John Arnold

John Arnold, MD

Senior Associate in Critical Care Medicine; Senior Associate in Perioperative Anesthesia

Professor of Anaesthesia, Harvard Medical School

  • Contact: 617-355-7327

  • Fax: 617-730-0453

Medical Services

Specialties

  • Anesthesia
  • Critical Care
  • Respiratory Care

Departments

  • Critical Care Medicine
  • Anesthesiology Perioperative and Pain Medicine

Programs

  • ECMO Program
To schedule an appointment:

Experience and Education

Education

Medical School

Harvard Medical School, 1984

Boston, MA

Internship, Pediatrics

Boston Children's Hospital, 1984 to 1985

Boston, MA

Residency, Anesthesia

Beth Israel Deaconess Medical Center, 1987 to 1989

Boston, MA

Residency, Pediatrics

Boston Children's Hospital, 1985 to 1987

Boston, MA

Fellowship, Pediatric Anesthesia

Boston Children's Hospital , 1989 to 1990

Boston, MA

Certifications

  • Anesthesiology, Pediatrics, Critical Care

Publications

Publications powered by Harvard Catalyst Profiles
  1. Walsh BK, Smallwood CD, Rettig JS, Thompson JE, Kacmarek RM, Arnold JH. Categorization in Mechanically Ventilated Pediatric Subjects: A Proposed Method to Improve Quality. Respir Care. 2016 Sep; 61(9):1168-78.
  2. Walsh BK, Betit P, Fink JB, Pereira LM, Arnold J. Characterization of Ribavirin Aerosol With Small Particle Aerosol Generator and Vibrating Mesh Micropump Aerosol Technologies. Respir Care. 2016 May; 61(5):577-85.
  3. Rettig JS, Smallwood CD, Walsh BK, Rimensberger PC, Bachman TE, Bollen CW, Duval EL, Gebistorf F, Markhorst DG, Tinnevelt M, Todd M, Zurakowski D, Arnold JH. High-Frequency Oscillatory Ventilation in Pediatric Acute Lung Injury: A Multicenter International Experience. Crit Care Med. 2015 Dec; 43(12):2660-7.
  4. Walsh BK, Davis MD, Hunt JF, Kheir JN, Smallwood CD, Arnold JH. The effects of lung recruitment maneuvers on exhaled breath condensate pH. J Breath Res. 2015 Sep; 9(3):036009.
  5. Wolf GK, Gómez-Laberge C, Rettig JS, Vargas SO, Smallwood CD, Prabhu SP, Vitali SH, Zurakowski D, Arnold JH. Mechanical ventilation guided by electrical impedance tomography in experimental acute lung injury. Crit Care Med. 2013 May; 41(5):1296-304.
  6. Gómez-Laberge C, Rettig JS, Smallwood CD, Boyd TK, Arnold JH, Wolf GK. Interaction of dependent and non-dependent regions of the acutely injured lung during a stepwise recruitment manoeuvre. Physiol Meas. 2013 Feb; 34(2):163-77.
  7. Kheir JN, Walsh BK, Smallwood CD, Rettig JS, Thompson JE, Gómez-Laberge C, Wolf GK, Arnold JH. Comparison of 2 lung recruitment strategies in children with acute lung injury. Respir Care. 2013 Aug; 58(8):1280-90.
  8. Wolf GK, Gómez-Laberge C, Kheir JN, Zurakowski D, Walsh BK, Adler A, Arnold JH. Reversal of dependent lung collapse predicts response to lung recruitment in children with early acute lung injury. Pediatr Crit Care Med. 2012 Sep; 13(5):509-15.
  9. Costello JM, O'Brien M, Wypij D, Shubert J, Salvin JW, Newburger JW, Laussen PC, Arnold JH, Fynn-Thompson F, Thiagarajan RR. Quality of life of pediatric cardiac patients who previously required extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2012 Jul; 13(4):428-34.
  10. Adler A, Amato MB, Arnold JH, Bayford R, Bodenstein M, Böhm SH, Brown BH, Frerichs I, Stenqvist O, Weiler N, Wolf GK. Whither lung EIT: where are we, where do we want to go and what do we need to get there? Physiol Meas. 2012 May; 33(5):679-94.
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  12. Turner DA, Heitz D, Cooper MK, Smith PB, Arnold JH, Bateman ST. Isoflurane for life-threatening bronchospasm: a 15-year single-center experience. Respir Care. 2012 Nov; 57(11):1857-64.
  13. Rettig JS, Arnold JH. High-frequency oscillatory ventilation: learning which way to turn the dials. Pediatr Crit Care Med. 2012 Mar; 13(2):242-4.
  14. Gómez-Laberge C, Arnold JH, Wolf GK. A unified approach for EIT imaging of regional overdistension and atelectasis in acute lung injury. IEEE Trans Med Imaging. 2012 Mar; 31(3):834-42.
