Tetralogy of Fallot (TOF) with Pulmonary Atresia Pediatric Research and Clinical Trials

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Contact the Heart Center

 In 1938, Children’s cardiac surgeon Robert Gross, MD, performed the world’s first successful surgery to correct a child’s heart defect. Since that time, we have gained recognition around the globe for our leadership in pediatric cardiology, and continue to make critical advances in the field. Two examples of our innovative approach are below.

Problem: Open heart surgery entails time in the hospital, discomfort, and some risk.

Innovative Solution: The Medtronic Melody Transcatheter Pulmonary Valve is a prosthetic valve that was developed to treat patients with congenital heart disease affecting the function of the pulmonary valve. The valve is implanted through a catheter procedure, rather than a more invasive open-heart surgical procedure. This makes the demands on your child's recovery much easier and far less intensive.

Cardiologists are Children’s were among the first to use this valve in its early developmental stage, and have extensive experience with it.

Like other prosthetic valves, the Melody Transcatheter Pulmonary Valve is likely to need replacement several times over the course of a patient's life due to wear and tear. However, since the Melody can be implanted through a catheter, there is minimal risk to the patient compared to valves that can only be implanted surgically.

Boston Children’s a world leader in pediatric research

Consistently ranked among the top pediatric hospitals in the United States, Boston Children’s is home to the world’s most extensive pediatric hospital research enterprise; and we partner with elite health care and biotech organizations around the globe. But as specialists in innovative, family-centered care, our physicians never forget that your child is precious, and not just a patient.

We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”
- Sandra L. Fenwick, President and CEO

Boston Children's Hospital 300 Longwood Avenue, Boston, MA 02115 617-355-6000 | 800-355-7944

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