Roger Breitbart

Roger Breitbart, MD

Chief, Inpatient Cardiology Division

Assistant Professor of Pediatrics, Harvard Medical School

Medical Services

Specialties

  • Pediatric Cardiology

Departments

  • Cardiology

Programs

  • Cardiology Consultation Service
  • Cardiac Inpatient Unit
  • Cardiology Outpatient Services
To schedule an appointment: Call 617-355-7696 or Request an Appointment

Experience and Education

Education

Undergraduate Degree

BA, Haverford College, 1977

Haverford, PA

Medical Degree

MD, Harvard Medical School, 1981

Boston, MA

Internship, Pediatrics

Boston Children's Hospital, 1981-1982

Boston, MA

Residency, Pediatrics

Boston Children's Hospital , 1982-1984

Boston, MA

Fellowship, Pediatric Cardiology

Boston Children's Hospital , 1984-1989

Boston, MA

Certifications

  • Pediatric Cardiology

  • American Board of Pediatrics

Publications

Publications powered by Harvard Catalyst Profiles
  1. Homsy J, Zaidi S, Shen Y, Ware JS, Samocha KE, Karczewski KJ, DePalma SR, McKean D, Wakimoto H, Gorham J, Jin SC, Deanfield J, Giardini A, Porter GA, Kim R, Bilguvar K, López-Giráldez F, Tikhonova I, Mane S, Romano-Adesman A, Qi H, Vardarajan B, Ma L, Daly M, Roberts AE, Russell MW, Mital S, Newburger JW, Gaynor JW, Breitbart RE, Iossifov I, Ronemus M, Sanders SJ, Kaltman JR, Seidman JG, Brueckner M, Gelb BD, Goldmuntz E, Lifton RP, Seidman CE, Chung WK. De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies. Science. 2015 Dec 4; 350(6265):1262-6.
  2. Atz AM, Zak V, Mahony L, Uzark K, Shrader P, Gallagher D, Paridon SM, Williams RV, Breitbart RE, Colan SD, Kaltman JR, Margossian R, Pasquali SK, Allen K, Lai WW, Korsin R, Marino BS, Mirarchi N, McCrindle BW. Survival data and predictors of functional outcome an average of 15?years after the Fontan procedure: the pediatric heart network Fontan cohort. Congenit Heart Dis. 2015 Jan-Feb; 10(1):E30-42.
  3. Wu FM, Opotowsky AR, Raza R, Harney S, Ukomadu C, Landzberg MJ, Valente AM, Breitbart RE, Singh MN, Gauvreau K, Jonas MM. Transient elastography may identify Fontan patients with unfavorable hemodynamics and advanced hepatic fibrosis. Congenit Heart Dis. 2014 Sep-Oct; 9(5):438-47.
  4. Quiñonez LG, Breitbart R, Tworetsky W, Lock JE, Marshall AC, Emani SM. Stented bovine jugular vein graft (Melody valve) for surgical mitral valve replacement in infants and children. J Thorac Cardiovasc Surg. 2014 Oct; 148(4):1443-9.
  5. McCrindle BW, Zak V, Breitbart RE, Mahony L, Shrader P, Lai WW, Burns KM, Colan SD, Williams RV, Goldberg D, Hill KD, Khaikin S, Atz AM. The relationship of patient medical and laboratory characteristics to changes in functional health status in children and adolescents after the Fontan procedure. Pediatr Cardiol. 2014 Apr; 35(4):632-40.
  6. Zaidi S, Choi M, Wakimoto H, Ma L, Jiang J, Overton JD, Romano-Adesman A, Bjornson RD, Breitbart RE, Brown KK, Carriero NJ, Cheung YH, Deanfield J, DePalma S, Fakhro KA, Glessner J, Hakonarson H, Italia MJ, Kaltman JR, Kaski J, Kim R, Kline JK, Lee T, Leipzig J, Lopez A, Mane SM, Mitchell LE, Newburger JW, Parfenov M, Pe'er I, Porter G, Roberts AE, Sachidanandam R, Sanders SJ, Seiden HS, State MW, Subramanian S, Tikhonova IR, Wang W, Warburton D, White PS, Williams IA, Zhao H, Seidman JG, Brueckner M, Chung WK, Gelb BD, Goldmuntz E, Seidman CE, Lifton RP. De novo mutations in histone-modifying genes in congenital heart disease. Nature. 2013 Jun 13; 498(7453):220-3.