  15. Wolf GK, Walsh BK, Green ML, Arnold JH. Electrical activity of the diaphragm during extubation readiness testing in critically ill children. Pediatr Crit Care Med. 2011 Nov; 12(6):e220-4.
  16. Ferguson LP, Walsh BK, Munhall D, Arnold JH. A spontaneous breathing trial with pressure support overestimates readiness for extubation in children. Pediatr Crit Care Med. 2011 Nov; 12(6):e330-5.
  17. Ventre KM, Wolf GK, Arnold JH. Pediatric respiratory diseases: 2011 update for the Rogers' Textbook of Pediatric Intensive Care. Pediatr Crit Care Med. 2011 May; 12(3):325-38.
  18. Green ML, Walsh BK, Wolf GK, Arnold JH. Electrocardiographic guidance for the placement of gastric feeding tubes: a pediatric case series. Respir Care. 2011 Apr; 56(4):467-71.
  19. Mehta NM, Turner D, Walsh B, Zurakowski D, Betit P, Wilson J, Arnold JH. Factors associated with survival in pediatric extracorporeal membrane oxygenation--a single-center experience. J Pediatr Surg. 2010 Oct; 45(10):1995-2003.
  20. Wolf GK, Grychtol B, Frerichs I, Zurakowski D, Arnold JH. Regional lung volume changes during high-frequency oscillatory ventilation. Pediatr Crit Care Med. 2010 Sep; 11(5):610-5.
  21. Grychtol B, Wolf GK, Adler A, Arnold JH. Towards lung EIT image segmentation: automatic classification of lung tissue state from analysis of EIT monitored recruitment manoeuvres. Physiol Meas. 2010 Aug; 31(8):S31-43.
  22. Wolf GK, Grychtol B, Boyd TK, Zurakowski D, Arnold JH. Regional overdistension identified with electrical impedance tomography in the perflubron-treated lung. Physiol Meas. 2010 Aug; 31(8):S85-95.
  23. Walsh BK, Craig N, Betit P, Thompson JE, Arnold JH. Respiratory distress associated with inadequate mechanical ventilator flow response in a neonate with congenital diaphragmatic hernia. Respir Care. 2010 Mar; 55(3):342-5.
  24. Wolf GK, Arnold JH. Synchronizing ventilatory support with the neural signal to breathe. Pediatr Crit Care Med. 2010 Jan; 11(1):142-3.
  25. O'Reilly EB, Montenegro B, Arnold J, Tomita S. Infant botulism mimicking Hirschprung's disease. J Pediatr Surg. 2009 Oct; 44(10):e5-7.
  26. Turner DA, Heitz D, Zurakowski D, Arnold JH. Automated measurement of the lower inflection point in a pediatric lung model. Pediatr Crit Care Med. 2009 Jul; 10(4):511-6.
  27. Adler A, Arnold JH, Bayford R, Borsic A, Brown B, Dixon P, Faes TJ, Frerichs I, Gagnon H, Gärber Y, Grychtol B, Hahn G, Lionheart WR, Malik A, Patterson RP, Stocks J, Tizzard A, Weiler N, Wolf GK. GREIT: a unified approach to 2D linear EIT reconstruction of lung images. Physiol Meas. 2009 Jun; 30(6):S35-55.
  28. Grychtol B, Wolf GK, Arnold JH. Differences in regional pulmonary pressure-impedance curves before and after lung injury assessed with a novel algorithm. Physiol Meas. 2009 Jun; 30(6):S137-48.
  29. Wolf GK, Sheeran P, Heitz D, Thompson JE, Arnold JH. Gas exchange and lung mechanics during high frequency ventilation in the perflubron-treated lung. Pediatr Crit Care Med. 2008 Nov; 9(6):641-6.
  30. Turner DA, Arnold JH. Improving our approach to sedation in the pediatric intensive care unit: is it time to inhale? Pediatr Crit Care Med. 2008 Mar; 9(2):233-4.
  31. Wolf GK, Arnold JH. Assessing the benefits of noninvasive ventilation: the tissue is the issue. Crit Care Med. 2008 Jan; 36(1):349-50.
  32. Wolf GK, Arnold JH. A (large) step toward improved lung protection. Pediatr Crit Care Med. 2008 Jan; 9(1):127-8.
  33. Wolf GK, Grychtol B, Frerichs I, van Genderingen HR, Zurakowski D, Thompson JE, Arnold JH. Regional lung volume changes in children with acute respiratory distress syndrome during a derecruitment maneuver. Crit Care Med. 2007 Aug; 35(8):1972-8.
  34. Wolf GK, Arnold JH. Measurement of deadspace compartments: on the road to somewhere. Pediatr Crit Care Med. 2007 Jul; 8(4):408-9.
  35. Mehta NM, Halwick DR, Dodson BL, Thompson JE, Arnold JH. Potential drug sequestration during extracorporeal membrane oxygenation: results from an ex vivo experiment. Intensive Care Med. 2007 Jun; 33(6):1018-24.
