO, Robson CD, Mack JW, Perez-Atayde AR, Marcus KJ, Grier HE, Healy GB, McGill TJ. Mucoepidermoid carcinoma of the parotid gland in children: A 10-year experience. Arch Otolaryngol Head Neck Surg. 2006 Apr; 132(4):375-80.
  50. Bernstein ML, Devidas M, Lafreniere D, Souid AK, Meyers PA, Gebhardt M, Stine K, Nicholas R, Perlman EJ, Dubowy R, Wainer IW, Dickman PS, Link MP, Goorin A, Grier HE. Intensive therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis: Pediatric Oncology Group/Children's Cancer Group Phase II Study 9457--a report from the Children's Oncology Group. J Clin Oncol. 2006 Jan 1; 24(1):152-9.
  51. Mack JW, Hilden JM, Watterson J, Moore C, Turner B, Grier HE, Weeks JC, Wolfe J. Parent and physician perspectives on quality of care at the end of life in children with cancer. J Clin Oncol. 2005 Dec 20; 23(36):9155-61.
  52. Meyers PA, Schwartz CL, Krailo M, Kleinerman ES, Betcher D, Bernstein ML, Conrad E, Ferguson W, Gebhardt M, Goorin AM, Harris MB, Healey J, Huvos A, Link M, Montebello J, Nadel H, Nieder M, Sato J, Siegal G, Weiner M, Wells R, Wold L, Womer R, Grier H. Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate. J Clin Oncol. 2005 Mar 20; 23(9):2004-11.
  53. Pappo AS, Devidas M, Jenkins J, Rao B, Marcus R, Thomas P, Gebhardt M, Pratt C, Grier HE. Phase II trial of neoadjuvant vincristine, ifosfamide, and doxorubicin with granulocyte colony-stimulating factor support in children and adolescents with advanced-stage nonrhabdomyosarcomatous soft tissue sarcomas: a Pediatric Oncology Group Study. J Clin Oncol. 2005 Jun 20; 23(18):4031-8.
  54. Viswanathan AN, Grier HE, Litman HJ, Perez-Atayde A, Tarbell NJ, Neuberg D, Shamberger RC, Marcus KJ. Outcome for children with group III rhabdomyosarcoma treated with or without radiotherapy. Int J Radiat Oncol Biol Phys. 2004 Mar 15; 58(4):1208-14.
  55. Mack JW, Grier HE. The Day One Talk. J Clin Oncol. 2004 Feb 1; 22(3):563-6.
  56. Rahbar R, Vargas SO, Miyamoto CR, Perez-Atayde AR, French CA, Robson CD, Licameli GR, Fletcher JA, Marcus KC, Grier HE, McGill TJ, Healy GB. The role of chromosomal translocation (15;19) in the carcinoma of the upper aerodigestive tract in children. Otolaryngol Head Neck Surg. 2003 Dec; 129(6):698-704.
  57. Marcus KJ, Shamberger R, Litman H, von Allmen D, Grupp SA, Nancarrow CM, Goldwein J, Grier HE, Diller L. Primary tumor control in patients with stage 3/4 unfavorable neuroblastoma treated with tandem double autologous stem cell transplants. J Pediatr Hematol Oncol. 2003 Dec; 25(12):934-40.
  58. Gorlick R, Anderson P, Andrulis I, Arndt C, Beardsley GP, Bernstein M, Bridge J, Cheung NK, Dome JS, Ebb D, Gardner T, Gebhardt M, Grier H, Hansen M, Healey J, Helman L, Hock J, Houghton J, Houghton P, Huvos A, Khanna C, Kieran M, Kleinerman E, Ladanyi M, Lau C, Malkin D, Marina N, Meltzer P, Meyers P, Schofield D, Schwartz C, Smith MA, Toretsky J, Tsokos M, Wexler L, Wigginton J, Withrow S, Schoenfeldt M, Anderson B. Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary. Clin Cancer Res. 2003 Nov 15; 9(15):5442-53.
