EDUCATION

Undergraduate Degree

  • University of Washington , 1998 , Seattle , WA

Graduate Degree

PhD, Biophysics
  • Harvard University , 2004 , Cambridge , MA

Medical School

  • Harvard Medical School , 2006 , Boston , MA

Internship

  • Boston Children's Hospital , 2009 , Boston , MA

Fellowship

Pediatric Cardiology
  • Boston Children's Hospital , 2011 , Boston , MA

Fellowship

Electrophysiology
  • Boston Children's Hospital , 2013 , Boston , MA

Philosophy of Care

Caring for patients is a humbling and tremendous privilege. Working with patients and their families to understand their cardiac condition and devise a management strategy together is a deeply rewarding experience. Understanding each individual patient's story is critically important to providing the highest quality care. This is especially true with patients that have forms of inherited cardiac conditions. Working in the Inherited Cardiac Arrhythmia Program provides a unique opportunity to combine my knowledge of basic cardiovascular science with the latest clinical research to help treat patients with channelopathies and other forms of genetic heart disease. Caring for patients is also tremendously inspiring and directly influences my work as a research scientist to develop novel therapies for patients with inherited cardiac disease.

PROFESSIONAL HISTORY

I went to the University of Washington in Seattle where I studied physics and biochemistry. I was lucky enough to work on a number of different research projects ranging from high-energy nuclear physics to microgravity. My medical degree and PhD in biophysics are from Harvard Medical and MIT, where I had the opportunity to work with Dr. David Clapham. Following graduation, I did my internship and residency in pediatrics at the Boston Combined Residency Program. It was here, working with patients at Boston Medical Center, that I developed my interest in long-term care of patients and their families.

I completed a fellowship in pediatric cardiology and acquired additional specialized training in electrophysiology and research. I started on staff at Boston Children's Hospital in 2013 as both a clinical electrophysiologist and a basic research scientist in the fields of inherited cardiac disease and arrhythmia. Under the mentorship of Dr. William Pu, I have developed a program to use induced pluripotent stem cells from patients as models of human cardiac disease to improve therapies for patients with inherited arrhythmia disorders.

