MEDICAL SERVICES

EDUCATION

Undergraduate Degree

  • Princeton University , 1982 , Princeton , NJ

Medical School

Medical Science in Clinical Investigation
  • Havard Medical School , 1987 , Boston , MA

Internship

  • Massachusetts General Hospital , 1988 , Boston , MA

Residency

Radiology
  • Massachusetts General Hospital , 1989 , Boston , MA

Residency

  • Massachusetts General Hospital , 1991 , Boston , MA

Fellowship

  • Massachusetts General Hospital , 1994 , Boston , MA

Graduate Degree

Medical Science in Clinical Investigation
  • Havard Medical School , 1997 , Boston , MA

CERTIFICATIONS

  • American Board of Internal Medicine, Cardiovascular Disease

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Choudhury S, Walsh C, Hirata M, Chen MH. International Academy of Cardiology, 23rd World Congress of Heart Disease. Congenital Heart Disease in Patients with Loss of Function FilaminA mutations: Genotype-Phenotype Correlations. 2018. View abstract
  2. Choudhury S, Hirata M, Walsh C, Chen MH. American Society of Echocardiolgraphy. Structural Cardiac Anomalies in LOF FilaminA mutation patients: the Role of Echocardiography. 2018. View abstract
  3. Bates JE, Keshavarz H, Rancati T, Yorke E, Gagliardi G, Aznar MC, Moiseenko B, Armenian S, Kremer L, Chen MH, Ronckers C, van der Pal H, Cutter D, Constine LS, Hodgson D. American Society of Clinical Oncology. Modeling Risk of Heart Failure in Survivors of Childhood Cancer: early results from the pediatric normal tissue effects in the Clinic Group (PENTEC). 2018. View abstract
  4. Heinzen EL, O'Neill AC, Zhu X, Allen AS, Bahlo M, Chelly J, Chen MH, Dobyns WB, Freytag S, Guerrini R, Leventer RJ, Poduri A, Robertson SP, Walsh CA, Zhang M. De novo and inherited private variants in MAP1B in periventricular nodular heterotopia. PLoS Genet. 2018 05; 14(5):e1007281. View abstract
  5. Chen MH, Choudhury S, Hirata M, Khalsa S, Chang B, Walsh CA. Thoracic aortic aneurysm in patients with loss of function Filamin A mutations: Clinical characterization, genetics, and recommendations. Am J Med Genet A. 2018 02; 176(2):337-350. View abstract
  6. Armenian SH, Hudson MM, Chen MH, Colan SD, Lindenfeld L, Mills G, Siyahian A, Gelehrter S, Dang H, Hein W, Green DM, Robison LL, Wong FL, Douglas PS, Bhatia S. Rationale and design of the Children's Oncology Group (COG) study ALTE1621: a randomized, placebo-controlled trial to determine if low-dose carvedilol can prevent anthracycline-related left ventricular remodeling in childhood cancer survivors at high risk for developing heart failure. BMC Cardiovasc Disord. 2016 10 04; 16(1):187. View abstract
  7. Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA. Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016 Aug 25; 166(5):1147-1162.e15. View abstract
  8. Henry NA, Doan RA, Chen MH, Zhang X, Walsh CA. Howard Hughes Medical Student Conference. Tissue Specific Intron Retention is a New Mechanism for FLNA mutation. 2016. View abstract
  9. Kuebler JD, Chen MH, Alexander ME, Rhodes J. Exercise Performance in Patients with D-Loop Transposition of the Great Arteries After Arterial Switch Operation: Long-Term Outcomes and Longitudinal Assessment. Pediatr Cardiol. 2016 Feb; 37(2):283-9. View abstract
  10. Chen MH and Walsh CA. FLNA-Related Periventricular Nodular Heterotopia. GeneReviews. 2015. View abstract
  11. Tanguturi SK, Lyatskaya Y, Chen Y, Catalano PJ, Chen MH, Yeo WP, Marques A, Truong L, Yeh M, Orlina L, Wong JS, Punglia RS, Bellon JR. Prospective assessment of deep inspiration breath-hold using 3-dimensional surface tracking for irradiation of left-sided breast cancer. Pract Radiat Oncol. 2015 Nov-Dec; 5(6):358-65. View abstract
