Epilepsy in Children | Diagnosis & Treatment

How is epilepsy diagnosed?

Many conditions other than epilepsy — such as stroke, fainting, problems with heartbeat or breath-holding spells — can cause symptoms that sometimes look like seizures. If you think your child has epilepsy, a neurologist will review your child’s medical history, perform a complete physical exam and may order some testing.

The main test used to diagnose epilepsy is an electroencephalogram (EEG), which measures electrical activity in the brain. A high-definition EEG allows clinicians to get a more detailed picture of your child’s brain activity.

Your child’s neurologist may also refer your child for other testing, which may include:

  • imaging tests, such as a MRI, PET or SPECT
  • MEG (magnetoencephalography)
  • TMS (transcranial magnetic stimulation)

These tests help the neurologist diagnose which of the two main types of epilepsy your child has. A child with focal onset (previously known as partial) epilepsy has seizures that have onset on one side of the brain. Children with generalized epilepsy have seizures that appear to begin over both sides of the brain.

While diagnosing the epilepsy itself, physicians will also watch for related problems, such as learning or behavior difficulties or depression. Neuropsychologists can conduct specialized testing to monitor your child’s cognitive abilities, learning, behavior, emotional well-being and social function. This will help in developing strategies so your child can function at the highest possible level.

How is epilepsy treated?

Epilepsy is a complex condition that affects each child in a different way. This means there’s no one treatment that works for every child with epilepsy. Common therapeutic approaches include medication, surgery and dietary changes.

Epilepsy medications

Medication remains the first line of treatment for epilepsy. There are many types of medications to treat seizures, including newer medications that have been developed over the past few decades. This gives your child’s doctor many options for treating seizures when traditional first-line medications don’t work.

Findings from recent research can help doctors further individualize medical treatment to help control seizures. Possible options include:

  • Chronotherapy: This approach involves carefully timing treatment to when seizures most often happen. It can often help medications work more effectively to control seizures.
  • Genetically tailored treatments: The Boston Children’s Epilepsy Genetics Program uses DNA sequencing to discover previously unknown genetic causes of seizures. Some of these disrupt brain biochemistry in a way that can be targeted with drugs.
  • Pharmacogenomics: Genetic differences in metabolism appear to affect children’s responses to medications. This information helps doctors choose the optimal treatment for each child.

Diet therapy

Diet therapy can sometimes be a good option for childhood epilepsy when medications don’t control seizures or cause intolerable side effects. It can be especially helpful for certain types of epilepsy, such as myoclonic astatic epilepsy (Doose syndrome).

A number of different diets can be used for epilepsy. These include the Classic Ketogenic Diet, the Modified Atkins Diet, the Medium Chain Triglyceride Diet and the Low Glycemic Index Treatment Diet. Which diet is best for your child will depend on the epilepsy diagnosis, your child’s age and eating habits, and family needs and preferences. It is possible and sometimes helpful to transition between the various diets.

Diet therapy takes a strong commitment, but it may offer children a better chance of seizure control than trying a new medication. Because there isn’t yet a good way to tell exactly how a child will respond to diet therapy, a trial of three to four months is usually recommended.

The ketogenic diet

The ketogenic diet has been shown to be effective for many children with epilepsy when drugs fail. It can provide control of seizures for about 30 percent of children with epilepsy.

In its strictest form, the ketogenic diet provides more than 90 percent of its calories through fat (compared to the 25 to 40 percent usually recommended for children). When the body burns fat for energy, rather than glucose from carbohydrates, it produces compounds known as ketone bodies. The increase in ketones is called ketosis. Experts believe ketosis reduces seizure activity in the brain, although exactly how this works is still unknown.

Though the diet is challenging, it’s easier than it used to be. As interest in the diet has increased, “keto-friendly” products have become more widely available. These include coconut oil, low-carbohydrate noodles, sugar-free syrups and flavorings, and nut flours.

The ketogenic diet is highly precise and restrictive. Because it can cause side effects, it should only be started under medical supervision. Before starting on the ketogenic diet, clinicians will assess your child’s nutritional status, diet preferences and calorie needs. If the diet seems like it will be feasible for your family, they will customize it to your child to achieve the best seizure control while meeting daily energy and nutrient needs. In some cases your child may start the diet while in the hospital. Special ketogenic formulas are available for infants or children who need to be fed though a tube.