CERTIFICATIONS

  • American Board of Pediatrics, General Pediatrics
  • American Board of Pediatrics, Pediatric Cardiology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. O'Leary ET, Gauvreau K, Alexander ME, Banka P, Bezzerides VJ, Fynn-Thompson F, Triedman JK, Walsh EP, Mah DY. Dual-Site Ventricular Pacing in Patients With Fontan Physiology and Heart Block: Does it Mitigate the Detrimental Effects of Single-Site Ventricular Pacing? JACC Clin Electrophysiol. 2018 Oct; 4(10):1289-1297. View abstract
  2. Frasier CR, Zhang H, Offord J, Dang LT, Auerbach DS, Shi H, Chen C, Goldman AM, Eckhardt LL, Bezzerides VJ, Parent JM, Isom LL. Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes. Stem Cell Reports. 2018 Sep 11; 11(3):626-634. View abstract
  3. Meziab O, Abrams DJ, Alexander ME, Bevilacqua L, Bezzerides V, Mah DY, Walsh EP, Triedman JK. Utility of incomplete right bundle branch block as an isolated ECG finding in children undergoing initial cardiac evaluation. Congenit Heart Dis. 2018 May; 13(3):419-427. View abstract
  4. Hinsley K, Evans-Langhorst M, Porter C, Chandler S, VanderPluym C, Triedman J, Bezzerides VJ. Low molecular weight heparin as an anticoagulation strategy for left-sided ablation procedures. Congenit Heart Dis. 2018 Mar; 13(2):222-225. View abstract
  5. Hylind RJ, Ladouceur VB, Fynn-Thompson F, Hourigan SE, Bezzerides VJ, Abrams DJ. Genotype-phenotype-guided medical and surgical intervention in long QT syndrome. HeartRhythm Case Rep. 2018 Jan; 4(1):14-17. View abstract
  6. Zhang D, Li Y, Heims-Waldron D, Bezzerides V, Guatimosim S, Guo Y, Gu F, Zhou P, Lin Z, Ma Q, Liu J, Wang DZ, Pu WT. Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation. Circ Res. 2018 Jan 05; 122(1):74-87. View abstract
  7. Chambers KD, Beausejour Ladouceur V, Alexander ME, Hylind RJ, Bevilacqua L, Mah DY, Bezzerides V, Triedman JK, Walsh EP, Abrams DJ. Cardiac Events During Competitive, Recreational, and Daily Activities in Children and Adolescents With Long QT Syndrome. J Am Heart Assoc. 2017 Sep 21; 6(9). View abstract
  8. Bezzerides VJ, Zhang A, Xiao L, Simonson B, Khedkar SA, Baba S, Ottaviano F, Lynch S, Hessler K, Rigby AC, Milan D, Das S, Rosenzweig A. Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders. Sci Rep. 2017 03 23; 7(1):346. View abstract
  9. Bezzerides VJ, Zhang D, Pu WT. Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ J. 2016 Dec 22; 81(1):12-21. View abstract
  10. Williams MR, Atkinson DB, Bezzerides VJ, Yuki K, Franklin K, Casta A, Alexander ME. Pausing With the Gauze: Inhibition of Temporary Pacemakers by Radiofrequency Scan During Cardiac Surgery. Anesth Analg. 2016 11; 123(5):1143-1148. View abstract
  11. Lin Z, Guo H, Cao Y, Zohrabian S, Zhou P, Ma Q, VanDusen N, Guo Y, Zhang J, Stevens SM, Liang F, Quan Q, van Gorp PR, Li A, Dos Remedios C, He A, Bezzerides VJ, Pu WT. Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Dev Cell. 2016 11 21; 39(4):466-479. View abstract
  12. Lerchenmüller C, Heißenberg J, Damilano F, Bezzeridis VJ, Krämer I, Bochaton-Piallat ML, Hirschberg K, Busch M, Katus HA, Peppel K, Rosenzweig A, Busch H, Boerries M, Most P. S100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1854-67. View abstract
  13. Bezzerides VJ, Platt C, Lerchenmüller C, Paruchuri K, Oh NL, Xiao C, Cao Y, Mann N, Spiegelman BM, Rosenzweig A. CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury. JCI Insight. 2016 Jun 16; 1(9). View abstract
  14. Liu X, Xiao J, Zhu H, Wei X, Platt C, Damilano F, Xiao C, Bezzerides V, Boström P, Che L, Zhang C, Spiegelman BM, Rosenzweig A. miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell Metab. 2015 Apr 07; 21(4):584-95. View abstract
  15. Ryall KA, Bezzerides VJ, Rosenzweig A, Saucerman JJ. Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation. J Mol Cell Cardiol. 2014 Jul; 72:74-84. View abstract
  16. Bezzerides V, Rosenzweig A. Saying yes to exercise and NO to cardiac injury. Circ Res. 2011 Jun 10; 108(12):1414-6. View abstract
  17. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE. Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol. 2004 Aug; 6(8):709-20. View abstract
  18. Bezzerides VJ, Clapham DE. SPIE- The International Society for Optical Engineering. Near-membrane protein dynamics revealed by evanescent field microscopy. 2004; (5467):326-337. View abstract
  19. Oancea E, Bezzerides VJ, Greka A, Clapham DE. Mechanism of persistent protein kinase D1 translocation and activation. Dev Cell. 2003 Apr; 4(4):561-74. View abstract
  20. Matula TJ, Bezzerides VJ, Himo PaulR, Couret LisaN, Olsen TW, Larry CrumA, Jarred SE, David KW, Robert RoyA. The effects of buoyancy on sonoluminescing bubbles. Acoustics research letters online : ARLO. 2000; (1):12-18. View abstract
  21. Bezzerides VJ, Matula TJ. The search for electrical discharges from single- and multi-bubble sonoluminescence. The Journal of the Acoustical Society of America. 1999; 1020(105). View abstract