  7. Atz AM, Travison TG, McCrindle BW, Mahony L, Glatz AC, Kaza AK, Breitbart RE, Colan SD, Kaltman JR, Margossian R, Pasquali SK, Wang Y, Gersony WM. Cardiac performance and quality of life in patients who have undergone the Fontan procedure with and without prior superior cavopulmonary connection. Cardiol Young. 2013 Jun; 23(3):335-43.
  8. Shuhaiber JH, Robinson B, Gauvreau K, Breitbart R, Mayer JE, Del Nido PJ, Pigula F. Outcome after repair of atrioventricular septal defect with tetralogy of Fallot. J Thorac Cardiovasc Surg. 2012 Feb; 143(2):338-43.
  9. Atz AM, Travison TG, McCrindle BW, Mahony L, Quartermain M, Williams RV, Breitbart RE, Lu M, Radojewski E, Margossian R, Covitz W, Gersony WM. Late status of Fontan patients with persistent surgical fenestration. J Am Coll Cardiol. 2011 Jun 14; 57(24):2437-43.
  10. Atz AM, Zak V, Breitbart RE, Colan SD, Pasquali SK, Hsu DT, Lu M, Mahony L, Paridon SM, Puchalski MD, Geva T, McCrindle BW. Factors associated with serum brain natriuretic peptide levels after the Fontan procedure. Congenit Heart Dis. 2011 Jul-Aug; 6(4):313-21.
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  12. Anderson PA, Breitbart RE, McCrindle BW, Sleeper LA, Atz AM, Hsu DT, Lu M, Margossian R, Williams RV. The Fontan patient: inconsistencies in medication therapy across seven pediatric heart network centers. Pediatr Cardiol. 2010 Nov; 31(8):1219-28.
  13. McCrindle BW, Zak V, Sleeper LA, Paridon SM, Colan SD, Geva T, Mahony L, Li JS, Breitbart RE, Margossian R, Williams RV, Gersony WM, Atz AM. Laboratory measures of exercise capacity and ventricular characteristics and function are weakly associated with functional health status after Fontan procedure. Circulation. 2010 Jan 5; 121(1):34-42.
  14. Greenway SC, Pereira AC, Lin JC, DePalma SR, Israel SJ, Mesquita SM, Ergul E, Conta JH, Korn JM, McCarroll SA, Gorham JM, Gabriel S, Altshuler DM, Quintanilla-Dieck Mde L, Artunduaga MA, Eavey RD, Plenge RM, Shadick NA, Weinblatt ME, De Jager PL, Hafler DA, Breitbart RE, Seidman JG, Seidman CE. De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nat Genet. 2009 Aug; 41(8):931-5.
  15. Anderson PA, Sleeper LA, Mahony L, Colan SD, Atz AM, Breitbart RE, Gersony WM, Gallagher D, Geva T, Margossian R, McCrindle BW, Paridon S, Schwartz M, Stylianou M, Williams RV, Clark BJ. Contemporary outcomes after the Fontan procedure: a Pediatric Heart Network multicenter study. J Am Coll Cardiol. 2008 Jul 8; 52(2):85-98.
  16. Blaufox AD, Sleeper LA, Bradley DJ, Breitbart RE, Hordof A, Kanter RJ, Stephenson EA, Stylianou M, Vetter VL, Saul JP. Functional status, heart rate, and rhythm abnormalities in 521 Fontan patients 6 to 18 years of age. J Thorac Cardiovasc Surg. 2008 Jul; 136(1):100-7, 107.e1.
  17. Conta JH, Breitbart RE. . Genomics of congenital heart disease. Willard HF, Ginsburg GS, editors., Handbook of genomic medicine. 2008; In Press.
  18. Atz AM, Cohen MS, Sleeper LA, McCrindle BW, Lu M, Prakash A, Breitbart RE, Williams RV, Sang CJ, Wernovsky G. Functional state of patients with heterotaxy syndrome following the Fontan operation. Cardiol Young. 2007 Sep; 17 Suppl 2:44-53.
  19. Kühn B, Peters J, Marx GR, Breitbart RE. Etiology, management, and outcome of pediatric pericardial effusions. Pediatr Cardiol. 2008 Jan; 29(1):90-4.
