"Working with families in the Inherited Cardiac Arrhythmia Program to define different aspects of inherited cardiac conditions is both an exciting challenge and incredible privilege. Each day brings new situations and different scenarios, but adopting a team approach to each different problem provides great satisfaction and will always be a unique and very humbling experience."

MEDIA

EDUCATION

Medical School

  • St. Mary's Hospital/Imperial College , London , UNITED KINGDOM

Internship

  • St. Mary's Hospital , London , UNITED KINGDOM

Graduate Degree

Pediatric
  • St. Mary’s, St. Thomas’, Northwick Park, Royal Brompton & Harefield Hospitals , London , UNITED KINGDOM

Fellowship

Cardiac Electrophysiology
  • Royal Brompton & Harefield, St. Bartholomew’s and The Heart/University College Hospitals , London , UNITED KINGDOM

My job as a cardiac electrophysiologist provides an amazing contrast between the varied world of human cardiac genetics and the myriad of different cardiac arrhythmias managed interventionally in the cardiac electrophysiology laboratory.

From the early days of my medical training, I have been fascinated by the complex relationship between human genetics and the associated clinical conditions - how one simple molecular change can lead to such wide ranging and varied conditions, and how understanding human genetics has helped unlock different biological pathways involved in inherited heart disorders. Working with families in the Inherited Cardiac Arrhythmia Program to define different aspects of inherited cardiac conditions is both an exciting challenge and incredible privilege.  Each day brings new situations and different scenarios, but adopting a team approach to each different problem provides great satisfaction and will always be a unique and very humbling experience.  

 

Equally challenging and satisfying, and yet requiring a complete different approach, is the interventional approach to arrhythmia management.  As a medical student watching a presentation of the treatment of a young patient with highly symptomatic Wolff-Parkinson-White syndrome, and seeing a picture of him on the summit of Mt. Kilimanjaro after a successful ablation was an inspirational and highly motivating experience.  To be able to eliminate symptoms in patients with arrhythmia allowing them to resume a normal quality of life remains as rewarding and satisfying today as performing my first ablation.   

PROFESSIONAL HISTORY

I received my medical education and post-graduate training in the United Kingdom, specializing in cardiology and electrophysiology.  My fellowships were in both pediatric and adult cardiology, and in 2007 I was appointed as a Consultant Cardiologist and Electrophysiologist at St. Bartholomew’s Hospital, the largest adult electrophysiology center in the UK, and also continued to perform pediatric electrophysiology at Great Ormond Street Hospital.  This dual appointment allowed for detailed evaluation of all family members with varying inherited cardiac condition, including ion channel disorders and cardiomyopathies.  In Boston we have developed a rapid access Inherited Cardiac Arrhythmia Program for all patients with a confirmed or suspected inherited/genetic component to their condition, which runs between Boston Children’s and Brigham & Women’s Hospitals allowing for continued clinical care within the family irrespective of age.  Patients are comprehensively investigated, including clinical and genetic diagnosis and risk stratification, and appropriate management strategies implemented, including cascade screening across extensive families.  We are currently developing a major collaboration with colleagues across New England.  

As an adult and pediatric electrophysiologist I also have extensive experience in the management of arrhythmias in the adult congenital population and this has been a major area of clinical and research activity.

