Robert C.  Fuhlbrigge

Robert Fuhlbrigge, MD, PhD

Assistant in Medicine

Associate Professor, Harvard Medical School

  • Contact: 617-355-6117

  • Fax: 617-730-0310

Medical Services

Specialties

  • Rheumatology
  • Autoinflammatory Disorders
  • Vasculitis

Departments

  • Medicine
  • Rheumatology

Programs

  • Rheumatology Program
  • Kawasaki Disease Program
To schedule an appointment: Call 617-355-6117

Experience and Education

Education

Graduate School

Washington University, 1989

St. Louis, MO

Medical School

Washington University, 1989

St. Louis, MO

Fellowship, Clinical

Northwick Park Hospital, 1992-1993

London, U.K.

Fellowship, Research

Boston Children's Hospital, 1993-1995

Boston, MA

Internship

St. Louis Children's Hospital, 1989-1990

St. Louis, MO

Residency

St. Louis Children's Hospital, 1990-1992

St. Louis, MO

Certifications

  • Pediatrics, Pediatric Rheumatology

Research

Associate Director: Dermatology Research Laboratories, Brigham and Women's Hospital Co-Director: Leukocyte Migration Core-Harvard Skin Disease Research Center Research interests include leukocyte migration, adhesion molecules, and cutaneous immunology