  59. Shamberger RC, LaQuaglia MP, Gebhardt MC, Neff JR, Tarbell NJ, Marcus KC, Sailer SL, Womer RB, Miser JS, Dickman PS, Perlman EJ, Devidas M, Linda SB, Krailo MD, Grier HE, Granowetter L. Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg. 2003 Oct; 238(4):563-7; discussion 567-8.
  60. Lo Nostro F, Grier H, Andreone L, Guerrero GA. Involvement of the gonadal germinal epithelium during sex reversal and seasonal testicular cycling in the protogynous swamp eel, Synbranchus marmoratus Bloch 1795 (Teleostei, Synbranchidae). J Morphol. 2003 Jul; 257(1):107-26.
  61. Goorin AM, Schwartzentruber DJ, Devidas M, Gebhardt MC, Ayala AG, Harris MB, Helman LJ, Grier HE, Link MP. Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. J Clin Oncol. 2003 Apr 15; 21(8):1574-80.
  62. Lo Nostro FL, Grier H, Meijide FJ, Guerrero GA. Ultrastructure of the testis in Synbranchus marmoratus (Teleostei, Synbranchidae): the germinal compartment. Tissue Cell. 2003 Apr; 35(2):121-32.
  63. Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, Gebhardt MC, Dickman PS, Perlman EJ, Meyers PA, Donaldson SS, Moore S, Rausen AR, Vietti TJ, Miser JS. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med. 2003 Feb 20; 348(8):694-701.
  64. Yang R, Sowers R, Mazza B, Healey JH, Huvos A, Grier H, Bernstein M, Beardsley GP, Krailo MD, Devidas M, Bertino JR, Meyers PA, Gorlick R. Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples. Clin Cancer Res. 2003 Feb; 9(2):837-44.
  65. French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15; 63(2):304-7.
  66. Loh ML, Ahn P, Perez-Atayde AR, Gebhardt MC, Shamberger RC, Grier HE. Treatment of infantile fibrosarcoma with chemotherapy and surgery: results from the Dana-Farber Cancer Institute and Children's Hospital, Boston. J Pediatr Hematol Oncol. 2002 Dec; 24(9):722-6.
  67. Marler JJ, Rubin JB, Trede NS, Connors S, Grier H, Upton J, Mulliken JB, Folkman J. Successful antiangiogenic therapy of giant cell angioblastoma with interferon alfa 2b: report of 2 cases. Pediatrics. 2002 Feb; 109(2):E37.
  68. Goorin AM, Harris MB, Bernstein M, Ferguson W, Devidas M, Siegal GP, Gebhardt MC, Schwartz CL, Link M, Grier HE. Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: a pediatric oncology group trial. J Clin Oncol. 2002 Jan 15; 20(2):426-33.
  69. Norwitz ER, Stern HM, Grier H, Lee-Parritz A. Placenta percreta and uterine rupture associated with prior whole body radiation therapy. Obstet Gynecol. 2001 Nov; 98(5 Pt 2):929-31.
  70. Smith LM, Anderson JR, Qualman SJ, Crist WM, Paidas CN, Teot LA, Pappo AS, Link MP, Grier HE, Wiener ES, Breneman JC, Raney RB, Maurer HM, Donaldson SS. Which patients with microscopic disease and rhabdomyosarcoma experience relapse after therapy? A report from the soft tissue sarcoma committee of the children's oncology group. J Clin Oncol. 2001 Oct 15; 19(20):4058-64.
  71. Parsons SK, Fishman SJ, Hoorntje LE, Jaramillo D, Marcus KC, Perez-Atayde AR, Kozakewich HP, Grier HE, Shamberger RC. Aggressive multimodal treatment of pleuropulmonary blastoma. Ann Thorac Surg. 2001 Sep; 72(3):939-42.
