Delayed Puberty / Delayed Sexual Development Pediatric Research and Clinical Trials

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At Children’s Hospital Boston, we’re known for our science-driven approach. In fact, we’re home to the world's most extensive pediatric hospital research enterprise; and we partner with elite health care and biotech organizations around the globe. But as specialists in innovative, family-centered care, our physicians never forget that your child is precious, and not just a patient.

Our Division of Endocrinology operates one of the nation's most extensive research programs focused on pediatric endocrine disorders. With more than 50 basic science and clinical researchers, we are attempting to unravel the genetic and biochemical underpinnings of the endocrine system.

Researcher Yee-Ming Chan, MD, PhD is studying kisspeptin, a hormone that’s thought to be involved in stimulating pubertal development. Understanding kisspeptin and the search for other factors that control the onset of puberty will allow doctors to answer basic questions about the control of puberty as well as develop better methods of diagnosis and treatment.
Diane Stafford, MD, and several of her Children’s colleagues are currently working on a study to definitively diagnose who is in puberty and who isn’t by using something called leuprolide stimulation testing. Their research involves analyzing test data from patients they’ve followed over the years and comparing who has progressed into puberty and who has proven to be “a false positive” and did not progress into puberty. The results could provide much-needed insight into which patients require treatment for precocious puberty and which do not.

We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”
- Sandra L. Fenwick, President and CEO

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