CERTIFICATIONS

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Hernández-Madrid A, Paul T, Abrams D, Aziz PF, Blom NA, Chen J, Chessa M, Combes N, Dagres N, Diller G, Ernst S, Giamberti A, Hebe J, Janousek J, Kriebel T, Moltedo J, Moreno J, Peinado R, Pison L, Rosenthal E, Skinner JR, Zeppenfeld K. Arrhythmias in congenital heart disease: a position paper of the European Heart Rhythm Association (EHRA), Association for European Paediatric and Congenital Cardiology (AEPC), and the European Society of Cardiology (ESC) Working Group on Grown-up Congenital heart disease, endorsed by HRS, PACES, APHRS, and SOLAECE. Europace. 2018 Mar 20. View abstract
  2. Meziab O, Abrams DJ, Alexander ME, Bevilacqua L, Bezzerides V, Mah DY, Walsh EP, Triedman JK. Utility of incomplete right bundle branch block as an isolated ECG finding in children undergoing initial cardiac evaluation. Congenit Heart Dis. 2018 Feb 12. View abstract
  3. Baruteau AE, Abrams DJ, Ho SY, Thambo JB, McLeod CJ, Shah MJ. Cardiac Conduction System in Congenitally Corrected Transposition of the Great Arteries and Its Clinical Relevance. J Am Heart Assoc. 2017 Dec 21; 6(12). View abstract
  4. Hylind RJ, Ladouceur VB, Fynn-Thompson F, Hourigan SE, Bezzerides VJ, Abrams DJ. Genotype-phenotype-guided medical and surgical intervention in long QT syndrome. HeartRhythm Case Rep. 2018 Jan; 4(1):14-17. View abstract
  5. Cirino AL, Harris S, Lakdawala NK, Michels M, Olivotto I, Day SM, Abrams DJ, Charron P, Caleshu C, Semsarian C, Ingles J, Rakowski H, Judge DP, Ho CY. Role of Genetic Testing in Inherited Cardiovascular Disease: A Review. JAMA Cardiol. 2017 Oct 01; 2(10):1153-1160. View abstract
  6. Chambers KD, Beausejour Ladouceur V, Alexander ME, Hylind RJ, Bevilacqua L, Mah DY, Bezzerides V, Triedman JK, Walsh EP, Abrams DJ. Cardiac Events During Competitive, Recreational, and Daily Activities in Children and Adolescents With Long QT Syndrome. J Am Heart Assoc. 2017 Sep 21; 6(9). View abstract
  7. Sherwin ED, Abrams DJ. Ebstein Anomaly. Card Electrophysiol Clin. 2017 06; 9(2):245-254. View abstract
  8. Abrams DJ. How to develop a clinic for sudden cardiac arrest survivors and families of non-survivors. Cardiol Young. 2017 Jan; 27(S1):S3-S9. View abstract
  9. Mah DY, Shakti D, Gauvreau K, Colan SD, Alexander ME, Abrams DJ, Brown DW. Relation of Left Atrial Size to Atrial Fibrillation in Patients Aged =22 Years. Am J Cardiol. 2017 Jan 01; 119(1):52-56. View abstract
  10. Beauséjour Ladouceur V, Abrams DJ. Whole-Exome Molecular Autopsy After Exertional Sudden Cardiac Death: Not a Panacea but a Step in the Right Direction. Circ Cardiovasc Genet. 2016 Jun; 9(3):210-2. View abstract
  11. Ezzat VA, Ryan MJ, O'Leary J, Ariti C, Deanfield J, Pandya B, Cullen S, Walker F, Khan F, Abrams DJ, Lambiase PD, Lowe MD. Radiofrequency ablation of atrial tachyarrhythmias in adults with tetralogy of Fallot - predictors of success and outcome. Cardiol Young. 2017 Mar; 27(2):284-293. View abstract
  12. Philip Saul J, Kanter RJ, Abrams D, Asirvatham S, Bar-Cohen Y, Blaufox AD, Cannon B, Clark J, Dick M, Freter A, Kertesz NJ, Kirsh JA, Kugler J, LaPage M, McGowan FX, Miyake CY, Nathan A, Papagiannis J, Paul T, Pflaumer A, Skanes AC, Stevenson WG, Von Bergen N, Zimmerman F. PACES/HRS expert consensus statement on the use of catheter ablation in children and patients with congenital heart disease: Developed in partnership with the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American Academy of Pediatrics (AAP), the American Heart Association (AHA), and the Association for European Pediatric and Congenital Cardiology (AEPC). Heart Rhythm. 2016 06; 13(6):e251-89. View abstract