  36. Turner DA, Arnold JH. Insights in pediatric ventilation: timing of intubation, ventilatory strategies, and weaning. Curr Opin Crit Care. 2007 Feb; 13(1):57-63.
  37. Wolf GK, Arnold JH. Electrical impedance tomography: Ready for prime time? Intensive Care Med. 2006 Sep; 32(9):1290-2.
  38. Curley MA, Harris SK, Fraser KA, Johnson RA, Arnold JH. State Behavioral Scale: a sedation assessment instrument for infants and young children supported on mechanical ventilation. Pediatr Crit Care Med. 2006 Mar; 7(2):107-14.
  39. Curley MA, Arnold JH, Thompson JE, Fackler JC, Grant MJ, Fineman LD, Cvijanovich N, Barr FE, Molitor-Kirsch S, Steinhorn DM, Matthay MA, Hibberd PL. Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome. J Crit Care. 2006 Mar; 21(1):23-32; discussion 32-7.
  40. Randolph AG, Forbes PW, Gedeit RG, Arnold JH, Wetzel RC, Luckett PM, O'Neil ME, Venkataraman ST, Meert KL, Cheifetz IM, Cox PN, Hanson JH. Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children. Pediatr Crit Care Med. 2005 Nov; 6(6):642-7.
  41. Mehta NM, Arnold JH. Genetic polymorphisms in acute respiratory distress syndrome: new approach to an old problem. Crit Care Med. 2005 Oct; 33(10):2443-5.
  42. Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay MA, Arnold JH. Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. JAMA. 2005 Jul 13; 294(2):229-37.
  43. Wolf GK, Arnold JH. Noninvasive assessment of lung volume: respiratory inductance plethysmography and electrical impedance tomography. Crit Care Med. 2005 Mar; 33(3 Suppl):S163-9.
  44. Ventre KM, Arnold JH. Patient in impending respiratory failure. Paediatr Respir Rev. 2004 Dec; 5(4):339, 341.
  45. Ventre KM, Arnold JH. High frequency oscillatory ventilation in acute respiratory failure. Paediatr Respir Rev. 2004 Dec; 5(4):323-32.
  46. Vitali SH, Arnold JH. Bench-to-bedside review: Ventilator strategies to reduce lung injury -- lessons from pediatric and neonatal intensive care. Crit Care. 2005 Apr; 9(2):177-83.
  47. Hardart GE, Hardart MK, Arnold JH. Intracranial hemorrhage in premature neonates treated with extracorporeal membrane oxygenation correlates with conceptional age. J Pediatr. 2004 Aug; 145(2):184-9.
  48. Arnold JH. Electrical impedance tomography: on the path to the Holy Grail. Crit Care Med. 2004 Mar; 32(3):894-5.
  49. Mehta NM, Arnold JH. Mechanical ventilation in children with acute respiratory failure. Curr Opin Crit Care. 2004 Feb; 10(1):7-12.
  50. Ventre KM, Arnold JH. Acute parenchymal disease in infants and children, in Fink MB, Shoemaker WC, et al (eds.), Textbook of Critical Care (5th edition), Elsevier, Philadelphia, in press. 2004.
  51. Cooper MK, Arnold JH. Respiratory Disorders: ECMO, in Cloherty JP, Stark AR, Eichenwald E (eds). Manual of Neonatal Care (5th edition), Williams & Wilkins, Philadelphia. 2004; 364-70.
  52. Wolf JK, Arnold JH. Assessment of alveolar recruitment: new approaches. Yearbook of Critical Care, in press. 2004.
  53. Randolph AG, Forbes P, Gedeit RG, Arnold JH, Wetzel R, Luckett PM, O’Neil ME, Venkataraman ST, Meert KL, Cheifetz IM, Cox PN, Hanson JH. Cumulative fluid balance does not influence weaning duration or extubation outcomes in children. Ped Crit Care Med, in press. 2004.
  54. Wolf GK, Arnold JH. Non-invasive assessment of lung volume: respiratory inductance plethysmography and electric impedance tomography. Critical Care Medicine, in press. 2004.
  55. Wolf GK, van Genderingen HR, Thompson JE, Watson K, Arnold JH. Changes in Lung Impedance Following Derecruitment During High Frequency Ventilation. Presented at the Pediatric Academic Societies Annual Meeting, San Francisco, CA. 2004.
  56. Mehta NM, Arnold JH. Sublingual capnometry in pediatric patients. Yearbook of Critical Care, in press. 2004.
  57. Vitali SH, Arnold JH. Bench-to-bedside review: Ventilator strategies to reduce lung injury- lessons from pediatric and neonatal intensive care. Critical Care Forum, in press. 2004.
  58. Vitali SH, Camerota AJ, Arnold JH. Anesthesia and analgesia, in Avery GB, Fletcher MA, MacDonald MG (eds.), Neonatology: Pathophysiology and Management of the Newborn (6th Edition), J.B. Lippincott, Philadelphia, in press. 2004.