  12. Barac A, Murtagh G, Carver JR, Chen MH, Freeman AM, Herrmann J, Iliescu C, Ky B, Mayer EL, Okwuosa TM, Plana JC, Ryan TD, Rzeszut AK, Douglas PS. Cardiovascular Health of Patients With Cancer and Cancer Survivors: A Roadmap to the Next Level. J Am Coll Cardiol. 2015 Jun 30; 65(25):2739-46. View abstract
  13. Armenian SH, Hudson MM, Mulder RL, Chen MH, Constine LS, Dwyer M, Nathan PC, Tissing WJ, Shankar S, Sieswerda E, Skinner R, Steinberger J, van Dalen EC, van der Pal H, Wallace WH, Levitt G, Kremer LC. Recommendations for cardiomyopathy surveillance for survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncol. 2015 Mar; 16(3):e123-36. View abstract
  14. Kuebler JA, Chen MH, Rhodes J. American College of Cardiology. Longitudinal Exercise Performance in Patients with D-loop Transposition of the Great Arteries after Arterial Switch Operation. 2015. View abstract
  15. Hasan BS, Lunze FI, Chen MH, Brown DW, Boudreau MJ, Rhodes J, McElhinney DB. Effects of transcatheter pulmonary valve replacement on the hemodynamic and ventricular response to exercise in patients with obstructed right ventricle-to-pulmonary artery conduits. JACC Cardiovasc Interv. 2014 May; 7(5):530-42. View abstract
  16. Chen MH, Blackington LH, Zhou J, Chu TF, Gauvreau K, Marcus KJ, Fisher DC, Diller LR, Ng AK. Blood pressure is associated with occult cardiovascular disease in prospectively studied Hodgkin lymphoma survivors after chest radiation. Leuk Lymphoma. 2014 Nov; 55(11):2477-83. View abstract
  17. Chen MH, Debbaut C, McEnaney K, Roberts A, Gauvreau K, Western K, Ireland C, Baird C, Jenkins K. American College of Cardiology. Clinical and Genetic Features of pulmonary vein stenosis. 2014. View abstract
  18. B Aleman, L Specht, MH Chen. ALERT—Adverse Late Effects of Cancer Treatment, Volume 2: Specific Normal Tissue Sites. Heart, Coronary Arteries, Aorta and Great Vessels, Arteries and Veins, Microcirculation. 2013. View abstract
  19. Lunze FI, Colan SD, Gauvreau K, Chen MH, Perez-Atayde AR, Blume ED, Singh TP. Cardiac allograft function during the first year after transplantation in rejection-free children and young adults. Circ Cardiovasc Imaging. 2012 Nov; 5(6):756-64. View abstract
  20. Hasan BS, Lunze FI, McElhinney DB, Stantcheva E, Brown DW, Rhodes J, Chen MH. Exercise stress echocardiographic assessment of outflow tract and ventricular function in patients with an obstructed right ventricular-to-pulmonary artery conduit after repair of conotruncal heart defects. Am J Cardiol. 2012 Nov 15; 110(10):1527-33. View abstract
  21. Chen MH, Abernathey E, Lunze F, Colan SD, O'Neill S, Bergersen L, Geva T, Blume ED. Utility of exercise stress echocardiography in pediatric cardiac transplant recipients: a single-center experience. J Heart Lung Transplant. 2012 May; 31(5):517-23. View abstract
  22. Steingart RM, Bakris GL, Chen HX, Chen MH, Force T, Ivy SP, Leier CV, Liu G, Lenihan D, Lindenfeld J, Maitland ML, Remick SC, Tang WH. Management of cardiac toxicity in patients receiving vascular endothelial growth factor signaling pathway inhibitors. Am Heart J. 2012 Feb; 163(2):156-63. View abstract
  23. MH Chen, T Force. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. Cardiotoxicity of Anti-cancer Therapeutics. 2012. View abstract
  24. Adams MJ, Chen MH, Hodgson D, Kinahan K, Marina N, Meeske K, Rosenthal D, Shankar S, Steinberger J, Armenian S. Children's Oncology Group. Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers. 2012. View abstract
