Arterial Ischemic Stroke Research and Innovation in Children

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Research on Arterial Ischemic Stroke from Boston Children's Hospital

The Stroke and Cerebrovascular Center and Cerebrovascular and Interventions Center at Boston Children’s Hospital conduct ongoing research to improve the care of children with arterial ischemic stroke and its complications. Our initiatives include:

  • Clot-busting treatment: Boston Children’s was part of the five-year Thrombolysis In Pediatric Stroke (TIPS) Study, which investigated the use of intravenous tissue plasminogen activator (tPA) for children with acute ischemic stroke. The results provide important clinical guidelines for tPA use and highlight the need for more pediatric stroke centers. Read more.
  • Reducing radiation exposure: New techniques have dramatically improved safety during diagnostic imaging and neurointerventions for stroke. We have demonstrated that it is possible to achieve high-quality imaging at low radiation doses.
  • Stroke imaging: Michael Rivkin, MD, and Amy Danehy, MD, in the Stroke and Cerebrovascular Center are investigating non-invasive perfusion magnetic resonance imaging (pMRI) as a method to look at the brain's blood supply and circulation in newborns and older children who are having or have had an arterial or venous stroke. pMRI avoids the need to inject dye to image the blood vessels, does not require an IV and poses no risk of damaging a blood vessel.
  • Cognitive outcomes after stroke in childhood: Christine Mrakotsky, PhD, in the Stroke and Cerebrovascular Center is studying children with extensive neuropsychological evaluations to determine the ways in which stroke affects children’s developing cognition.
  • International Pediatric Stroke Study: Led at Boston Children’s by Michael Rivkin, MD, Laura Lehman, MD, and Cameron Trenor, MD, this study is collecting standardized data on the diagnosis, treatment and outcome of newborns and older children with stroke. The data are being shared in a repository with clinicians around the world.
Boston Children’s is so much more than a hospital—it’s a community of researchers, clinicians, administrators, support staff, innovators, teachers, patients and families, all working together to make the impossible possible. ”
- Sandra L. Fenwick, President and CEO

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