Publications

Publications powered by Harvard Catalyst Profiles
  1. Henderson LA, Volpi S, Frugoni F, Janssen E, Kim S, Sundel RP, Dedeoglu F, Lo MS, Hazen MM, Beth Son M, Mathieu R, Zurakowski D, Yu N, Lebedeva T, Fuhlbrigge RC, Walter JE, Nee Lee Y, Nigrovic PA, Notarangelo LD. Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2016 Jul; 68(7):1758-68.
  2. Bohr AH, Fuhlbrigge RC, Pedersen FK, de Ferranti SD, Müller K. Premature subclinical atherosclerosis in children and young adults with juvenile idiopathic arthritis. A review considering preventive measures. Pediatr Rheumatol Online J. 2016; 14(1):3.
  3. Bhela S, Kempsell C, Manohar M, Dominguez-Villar M, Griffin R, Bhatt P, Kivisakk-Webb P, Fuhlbrigge R, Kupper T, Weiner H, Baecher-Allan C. Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6. J Immunol. 2015 Mar 1; 194(5):2180-9.
  4. Sackstein R, Fuhlbrigge R. Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assay. Methods Mol Biol. 2015; 1312:399-410.
  5. Freeman S, Bhatt A, Pedamallu C, King S, Duke F, Jung J, Lawton M, Anderson E, Fuhlbrigge RC, Kenna M, Licameli G, Meyerson M, Dedeoglu F. A121: in search of infectious triggers of periodic Fever, aphthous stomatitis, pharyngitis and adenitis syndrome. Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S158.
  6. Henderson LA, Volpi S, Frugoni F, Kim S, Janssen E, Sundel RP, Dedeoglu F, Lo MS, Hazen MM, Mathieu R, Fuhlbrigge RC, Lee YN, Nigrovic PA, Notarangelo LD. A119: deep sequencing analysis of the T regulatory and T effector repertoire in juvenile idiopathic arthritis. Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S156.
  7. Wu EY, Li SC, Torok KS, Virkud Y, Fuhlbrigge R, Rabinovich CE. A28: Description of the Juvenile Localized Scleroderma Subgroup of the CARRA Registry. Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S43-4.
  8. Henderson LA, King SL, Ameri S, Martin SD, Simmons BP, Nigrovic PA, Fuhlbrigge RC. A161: Novel 3-Dimensional Explant Method Facilitates the Study of Lymphocyte Populations in the Synovium and Reveals a Large Population of Resident Memory T cells in Rheumatoid Arthritis. Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S209.
  9. Vander Lugt B, Tubo NJ, Nizza ST, Boes M, Malissen B, Fuhlbrigge RC, Kupper TS, Campbell JJ. CCR7 plays no appreciable role in trafficking of central memory CD4 T cells to lymph nodes. J Immunol. 2013 Sep 15; 191(6):3119-27.
  10. Kentsis A, Shulman A, Ahmed S, Brennan E, Monuteaux MC, Lee YH, Lipsett S, Paulo JA, Dedeoglu F, Fuhlbrigge R, Bachur R, Bradwin G, Arditi M, Sundel RP, Newburger JW, Steen H, Kim S. Urine proteomics for discovery of improved diagnostic markers of Kawasaki disease. EMBO Mol Med. 2013 Feb; 5(2):210-20.
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  12. Ercan A, Barnes MG, Hazen M, Tory H, Henderson L, Dedeoglu F, Fuhlbrigge RC, Grom A, Holm IA, Kellogg M, Kim S, Adamczyk B, Rudd PM, Son MB, Sundel RP, Foell D, Glass DN, Thompson SD, Nigrovic PA. Multiple juvenile idiopathic arthritis subtypes demonstrate proinflammatory IgG glycosylation. Arthritis Rheum. 2012 Sep; 64(9):3025-33.
  13. Chang DK, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, Lo A, Yammanuru A, Hubbard L, Sheehan J, Campbell JJ, Zhu Q, Kupper TS, Marasco WA. Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells. Mol Cancer Ther. 2012 Nov; 11(11):2451-61.
