Brain arteriovenous malformations pediatric research and clinical trials

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Contact the Cerebrovascular Surgery and Interventions Center

The Cerebrovascular Surgery and Interventions Center conducts ongoing research to improve diagnostic and therapeutic approaches to brain AVMs and other forms of cerebrovascular disease (CVD). Our clinical research is complemented by basic science discoveries in the Vascular Biology Program

Your child’s brain model is ready

Turning to 3D printing technology, the Center has begun creating plastic models that faithfully reproduce the brain anatomy of patients with CVD. These models, using data from the child’s brain scans, help our surgeons and neurointerventionalists plan and “walk through” procedures ahead of time.

CVD biomarkers

Neurosurgeon Edward Smith, MD, is beginning to identify telltale proteins in the urine of patients with brain AVMs and other cerebrovascular disorders. These “biomarkers” may help in diagnosing and monitoring AVMs, reducing families’ need to travel to Boston Children’s for follow-up imaging studies. Dr. Smith has already validated the utility of urine biomarkers of several kinds of brain tumors. Read more.

Refining catheter procedures

A variety of novel techniques developed and trialed here have allowed safe use of catheters and endovascular devices in infants’ tiny vessels. We also successfully adopted Onyx, an improved material used in catheter embolization procedures in adults, to treat cerebral and spinal AVMs and other CVD conditions in children. We have an unparalleled safety record in treating children with this condition.

Reducing brain hemorrhage

Advances in understanding the risk for brain hemorrhage in children with AVMs have helped us select the best treatment options.

CVD Dynamic Database

Our comprehensive patient database, representing the largest experience with pediatric CVD disease in the world, provides rich source material for ongoing studies, innovation and quality improvement. The database allows us to track long-term outcomes of children with brain AVMs, compare the results of different procedures and evaluate newly adopted interventions.

See some of our published papers on brain AVMs.

We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”
- Sandra L. Fenwick, President and CEO

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