  25. Chen MH, Colan SD, Diller L. Cardiovascular disease: cause of morbidity and mortality in adult survivors of childhood cancers. Circ Res. 2011 Mar 04; 108(5):619-28. View abstract
  26. Daly KP, Colan SD, Blume ED, Margossian R, Gauvreau K, Duncan C, Lehmann LE, Chen MH. Changes in echocardiographic measures of systolic and diastolic function in children 1 year after hematopoietic SCT. Bone Marrow Transplant. 2011 Dec; 46(12):1532-9. View abstract
  27. Chen MH, Hudes G. Cardiac Co-Morbidity Boards: Cardiotoxicity of Tyrosine Kinase Inhibitors. ASCO CME Teaching Series 2011. 2011. View abstract
  28. Chen MH. Late cardiovascular effects of anthracycline in childhood cancer survivors: Interview with the Expert: Dr. Ming Hui Chen. Fudan Journal of Pediatrics. 2010. View abstract
  29. Galper SL, Yu JB, Mauch PM, Strasser JF, Silver B, Lacasce A, Marcus KJ, Stevenson MA, Chen MH, Ng AK. Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation. Blood. 2011 Jan 13; 117(2):412-8. View abstract
  30. Demetri GD, Heinrich MC, Fletcher JA, Fletcher CD, Van den Abbeele AD, Corless CL, Antonescu CR, George S, Morgan JA, Chen MH, Bello CL, Huang X, Cohen DP, Baum CM, Maki RG. Molecular target modulation, imaging, and clinical evaluation of gastrointestinal stromal tumor patients treated with sunitinib malate after imatinib failure. Clin Cancer Res. 2009 Sep 15; 15(18):5902-9. View abstract
  31. Chen MH. Cardiac dysfunction induced by novel targeted anticancer therapy: an emerging issue. Curr Cardiol Rep. 2009 May; 11(3):167-74. View abstract
  32. Kerkela R, Woulfe KC, Durand JB, Vagnozzi R, Kramer D, Chu TF, Beahm C, Chen MH, Force T. Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin Transl Sci. 2009 Feb; 2(1):15-25. View abstract
  33. Chen MH, Kerkelä R, Force T. Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics. Circulation. 2008 Jul 01; 118(1):84-95. View abstract
  34. Chen MH, Rupnick MA, Chu T, Force T, Demetri GD. Cardiotoxicity of the tyrosine kinase inhibitor- sunitinib. Lancet. 2008. View abstract
  35. Shankar SM, Marina N, Hudson MM, Hodgson DC, Adams MJ, Landier W, Bhatia S, Meeske K, Chen MH, Kinahan KE, Steinberger J, Rosenthal D. Monitoring for cardiovascular disease in survivors of childhood cancer: report from the Cardiovascular Disease Task Force of the Children's Oncology Group. Pediatrics. 2008 Feb; 121(2):e387-96. View abstract
  36. MH Chen, T Force. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. Cardiotoxicity of Anti-Cancer Therapeutics. 2008. View abstract
  37. Adams MJ, Chen MH, Hodgson D, Kinahan K, Marina N, Meeske K, Rosenthal D, Shankar S, Steinberger J, Armenian S. Children's Oncology Group. Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers. 2008. View abstract
  38. Chu TF, Rupnick MA, Kerkela R, Dallabrida SM, Zurakowski D, Nguyen L, Woulfe K, Pravda E, Cassiola F, Desai J, George S, Morgan JA, Harris DM, Ismail NS, Chen JH, Schoen FJ, Van den Abbeele AD, Demetri GD, Force T, Chen MH. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet. 2007 Dec 15; 370(9604):2011-9. View abstract
  39. Chen-Plotkin AS, Vossel KA, Samuels MA, Chen MH . Encephalopathy, stroke and myocardial infarction as complications of dimethyl sulfoxide use in stem cell transplantation. Neurology. 2007; 68:859-861.. View abstract
  40. E. Bermudez and MH Chen. Stress Echocardiography: Indications and Protocols. Essential Echocardiography; a Practical Handbook with DVD (solomon and bulwer). 2007; 149-160. View abstract
  41. Feng Y, Chen MH, Moskowitz I, Lu Q, Liu H, Mendonza A, Yoshida Y, Vidali L, Nakamura F, Jessell T, Flanagan J, Kwiatkowski DJ, Walsh CA. Filamin A is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Nat Acad Sci. 2006; 103(52):19836-19841.. View abstract