  14. Li SC, Torok KS, Pope E, Dedeoglu F, Hong S, Jacobe HT, Rabinovich CE, Laxer RM, Higgins GC, Ferguson PJ, Lasky A, Baszis K, Becker M, Campillo S, Cartwright V, Cidon M, Inman CJ, Jerath R, O'Neil KM, Vora S, Zeft A, Wallace CA, Ilowite NT, Fuhlbrigge RC. Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma. Arthritis Care Res (Hoboken). 2012 Aug; 64(8):1175-85.
  15. Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med. 2012 Aug; 18(8):1248-53.
  16. Wang JX, Bair AM, King SL, Shnayder R, Huang YF, Shieh CC, Soberman RJ, Fuhlbrigge RC, Nigrovic PA. Ly6G ligation blocks recruitment of neutrophils via a ß2-integrin-dependent mechanism. Blood. 2012 Aug 16; 120(7):1489-98.
  17. Jiang X, Clark RA, Liu L, Wagers AJ, Fuhlbrigge RC, Kupper TS. Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature. 2012 Mar 8; 483(7388):227-31.
  18. Tian T, Dubin K, Jin Q, Qureshi A, King SL, Liu L, Jiang X, Murphy GF, Kupper TS, Fuhlbrigge RC. Disruption of TNF-a/TNFR1 function in resident skin cells impairs host immune response against cutaneous vaccinia virus infection. J Invest Dermatol. 2012 May; 132(5):1425-34.
  19. Peiser M, Tralau T, Heidler J, Api AM, Arts JH, Basketter DA, English J, Diepgen TL, Fuhlbrigge RC, Gaspari AA, Johansen JD, Karlberg AT, Kimber I, Lepoittevin JP, Liebsch M, Maibach HI, Martin SF, Merk HF, Platzek T, Rustemeyer T, Schnuch A, Vandebriel RJ, White IR, Luch A. Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects. Current knowledge assembled at an international workshop at BfR, Germany. Cell Mol Life Sci. 2012 Mar; 69(5):763-81.
  20. Merzaban JS, Burdick MM, Gadhoum SZ, Dagia NM, Chu JT, Fuhlbrigge RC, Sackstein R. Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells. Blood. 2011 Aug 18; 118(7):1774-83.
  21. Vander Lugt B, Beck ZT, Fuhlbrigge RC, Hacohen N, Campbell JJ, Boes M. TGF-ß suppresses ß-catenin-dependent tolerogenic activation program in dendritic cells. PLoS One. 2011; 6(5):e20099.
  22. Fuhlbrigge RC, Chaiban R. The immune system, the skin, and childhood rheumatic disease. Curr Rheumatol Rep. 2011 Apr; 13(2):103-9.
  23. Koduru S, Kumar L, Massaad MJ, Ramesh N, Le Bras S, Ozcan E, Oyoshi MK, Kaku M, Fujiwara Y, Kremer L, King S, Fuhlbrigge R, Rodig S, Sage P, Carman C, Alcaide P, Luscinskas FW, Geha RS. Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16252-6.
  24. Yamanaka K, Fuhlbrigge RC, Mizutani H, Kupper TS. Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphoma. Arch Dermatol Res. 2010 Aug; 302(6):453-9.
  25. Ozen S, Fuhlbrigge RC. Update in paediatric vasculitis. Best Pract Res Clin Rheumatol. 2009 Oct; 23(5):679-88.
  26. Clark RA, Fuhlbrigge RC. Immunology and skin disease 2009: frontiers in cutaneous immunology. J Invest Dermatol. 2009 Aug; 129(8):1849-51.
  27. Kim S, El-Hallak M, Dedeoglu F, Zurakowski D, Fuhlbrigge RC, Sundel RP. Complete and sustained remission of juvenile dermatomyositis resulting from aggressive treatment. Arthritis Rheum. 2009 Jun; 60(6):1825-30.
  28. Bianchi T, Pincus LB, Wurbel MA, Rich BE, Kupper TS, Fuhlbrigge RC, Boes M. Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice. J Immunol. 2009 Apr 15; 182(8):4665-74.
  29. Sackstein R, Fuhlbrigge R. Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assay. Methods Mol Biol. 2009; 536:343-54.
  30. Tian T, Liu L, Freyschmidt EJ, Murphy GF, Kupper TS, Fuhlbrigge RC. Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus. J Invest Dermatol. 2009 Jan; 129(1):70-8.
  31. Ota S, Cron RQ, Schanberg LE, O'Neil K, Mellins ED, Fuhlbrigge RC, Feldman BM. Research priorities in pediatric rheumatology: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus. Pediatr Rheumatol Online J. 2008; 6:5.
