Moebius syndrome Pediatric Research and Clinical Trials

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Research & Innovation in Developmental Medicine

At Boston Children’s Hospital, our care is informed by our research, and our discoveries in the laboratory strengthen the care we provide at each child's bedside. Children’s scientific research program is one of the largest and most active of any pediatric hospital in the world.

In particular, our neurology and plastic and oral surgery researchers are yielding crucial insights into the causes and progression of disorders like Moebius syndrome, paving the way for promising new treatments.

Some of our latest research endeavors include:

Understanding how babies’ brains interpret facial emotions
Charles A. Nelson, PhD, research director of Boston Children’s Division of Developmental Medicine, is studying how babies and children process faces and facial emotion, using techniques that monitor electrical and metabolic activity in the brain.

How do genetics influence eye movement disorders?
Boston Children’s neurologist Elizabeth Engle, MD, and her team are exploring the genetic causes of the complex eye movement syndromes known as congenital cranial dysinnervation disorders.

Analyzing the genetics of misaligned eyes
Boston Children’s has initiated a large, ongoing study to determine the genetic basis for childhood strabismus. Because adult strabismus is often a condition that carries over from childhood, this research is highly pertinent to sufferers of adult strabismus, as well.

Clinical trials

Boston Children’s is known for pioneering some of the most effective diagnostic tools, therapies and preventive approaches in pediatric medicine. A significant part of our success comes from our commitment to research—and to advancing the frontiers of health care by conducting clinical trials.

Boston Children’s coordinates hundreds of clinical trials at any given time. Clinical trials are studies that may involve:

  • evaluating the effectiveness of a new drug therapy
  • testing a new diagnostic procedure or device
  • examining a new treatment method for a particular condition
  • taking a closer look at the causes and progression of specific diseases 

Boston Children’s is involved in several multi-site clinical trials and studies. While all patients must meet strict criteria in order to be eligible for a clinical trial, your child may be eligible to take part in a study. Before considering this option, you should be sure to:

  • consult with your child’s treating physician and treatment team
  • gather as much information as possible about the specific course of action outlined in the trial
  • do your own research about the latest breakthroughs relating to your child’s condition 

Taking part in a clinical trial at Boston Children’s is entirely voluntary. Our team will be sure to fully address any questions you may have, and you may remove your child from the medical study at any time. 

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Learn how Boston Children's is using stem cells in the fight against neurological disorders.

We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”
- Sandra L. Fenwick, President and CEO

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