  59. Arnold JH. Electrical impedance tomography: on the path to the Holy Grail. Crit Care Med 32: 894-895, 2004. 2004; 32:894-5.
  60. Downard CD, Betit P, Chang RW, Garza JJ, Arnold JH, Wilson JM. Impact of AMICAR on hemorrhagic complications of ECMO: a ten-year review. J Pediatr Surg. 2003 Aug; 38(8):1212-6.
  61. Doctor A, Al-Khadra E, Tan P, Watson KF, Diesen DL, Workman LJ, Thompson JE, Rose CE, Arnold JH. Extended high-frequency partial liquid ventilation in lung injury: gas exchange, injury quantification, and vapor loss. J Appl Physiol (1985). 2003 Sep; 95(3):1248-58.
  62. Randolph AG, Meert KL, O'Neil ME, Hanson JH, Luckett PM, Arnold JH, Gedeit RG, Cox PN, Roberts JS, Venkataraman ST, Forbes PW, Cheifetz IM. The feasibility of conducting clinical trials in infants and children with acute respiratory failure. Am J Respir Crit Care Med. 2003 May 15; 167(10):1334-40.
  63. Curley MAQ, Dodson BL, Arnold JH. Designing a Nurse-Implemented Sedation Algorithm for Use in a Pediatric Intensive Care Unit – A Preliminary Report. Ped Crit Care Med. 2003; 4:A158.
  64. Lee LK, Shannon M, Arnold JH. The use of high frequency oscillatory ventilation in hydrocarbon pneumonitis. Int J Med Toxicol. 2003; 6:6.
  65. Goins RA, Ascher D, Waecker N, Arnold J, Moorefield E. Comparison of fluconazole and nystatin oral suspensions for treatment of oral candidiasis in infants. Pediatr Infect Dis J. 2002 Dec; 21(12):1165-7.
  66. Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert KL, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial. JAMA. 2002 Nov 27; 288(20):2561-8.
  67. Arnold JH. To recruit or not derecruit: that is the question. Crit Care Med. 2002 Aug; 30(8):1925-7.
  68. Randolph AG, Venkataraman S, Gedeit R, Hanson J, Meert K, Luckett P, Arnold JH, Lilley M, Thompson J, Cheifetz I, Wetzel R, Cox P, Roberts J. Weaning critically ill children from ventilatory support: a randomized trial comparing two protocols to standard care. Am J Resp Crit Care Med. 2002; 165:A156.
  69. Brazelton TB, Watson KF, Murphy M, Al-Khadra E, Thompson JE, Arnold JH. Identification of optimal lung volume during high-frequency oscillatory ventilation using respiratory inductive plethysmography. Crit Care Med. 2001 Dec; 29(12):2349-59.
  70. Priebe GP, Arnold JH. High-frequency oscillatory ventilation in pediatric patients. Respir Care Clin N Am. 2001 Dec; 7(4):633-45.
  71. Arnold JH. Measurement of the alveolar deadspace: are we there yet? Crit Care Med. 2001 Jun; 29(6):1287-8.
  72. Doctor A, Price B, Bhargava N, DiCanzio J, Arnold JH. High-frequency oscillatory ventilation of the perfluorocarbon-filled lung: dose-response relationships in an animal model of acute lung injury. Crit Care Med. 2001 Apr; 29(4):847-54.
  73. Bateman ST, Doctor A, Price B, Murphy MA, Thompson JE, Zurakowski D, Taylor GA, Arnold JH. Optimizing intrapulmonary perfluorocarbon distribution: fluoroscopic comparison of mode of ventilation and body position. Crit Care Med. 2001 Mar; 29(3):601-8.
  74. Hardart GE, Hardart KM, Arnold JH. The effect of post-gestational age on the incidence of intracranial hemorrhage in premature infants treated with extracorporeal membrane oxygenation. Crit Care Med. 2001; 29:A140.
  75. Randolph AG, Venkataraman S, Hanson J, Luckett P, Gedeit R, Meert K, Wetzel R, Cheifetz I, Cox P, Roberts J, Lilley M, Thompson J, Arnold JH. Evaluation of a pediatric extubation readiness test. Crit Care Med. 2001; 29:A142.
  76. Arnold JH, Anas NG, Luckett P, Cheifetz IM, Reyes G, Newth CJ, Kocis KC, Heidemann SM, Hanson JH, Brogan TV, Bohn DJ. High-frequency oscillatory ventilation in pediatric respiratory failure: a multicenter experience. Crit Care Med. 2000 Dec; 28(12):3913-9.
  77. Arnold JH. High-frequency ventilation in the pediatric intensive care unit. Pediatr Crit Care Med. 2000 Oct; 1(2):93-9.
  78. Arnold JH. High-frequency oscillatory ventilation and partial liquid ventilation: liquid breathing to a different beat (frequency) Crit Care Med. 2000 Jul; 28(7):2660-2.