  32. Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH. Identification of cells initiating human melanomas. Nature. 2008 Jan 17; 451(7176):345-9.
  33. Yamanaka K, Dimitroff CJ, Fuhlbrigge RC, Kakeda M, Kurokawa I, Mizutani H, Kupper TS. Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression. J Allergy Clin Immunol. 2008 Jan; 121(1):148-157.e3.
  34. Clark RA, Fuhlbrigge RC. Meeting report of immunology and skin disease: new perspectives. J Invest Dermatol. 2007 Aug; 127(8):1838-41.
  35. Weishaupt C, Munoz KN, Buzney E, Kupper TS, Fuhlbrigge RC. T-cell distribution and adhesion receptor expression in metastatic melanoma. Clin Cancer Res. 2007 May 1; 13(9):2549-56.
  36. El-Hallak M, Binstadt BA, Leichtner AM, Bennett CM, Neufeld EJ, Fuhlbrigge RC, Zurakowski D, Sundel RP. Clinical effects and safety of rituximab for treatment of refractory pediatric autoimmune diseases. J Pediatr. 2007 Apr; 150(4):376-82.
  37. Fuhlbrigge RC, Weishaupt C. Adhesion molecules in cutaneous immunity. Semin Immunopathol. 2007 Apr; 29(1):45-57.
  38. Alcaide P, King SL, Dimitroff CJ, Lim YC, Fuhlbrigge RC, Luscinskas FW. The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo. J Invest Dermatol. 2007 Aug; 127(8):1964-72.
  39. El-Hallak M, Binstadt BA, Leichtner AM, Bennett CM, Neufeld EJ, Fuhlbrigge RC, Zurakowski D, Sundel RP. Clinical effects and safety of rituximab for treatment of refractory pediatric autoimmune diseases. J Pediatrics. 2007; 150:376-82.
  40. Weishaupt, C, KN Munoz, E Buzney, TS Kupper, and RC Fuhlbrigge. Dysregulation of vascular adhesion molecules in metastatic melanoma. Clinical Cancer Research. 2007; 13(9):2549-56.
  41. Tian T, L Liu, E-J Freyschmidt, G Murphy, TS Kupper and RC Fuhlbrigge. Modulation of Immune Response to Vaccinia Virus Scarification in K14/IL-1á Transgenic Mice. Journal of Virology. 2007; Submitted.
  42. Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS. The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J Immunol. 2006 Oct 1; 177(7):4488-94.
  43. Liu L, Fuhlbrigge RC, Karibian K, Tian T, Kupper TS. Dynamic programming of CD8+ T cell trafficking after live viral immunization. Immunity. 2006 Sep; 25(3):511-20.
  44. Goldbach-Mansky R, Dailey NJ, Canna SW, Gelabert A, Jones J, Rubin BI, Kim HJ, Brewer C, Zalewski C, Wiggs E, Hill S, Turner ML, Karp BI, Aksentijevich I, Pucino F, Penzak SR, Haverkamp MH, Stein L, Adams BS, Moore TL, Fuhlbrigge RC, Shaham B, Jarvis JN, O'Neil K, Vehe RK, Beitz LO, Gardner G, Hannan WP, Warren RW, Horn W, Cole JL, Paul SM, Hawkins PN, Pham TH, Snyder C, Wesley RA, Hoffmann SC, Holland SM, Butman JA, Kastner DL. Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. N Engl J Med. 2006 Aug 10; 355(6):581-92.
  45. Sackstein R, Fuhlbrigge R. The blot rolling assay: a method for identifying adhesion molecules mediating binding under shear conditions. Methods Mol Biol. 2006; 341:217-26.
  46. Goldbach-Mansky, R., N. Dailey, S. Canna, A. Gelabert, J. Jones, B. Rubin, J. Kim, C. Brewer, C. Zalewski, E. Wiggs, S. Hill, M. Turner, B. Karp, I. Aksentijevich, F. Pucino, S. Penzak , M. Haverkamp, L. Stein, B.S. Adams, T.L. Moore, R. Fuhlbrigge, B. Shaham, J. Jarvis, R. Vehe, L. Beitz, G. Gardner, W. Hannan, R. Warren, W. Horn, J.L. Cole, S. Paul, P. Hawkins, T. Hang Pham, C. Snyder, J. Butman, S. Hoffman, S.M. Holland, and D.L. Kastner. Neonatal Onset Multisystem Inflammatory Disease––A Disorder of Interleukin 1 Signaling Responsive to Anakinra. New England Journal of Medicine. 2006; 355(6):581-92.