Because ketogenic diets are not nutritionally balanced, children will need to take vitamin and mineral supplements. Clinicians will also need to check your child’s ketone levels periodically and may need to change the diet to maintain ketosis.

Children usually stay on the diet for about two years. At that point, your child will slowly transition back to a regular diet, and some children are able to remain seizure-free.

Noninvasive brain stimulation

This approach, also known as neuromodulation, is beginning to be tested as a treatment for drug-resistant epilepsy that cannot be effectively or safely treated with surgery. It applies a magnet or small electrical currents to the scalp, changing brain excitability. There are two main types of brain stimulation:

  • Transcranial magnetic stimulation (TMS) involves placing a magnet over a child’s scalp. The magnet generates a powerful, fluctuating magnetic field that induces small electrical currents in the brain that reduce brain excitability. Two TMS devices are FDA-approved for adults with major depression and another for the treatment of migraine. While there is no FDA-approved TMS treatment for children, a TMS device that helps identify motor and speech cortical areas before brain surgery is approved for all ages. In addition, TMS is now being studied at Boston Children’s Hospital as a treatment for certain types of epilepsy.
  • Transcranial direct-current stimulation (tDCS) applies a weak, direct current to the brain via scalp electrodes to decrease firing in selected areas. Though tDCS is currently not FDA-approved, a growing number of studies support its use in pain suppression, certain psychiatric disorders, and stroke.

Surgery

When seizures don’t respond to medication or other treatments, your child’s doctor may recommend an evaluation to see if surgery is an option. Surgical evaluations are done in the hospital over five to seven days. During this time, clinicians will study your child’s seizures and learn exactly what area of the brain they are coming from. If surgery is an option for your child, the care team will discuss what type of surgery they recommend. These may include:

  • Focal resection: If the care team can pinpoint the “focal point” — the specific area of your child's brain that is over-firing and causing the seizures — your child may be able to have surgery to remove the abnormal brain tissue without harming neighboring brain areas. This procedure, called “resective” surgery, can often stop the seizures entirely, and most children function normally afterward.
  • Corpus callosotomy: This procedure involves cutting the major fibers that connect the two halves (hemispheres) of the brain. This cuts off communication between the two hemispheres and can prevent seizures from spreading from one side of your child's brain to the other. Corpus callosotomy is particularly effective for children who experience severe “drop attacks” in which they lose consciousness. The seizures won’t usually go away, but in most cases they become milder and less disabling. Corpus callosotomy occasionally produces problems with behavior, cognition or motor function.
  • Hemispherectomy: A hemispherectomy involves removing or disabling one half (hemisphere) of the brain. This procedure may be used if seizures are coming from a broad area of a single hemisphere. It is only recommended for very severe epilepsy that has not responded to medications and other less aggressive surgeries. It can cause serious side effects, including motor and language skill loss, which must be weighed against the severity of the epilepsy symptoms themselves. When used appropriately, hemispherectomy can be extremely rewarding.
  • Vagus nerve stimulation: If your child’s seizures are not controlled by medication or diet, and if brain surgery cannot be done safely, vagus nerve stimulation (VNS) may be an option. For VNS, the surgeon implants a small stimulator (much like a heart pacemaker) under the skin below the left collarbone or into the armpit area. Small wires attached to the stimulator deliver small pulses of electricity to the vagus nerve, one of the major nerves running along the neck to the brain. The device is then set to stimulate the nerve at regular intervals, such as 30 seconds every five minutes; a neurologist will fine-tune the settings during follow-up visits. Seizures usually don’t go away completely with VNS, but most children see a reduction in their number and severity. Many are able to reduce their medications, giving them greater flexibility and confidence.

Experimental treatments

If your child's seizures are not well managed by existing therapies, your care team may recommend enrolling in a clinical trial of a new drug or other experimental treatment. Being in a study sometimes means that your child has a 50-50 chance of receiving the new treatment, at least in the beginning. Each study has different ground rules, so it’s worth inquiring.