  13. De Ferrari GM, Dusi V, Spazzolini C, Bos JM, Abrams DJ, Berul CI, Crotti L, Eldar M, Kharlap M, Khoury A, Krahn AD, Leenhardt A, Moir CR, Odero A, Nordkamp LO, Paul T, I Noguer FR, Shkolnikova M, Till J, Wilde AA, Ackerman MJ, Schwartz PJ. Response to Letters Regarding Article, "Clinical Management of Catecholaminergic Polymorphic Ventricular Tachycardia: The Role of Left Cardiac Sympathetic Denervation". Circulation. 2016 Jan 26; 133(4):e366-7. View abstract
  14. Abrams DJ, Kirkby C, Page SP, Earley MJ, Nitiou D, Kelsell DP, Schilling RJ. Evolution of Electrocardiographic and Structural Features Over 3 Decades in Arrhythmogenic Cardiomyopathy. Circulation. 2015 Jun 23; 131(25):2233-5. View abstract
  15. De Ferrari GM, Dusi V, Spazzolini C, Bos JM, Abrams DJ, Berul CI, Crotti L, Davis AM, Eldar M, Kharlap M, Khoury A, Krahn AD, Leenhardt A, Moir CR, Odero A, Olde Nordkamp L, Paul T, Rosés I Noguer F, Shkolnikova M, Till J, Wilde AA, Ackerman MJ, Schwartz PJ. Clinical Management of Catecholaminergic Polymorphic Ventricular Tachycardia: The Role of Left Cardiac Sympathetic Denervation. Circulation. 2015 Jun 23; 131(25):2185-93. View abstract
  16. Correa R, Sherwin ED, Kovach J, Mah DY, Alexander ME, Cecchin F, Walsh EP, Triedman JK, Abrams DJ. Mechanism and ablation of arrhythmia following total cavopulmonary connection. Circ Arrhythm Electrophysiol. 2015 Apr; 8(2):318-25. View abstract
  17. DeWitt ES, Triedman JK, Cecchin F, Mah DY, Abrams DJ, Walsh EP, Gauvreau K, Alexander ME. Time dependence of risks and benefits in pediatric primary prevention implantable cardioverter-defibrillator therapy. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1057-63. View abstract
  18. DeWitt ES, Abrams DJ. Implantable cardioverter-defibrillators in children. Arch Dis Child. 2015 Mar; 100(3):265-70. View abstract
  19. Giudici V, Spanaki A, Hendry J, Mead-Regan S, Field E, Zuccotti GV, Abrams D, Lowe M, Kaski JP. Sudden arrhythmic death syndrome: diagnostic yield of comprehensive clinical evaluation of pediatric first-degree relatives. Pacing Clin Electrophysiol. 2014 Dec; 37(12):1681-5. View abstract
  20. Abrams DJ, Macrae CA. Long QT syndrome. Circulation. 2014 Apr 08; 129(14):1524-9. View abstract
  21. McMillan MR, Day TG, Bartsota M, Mead-Regan S, Bryant R, Mangat J, Abrams D, Lowe M, Kaski JP. Feasibility and outcomes of ajmaline provocation testing for Brugada syndrome in children in a specialist paediatric inherited cardiovascular diseases centre. Open Heart. 2014; 1(1):e000023. View abstract
  22. Correa R, Walsh EP, Alexander ME, Mah DY, Cecchin F, Abrams DJ, Triedman JK. Transbaffle mapping and ablation for atrial tachycardias after mustard, senning, or Fontan operations. J Am Heart Assoc. 2013 Sep 19; 2(5):e000325. View abstract
  23. Mah DY, Miyake CY, Sherwin ED, Walsh A, Anderson MJ, Western K, Abrams DJ, Alexander ME, Cecchin F, Walsh EP, Triedman JK. The use of an integrated electroanatomic mapping system and intracardiac echocardiography to reduce radiation exposure in children and young adults undergoing ablation of supraventricular tachycardia. Europace. 2014 Feb; 16(2):277-83. View abstract
  24. Mah DY, Alexander ME, Banka P, Abrams DJ, Triedman JK, Walsh EP, Fynn-Thompson F, Mayer JE, Cecchin F. The role of cardiac resynchronization therapy for arterial switch operations complicated by complete heart block. Ann Thorac Surg. 2013 Sep; 96(3):904-9. View abstract
  25. Brugada J, Blom N, Sarquella-Brugada G, Blomstrom-Lundqvist C, Deanfield J, Janousek J, Abrams D, Bauersfeld U, Brugada R, Drago F, de Groot N, Happonen JM, Hebe J, Yen Ho S, Marijon E, Paul T, Pfammatter JP, Rosenthal E. Pharmacological and non-pharmacological therapy for arrhythmias in the pediatric population: EHRA and AEPC-Arrhythmia Working Group joint consensus statement. Europace. 2013 Sep; 15(9):1337-82. View abstract