  47. Fuhlbrigge, R.C., S.L. King, R. Sackstein, and T.S. Kupper. CD43 is a Ligand for E-selectin on Human Skin Homing T Cells. ePub Nov 2005. Blood. 2006; 107:1421-6.
  48. Liu L., RC Fuhlbrigge, K Karibian, T Tian, TS Kupper. 2006. . Dynamic programming of CD8+ T cell trafficking after live viral immunization. Immunity 25(3):511-20. 2006; 25(3):511-20.
  49. Hirahara, K., L. Liu, R.A. Clark, K. Yamanaka, R.C. Fuhlbrigge, and T.S. Kupper. The Majority of Human Peripheral Blood CD4+CD25highFoxp3+ Regulatory T Cells Bear Functional Skin-Homing Receptors. Journal of Immunology. 2006; 177:4488-4494.
  50. Fuhlbrigge RC, King SL, Sackstein R, Kupper TS. CD43 is a ligand for E-selectin on CLA+ human T cells. Blood. 2006 Feb 15; 107(4):1421-6.
  51. Gallego MD, de la Fuente MA, Anton IM, Snapper S, Fuhlbrigge R, Geha RS. WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha. Int Immunol. 2006 Feb; 18(2):221-32.
  52. Binstadt BA, Levine JC, Nigrovic PA, Gauvreau K, Dedeoglu F, Fuhlbrigge RC, Weindling SN, Newburger JW, Sundel RP. Coronary artery dilation among patients presenting with systemic-onset juvenile idiopathic arthritis. Pediatrics. 2005 Jul; 116(1):e89-93.
  53. Liu L, Xu Z, Fuhlbrigge RC, Peña-Cruz V, Lieberman J, Kupper TS. Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion. J Virol. 2005 Jun; 79(12):7363-70.
  54. Kupper TS, Fuhlbrigge RC. Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol. 2004 Mar; 4(3):211-22.
  55. Chong BF, Murphy JE, Kupper TS, Fuhlbrigge RC. E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system. J Immunol. 2004 Feb 1; 172(3):1575-81.
  56. Chong, B.F., J.E. Murphy, T.S. Kupper, R.C. Fuhlbrigge . E-selectin, TARC/CCL17 and ICAM-1 are constitutively co-expressed in dermal microvessels: a foundation for a cutaneous immunosurveillance mechanism. Journal of Immunology. 2004; 172:1575-1581.
  57. Binstadt BA, Caldas AM, Turvey SE, Stone KD, Weinstein HJ, Jackson J, Fuhlbrigge RC, Sundel RP. Rituximab therapy for multisystem autoimmune diseases in pediatric patients. J Pediatr. 2003 Nov; 143(5):598-604.
  58. Nigrovic PA, Fuhlbrigge RC, Sundel RP. Raynaud's phenomenon in children: a retrospective review of 123 patients. Pediatrics. 2003 Apr; 111(4 Pt 1):715-21.
  59. Binstadt, B.A., A.M.C. Caldas, S.E., Turvey, H.J. Weinstein, J. M. Jackson, R.C. Fuhlbrigge and R.P. Sundel . Rituximab Therapy for Mulstisystem Autoimmune Disease in Pediatric Patients. Journal of Pediatrics. 2003; 143(5):598-604.
  60. Ferenczi K, Fuhlbrigge RC, Pinkus J, Pinkus GS, Kupper TS. Increased CCR4 expression in cutaneous T cell lymphoma. J Invest Dermatol. 2002 Dec; 119(6):1405-10.
  61. Fisler RE, Liang MG, Fuhlbrigge RC, Yalcindag A, Sundel RP. Aggressive management of juvenile dermatomyositis results in improved outcome and decreased incidence of calcinosis. J Am Acad Dermatol. 2002 Oct; 47(4):505-11.
  62. Fuhlbrigge RC, King SL, Dimitroff CJ, Kupper TS, Sackstein R. Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots. J Immunol. 2002 Jun 1; 168(11):5645-51.
  63. Pendl GG, Robert C, Steinert M, Thanos R, Eytner R, Borges E, Wild MK, Lowe JB, Fuhlbrigge RC, Kupper TS, Vestweber D, Grabbe S. Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1. Blood. 2002 Feb 1; 99(3):946-56.
  64. Ferenczi K, Fuhlbrigge RC, Pinkus J, Pinkus GS, Kupper TS . Increased CCR4 Expression in Cutaneous T Cell Lymphom. A. J Invest Dermatol. 2002; 119(6):1405-10.
  65. Fuhlbrigge, R.C., S.L. King, C.J. Dimitroff and R. Sackstein. . Direct, Real-time Observation of E- and P- Selectin Mediated Rolling on Cutaneous Lymphocyte-Associated Antigen Immobilized on Western Blots. Journal of Immunology. 2002; 168:5645-5651.
