Toxic epidermal necrolysis progresses fast, usually within three days. For this reason, treatment usually includes hospitalization, often in the burn unit. If a medication is causing the skin reaction, it is discontinued.

Treatment may include one, or several, of the following:

• isolation to prevent infection
• protective bandages
• intravenous fluid and electrolytes
• antibiotics
• intravenous immunoglobulin G (IVIG)