  79. Curley MA, Thompson JE, Arnold JH. The effects of early and repeated prone positioning in pediatric patients with acute lung injury. Chest. 2000 Jul; 118(1):156-63.
  80. Bateman ST, Arnold JH. Acute respiratory failure in children. Curr Opin Pediatr. 2000 Jun; 12(3):233-7.
  81. Arnold JH. Partial liquid breathing: are we headed in the right direction? Crit Care Med. 2000 May; 28(5):1675-6.
  82. Medalion B, Blackstone EH, Lytle BW, White J, Arnold JH, Cosgrove DM. Aortic valve replacement: is valve size important? J Thorac Cardiovasc Surg. 2000 May; 119(5):963-74.
  83. Arnold JH, Stenz RI, Grenier B, Thompson JE. Single-breath CO2 analysis as a predictor of lung volume change in a model of acute lung injury. Crit Care Med. 2000 Mar; 28(3):760-4.
  84. Arnold JH. Innovative methods of respiratory support in infants and children. Clinical Pediatric Anesthesia. 2000; 6:29-34.
  85. Bateman ST, Arnold JH. Acute respiratory failure: pediatrics. Curr Opin Pediatr. 2000; 12:233-7.
  86. Arnold JH. High frequency ventilation in the pediatric intensive care unit. Ped Crit Care Med 1:93-99, 2000. 2000; 1:93-9.
  87. Doctor A, Al-Khadra E, Tan P, Watson K, Thompson J, Arnold JH. Extended high frequency partial liquid ventilation in lung injury: gas exchange and lung injury scores. Am J Resp Crit Care Med. 2000; 161:A46.
  88. Brazelton TB, Watson KF, Thompson JE, Arnold JH. Identification of optimal lung volume during high frequency oscillatory ventilation using inductive plethysmography. Am J Resp Crit Care Med. 2000; 161:A47.
  89. Arnold JH. Volatile anesthetic use in the pediatric ICU. Clinical Pediatric Anesthesia 6: 41-42, 2000. 2000; 6:41-2.
  90. Curley MAQ, Thompson JE, Fackler JC, Arnold JH. Effect of prone positioning on clinical outcomes in pediatric patients with acute lung injury (ALI)/ARDS. Am J Resp Crit Care Med. 2000; 161:A81.
  91. Doctor A, Al-Khadra E, Watson K, Thompson J, Arnold JH.. Perfluorocarbon (PFC) vapor loss during high frequency ventilation: effect of intrapulmonary PFC distribution. Am J Resp Crit Care Med. 2000; 161:A46.
  92. Doctor A, Mazzoni MC, DelBalzo U, DiCanzio J, Arnold JH. High-frequency oscillatory ventilation of the perfluorocarbon-filled lung: preliminary results in an animal model of acute lung injury. Crit Care Med. 1999 Nov; 27(11):2500-7.
  93. Fackler J, Arnold J. When knowing is not understanding. Crit Care Med. 1999 Nov; 27(11):2598-9.
  94. Arnold JH. Partial liquid breathing: more questions than answers. Crit Care Med. 1999 Sep; 27(9):2058-60.
  95. Arnold JH. Surfactant replacement in acute lung injury--the saga continues. Crit Care Med. 1999 Jan; 27(1):31-2.
  96. Brazelton TB, Watson KF, Thompson JE, Arnold JH. . Bench validation of respiratory inductive plethysmography in determining the end expiratory lung volume during high frequency ventilation. Ped Res. 1999; 45:37A.
  97. Doctor A, Price B, Murphy M, Bhargava N, Thompson J, Arnold JH. High frequency partial liquid ventilation in lung injury: dose-response and frequency manipulation data. Am J Resp Crit Care Med. 1999; 159:A78.
  98. Goldstein B, Arnold JH (eds). . Pediatric Respiratory Failure. New Horizons: The Science and Practice of Acute Medicine. 1999; 7:275-439.
  99. Doctor A, Arnold JH. Mechanical support of acute lung injury: options for strategic ventilation. New Horizons. 1999; 7:359-373.
  100. Brazelton TB, Watson KF, Thompson JE, Arnold JH. Respiratory inductive plethysmography is stable during high frequency ventilation. Ped Res. 1999; 45:38A.
  101. Camerota AJ, Arnold JH. Anesthesia and analgesia, in Avery GB, Fletcher MA, MacDonald MG (eds.), Neonatology: Pathophysiology and Management of the Newborn (5th Edition), J.B. Lippincott, Philadelphia. 1999; 1447-59.
  102. Bateman ST, Doctor A, Price BW, Murphy MA, Bhargava N, Taylor G, Thompson, JE, Arnold JH. Fluoroscopic comparisons of intrapulmonary perfluorocarbon distribution: supine vs. prone position using either conventional or high frequency oscillatory ventilation. Am J Resp Crit Care Med. 1999; 159:A602.