  66. Armerding D, Fuhlbrigge RC, Kieffer JD, Kupper TS. Tonsillar B cells do not express PSGL-1, but a significant fraction displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activity. Int Arch Allergy Immunol. 2001 Sep; 126(1):78-90.
  67. Kieffer JD, Fuhlbrigge RC, Armerding D, Robert C, Ferenczi K, Camphausen RT, Kupper TS. Neutrophils, monocytes, and dendritic cells express the same specialized form of PSGL-1 as do skin-homing memory T cells: cutaneous lymphocyte antigen. Biochem Biophys Res Commun. 2001 Jul 20; 285(3):577-87.
  68. Dimitroff CJ, Lee JY, Rafii S, Fuhlbrigge RC, Sackstein R. CD44 is a major E-selectin ligand on human hematopoietic progenitor cells. J Cell Biol. 2001 Jun 11; 153(6):1277-86.
  69. Dimitroff, C.J., J.Y. Lee, S. Rafii, R.C. Fuhlbrigge and R. Sackstein . CD44 is a major E-Selectin Ligand on Human Hemotpoetic Progenitor Cells. Journal of Cell Biology. 2001; 153(6):1277-86.
  70. Artlett, C.M., F.W. Miller, L.G. Rider, et al. for the Childhood Myositis Heterogeneity Collaborative Study Group. . Persistent maternally-derived peripheral michrochimerism is associated with the juvenile idiopathic inflammatory myopathies. Rheumatology. 2001; 40:1279-84.
  71. Dimitroff CJ, Lee JY, Fuhlbrigge RC, Sackstein R. A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells. Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25):13841-6.
  72. Eberhard BA, Sundel RP, Newburger JW, Baker A, Fuhlbrigge RC, Burns JC, Gellis SE. Psoriatic eruption in Kawasaki disease. J Pediatr. 2000 Oct; 137(4):578-80.
  73. Robert, C. Fuhlbrigge, M.D., Ph.D. Apparatus and Methods for Identifying Ligands. 2000.
  74. Carcamo AS, Fuhlbrigge RC, Hong R, Gullans SR, Kupper TS. Comparative analysis of the global transcriptional profile of human skin-homing memory T lymphocytes vs. non-skin homing memory and naive T lymphocytes J Invest Dermatol. 2000 Aug; 115(2):332.
  75. Fuhlbrigge, R.C. and T.S. Kupper. . Molecular mechanisms of allergic skin responses. Allergic Skin Diseases. Editors: Leung and Greaves. 2000; 29-51.
  76. Dimitroff, C.J., J. Lee, R.C. Fuhlbrigge and R. Sackstein. . A Distinct Glycoform of CD44 is an L-selectin Ligand on Human Hematopoietic Progenitor Cells. Proceedings of the National Academy of Sciences (USA). 2000; 97(25):13,814 - 13,13846.
  77. Carcamo, A.S., R.C. Fuhlbrigge, R. Hong, S.R. Gullans and T.S.; Kupper. . Comparative analysis of the global transcriptional profile of human skin-homing memory T lymphocytes vs. non-skin homing memory and naive T lymphocytes. Journal of Investigative Dermatology. 2000; 115(2):332.
  78. Robert C, Fuhlbrigge RC, Kieffer JD, Ayehunie S, Hynes RO, Cheng G, Grabbe S, von Andrian UH, Kupper TS. Interaction of dendritic cells with skin endothelium: A new perspective on immunosurveillance. J Exp Med. 1999 Feb 15; 189(4):627-36.
  79. Alon R, Chen S, Fuhlbrigge R, Puri KD, Springer TA. The kinetics and shear threshold of transient and rolling interactions of L-selectin with its ligand on leukocytes. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11631-6.
  80. Clark RA, Fuhlbrigge RC, Springer TA. L-Selectin ligands that are O-glycoprotease resistant and distinct from MECA-79 antigen are sufficient for tethering and rolling of lymphocytes on human high endothelial venules. J Cell Biol. 1998 Feb 9; 140(3):721-31.