  26. Mah DY, Sherwin ED, Alexander ME, Cecchin F, Abrams DJ, Walsh EP, Triedman JK. The electrophysiological characteristics of accessory pathways in pediatric patients with intermittent preexcitation. Pacing Clin Electrophysiol. 2013 Sep; 36(9):1117-22. View abstract
  27. Sawhney V, Brouilette S, Abrams D, Schilling R, O'Brien B. Current genomics in cardiovascular medicine. Curr Genomics. 2012 Sep; 13(6):446-62. View abstract
  28. Page SP, Archbold A, Abrams DJ. Chest pain and ST elevation. BMJ. 2012 Jun 27; 344:e4323. View abstract
  29. Sherwin ED, Walsh EP, Abrams DJ. Variable QRS morphologies in Ebstein's anomaly: what is the mechanism? Heart Rhythm. 2013 Jun; 10(6):933-7. View abstract
  30. Cabral RM, Tattersall D, Patel V, McPhail GD, Hatzimasoura E, Abrams DJ, South AP, Kelsell DP. The DSPII splice variant is crucial for desmosome-mediated adhesion in HaCaT keratinocytes. J Cell Sci. 2012 Jun 15; 125(Pt 12):2853-61. View abstract
  31. Blaydon DC, Biancheri P, Di WL, Plagnol V, Cabral RM, Brooke MA, van Heel DA, Ruschendorf F, Toynbee M, Walne A, O'Toole EA, Martin JE, Lindley K, Vulliamy T, Abrams DJ, MacDonald TT, Harper JI, Kelsell DP. Inflammatory skin and bowel disease linked to ADAM17 deletion. N Engl J Med. 2011 Oct 20; 365(16):1502-8. View abstract
  32. Wren C, Vogel M, Lord S, Abrams D, Bourke J, Rees P, Rosenthal E. Accuracy of algorithms to predict accessory pathway location in children with Wolff-Parkinson-White syndrome. Heart. 2012 Feb; 98(3):202-6. View abstract
  33. Abrams D. Wherein lies children's intergroup bias? Egocentrism, social understanding, and social projection. Child Dev. 2011 Sep-Oct; 82(5):1579-93. View abstract
  34. Diab IG, Hunter RJ, Kamdar R, Berriman T, Duncan E, Richmond L, Baker V, Abrams D, Earley MJ, Sporton S, Schilling RJ. Does ventricular dyssynchrony on echocardiography predict response to cardiac resynchronisation therapy? A randomised controlled study. Heart. 2011 Sep; 97(17):1410-6. View abstract
  35. Page SP, Siddiqui MS, Finlay M, Hunter RJ, Abrams DJ, Dhinoja M, Earley MJ, Sporton SC, Schilling RJ. Catheter ablation for atrial fibrillation on uninterrupted warfarin: can it be done without echo guidance? J Cardiovasc Electrophysiol. 2011 Mar; 22(3):265-70. View abstract
  36. Abrams DJ, Perkin MA, Skinner JR. [Long QT syndrome]. Praxis (Bern 1994). 2010 Jul 07; 99(14):854-8. View abstract
  37. Cabral RM, Wan H, Cole CL, Abrams DJ, Kelsell DP, South AP. Identification and characterization of DSPIa, a novel isoform of human desmoplakin. Cell Tissue Res. 2010 Jul; 341(1):121-9. View abstract
  38. Abrams DJ, Perkin MA, Skinner JR. Long QT syndrome. BMJ. 2010 Jan 08; 340:b4815. View abstract
  39. Opel A, Murray S, Kamath N, Dhinoja M, Abrams D, Sporton S, Schilling R, Earley M. Cryoablation versus radiofrequency ablation for treatment of atrioventricular nodal reentrant tachycardia: cryoablation with 6-mm-tip catheters is still less effective than radiofrequency ablation. Heart Rhythm. 2010 Mar; 7(3):340-3. View abstract
  40. Hunter RJ, Diab I, Thomas G, Duncan E, Abrams D, Dhinoja M, Sporton S, Earley MJ, Schilling RJ. Validation of a classification system to grade fractionation in atrial fibrillation and correlation with automated detection systems. Europace. 2009 Dec; 11(12):1587-96. View abstract
  41. Finlay M, Sawhney V, Schilling R, Thomas G, Duncan E, Hunter R, Virdi G, Abrams D, Sporton S, Dhinoja M, Earley M. Uninterrupted warfarin for periprocedural anticoagulation in catheter ablation of typical atrial flutter: a safe and cost-effective strategy. J Cardiovasc Electrophysiol. 2010 Feb; 21(2):150-4. View abstract