  72. Wiener ES, Anderson JR, Ojimba JI, Lobe TE, Paidas C, Andrassy RJ, Raney RB, Qualman SJ, Donaldson SS, Maurer HM, Link MP, Crist WM, Grier HE. Controversies in the management of paratesticular rhabdomyosarcoma: is staging retroperitoneal lymph node dissection necessary for adolescents with resected paratesticular rhabdomyosarcoma? Semin Pediatr Surg. 2001 Aug; 10(3):146-52.
  73. Ferguson WS, Harris MB, Goorin AM, Gebhardt MC, Link MP, Shochat SJ, Siegal GP, Devidas M, Grier HE. Presurgical window of carboplatin and surgery and multidrug chemotherapy for the treatment of newly diagnosed metastatic or unresectable osteosarcoma: Pediatric Oncology Group Trial. J Pediatr Hematol Oncol. 2001 Aug-Sep; 23(6):340-8.
  74. Shamberger RC, Grier HE. Ewing's sarcoma/primitive neuroectodermal tumor of the chest wall. Semin Pediatr Surg. 2001 Aug; 10(3):153-60.
  75. Kenney LB, Laufer MR, Grant FD, Grier H, Diller L. High risk of infertility and long term gonadal damage in males treated with high dose cyclophosphamide for sarcoma during childhood. Cancer. 2001 Feb 1; 91(3):613-21.
  76. Wolfe J, Klar N, Grier HE, Duncan J, Salem-Schatz S, Emanuel EJ, Weeks JC. Understanding of prognosis among parents of children who died of cancer: impact on treatment goals and integration of palliative care. JAMA. 2000 Nov 15; 284(19):2469-75.
  77. Grupp SA, Stern JW, Bunin N, Nancarrow C, Ross AA, Mogul M, Adams R, Grier HE, Gorlin JB, Shamberger R, Marcus K, Neuberg D, Weinstein HJ, Diller L. Tandem high-dose therapy in rapid sequence for children with high-risk neuroblastoma. J Clin Oncol. 2000 Jul; 18(13):2567-75.
  78. Baker KS, Anderson JR, Link MP, Grier HE, Qualman SJ, Maurer HM, Breneman JC, Wiener ES, Crist WM. Benefit of intensified therapy for patients with local or regional embryonal rhabdomyosarcoma: results from the Intergroup Rhabdomyosarcoma Study IV. J Clin Oncol. 2000 Jun; 18(12):2427-34.
  79. Shamberger RC, Laquaglia MP, Krailo MD, Miser JS, Pritchard DJ, Gebhardt MC, Healey JH, Tarbell NJ, Fryer CJ, Meyers PA, Grier HE. Ewing sarcoma of the rib: results of an intergroup study with analysis of outcome by timing of resection. J Thorac Cardiovasc Surg. 2000 Jun; 119(6):1154-61.
  80. Wolfe J, Grier HE, Klar N, Levin SB, Ellenbogen JM, Salem-Schatz S, Emanuel EJ, Weeks JC. Symptoms and suffering at the end of life in children with cancer. N Engl J Med. 2000 Feb 3; 342(5):326-33.
  81. Grier HE. Soft tissue sarcoma: apples, oranges, and passion fruit. J Clin Oncol. 1999 Dec; 17(12):3695-6.
  82. Pappo AS, Anderson JR, Crist WM, Wharam MD, Breitfeld PP, Hawkins D, Raney RB, Womer RB, Parham DM, Qualman SJ, Grier HE. Survival after relapse in children and adolescents with rhabdomyosarcoma: A report from the Intergroup Rhabdomyosarcoma Study Group. J Clin Oncol. 1999 Nov; 17(11):3487-93.
  83. McLean TW, Hertel C, Young ML, Marcus K, Schizer MA, Gebhardt M, Weinstein HJ, Perez-Atayde A, Grier HE. Late events in pediatric patients with Ewing sarcoma/primitive neuroectodermal tumor of bone: the Dana-Farber Cancer Institute/Children's Hospital experience. J Pediatr Hematol Oncol. 1999 Nov-Dec; 21(6):486-93.