  20. Gurley SB, Allred A, Le TH, Griffiths R, Mao L, Philip N, Haystead TA, Donoghue M, Breitbart RE, Acton SL, Rockman HA, Coffman TM. Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J Clin Invest. 2006 Aug; 116(8):2218-25.
  21. Lin J, Greenway SC, Breitbart RE, Hastings JR, Pereira AC, Seidman CS, Seidman JG. . Synthetic Oligonucleotide Multiplex Ligation-dependent Probe Amplification (MLPA) for the Detection of Novel Deletions in Candidate Genes Causing Tetralogy of Fallot. AHA. 2006; Submitted.
  22. Naito Y, Jain M, Force T, Ngoy S, Shi J, Cui L, Jeyaseelan R, Breitbart RE, Liao R. CARK, a novel cacardiac specific kinase, mediates structural remodeling and contractile function following myocardial infarction. AHA. 2006; submitted.
  23. Breitbart RE. . Pericardial Diseases. Keane JB, Lock, JE, Fyler DC, editors., Nadas’ Pediatric Cardiology. 2006; 459-466.
  24. Breitbart RE, Fyler DC. Tetralogy of Fallot. Keane JB, Lock, JE, Fyler DC, editors., Nadas’ Pediatric Cardiology. 2006; 559-579.
  25. Rodrigue-Way A, Burkhoff D, Geesaman BJ, Golden S, Xu J, Pollman MJ, Donoghue M, Jeyaseelan R, Houser S, Breitbart RE, Marks A, Acton S. Sarcomeric genes involved in reverse remodeling of the heart during left ventricular assist device support. J Heart Lung Transplant. 2005 Jan; 24(1):73-80.
  26. Cua CL, Sanghavi D, Voss S, Laussen PC, del Nido P, Marshall A, Breitbart RE. Right ventricular pseudoaneurysm after modified Norwood procedure. Ann Thorac Surg. 2004 Oct; 78(4):e72-3.
  27. Donoghue M, Wakimoto H, Maguire CT, Acton S, Hales P, Stagliano N, Fairchild-Huntress V, Xu J, Lorenz JN, Kadambi V, Berul CI, Breitbart RE. Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins. J Mol Cell Cardiol. 2003 Sep; 35(9):1043-53.
  28. Acton S, Jeyaseelan R, Kadambi VJ, Breitbart RE. Array transcription profiling: molecular phenotyping of rodent cardiovascular models. Hoit BD, Walsh RA, editors. Cardiovascular physiology in the genetically engineered mouse. 2002; 53-61.
  29. Ross JS, Stagliano NE, Donovan MJ, Breitbart RE, Ginsburg GS. Atherosclerosis: a cancer of the blood vessels? Am J Clin Pathol. 2001 Dec; 116 Suppl:S97-107.
  30. Ross JS, Stagliano NE, Donovan MJ, Breitbart RE, Ginsburg GS. Atherosclerosis and cancer: common molecular pathways of disease development and progression. Ann N Y Acad Sci. 2001 Dec; 947:271-92; discussion 292-3.
  31. Herman MP, Sukhova GK, Libby P, Gerdes N, Tang N, Horton DB, Kilbride M, Breitbart RE, Chun M, Schönbeck U. Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling. Circulation. 2001 Oct 16; 104(16):1899-904.
  32. Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res. 2000 Sep 1; 87(5):E1-9.
  33. Angelo S, Lohr J, Lee KH, Ticho BS, Breitbart RE, Hill S, Yost HJ, Srivastava D. Conservation of sequence and expression of Xenopus and zebrafish dHAND during cardiac, branchial arch and lateral mesoderm development. Mech Dev. 2000 Jul; 95(1-2):231-7.
  34. Park M, Lewis C, Turbay D, Chung A, Chen JN, Evans S, Breitbart RE, Fishman MC, Izumo S, Bodmer R. Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes. Proc Natl Acad Sci U S A. 1998 Aug 4; 95(16):9366-71.
  35. Fishman MC, Stainier DY, Breitbart RE, Westerfield M. Zebrafish: genetic and embryological methods in a transparent vertebrate embryo. Methods Cell Biol. 1997; 52:67-82.
  36. Lee KH, Xu Q, Breitbart RE. A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. Dev Biol. 1996 Dec 15; 180(2):722-31.
