Childen's Hospital Boston  300 Longwood Avenue
Boston, MA 02115
(617) 355-6000
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Clinical Services (Pulmonary Vein Stenosis Program):
About Pulmonary Vein Stenosis
Pulmonary vein stenosis is a condition in which there is an obstruction (blockage) in the blood vessels that bring oxygen-rich blood from the lungs back to the heart. Stenosis occurs due to an abnormal process that thickens and narrows the walls in the veins. Pulmonary vein stenosis frequently progresses. As a result, total obstruction or partial loss of flow to a vessel or vessels may occur.

This condition may occur as a complicating feature of complex congenital heart disease, but it may also occur in infants with otherwise normal hearts. When pulmonary vein stenosis occurs in children without congenital heart defects, it occurs in early infancy and usually progresses very rapidly. Infants with this disease may seem well for weeks before they develop difficulty breathing and low oxygen levels. They may become quite ill quickly. The effects of the disease vary in children with co-existing congenital heart defects.

Causes
Progressive pulmonary vein stenosis is thought to result from the uncontrolled growth of connective tissue cells, which causes the blockage in the pulmonary veins. The cells are thought to be myofibroblast-like. These cells are normally in our bodies and function in wound healing.

The cells are also known to grow abnormally in several different disease processes in both children and adults. It appears that this cell type plays a role in the development of pulmonary vein stenosis. Current treatment focuses upon removal of the obstruction and prevention of progression and recurrence of this abnormal cell growth.

Symptoms
  • shortness of breath, rapid breathing
  • fatigue
  • poor feeding
  • paleness or cyanosis
  • fast heartbeat
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Pulmonary vein affected by vein stenosis
Pulmonary vein affected by vein stenosis
Normal Pulmonary Vein
Normal Pulmonary Vein
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