Conditions + Treatments

Hydronephrosis Pediatric Research and Clinical Trials

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Contact the Department of Urology

  • 1-617-355-7796

In addition to leading the way in the use of robotic surgery, Boston Children’s Hospital is always working toward more effective treatments for children with urologic disorders. Our urology department has been conducting several projects that hold great promise for improving the lives of children with hydronephrosis.     

Finding the genetic markers of vesicoureteral reflux (VUR): One of the more common causes of hydronephrosis, VUR has long been difficult for physicians to manage. In addition, it has often been frustrating for parents because there is currently no way to detect which children are at risk.

To diagnose VUR, physicians must pass a catheter up the urinary tract into the bladder. Our researchers aim to replace that procedure with a simple genetic test. They also hope to offer a way to predict which children have VUR that will not resolve on its own.

Using proteins to target kidney obstruction: A team led by Richard Lee, MD, is studying proteins in the urine to identify illnesses at an earlier age. Specifically, the team hopes to be able to predict risk for VUR. Another goal is to detect changes in the bladder tissue that may tell whether a child’s hydronephrosis is getting worse.


Boston Children’s is so much more than a hospital—it’s a community of researchers, clinicians, administrators, support staff, innovators, teachers, patients and families, all working together to make the impossible possible. ”
- Sandra L. Fenwick, President and CEO

Boston Children's Hospital
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