  84. Blakely ML, Lobe TE, Anderson JR, Donaldson SS, Andrassy RJ, Parham DM, Wharam MD, Qualman SJ, Wiener ES, Grier HE, Crist WM. Does debulking improve survival rate in advanced-stage retroperitoneal embryonal rhabdomyosarcoma? J Pediatr Surg. 1999 May; 34(5):736-41; discussion 741-2.
  85. Rubin BP, Chen CJ, Morgan TW, Xiao S, Grier HE, Kozakewich HP, Perez-Atayde AR, Fletcher JA. Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion: cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma. Am J Pathol. 1998 Nov; 153(5):1451-8.
  86. Pousti TJ, Upton J, Loh M, Grier H. Congenital fibrosarcoma of the upper extremity. Plast Reconstr Surg. 1998 Sep; 102(4):1158-62.
  87. Skapek SX, Hawk BJ, Hoffer FA, Dahl GV, Granowetter L, Gebhardt MC, Ferguson WS, Grier HE. Combination chemotherapy using vinblastine and methotrexate for the treatment of progressive desmoid tumor in children. J Clin Oncol. 1998 Sep; 16(9):3021-7.
  88. Zerbini MC, Sredni ST, Grier H, Cristofani LM, Latorre MR, Hollister KA, Alves VA, Weinberg DS, Perez-Atayde AR. Primary malignant epithelial tumors of the liver in children: a study of DNA content and oncogene expression. Pediatr Dev Pathol. 1998 Jul-Aug; 1(4):270-80.
  89. Langevin AM, Casto DT, Thomas PJ, Weitman SD, Kretschmar C, Grier H, Pratt C, Dubowy R, Bernstein M, Blaney S, Vietti T. Phase I trial of 9-aminocamptothecin in children with refractory solid tumors: a Pediatric Oncology Group study. J Clin Oncol. 1998 Jul; 16(7):2494-9.
  90. Maurici D, Perez-Atayde A, Grier HE, Baldini N, Serra M, Fletcher JA. Frequency and implications of chromosome 8 and 12 gains in Ewing sarcoma. Cancer Genet Cytogenet. 1998 Jan 15; 100(2):106-10.
  91. Marcus KC, Grier HE, Shamberger RC, Gebhardt MC, Perez-Atayde A, Silver B, Tarbell NJ. Childhood soft tissue sarcoma: a 20-year experience. J Pediatr. 1997 Oct; 131(4):603-7.
  92. Grier HE. The Ewing family of tumors. Ewing's sarcoma and primitive neuroectodermal tumors. Pediatr Clin North Am. 1997 Aug; 44(4):991-1004.
  93. West DC, Grier HE, Swallow MM, Demetri GD, Granowetter L, Sklar J. Detection of circulating tumor cells in patients with Ewing's sarcoma and peripheral primitive neuroectodermal tumor. J Clin Oncol. 1997 Feb; 15(2):583-8.
  94. Tubergen DG, Stewart CF, Pratt CB, Zamboni WC, Winick N, Santana VM, Dryer ZA, Kurtzberg J, Bell B, Grier H, Vietti TJ. Phase I trial and pharmacokinetic (PK) and pharmacodynamics (PD) study of topotecan using a five-day course in children with refractory solid tumors: a pediatric oncology group study. J Pediatr Hematol Oncol. 1996 Nov; 18(4):352-61.
  95. Collins JJ, Geake J, Grier HE, Houck CS, Thaler HT, Weinstein HJ, Twum-Danso NY, Berde CB. Patient-controlled analgesia for mucositis pain in children: a three-period crossover study comparing morphine and hydromorphone. J Pediatr. 1996 Nov; 129(5):722-8.
  96. Frazier AL, Grier HE, Green DM. Treatment of endodermal sinus tumor in children using a regimen that lacks bleomycin. Med Pediatr Oncol. 1996 Aug; 27(2):69-73.