  103. Curley MAQ, Thompson JE, Arnold JH. Effects of early and repeated prone positioning in pediatric patients with acute lung injury. Crit Care Med. 1999; 27:A125.
  104. Arnold JH. Taking the low (stretch) road. Chest. 1998 Oct; 114(4):955-7.
  105. Medalion B, Lytle BW, McCarthy PM, Stewart RW, Arheart KL, Arnold JH, Loop FD, Cosgrove DM. Aortic valve replacement for octogenarians: are small valves bad? Ann Thorac Surg. 1998 Sep; 66(3):699-705; discussion 705-6.
  106. Stenz RI, Grenier B, Thompson JE, Arnold JH. Single-breath CO2 analysis as a predictor of lung volume in a healthy animal model during controlled ventilation. Crit Care Med. 1998 Aug; 26(8):1409-13.
  107. Doctor A, Ibla JC, Grenier BM, Zurakowski D, Ferretti ML, Thompson JE, Lillehei CW, Arnold JH. Pulmonary blood flow distribution during partial liquid ventilation. J Appl Physiol (1985). 1998 May; 84(5):1540-50.
  108. Arnold JH. Liquid ventilation: recent concepts, in Salvo I, Vidysagar D (eds.), Anaesthesia and Intensive Care in Neonates and Children, Springer-Verlag, Milan. 1998; 243-51.
  109. Doctor A, Price B, Murphy M, Bhargava N, Thompson J, Arnold JH. High frequency partial liquid ventilation in lung injury: dose-response data. Ped Res. 1998; 43:35A.
  110. Arnold JH. High frequency ventilation. Respiratory Care. 1998; 43:961-65.
  111. Arnold JH, Fackler JC. Anesthetic principles and operating room anesthesia regimens, in Fuhrman BP, Zimmerman JJ (eds.), Pediatric Critical Care (2nd edition), C.V. Mosby, St. Louis. 1998; 1353-62.
  112. Arnold JH. High frequency ventilation, in Salvo I, Vidysagar D (eds.), Anaesthesia and Intensive Care in Neonates and Children, Springer-Verlag, Milan. 1998; 219-25.
  113. Bateman ST, Doctor A, Price BW, Murphy MA, Bhargava N, Taylor G, Thompson, JE, Arnold JH. Optimizing intrapulmonary perfluorocarbon: dosing method and mode of ventilation. Ped Res. 1998; 43:34A.
  114. Arnold JH, Stenz RI, Grenier B, Thompson JE, Arnold LW. Noninvasive determination of cardiac output in a model of acute lung injury. Crit Care Med. 1997 May; 25(5):864-8.
  115. Green TP, Fackler JC, Steinhart C, Bohn DJ, Heulitt MJ, Newth CJK, Hirschl RB, Nichols D, Klein MD, Martin L, Arnold JH, Ware J. Improved outcome for acute hypoxemic respiratory failure in children: interim results of a prospective, multi-institutional study from the PARF Study Group. Ped Res. 1997; 41:33A.
  116. Doctor A, Mazzoni M, DelBalzo U, Arnold J. Histopathology of acute lung injury: high frequency oscillation of the perfluorocarbon-filled lung. Ped Res. 1997; 41:32A.
  117. Doctor A, Mazzoni M, DelBalzo U, Arnold J. High frequency oscillation of the perfluorocarbon-filled lung: preliminary results in an animal model of acute lung injury. Ped Res 41: 32A, 1997. 1997; 41:32A.
  118. Arnold JH, Stenz RI, Thompson JE, Arnold LW. Noninvasive determination of cardiac output using single breath CO2 analysis. Crit Care Med. 1996 Oct; 24(10):1701-5.
  119. Ibla JC, Arnold JH, Thompson JE, Breuer CK, Benjamin PK, Lillehei CW. Effects of nitric oxide on hyperinflation-induced pulmonary hypertension in the isolated-perfused lung. Crit Care Med. 1996 Aug; 24(8):1388-95.
  120. Arnold JH. High frequency oscillatory ventilation: theory and practice in paediatric patients. Paediatr Anaesth. 1996; 6(6):437-41.
  121. Arnold JH. Liquid breathing: stretching the technological envelope. Crit Care Med. 1996 Jan; 24(1):4-6.
  122. Arnold JH, Thompson JE, Arnold LW. Single breath CO2 analysis: description and validation of a method. Crit Care Med. 1996 Jan; 24(1):96-102.
  123. Doctor A, Ibla J, Grenier B, Thompson J, Lillehei C, Arnold J. Redistribution of regional pulmonary blood flow during partial liquid ventilation. Ped Res. 1996; 39:46A.
  124. Arnold JH. High frequency oscillatory ventilation: theory and practice in pediatric patients. Paediatric Anesthesia. 1996; 6:437-41.
  125. Fackler JC, Arnold JH, Nichols D, Rogers MC. Acute Respiratory Failure Syndrome. In Rogers MC, (ed.), Textbook of Pediatric Intensive Care, 3rd Edition, Williams & Wilkins, Baltimore. 1996; 197-233.