  42. Desai J, Yassa L, Marqusee E, George S, Frates MC, Chen MH, Morgan JA, Dychter SS, Larsen PR, Demetri GD, Alexander EK. Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors. Ann Intern Med. 2006 Nov 07; 145(9):660-4. View abstract
  43. Nguyen L, Chu T, Mauch P, Diller L, Ng A, Chen MH. Cardiac irradiation during mediastinal radiation for Hodgkin’s Disease. NCI Conference for Cancer Survivors. 2006. View abstract
  44. Desai J, Yassa L, Marqusee E, George S, Frates MC, Chen MH, Morgan J, Dychter SS, Larsen PR, Demetri GD, Alexander EK . Primary hypothyroidism is a common complication of sunitinib therapy in patients with gastrointestinal stromal tumors. Ann Int Med. 2006; 145(9):660-664.. View abstract
  45. Gregory SA, Yepes CB, Byrne JG, D'Ambra MN, Chen MH. Atrial endocarditis--the importance of the regurgitant jet lesion. Echocardiography. 2005 May; 22(5):426-30. View abstract
  46. Sheen Vl, Janset AN, Chen MH, Parrini E, Morgan T, Ravenscroft R et al. FLNA mutations cause a variant Ehlers-Danlos syndrome associated with periventricular heterotopia. Neurology 2005;64(2)254-62. Neurology. 2005; 64(2):254-262. View abstract
  47. Chen MH, Cooper M. Echoquest. 2003. View abstract
  48. Soteriades ES, Evans JC, Larson MG, Chen MH, Chen L, Benjamin EJ, Levy D. Incidence and prognosis of syncope. N Engl J Med. 2002 Sep 19; 347(12):878-85. View abstract
  49. Chen MH, Cash EP, Danias PG, Kissinger KV, Bornstein BA, Rhodes LM, Harris JR, Gelman R, Manning WJ. Respiratory maneuvers decrease irradiated cardiac volume in patients with left-sided breast cancer. J Mag Reson Imag. 2002; 4(2):265-271. View abstract
  50. Bermudez E, Chen MH. Cardiac effects of propofol for transesophageal-guided cardioversion. Heart Dis. 2002; 4(6):355-7. View abstract
  51. Alvarez Ginzo A, Chen MH. Post-surgical left ventricular pseudoaneurysm. Texas Heart Institute Journal. 2002; 29(3):220-21. View abstract
  52. Chen, MH. Cardiac Ultrasound Curriculum for First Year Cardiac Fellows (Brigham and Women's Hospital). 2001. View abstract
  53. Lu HM, Cash E, Chen MH, Chin L, Manning WJ, Harris J, Bornstein B. Reduction of cardiac volume in left-breast treatment fields by respiratory maneuvers: a CT study. Int J Radiat Oncol Biol Phys. 2000 Jul 01; 47(4):895-904. View abstract
  54. Chen L, Chen MH, Larson MG, Evans J, Benjamin EJ, Levy D. Risk factors for syncope in a community-based sample (the Framingham Heart Study). Am J Cardiol. 2000 May 15; 85(10):1189-93. View abstract
  55. Chen MH. Integration of Managed Care into Clinical Practice. 2000. View abstract
  56. Douglas PS, Katz SE, Weinberg EO, Chen MH, Bishop SP, Lorell BH. Hypertrophic remodeling: gender differences in the early response to left ventricular pressure overload. J Am Coll Cardiol. 1998 Oct; 32(4):1118-25. View abstract
  57. Chen MH, Chuang ML, Bornstein BA, Gelman R, Harris JR, Manning WJ. Impact of respiratory maneuvers on cardiac volume within left-breast radiation portals. Circulation. 1997 Nov 18; 96(10):3269-72. View abstract
  58. Haider AW, Chen L, Larson MG, Evans JC, Chen MH, Levy D. Antecedent hypertension confers increased risk for adverse outcomes after initial myocardial infarction. Hypertension. 1997 Nov; 30(5):1020-4. View abstract
  59. Sagie A, Freitas N, Chen MH, Marshall JE, Weyman AE, Levine RA. Echocardiographic assessment of mitral stenosis and its associated valvular lesions in 205 patients and lack of association with mitral valve prolapse. J Am Soc Echocardiogr. 1997 Mar; 10(2):141-8. View abstract
