Delayed Puberty / Delayed Sexual Development Pediatric Research and Clinical Trials

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At Children’s Hospital Boston, we’re known for our science-driven approach. In fact, we’re home to the world's most extensive pediatric hospital research enterprise; and we partner with elite health care and biotech organizations around the globe. But as specialists in innovative, family-centered care, our physicians never forget that your child is precious, and not just a patient.

Our Division of Endocrinology operates one of the nation's most extensive research programs focused on pediatric endocrine disorders. With more than 50 basic science and clinical researchers, we are attempting to unravel the genetic and biochemical underpinnings of the endocrine system.

Researcher Yee-Ming Chan, MD, PhD is studying kisspeptin, a hormone that’s thought to be involved in stimulating pubertal development. Understanding kisspeptin and the search for other factors that control the onset of puberty will allow doctors to answer basic questions about the control of puberty as well as develop better methods of diagnosis and treatment.
Diane Stafford, MD, and several of her Children’s colleagues are currently working on a study to definitively diagnose who is in puberty and who isn’t by using something called leuprolide stimulation testing. Their research involves analyzing test data from patients they’ve followed over the years and comparing who has progressed into puberty and who has proven to be “a false positive” and did not progress into puberty. The results could provide much-needed insight into which patients require treatment for precocious puberty and which do not.

Boston Children’s is so much more than a hospital—it’s a community of researchers, clinicians, administrators, support staff, innovators, teachers, patients and families, all working together to make the impossible possible. ”
- Sandra L. Fenwick, President and CEO

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