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The Dana-Farber Cancer Institute and Children's Hospital Boston are currently conducting a research study in patients who have multi-vessel (greater than two vessels) pulmonary vein stenosis. The purpose of this study is to determine the effectiveness of using two standard chemotherapy medications to treat patients with pulmonary vein stenosis.
The study involves treatment with vinblastine and methotrexate, two medications used safely for decades to treat childhood tumors. Multi-vessel pulmonary vein stenosis is not thought to be a tumor, but it does share a common feature with tumors: the unwanted growth of cells.
These medications are given through a long-term intravenous line. They have a low side-effect profile and have been well tolerated in infants, children and adults. The goal of treatment is to stabilize the process to improve life expectancy and the overall quality of life. The ongoing trial involves weekly treatment for one year, and often can be coordinated close to a patient's home area.
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