  37. Ticho BS, Stainier DY, Fishman MC, Breitbart RE. Three zebrafish MEF2 genes delineate somitic and cardiac muscle development in wild-type and mutant embryos. Mech Dev. 1996 Oct; 59(2):205-18.
  38. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 1996 Feb 9; 84(3):491-5.
  39. Breitbart RE, London B, Nguyen HT, Satler CA. Recent advances in the Laboratory of Molecular and Cellular Cardiology. Ann Thorac Surg. 1995 Dec; 60(6 Suppl):S509-12.
  40. Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B. A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. Development. 1993 Aug; 118(4):1095-106.
  41. Leifer D, Krainc D, Yu YT, McDermott J, Breitbart RE, Heng J, Neve RL, Kosofsky B, Nadal-Ginard B, Lipton SA. MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proc Natl Acad Sci U S A. 1993 Feb 15; 90(4):1546-50.
  42. Yu YT, Breitbart RE, Smoot LB, Lee Y, Mahdavi V, Nadal-Ginard B. Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev. 1992 Sep; 6(9):1783-98.
  43. Nadal-Ginard B, Smith CW, Patton JG, Breitbart RE. Alternative splicing is an efficient mechanism for the generation of protein diversity: contractile protein genes as a model system. Adv Enzyme Regul. 1991; 31:261-86.
  44. Breitbart RE, Nadal-Ginard B. Tissue specific alternative splicing in the troponin T multigene family. Renkawitz R, editor. Tissue Specific Gene Expression. 1989; 199-215.
  45. Smith CWJ, Gallego ME, Andreadis A, Breitbart RE, et al. . Alternative splicing of contractile protein minigene constructs is directed by cis and trans mechanisms. Mechanisms of control of gene expression. 1988; 67:265-77.
  46. Breitbart RE, Nadal-Ginard B. Developmentally induced, muscle-specific trans factors control the differential splicing of alternative and constitutive troponin T exons. Cell. 1987 Jun 19; 49(6):793-803.
  47. Breitbart RE, Andreadis A, Nadal-Ginard B. Alternative splicing: a ubiquitous mechanism for the generation of multiple protein isoforms from single genes. Annu Rev Biochem. 1987; 56:467-95.
  48. Ginard B. Gallego M, Andreadis A, Breitbart RE, et al. . Promoter selection and alternative pre-mRNA splicing are used to generate complex contractile protein phenotypes. Norman AW, Vanaman TC, Means AR, editors. Calcium-binding Proteins in Health and Disease. 1987; 518-532.
  49. Breitbart RE, Nadal-Ginard B. Complete nucleotide sequence of the fast skeletal troponin T gene. Alternatively spliced exons exhibit unusual interspecies divergence. J Mol Biol. 1986 Apr 5; 188(3):313-24.
  50. Nadal-Ginard B, Breitbart RE, Strehler EE, et al. Alternative splicing: a common mechanism for the generation of contractile protein diversity from single genes. Molecular biology of muscle development. 1986; 29:387-410.
  51. Breitbart RE, Nguyen HT, Medford RM, Destree AT, Mahdavi V, Nadal-Ginard B. Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene. Cell. 1985 May; 41(1):67-82.
  52. Kaplan MM, Breitbart R. Conversion of thyroxine to triiodothyronine in the anterior pituitary gland and the influence of this process on thyroid status. Horm Metab Res Suppl. 1984; 14:79-85.
  53. Kaplan MM, Tatro JB, Breitbart R, Larsen PR. Comparison of thyroxine and 3,3',5'-triiodothyronine metabolism in rat kidney and liver homogenates. Metabolism. 1979 Nov; 28(11):1139-46.
To schedule an appointment: Call 617-355-7696 or Request an Appointment

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