  126. Arnold JH, Berde CB. Sedation in the intensive care unit, in Todres D, Fugate J (eds.), A Practice of Pediatric Intensive Care, Little, Brown and Co., Boston. 1996; 582-94.
  127. Arnold JH, Bower LK, Thompson JE. Respiratory deadspace measurements in neonates with congenital diaphragmatic hernia. Crit Care Med. 1995 Feb; 23(2):371-5.
  128. Arnold JH, Stenz R, Grenier B, Thompson JE, Arnold LW. Single breath CO2 analysis in an animal model of acute lung injury and pulmonary hypoperfusion. Anesthesiology. 1995; 83:A465.
  129. Arnold JH. Loughlin GM, Eigen H (eds.), Respiratory Disease in Children: Diagnosis and Management. Crit Care Med. 1995; 23:1795.
  130. Stenz R, Grenier B, Thompson JE, Arnold JH. Single breath CO2 analysis as a predictor of lung volume in a healthy animal model. Anesthesiology 83:A1221, 1995. 1995; 83:A1221.
  131. Ibla JC, Arnold JH, Thompson J, Breuer C, Benjamin P, Lillehei C. The effect of nitric oxide on overdistension induced pulmonary hypertension in an isolated perfused sheep lung model. Crit Care Med. 1995; 23:A216.
  132. Arnold JH, Hanson JH, Toro-Figuero LO, Gutiérrez J, Berens RJ, Anglin DL. Prospective, randomized comparison of high-frequency oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure. Crit Care Med. 1994 Oct; 22(10):1530-9.
  133. Lillehei CW, Shamberger RC, Mayer JE, Burke RP, Koka BV, Arnold J, Wessel DL, Lanzberg M, Palazzo R. Size disparity in pediatric lung transplantation. J Pediatr Surg. 1994 Aug; 29(8):1152-5; discussion 1155-6.
  134. Burns J, Arnold JH. Pediatric critical care. Curr Opin Pediatr. 1994 Jun; 6(3):295-302.
  135. Adatia I, Lillehei C, Arnold JH, Thompson JE, Palazzo R, Fackler JC, Wessel DL. Inhaled nitric oxide in the treatment of postoperative graft dysfunction after lung transplantation. Ann Thorac Surg. 1994 May; 57(5):1311-8.
  136. Anand KJ, Arnold JH. Opioid tolerance and dependence in infants and children. Crit Care Med. 1994 Feb; 22(2):334-42.
  137. Arnold JH, Anand KJS. Anesthesia and analgesia. in Avery GB, Fletcher MA, MacDonald MG (eds.), Neonatology: Pathophysiology and Management of the Newborn (4th Edition), J.B. Lippincott, Philadelphia. 1994; 1334-45.
  138. Burns J, Arnold JH. Current opinion in pediatrics: pediatric critical care. Current Science. 1994; 6:295-302.
  139. Arnold JH, Hanson JH, Pediatric HFOV Study Group. . Outcome of pediatric patients managed with high frequency oscillatory ventilation. Anesthesiology. 1994; 81:A269.
  140. Arnold JH, Thompson JE, Tabor T. Single breath CO2 analysis: bench validation in a lung model. Ped Res. 1994; 35:49A.
  141. Arnold JH, Arnold LW, Thompson JE, Tabor T. Single breath CO2 analysis in a model of pulmonary hypoperfusion. Ped Res. 1994; 35:48A.
  142. Arnold JH, Thompson JE, Benjamin PK. Respiratory deadspace measurements in neonates during extracorporeal membrane oxygenation. Crit Care Med. 1993 Dec; 21(12):1895-900.
  143. Arnold JH, Truog RD, Molengraft JA. Tolerance to isoflurane during prolonged administration. Anesthesiology. 1993 May; 78(5):985-8.
  144. Arnold JH, Truog RD, Rice SA. Prolonged administration of isoflurane to pediatric patients during mechanical ventilation. Anesth Analg. 1993 Mar; 76(3):520-6.
  145. Arnold JH, Truog RD, Thompson JE, Fackler JC. High-frequency oscillatory ventilation in pediatric respiratory failure. Crit Care Med. 1993 Feb; 21(2):272-8.
  146. Arnold JH, Benjamin PK, Thompson JE. Changes in dynamic lung compliance and VD/VT ratio during ECMO. Presented at the 8th Annual Children's Hospital National Medical Center ECMO Symposium. 1993.
  147. Waisel DB, Brunner JX, Arnold JH, Kohane I, Fackler JC. PEFIOS: A PEEP-FiO2-SpO2 closed loop controller of arterial oxygen saturation. Anesthesiology. 1993; 79:A287.
  148. Arnold JH, Hanson JH, Anglin DL. Prospective randomized comparison of high frequency oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure. Anesthesiology. 1993; 79:A1221.