  97. Collins JJ, Grier HE, Sethna NF, Wilder RT, Berde CB. Regional anesthesia for pain associated with terminal pediatric malignancy. Pain. 1996 Apr; 65(1):63-9.
  98. Gorlin JB, Humphreys D, Kent P, Galacki D, Kevy SV, Grupp S, Diller L, Weinstein H, Grier H, Shamberger R. Pediatric large volume peripheral blood progenitor cell collections from patients under 25 kg: a primer. J Clin Apher. 1996; 11(4):195-203.
  99. Collins JJ, Berde CB, Grier HE, Nachmanoff DB, Kinney HC. Massive opioid resistance in an infant with a localized metastasis to the midbrain periaqueductal gray. Pain. 1995 Nov; 63(2):271-5.
  100. Hurwitz CA, Mounce KG, Grier HE. Treatment of patients with acute myelogenous leukemia: review of clinical trials of the past decade. J Pediatr Hematol Oncol. 1995 Aug; 17(3):185-97.
  101. van Hoff J, Grier HE, Douglass EC, Green DM. Etoposide, ifosfamide, and cisplatin therapy for refractory childhood solid tumors. Response and toxicity. Cancer. 1995 Jun 15; 75(12):2966-70.
  102. Healey EA, Shamberger RC, Grier HE, Loeffler JS, Tarbell NJ. A 10-year experience of pediatric brachytherapy. Int J Radiat Oncol Biol Phys. 1995 May 15; 32(2):451-5.
  103. Collins JJ, Grier HE, Kinney HC, Berde CB. Control of severe pain in children with terminal malignancy. J Pediatr. 1995 Apr; 126(4):653-7.
  104. Baruchel S, Bernstein M, Whitehead VM, Devine S, Bell B, Dubowy R, Grier H, Kretschmar C, Langevin AM, Vietti T. A phase I study of acivicin in refractory pediatric solid tumors. A Pediatric Oncology Group study. Invest New Drugs. 1995; 13(3):211-6.
  105. Shamberger RC, Grier HE. Chest wall tumors in infants and children. Semin Pediatr Surg. 1994 Nov; 3(4):267-76.
  106. Hoffer FA, Gianturco LE, Fletcher JA, Grier HE. Percutaneous biopsy of peripheral primitive neuroectodermal tumors and Ewing's sarcomas for cytogenetic analysis. AJR Am J Roentgenol. 1994 May; 162(5):1141-2.
  107. Perlman EJ, Dickman PS, Askin FB, Grier HE, Miser JS, Link MP. Ewing's sarcoma--routine diagnostic utilization of MIC2 analysis: a Pediatric Oncology Group/Children's Cancer Group Intergroup Study. Hum Pathol. 1994 Mar; 25(3):304-7.
  108. Shamberger RC, Tarbell NJ, Perez-Atayde AR, Grier HE. Malignant small round cell tumor (Ewing's-PNET) of the chest wall in children. J Pediatr Surg. 1994 Feb; 29(2):179-84; discussion 184-5.
  109. Schofield DE, Fletcher JA, Grier HE, Yunis EJ. Fibrosarcoma in infants and children. Application of new techniques. Am J Surg Pathol. 1994 Jan; 18(1):14-24.
  110. Bernstein ML, Whitehead VM, Grier H, Dubowy R, Land V, Devine S, Murphy S, Kung F. A phase I trial of fazarabine in refractory pediatric solid tumors. A Pediatric Oncology Group study. Invest New Drugs. 1993 Nov; 11(4):309-12.
  111. Downing JR, Head DR, Parham DM, Douglass EC, Hulshof MG, Link MP, Motroni TA, Grier HE, Curcio-Brint AM, Shapiro DN. Detection of the (11;22)(q24;q12) translocation of Ewing's sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reaction. Am J Pathol. 1993 Nov; 143(5):1294-300.