  60. McConnell MV, Khasgiwala VC, Savord BJ, Chen MH, Chuang ML, Edelman RR, Manning WJ. Prospective adaptive navigator correction for breath-hold MR coronary angiography. Magn Reson Med. 1997 Jan; 37(1):148-52. View abstract
  61. Chuang ML, Chen MH, Khasgiwala VC, McConnell MV, Edelman RR, Manning WJ. Adaptive correction of imaging plane position in segmented K-space cine cardiac MR imaging. J Mag Reson Imag. 1997; Magn Res Med 37:811-814. View abstract
  62. McConnell MV, Khasgiwala VC, Savord BJ, Chen MH, Chuang ML, Edelman RR, Manning WJ. Magnetic resonance coronary angiography during free breathing: comparison of navigator locations and respiratory suppression methods. Am J Roentgenol. 1997; 168:1369-1375. View abstract
  63. Chen L, Ma L, de Prada VA, Chen M, Feng YJ, Waters D, Gillam L, Chen C. Effects of beta-blockade and atropine on ischemic responses in left ventricular regions subtending coronary stenosis during dobutamine stress echocardiography. J Am Coll Cardiol. 1996 Dec; 28(7):1866-76. View abstract
  64. Vazquez de Prada JA, Chen MH, Guerrero JL, Padial LR, Jiang L, Schwammenthal E, Sagie A, Weyman AE, Levine RA, Chen C. Intracardiac echocardiography: in vitro and in vivo validation for right ventricular volume and function. Am Heart J. 1996 Feb; 131(2):320-8. View abstract
  65. Chen C, Li L, Chen LL, Prada JV, Chen MH, Fallon JT, Weyman AE, Waters D, Gillam L. Incremental doses of dobutamine induce a biphasic response in dysfunctional left ventricular regions subtending coronary stenoses. Circulation. 1995 Aug 15; 92(4):756-66. View abstract
  66. Vazquez de Prada JA, Jiang L, Chen MH, Padial LR, Guerrero JL, Schwammenthal E, King ME, Weyman AE, Chen C, Levine RA. Intracardiac ultrasonographic assessment of atrial septal defect area: in vitro validation and technical considerations. Am Heart J. 1995 Aug; 130(2):302-6. View abstract
  67. Padial LR, Chen MH, Vuille C, Guerrero JL, Weyman AE, Picard MH. Pulsatile pressure affects the velocity of decay of echocardiographic contrast agents. J Am Soc Echocardiogr. 1995; 8:285-292.. View abstract
  68. Chen C, Guerrero JL, Vazquez de Prada JA, Padial LR, Schwammenthal E, Chen MH, Jiang L, Svizzero T, Simon H, Thomas JD, et al. Intracardiac ultrasound measurement of volumes and ejection fraction in normal, infarcted, and aneurysmal left ventricles using a 10-MHz ultrasound catheter. Circulation. 1994 Sep; 90(3):1481-91. View abstract
  69. Hendel RC, Chen MH, L'Italien G, Newell JB, Eagle KA. Gender differences in clinical markers and dipyridimole-thallium imaging in the prediction of perioperative and long-term cardiac events after vascular surgery. Circulation. 1994; 91:1044-1051.. View abstract
  70. Chen MH, Weyman AE. Echo-doppler assessment of prosthetic heart valves: what is the meaning for the clinician?. ACC Curr. Jour. Rev. 1994; (Nov-Dec). View abstract
  71. Saul JP, Berger RD, Albrecht P, Stein SP, Chen MH, Cohen RJ. Transfer function analysis of the circulation: unique insights into cardiovascular regulation. Am J Physiol. 1991 Oct; 261(4 Pt 2):H1231-45. View abstract
  72. Chen MH, Berger RD, Saul JP, Stevenson K, Cohen K, Cohen RJ. Transfer function analysis of the autonomic response to respiratory activity druing random interval breathing: II. Respiratory sinus arrhythmia. Am. J. Physiol. 1989; 25:H153-H161.. View abstract
  73. Chen MH, Berger RD, Saul JP, Stevenson K, Cohen RJ. Transfer function analysis of the autonomic response to respiratory activity during random interval breathing. Comput Cardiol. 1987; 13:149-52. View abstract
  74. Berger RD, Chen MH, Saul JP. Method and Apparatus for the Assessment of Autonomic Response by Broad-band Excitation. 1986. View abstract