  42. Kistler PM, Ho SY, Rajappan K, Morper M, Harris S, Abrams D, Sporton SC, Schilling RJ. Electrophysiologic and anatomic characterization of sites resistant to electrical isolation during circumferential pulmonary vein ablation for atrial fibrillation: a prospective study. J Cardiovasc Electrophysiol. 2007 Dec; 18(12):1282-8. View abstract
  43. Abrams DJ, Earley MJ, Sporton SC, Kistler PM, Gatzoulis MA, Mullen MJ, Till JA, Cullen S, Walker F, Lowe MD, Deanfield JE, Schilling RJ. Comparison of noncontact and electroanatomic mapping to identify scar and arrhythmia late after the Fontan procedure. Circulation. 2007 Apr 03; 115(13):1738-46. View abstract
  44. Abrams DJ. Invasive electrophysiology in paediatric and congenital heart disease. Heart. 2007 Mar; 93(3):383-91. View abstract
  45. Kistler PM, Rajappan K, Jahngir M, Earley MJ, Harris S, Abrams D, Gupta D, Liew R, Ellis S, Sporton SC, Schilling RJ. The impact of CT image integration into an electroanatomic mapping system on clinical outcomes of catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2006 Oct; 17(10):1093-101. View abstract
  46. Abrams DJ, Earley MJ, Sporton SC, Schilling RJ. Successful ablation of atrioventricular nodal reentry tachycardia following the atriopulmonary Fontan procedure. Europace. 2006 Oct; 8(10):907-10. View abstract
  47. Earley MJ, Abrams DJ, Sporton SC, Schilling RJ. Validation of the noncontact mapping system in the left atrium during permanent atrial fibrillation and sinus rhythm. J Am Coll Cardiol. 2006 Aug 01; 48(3):485-91. View abstract
  48. Earley MJ, Showkathali R, Alzetani M, Kistler PM, Gupta D, Abrams DJ, Horrocks JA, Harris SJ, Sporton SC, Schilling RJ. Radiofrequency ablation of arrhythmias guided by non-fluoroscopic catheter location: a prospective randomized trial. Eur Heart J. 2006 May; 27(10):1223-9. View abstract
  49. Kistler PM, Earley MJ, Harris S, Abrams D, Ellis S, Sporton SC, Schilling RJ. Validation of three-dimensional cardiac image integration: use of integrated CT image into electroanatomic mapping system to perform catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2006 Apr; 17(4):341-8. View abstract
  50. Abrams D, Rigby ML. Transhepatic pulmonary artery stenting via a short intravascular sheath following neonatal repair of truncus arteriosus. Catheter Cardiovasc Interv. 2005 Oct; 66(2):277-80. View abstract
  51. Abrams D, Schilling R. Mechanism and mapping of atrial arrhythmia in the modified Fontan circulation. Heart Rhythm. 2005 Oct; 2(10):1138-44. View abstract
  52. Earley MJ, Abrams DJ, Staniforth AD, Sporton SC, Schilling RJ. Catheter ablation of permanent atrial fibrillation: medium term results. Heart. 2006 Feb; 92(2):233-8. View abstract
  53. Abrams DJ, Kilner P, Till JA, Shore DF, Sethia B, Franklin RC, Magee AG. Prolapse of the antero-superior leaflet of the tricuspid valve secondary to congenital anomalies of the valvar and sub-valvar apparatus: a rare cause of severe tricuspid regurgitation. Cardiol Young. 2005 Aug; 15(4):417-21. View abstract
  54. Abrams DJ, Rigby ML, Daubeney PE. Images in cardiovascular medicine. Membranous pulmonary atresia treated by radiofrequency-assisted balloon pulmonary valvotomy. Circulation. 2003 Apr 22; 107(15):e98-9. View abstract
  55. Cotton DJ, Powderly WG, Feinberg J, Abrams DI, Chaisson RE, Wheat LJ, Finkelstein DM, Tallman V, Zimmer B, Berzon R, et al. Guidelines for the design and conduct of AIDS clinical trials. AIDS Clinical Trials Group. Clin Infect Dis. 1993 Jun; 16(6):816-22; discussion 823-4. View abstract
  56. Jacobson MA, Abrams DI, Volberding PA, Bacchetti P, Wilber J, Chaisson RE, Crowe S, Howard W, Moss A. Serum beta 2-microglobulin decreases in patients with AIDS or ARC treated with azidothymidine. J Infect Dis. 1989 Jun; 159(6):1029-36. View abstract