  112. Bernstein ML, Whitehead VM, Devine S, Grier H, Kung F, Krischer J, Dreyer Z, Bell B, Land V, Buchanan GR, et al. Ifosfamide with mesna uroprotection and etoposide in recurrent, refractory acute leukemia in childhood. A Pediatric Oncology Group Study. Cancer. 1993 Sep 1; 72(5):1790-4.
  113. Ho PT, Estroff JA, Kozakewich H, Shamberger RC, Lillehei CW, Grier HE, Diller L. Prenatal detection of neuroblastoma: a ten-year experience from the Dana-Farber Cancer Institute and Children's Hospital. Pediatrics. 1993 Sep; 92(3):358-64.
  114. Saenz NC, Schnitzer JJ, Eraklis AE, Hendren WH, Grier HE, Macklis RM, Shamberger RC. Posterior mediastinal masses. J Pediatr Surg. 1993 Feb; 28(2):172-6.
  115. West DC, Shamberger RC, Macklis RM, Kozakewich HP, Wayne AS, Kreissman SG, Korf BR, Lavally B, Grier HE. Stage III neuroblastoma over 1 year of age at diagnosis: improved survival with intensive multimodality therapy including multiple alkylating agents. J Clin Oncol. 1993 Jan; 11(1):84-90.
  116. Truog RD, Berde CB, Mitchell C, Grier HE. Barbiturates in the care of the terminally ill. N Engl J Med. 1992 Dec 3; 327(23):1678-82.
  117. Nitschke R, Pratt C, Harris M, Krischer J, Vietti TJ, Grier H, Kamps W, Toledano S. Evaluation of CHIP (iproplatin) in recurrent pediatric malignant solid tumors. A phase II study (Pediatric Oncology Group). Invest New Drugs. 1992 Jul; 10(2):93-6.
  118. Grier HE, Gelber RD, Link MP, Camitta BP, Clavell LA, Weistein HJ. Intensive sequential chemotherapy for children with acute myelogenous leukemia: VAPA, 80-035, and HI-C-Daze. Leukemia. 1992; 6 Suppl 2:48-51.
  119. Shamberger RC, Allarde-Segundo A, Kozakewich HP, Grier HE. Surgical management of stage III and IV neuroblastoma: resection before or after chemotherapy? J Pediatr Surg. 1991 Sep; 26(9):1113-7; discussion 1117-8.
  120. Paul SR, Tarbell NJ, Korf B, Kretschmar CS, Lavally B, Grier HE. Stage IV neuroblastoma in infants. Long-term survival. Cancer. 1991 Mar 15; 67(6):1493-7.
  121. Burke E, Li FP, Janov AJ, Batter S, Grier H, Goorin A. Cancer in relatives of survivors of childhood sarcoma. Cancer. 1991 Mar 1; 67(5):1467-9.
  122. Lack EE, Schloo BL, Azumi N, Travis WD, Grier HE, Kozakewich HP. Undifferentiated (embryonal) sarcoma of the liver. Clinical and pathologic study of 16 cases with emphasis on immunohistochemical features. Am J Surg Pathol. 1991 Jan; 15(1):1-16.
  123. Fletcher JA, Kozakewich HP, Pavelka K, Grier HE, Shamberger RC, Korf B, Morton CC. Consistent cytogenetic aberrations in hepatoblastoma: a common pathway of genetic alterations in embryonal liver and skeletal muscle malignancies? Genes Chromosomes Cancer. 1991 Jan; 3(1):37-43.
  124. Blyth B, Mandell J, Bauer SB, Colodny AH, Grier HE, Weinstein HJ, Tarbell NJ, Hendren WH, Retik AB. Paratesticular rhabdomyosarcoma: results of therapy in 18 cases. J Urol. 1990 Dec; 144(6):1450-3.
  125. Berde CB, Sethna NF, Fisher DE, Kahn CH, Chandler P, Grier HE. Celiac plexus blockade for a 3-year-old boy with hepatoblastoma and refractory pain. Pediatrics. 1990 Nov; 86(5):779-81.