  81. Fuhlbrigge, RC, D. Samler and R.P. Sundel. . Aggressive Management of Juvenile Dermatomyositis (JDMS) Prevents Calcinosis. Proceedings of Park City IV: Pediatric Rheumatology Into The Next Century. 1998.
  82. Clark, R.A., R.C. Fuhlbrigge and T.A. Springer. . L-selectin ligands that are O-glycoprotease-resistant and distinct from MECA-79 antigen are sufficient for tethering and rolling of lymphocytes on human high endothelial venules. Journal of Cell Biology. 1998; 140 (3):721-731.
  83. Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature. 1997 Oct 30; 389(6654):978-81.
  84. Kitayama J, Fuhlbrigge RC, Puri KD, Springer TA. P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions. J Immunol. 1997 Oct 15; 159(8):3929-39.
  85. Chen S, Alon R, Fuhlbrigge RC, Springer TA. Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins. Proc Natl Acad Sci U S A. 1997 Apr 1; 94(7):3172-7.
  86. 16. Kitayama, J., R.C. Fuhlbrigge, K.D. Puri, and T.A. Springer. . P-selectin, L-selectin, and alpha(4) integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions. 1997; Journal of Immunology:159.
  87. Chen, S., R. Alon, R.C. Fuhlbrigge and T.A. Springer. . Rolling and transient tethering of leukocytes on antibodies reveal specialization of selectins. Proceedings of the National Academy of Science USA. 1997; 94:3172-3177.
  88. Alon R, Fuhlbrigge RC, Finger EB, Springer TA. Interactions through L-selectin between leukocytes and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow. J Cell Biol. 1996 Nov; 135(3):849-65.
  89. Fuhlbrigge RC, Alon R, Puri KD, Lowe JB, Springer TA. Sialylated, fucosylated ligands for L-selectin expressed on leukocytes mediate tethering and rolling adhesions in physiologic flow conditions. J Cell Biol. 1996 Nov; 135(3):837-48.
  90. Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, Springer TA. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) J Exp Med. 1996 Sep 1; 184(3):1101-9.
  91. Alon R., R.C. Fuhlbrigge and T.A. Springer. . Leukocyte ligands for L-selectin nucleate rolling adhesions on vascular selectins and VCAM-1. Journal of Cell Biology. 1996; 135(3):849-865.
  92. Bleuel, C.C., R.C. Fuhlbrigge, J.M. Casasnovas, A. Aiuti and T.A. Springer. . A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). Journal of Experimental Medicine. 1996; 184:1101-1109.
  93. Alon R, Feizi T, Yuen CT, Fuhlbrigge RC, Springer TA. Glycolipid ligands for selectins support leukocyte tethering and rolling under physiologic flow conditions. J Immunol. 1995 May 15; 154(10):5356-66.
  94. Alon, R., T. Feizi, C.-T. Yuen, R.C. Fuhlbrigge and T.A. Springer. . Glycolipid ligands for selectins support leukocyte tethering and rolling adhesions under physiologic flow conditions. Journal of Immunology. 1995; 154(10):5356-5366 .
  95. Hawrylowicz CM, Duncan LM, Fuhlbrigge RC, Unanue ER. Regulation of antigen presentation. II. Anti-Ig and IL-2 induce IL-1 production by murine splenic B cells. J Immunol. 1989 May 15; 142(10):3361-8.
  96. Fuhlbrigge RC, Hogquist KA, Unanue ER, Chaplin DD. Molecular biology and genetics of interleukin-1. Year Immunol. 1989; 5:21-37.
  97. Hawrylowicz, C.M., L.M. Duncan, R.C. Fuhlbrigge and E.R. Unanue . Regulation of antigen presentation II: Anti-Ig and IL-2 induce IL-1 production by murine splenic B cells. Journal of Immunology. 1989; 142(10):3361-3368.
  98. Fuhlbrigge RC, Sheehan KC, Schreiber RD, Chaplin DD, Unanue ER. Monoclonal antibodies to murine IL-1 alpha. Production, characterization, and inhibition of membrane-associated IL-1 activity. J Immunol. 1988 Oct 15; 141(8):2643-50.
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