Hepatocellular Carcinoma Pediatric Research and Clinical Trials

What is the latest research on hepatoblastoma?

Dana-Farber/Boston Children’s Cancer and Blood Disorders Center are conductsing numerous research studies that will help clinicians better understand and treat cancers, such as hepatocellular carcinoma.

We participate in the current treatment protocols of the national Pediatric Oncology Group/Children's Oncology Group.

Other types of treatments currently being studied include:

  • Biological therapies — A a wide range of substances that may be able to involve the body's own immune system to fight cancer or lessen harmful side effects of some treatments

  • New ways of delivering chemotherapy — Researchers are studying new delivery strategies,  such as putting chemotherapy directly into the liver

  • Cryotherapy — Surgeons are studying new ways of using this existing treatment, — which uses extreme cold to destroy unwanted tissue — for liver cancer.

For an overview of cancer-related treatment and research at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, click here.

Treating hepatitis in children

As discussed above a hepatitis B infection in childhood makes your child more susceptible to hepatocellular tumors.

Maureen M. Jonas, MD, medical director of the Children’s Liver Transplant Program, has led research focused on liver disease in children with emphasis on viral hepatitis.

She was the principal investigator in several international trials where to test drugs that that are effective in treating adults with chronic hepatitis B were ontested in children.

Dr. Jonas's work has been published in the New England Journal of Medicine, Hepatology, Pediatric Infectious Disease Journal and other major medical journals.