  126. Grier HE. Ewing's sarcoma of bone. Curr Opin Oncol. 1990 Jun; 2(3):491-4.
  127. Slavc I, Ellenbogen R, Jung WH, Vawter GF, Kretschmar C, Grier H, Korf BR. myc gene amplification and expression in primary human neuroblastoma. Cancer Res. 1990 Mar 1; 50(5):1459-63.
  128. Grier HE, Gelber RD, Clavell LA, Camitta BM, Link MP, Garcea MJ, Weinstein HJ. Intensive sequential chemotherapy for children with acute myelogenous leukemia. Haematol Blood Transfus. 1990; 33:193-7.
  129. Shamberger RC, Grier HE, Weinstein HJ, Perez-Atayde AR, Tarbell NJ. Chest wall tumors in infancy and childhood. Cancer. 1989 Feb 15; 63(4):774-85.
  130. Berde CB, Fischel N, Filardi JP, Coe CS, Grier HE, Bernstein SC. Caudal epidural morphine analgesia for an infant with advanced neuroblastoma: report of a case. Pain. 1989 Feb; 36(2):219-23.
  131. Antman KH, Ryan L, Elias A, Sherman D, Grier HE. Response to ifosfamide and mesna: 124 previously treated patients with metastatic or unresectable sarcoma. J Clin Oncol. 1989 Jan; 7(1):126-31.
  132. Mirro J, Kalwinsky DK, Grier HE, Santana VM, Mason C, Murphy SB, Dahl GV. Effective reinduction therapy for childhood acute nonlymphoid leukemia using simultaneous continuous infusions of teniposide and amsacrine. Cancer Chemother Pharmacol. 1989; 24(2):123-7.
  133. Grier HE, Gelber RD, Camitta BM, Delorey MJ, Link MP, Price KN, Leavitt PR, Weinstein HJ. Prognostic factors in childhood acute myelogenous leukemia. J Clin Oncol. 1987 Jul; 5(7):1026-32.
  134. Weinstein H, Grier H, Gelber R, Camitta B, Link M, Delorey M, Price K. Postremission induction intensive sequential chemotherapy for children with AML--treatment results and prognostic factors. Haematol Blood Transfus. 1987; 30:88-92.
  135. Grier HE, Weinstein HJ, Révész T, Houlihan PW, Greenhalgh CL, Nathan DG, Tantravahi R. Cytogenetic evidence for involvement of erythroid progenitors in a child with therapy linked myelodysplasia. Br J Haematol. 1986 Nov; 64(3):513-9.
  136. Shamberger RC, Weinstein HJ, Grier HE, Levey RH. The surgical management of fungal pulmonary infections in children with acute myelogenous leukemia. J Pediatr Surg. 1985 Dec; 20(6):840-4.
  137. Grier HE, Perez-Atayde AR, Weinstein HJ. Chemotherapy for inoperable infantile fibrosarcoma. Cancer. 1985 Oct 1; 56(7):1507-10.
  138. Grier HE, Weinstein HJ. Acute nonlymphocytic leukemia. Pediatr Clin North Am. 1985 Jun; 32(3):653-68.
  139. Reid MM, Tantravahi R, Grier HE, O'Toole S, Miller BA, Lipton JM, Weinstein HJ, Nathan DG. Detection of leukemia-related karyotypes in granulocyte/macrophage colonies from a patient with acute myelomonocytic leukemia. N Engl J Med. 1983 Jun 2; 308(22):1324-8.
  140. Abney TO, Grier H, Mahesh VB. Estradiol binding capacity in the cryptorchid rat testis. Endocrinology. 1977 Sep; 101(3):975-83.
  141. Bhalla VK, Haskell J, Grier H, Mahesh VB. Gonadotropin binding factor(s). Extraction of high affinity gonadotropin binding sites from rat testis and partial characterization of their interaction with human follitropin, lutropin, and choriogonadotropin. J Biol Chem. 1976 Aug 25; 251(16):4947-57.
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