  149. Teaching Video. "High frequency oscillatory ventilation in pediatric respiratory failure". 1993.
  150. Arnold JH, Truog RD, Rice SA. Prolonged administration of isoflurane to pediatric patients during mechanical ventilation. Presented at the 6th Annual Pediatric Critical Care Colloquium. 1993.
  151. Josephs LG, Arnold JH, Sawyers JL. Laparoscopic highly selective vagotomy. J Laparoendosc Surg. 1992 Jun; 2(3):151-3.
  152. Coltharp WH, Arnold JH, Alford WC, Burrus GR, Glassford DM, Lea JW, Petracek MR, Starkey TD, Stoney WS, Thomas CS, et al. Videothoracoscopy: improved technique and expanded indications. Ann Thorac Surg. 1992 May; 53(5):776-8; discussion 779.
  153. Truog RD, Arnold JH. The "ethics of evidence" and randomized controlled trials. J Clin Ethics. 1992; 3(1):65-7.
  154. Arnold JH, Fackler JC. Anesthetic principles and operating room anesthesia regimens. in Fuhrman BP, Zimmerman JJ (eds.), Pediatric Critical Care, C.V. Mosby, St. Louis. 1992; 1265-73.
  155. Arnold JH, Benjamin PK, Thompson JE. Changes in VD/VT in infants with pulmonary hypertension during extracorporeal membrane oxygenation (ECMO). Anesthesiology. 1992; 77:A240.
  156. Arnold JH, Truog RD. Sedation in neonatal and pediatric intensive care. Sedation in neonatal and pediatric intensive care, Journal of Intensive Care Medicine. 1992; 7:244-60.
  157. Arnold JH, Truog RD, Thompson JE, Fackler JC. High frequency oscillatory ventilation in pediatric respiratory failure. Presented at the 5th Annual Pediatric Critical Care Colloquium. 1992.
  158. Arnold JH, Benjamin PK, Thompson JE. Online measurement ofV CO2 during mechanical ventilation in infants. Anesthesiology. 1992; 77:A467.
  159. Arnold JH, Truog RD, Scavone JM, Fenton T. Changes in the pharmacodynamic response to fentanyl in neonates during continuous infusion. J Pediatr. 1991 Oct; 119(4):639-43.
  160. Truog RD, Arnold JH, Rockoff MA. Sedation before ventilator withdrawal: medical and ethical considerations. J Clin Ethics. 1991; 2(2):127-9.
  161. Arnold JH, Truog RD, Scavone JM. Fentanyl binding to the ECMO circuit: is the process saturable? Presented at the 7th Annual Children's Hospital National Medical Center ECMO Symposium. 1991.
  162. Arnold JH, Truog RD, Scavone JM. Plasma levels of midazolam during ECMO. Presented at the 7th Annual Children's Hospital National Medical Center ECMO Symposium. 1991.
  163. Arnold JH, Truog RD, Orav EJ, Scavone JM, Hershenson MB. Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation. Anesthesiology. 1990 Dec; 73(6):1136-40.
  164. Truog RD, Arnold JH, Fackler JC. ECMO: Ethical allocation of a scarce medical resource. Presented at the 6th Annual Children's Hospital National Medical Center ECMO Symposium. 1990.
  165. Kupsky WJ, Kinney HC, Arnold JH, Truog RD, Vacanti JP. Neuropathologic findings in 23 neonates treated with extracorporeal membrane oxygenation. Presented at the 6th Annual Children's Hospital National Medical Center ECMO Symposium. 1990.
  166. Truog RD, Arnold JH, Fackler JC. Scarce ICU resources and the obligation to limit therapy. Presented at the annual meeting of the American Academy of Pediatrics. 1990.
  167. Arnold JH, Truog RD. Sedation for infants undergoing extracorporeal membrane oxygenation. Presented at the 6th Annual Children's Hospital National Medical Center ECMO Symposium. 1990.
  168. Arnold JH, Truog RD. Rapid development of tolerance during fentanyl infusion. Anesthesiology. 1990; 73:A406.
  169. Arnold JH, Truog RD, Hershenson MB. Neonatal abstinence syndrome in infants sedated with fentanyl. Anesthesiology. 1989; 71:A218.
  170. Kupsky WJ, Kinney HC, Lidov HGW, Arnold JH, Truog R, Vacanti JP. Neuropathology of infants dying after extracorporeal membrane oxygenation. J Neuropathol Exp Neurol. 1989; 48:307.
  171. Arnold JH, Scott AV, Spitznagel JK. Specificity of PPD skin tests in childhood tuberculin converters: comparison with mycobacterial species from tissues and secretions. J Pediatr. 1970 Apr; 76(4):512-22.
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